Machine Learning Can Make Lab Testing More Precise
An analysis of over 2 billion lab test results suggests a deep learning model can help create personalized reference ranges, which in turn would enable clinicians to monitor health and disease better.Paul Cerrato, MA, senior research analyst and communications specialist, Mayo Clinic Platform and John Halamka, M.D., president, Mayo Clinic Platform, wrote this article.Almost every patient has blood drawn to measure a variety of metabolic markers. Typically, test results come back as a numeric or text value accompanied by a reference range which represents normal values. If total serum cholesterol level is below 200 mg/dl or...
Source: Life as a Healthcare CIO - October 21, 2021 Category: Information Technology Source Type: blogs
A 52 year old female with chest pain
Written by Pendell Meyers, edits by Steve SmithA 52 year old female with history of hypothyroidism and smoking presented to the ED with an episode of chest pain that began suddenly around 1500 while sitting down at work. She states it felt like a central chest pressure that radiated to her jaw. The pain had been persistently present since since 1500 (seen at 1615 in the ED), but had waxed and waned in severity, with the initial onset of pain being the worst. She had dyspnea and diaphoresis when the pain began. Coworkers called EMS who administered aspirin and NTG, which the patient says did not relieve her pain. During ini...
Source: Dr. Smith's ECG Blog - August 16, 2021 Category: Cardiology Authors: Pendell Source Type: blogs
Fight Aging! Newsletter, March 29th 2021
Discussion of Systemic Inflammation and its Contribution to Dementia
Fisetin Reduces D-Galactose Induced Cognitive Loss in Mice
Reprogramming Cancer Cells into Normal Somatic Cells
Considering Longevity Medicine and the Education of Physicians
Researchers Generate Thyroid Organoids Capable of Restoring Function in Mice
In Search of Transcriptional Signatures of Aging
A Pace of Aging Biomarker Correlates with Manifestations of Aging
Targeting Tissues with Extracellular Vesicles
Calorie Restriction Slows Aging of the Gut Microbiome in Mice
Mitochondrial DNA Heteroplasmy in the Aging Heart
Evidence...
Source: Fight Aging! - March 28, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Researchers Generate Thyroid Organoids Capable of Restoring Function in Mice
When building functional organ tissue from the starting point of pluripotent stem cells, a different recipe is required for each different tissue type. Good progress is being made in establishing these recipes, and over the past decade the research community has steadily expanded the number of organs for which tissue engineered organoids can be constructed. An organoid is a millimeter-scale segment of functional organ tissue, only lacking the blood vessel network needed to support larger structures. Organoids are very useful in research, but in many cases can also be used to restore lost organ function when transplanted in...
Source: Fight Aging! - March 22, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
February 2021: Clinical Presentation Provides Clue to Toxicity
A 43-year-old man with a history of bipolar disorder, hypertension, and asthma presented with altered mental status and a tremor. He reported increasing fatigue and hand tremors for one day. He said he and his family recently had food poisoning with vomiting and diarrhea for several days. Those symptoms had resolved. He continued to take all of his prescribed medications, which included lithium carbonate (Lithobid) 800 mg BID and amlodipine 10 mg daily.His initial vital signs were a heart rate of 104 bpm, a blood pressure of 136/82 mm Hg, a respiratory rate of 16 bpm, an oxygen saturation of 99% on room air, and a temperat...
Source: The Tox Cave - January 29, 2021 Category: Emergency Medicine Tags: Blog Posts Source Type: blogs
Sarah ’ s Wheat Belly health and life transformation
Sarah’s story reminds us how the simple matter of diet can shape our lives for decades, affecting energy, body weight, emotional health–just about every aspect of our physical and social lives before we finally stumble on the right answers. After many years of struggling with poor health, relying on prescription medications that never addressed underlying causes, it therefore came as a surprise to Sarah that she could indeed achieve magnificent health without the drugs by simply following the diet programmed into human genetic code and supplementing nutrients that are deficient in modern life.
...
Source: Wheat Belly Blog - January 28, 2021 Category: Cardiology Authors: Dr. Davis Tags: Open grain-free Inflammation joint pain wheat belly Source Type: blogs
Treating mild hypothyroidism: Benefits still uncertain
Your thyroid, a tiny, butterfly-shaped gland located in front of your windpipe (trachea) and below your voice box (larynx) can have a profound impact on your health and well-being. Throughout life, your thyroid is constantly producing hormones that influence your metabolism. These hormones affect your mood, energy, body temperature, weight, heart, and more.
A brief overview of hypothyroidism
Your thyroid produces two kinds of thyroid hormones: T4, or thyroxine, and T3, or triiodothyronine. These hormones influence every cell, tissue, and organ in your body, from your muscles, bones, and skin to your digestive tract, brain,...
Source: Harvard Health Blog - September 28, 2020 Category: Consumer Health News Authors: Jeffrey Garber, MD, FACP, MACE Tags: Drugs and Supplements Heart Health Thyroid Disorders Source Type: blogs
General examination – hands and feet
General examination – hands and feet
Cyanosis and pallor can be noted in the tips of the digits in both central and peripheral cyanosis. Severe jaundice may be visible in the palms and soles, especially in small infants.
