TSH Receptor Reduces Hemoglobin S Polymerization and Increases Deformability and Adhesion of Sickle Erythrocytes
Anemia. 2024 Apr 2;2024:7924015. doi: 10.1155/2024/7924015. eCollection 2024.ABSTRACTSCD is a hereditary disorder caused by genetic mutation in the beta-globin gene, resulting in abnormal hemoglobin, HbS that forms sickle-shaped erythrocytes under hypoxia. Patients with SCD have endocrine disorders and it was described that 7% of these patients have clinical hypothyroidism. Recent studies have shown that mature erythrocytes possess TSH receptors. Thus, we aimed to assess the effects of TSH on SCD erythrocytes. The experiments were conducted using different concentrations of TSH (1, 2, 3, and 5 mIU/L). In HbS polymerization...
Source: Anemia - April 10, 2024 Category: Hematology Authors: Evelyn Mendon ça-Reis Camila Cristina Guimar ães-Nobre Lyzes Rosa Teixeira-Alves Leandro Miranda-Alves Clemilson Berto-Junior Source Type: research
Protective effect of platelet-rich plasma against structural and functional changes of the adult rat testis in carbimazole-induced hypothyroidism
CONCLUSION: PRP appears to prevent the structural changes in the testes and the deterioration in sperm quality caused by CBZ-induced HT. This protective effect is likely due to mitigation of oxidative damage and elevation of testosterone levels.PMID:38599887 | DOI:10.5653/cerm.2023.06695 (Source: Clinical and Experimental Reproductive Medicine)
Source: Clinical and Experimental Reproductive Medicine - April 10, 2024 Category: Reproduction Medicine Authors: Hossein Bordbar Masoud Sattar-Shamsabadi Farzaneh Dehghani Fatemeh Karimi Source Type: research
TSH Receptor Reduces Hemoglobin S Polymerization and Increases Deformability and Adhesion of Sickle Erythrocytes
Anemia. 2024 Apr 2;2024:7924015. doi: 10.1155/2024/7924015. eCollection 2024.ABSTRACTSCD is a hereditary disorder caused by genetic mutation in the beta-globin gene, resulting in abnormal hemoglobin, HbS that forms sickle-shaped erythrocytes under hypoxia. Patients with SCD have endocrine disorders and it was described that 7% of these patients have clinical hypothyroidism. Recent studies have shown that mature erythrocytes possess TSH receptors. Thus, we aimed to assess the effects of TSH on SCD erythrocytes. The experiments were conducted using different concentrations of TSH (1, 2, 3, and 5 mIU/L). In HbS polymerization...
Source: Anemia - April 10, 2024 Category: Hematology Authors: Evelyn Mendon ça-Reis Camila Cristina Guimar ães-Nobre Lyzes Rosa Teixeira-Alves Leandro Miranda-Alves Clemilson Berto-Junior Source Type: research
Protective effect of platelet-rich plasma against structural and functional changes of the adult rat testis in carbimazole-induced hypothyroidism
CONCLUSION: PRP appears to prevent the structural changes in the testes and the deterioration in sperm quality caused by CBZ-induced HT. This protective effect is likely due to mitigation of oxidative damage and elevation of testosterone levels.PMID:38599887 | DOI:10.5653/cerm.2023.06695 (Source: Clinical and Experimental Reproductive Medicine)
Source: Clinical and Experimental Reproductive Medicine - April 10, 2024 Category: Reproduction Medicine Authors: Hossein Bordbar Masoud Sattar-Shamsabadi Farzaneh Dehghani Fatemeh Karimi Source Type: research
Changes in TgAb and TPOAb titers are greater in thyrotoxicosis than isolated hypothyroidism induced by PD-1 blockade
Endocr J. 2024 Apr 11. doi: 10.1507/endocrj.EJ23-0480. Online ahead of print.ABSTRACTAnti-thyroglobulin antibodies (TgAb) and/or anti-thyroid peroxidase antibodies (TPOAb) positivity at baseline is a risk marker for thyroid immune-related adverse events (thyroid-irAEs) in anti-programmed cell death-1 antibody (PD-1-Ab) treatment; however, it is unknown if TgAb and TPOAb titers are associated with clinical characteristics of thyroid-irAEs. Among 586 patients treated with PD-1-Ab at Nagoya University Hospital between 2 November 2015 and 30 September 2021, 57 patients developed thyroid-irAEs (thyrotoxicosis [n = 38]; hypothyr...