Clubbing of digits may be noted in cyanotic heart diseases as well many other non cardiac conditions. In clubbing, initially there is fluctuation of nail bed (Grade 1) followed by obliteration of angle between nail and adjacent skin fold (Lovibond angle – Grade 2). Later there is curvature of the nails (parrot beaking – Grade 3). Grade 4 or hypertrophic osteoarthropathy is not common in cardiova...
Source: Cardiophile MD - September 22, 2020 Category: Cardiology Authors: Prof. Dr. Johnson Francis Tags: HBC Heberden’s nodes Janeway lesions Lovibond angle Osler’s nodes Pitting edema Polydactyly Source Type: blogs
Insulin Resistance: the silent killer that you can completely reverse – even if your doctor doesn ’ t know how
You may have already heard the term “insulin resistance,” as it has been widely discussed by doctors and the media. But did you know that you can reduce or reverse it in the vast majority of people?
Insulin resistance, i.e., the inability of the body’s cells, especially liver, muscle, and brain, to respond to insulin and allow blood sugar to enter cells, drives numerous abnormal health conditions including type 2 diabetes, hypertension, coronary heart disease, fatty liver, Alzheimer’s dementia, and cancer. It is therefore a driving force behind so many modern and common chronic health conditions.
Yo...
Source: Wheat Belly Blog - March 12, 2020 Category: Cardiology Authors: Dr. Davis Tags: Open can belly fat can insulin resistance be reversed lose weight reduce belly fat reverse inflammation visceral fat wheat belly Source Type: blogs
Ride the Fluid Wave Before Performing a Paracentesis
Before you break out the bottles for a paracentesis, you may want to consider doing a test for ascites. Many procedures require executing an old-school test before even looking at a result or grabbing an ultrasound machine. Knowing what to look for on a physical exam may guide your practice and intervention dramatically. Using noninvasive tools first could help your patient avoid other tedious or unnecessary testing, which may also result in lost time. Incorporating ultrasound into your practice may also help you nail a diagnosis or allow you to perform a procedure better than you expected.A markedly distended abdomen d...
Source: The Procedural Pause - January 2, 2020 Category: Emergency Medicine Tags: Blog Posts Source Type: blogs
“ Wheat Belly hit like a bomb ” : Author Dana Carpender reviews the Revised & Expanded Edition of Wheat Belly
Dana Carpender, friend and author of many low-carb cookbooks, provided this review of my new Revised & Expanded Wheat Belly, below.
For more of Dana’s signature wit and conversation, you can join her on her engaging Facebook page “Hold the toast press” or visit her Amazon page that lists all her wonderful low-carb cookbooks.
It’s funny how things happen. Nine years ago I had already been eating a low carbohydrate diet for 16 years. During that time I had occasionally eaten low carb tortillas and low carb bread. These things were hardly a staple of my diet, but I kept ’em around for the oc...
Source: Wheat Belly Blog - December 8, 2019 Category: Cardiology Authors: Dr. Davis Tags: Open autoimmune joint pain wheat belly Source Type: blogs
Do not become iodine toxic
The post Do not become iodine toxic appeared first on Dr. William Davis. (Source: Wheat Belly Blog)
Source: Wheat Belly Blog - November 8, 2019 Category: Cardiology Authors: Dr. Davis Tags: Wheat Belly Lifestyle hypothyroid iodine Source Type: blogs
Is there a role for surgery in treating Hashimoto ’s thyroiditis?
This study raises the possibility of a role for surgery for patients with Hashimoto’s thyroiditis who continue to feel poorly despite optimal treatment with thyroid hormone.
However, the study, while well done, is a relatively small one. We need longer-term follow up and confirmation with additional studies done on diverse populations.
It’s also important to consider that thyroid surgery in patients with advanced Hashimoto’s thyroiditis is difficult. Rates of complications, including injury to the laryngeal nerve (which controls voice) and the parathyroid glands (which maintain normal blood calcium levels), are incre...
Source: Harvard Health Blog - August 12, 2019 Category: Consumer Health News Authors: Jeffrey Garber, MD, FACP, FACE Tags: Health Thyroid Disorders Source Type: blogs
Need to check your thyroid? Maybe not
As medical science advances, we have more tests and biomarkers available to help identify illnesses. Yet overdiagnosis and overtreatment that may occur following abnormal results can cause dangerous adverse effects and costly consequences. Hypothyroidism — a lower than normal range of thyroid hormones — may be the poster child for this problem because it is such a common condition.
What is hypothyroidism?
At the front of your neck lies the thyroid, a butterfly-shaped gland that makes the hormone T4. When released into the bloodstream, T4 converts to T3, the most active form of thyroid hormone. Having sufficient levels ...
Source: Harvard Health Blog - July 22, 2019 Category: Consumer Health News Authors: Marcelo Campos, MD Tags: Autoimmune diseases Fatigue Tests and procedures Thyroid Disorders Source Type: blogs
What ’ s the best source of iodine?
The post What’s the best source of iodine? appeared first on Dr. William Davis. (Source: Wheat Belly Blog)
Source: Wheat Belly Blog - July 13, 2019 Category: Cardiology Authors: Dr. Davis Tags: Iodine goiter hypothyroid Source Type: blogs