Source: Endocrine Journal - April 10, 2024 Category: Endocrinology Authors: Ayana Yamagami Shintaro Iwama Tomoko Kobayashi Xin Zhou Yoshinori Yasuda Takayuki Okuji Masaaki Ito Tetsushi Izuchi Masahiko Ando Takeshi Onoue Takashi Miyata Mariko Sugiyama Daisuke Hagiwara Hidetaka Suga Ryoichi Banno Hiroshi Arima Source Type: research
TSH Receptor Reduces Hemoglobin S Polymerization and Increases Deformability and Adhesion of Sickle Erythrocytes
Anemia. 2024 Apr 2;2024:7924015. doi: 10.1155/2024/7924015. eCollection 2024.ABSTRACTSCD is a hereditary disorder caused by genetic mutation in the beta-globin gene, resulting in abnormal hemoglobin, HbS that forms sickle-shaped erythrocytes under hypoxia. Patients with SCD have endocrine disorders and it was described that 7% of these patients have clinical hypothyroidism. Recent studies have shown that mature erythrocytes possess TSH receptors. Thus, we aimed to assess the effects of TSH on SCD erythrocytes. The experiments were conducted using different concentrations of TSH (1, 2, 3, and 5 mIU/L). In HbS polymerization...
Source: Anemia - April 10, 2024 Category: Hematology Authors: Evelyn Mendon ça-Reis Camila Cristina Guimar ães-Nobre Lyzes Rosa Teixeira-Alves Leandro Miranda-Alves Clemilson Berto-Junior Source Type: research
Protective effect of platelet-rich plasma against structural and functional changes of the adult rat testis in carbimazole-induced hypothyroidism
CONCLUSION: PRP appears to prevent the structural changes in the testes and the deterioration in sperm quality caused by CBZ-induced HT. This protective effect is likely due to mitigation of oxidative damage and elevation of testosterone levels.PMID:38599887 | DOI:10.5653/cerm.2023.06695 (Source: Clinical and Experimental Reproductive Medicine)
Source: Clinical and Experimental Reproductive Medicine - April 10, 2024 Category: Reproduction Medicine Authors: Hossein Bordbar Masoud Sattar-Shamsabadi Farzaneh Dehghani Fatemeh Karimi Source Type: research
Changes in TgAb and TPOAb titers are greater in thyrotoxicosis than isolated hypothyroidism induced by PD-1 blockade
Endocr J. 2024 Apr 11. doi: 10.1507/endocrj.EJ23-0480. Online ahead of print.ABSTRACTAnti-thyroglobulin antibodies (TgAb) and/or anti-thyroid peroxidase antibodies (TPOAb) positivity at baseline is a risk marker for thyroid immune-related adverse events (thyroid-irAEs) in anti-programmed cell death-1 antibody (PD-1-Ab) treatment; however, it is unknown if TgAb and TPOAb titers are associated with clinical characteristics of thyroid-irAEs. Among 586 patients treated with PD-1-Ab at Nagoya University Hospital between 2 November 2015 and 30 September 2021, 57 patients developed thyroid-irAEs (thyrotoxicosis [n = 38]; hypothyr...
Source: Endocrine Journal - April 10, 2024 Category: Endocrinology Authors: Ayana Yamagami Shintaro Iwama Tomoko Kobayashi Xin Zhou Yoshinori Yasuda Takayuki Okuji Masaaki Ito Tetsushi Izuchi Masahiko Ando Takeshi Onoue Takashi Miyata Mariko Sugiyama Daisuke Hagiwara Hidetaka Suga Ryoichi Banno Hiroshi Arima Source Type: research
TSH Receptor Reduces Hemoglobin S Polymerization and Increases Deformability and Adhesion of Sickle Erythrocytes
Anemia. 2024 Apr 2;2024:7924015. doi: 10.1155/2024/7924015. eCollection 2024.ABSTRACTSCD is a hereditary disorder caused by genetic mutation in the beta-globin gene, resulting in abnormal hemoglobin, HbS that forms sickle-shaped erythrocytes under hypoxia. Patients with SCD have endocrine disorders and it was described that 7% of these patients have clinical hypothyroidism. Recent studies have shown that mature erythrocytes possess TSH receptors. Thus, we aimed to assess the effects of TSH on SCD erythrocytes. The experiments were conducted using different concentrations of TSH (1, 2, 3, and 5 mIU/L). In HbS polymerization...
Source: Anemia - April 10, 2024 Category: Hematology Authors: Evelyn Mendon ça-Reis Camila Cristina Guimar ães-Nobre Lyzes Rosa Teixeira-Alves Leandro Miranda-Alves Clemilson Berto-Junior Source Type: research
Protective effect of platelet-rich plasma against structural and functional changes of the adult rat testis in carbimazole-induced hypothyroidism
CONCLUSION: PRP appears to prevent the structural changes in the testes and the deterioration in sperm quality caused by CBZ-induced HT. This protective effect is likely due to mitigation of oxidative damage and elevation of testosterone levels.PMID:38599887 | DOI:10.5653/cerm.2023.06695 (Source: Clinical and Experimental Reproductive Medicine)
Source: Clinical and Experimental Reproductive Medicine - April 10, 2024 Category: Reproduction Medicine Authors: Hossein Bordbar Masoud Sattar-Shamsabadi Farzaneh Dehghani Fatemeh Karimi Source Type: research
Changes in TgAb and TPOAb titers are greater in thyrotoxicosis than isolated hypothyroidism induced by PD-1 blockade
Endocr J. 2024 Apr 11. doi: 10.1507/endocrj.EJ23-0480. Online ahead of print.ABSTRACTAnti-thyroglobulin antibodies (TgAb) and/or anti-thyroid peroxidase antibodies (TPOAb) positivity at baseline is a risk marker for thyroid immune-related adverse events (thyroid-irAEs) in anti-programmed cell death-1 antibody (PD-1-Ab) treatment; however, it is unknown if TgAb and TPOAb titers are associated with clinical characteristics of thyroid-irAEs. Among 586 patients treated with PD-1-Ab at Nagoya University Hospital between 2 November 2015 and 30 September 2021, 57 patients developed thyroid-irAEs (thyrotoxicosis [n = 38]; hypothyr...
Source: Endocrine Journal - April 10, 2024 Category: Endocrinology Authors: Ayana Yamagami Shintaro Iwama Tomoko Kobayashi Xin Zhou Yoshinori Yasuda Takayuki Okuji Masaaki Ito Tetsushi Izuchi Masahiko Ando Takeshi Onoue Takashi Miyata Mariko Sugiyama Daisuke Hagiwara Hidetaka Suga Ryoichi Banno Hiroshi Arima Source Type: research
TSH Receptor Reduces Hemoglobin S Polymerization and Increases Deformability and Adhesion of Sickle Erythrocytes
Anemia. 2024 Apr 2;2024:7924015. doi: 10.1155/2024/7924015. eCollection 2024.ABSTRACTSCD is a hereditary disorder caused by genetic mutation in the beta-globin gene, resulting in abnormal hemoglobin, HbS that forms sickle-shaped erythrocytes under hypoxia. Patients with SCD have endocrine disorders and it was described that 7% of these patients have clinical hypothyroidism. Recent studies have shown that mature erythrocytes possess TSH receptors. Thus, we aimed to assess the effects of TSH on SCD erythrocytes. The experiments were conducted using different concentrations of TSH (1, 2, 3, and 5 mIU/L). In HbS polymerization...
Source: Anemia - April 10, 2024 Category: Hematology Authors: Evelyn Mendon ça-Reis Camila Cristina Guimar ães-Nobre Lyzes Rosa Teixeira-Alves Leandro Miranda-Alves Clemilson Berto-Junior Source Type: research
Protective effect of platelet-rich plasma against structural and functional changes of the adult rat testis in carbimazole-induced hypothyroidism
CONCLUSION: PRP appears to prevent the structural changes in the testes and the deterioration in sperm quality caused by CBZ-induced HT. This protective effect is likely due to mitigation of oxidative damage and elevation of testosterone levels.PMID:38599887 | DOI:10.5653/cerm.2023.06695 (Source: Clinical and Experimental Reproductive Medicine)
Source: Clinical and Experimental Reproductive Medicine - April 10, 2024 Category: Reproduction Medicine Authors: Hossein Bordbar Masoud Sattar-Shamsabadi Farzaneh Dehghani Fatemeh Karimi Source Type: research
TSH Receptor Reduces Hemoglobin S Polymerization and Increases Deformability and Adhesion of Sickle Erythrocytes
Anemia. 2024 Apr 2;2024:7924015. doi: 10.1155/2024/7924015. eCollection 2024.ABSTRACTSCD is a hereditary disorder caused by genetic mutation in the beta-globin gene, resulting in abnormal hemoglobin, HbS that forms sickle-shaped erythrocytes under hypoxia. Patients with SCD have endocrine disorders and it was described that 7% of these patients have clinical hypothyroidism. Recent studies have shown that mature erythrocytes possess TSH receptors. Thus, we aimed to assess the effects of TSH on SCD erythrocytes. The experiments were conducted using different concentrations of TSH (1, 2, 3, and 5 mIU/L). In HbS polymerization...
Source: Anemia - April 10, 2024 Category: Hematology Authors: Evelyn Mendon ça-Reis Camila Cristina Guimar ães-Nobre Lyzes Rosa Teixeira-Alves Leandro Miranda-Alves Clemilson Berto-Junior Source Type: research
Protective effect of platelet-rich plasma against structural and functional changes of the adult rat testis in carbimazole-induced hypothyroidism
CONCLUSION: PRP appears to prevent the structural changes in the testes and the deterioration in sperm quality caused by CBZ-induced HT. This protective effect is likely due to mitigation of oxidative damage and elevation of testosterone levels.PMID:38599887 | DOI:10.5653/cerm.2023.06695 (Source: Clinical and Experimental Reproductive Medicine)
Source: Clinical and Experimental Reproductive Medicine - April 10, 2024 Category: Reproduction Medicine Authors: Hossein Bordbar Masoud Sattar-Shamsabadi Farzaneh Dehghani Fatemeh Karimi Source Type: research
