Serotonergic Synergy in the Pharmacotherapy of Acute Posttraumatic Stress Disorder Exacerbation: A Case Report.
CONCLUSION: These medications each have relatively rapid onset and unique serotonergic activities. Given the role of serotonin in fear conditioning and traumatic memory consolidation, these treatments could be of significant benefit for PTSD patients, especially in the acute setting. We believe the treatments warrant further research to determine whether they are potential alternatives for anxiolytics like benzodiazepines, which are frequently used clinically but have evidence of risks in and little efficacy for PTSD.
PMID: 28051993 [PubMed - in process] (Source: Military Medicine)
Source: Military Medicine - January 5, 2017 Category: Global & Universal Tags: Mil Med Source Type: research
Refractory Cutaneous IgA Vasculitis Treated with Omega-3 Fatty Acids
Conclusions: O3FA can be useful to control cutaneous IgAV.Case Rep Dermatol 2016;8:333 –340 (Source: Case Reports in Dermatology)
Source: Case Reports in Dermatology - November 29, 2016 Category: Dermatology Source Type: research
Pharmacological interventions for pruritus in adult palliative care patients.
CONCLUSIONS: Different interventions tended to be effective for CP and UP. However, therapies for patients with malignancies are still lacking. Due to the small sample sizes in most meta-analyses and the heterogeneous methodological quality of the included trials, the results should be interpreted cautiously in terms of generalisability.
PMID: 27849111 [PubMed - as supplied by publisher] (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - November 15, 2016 Category: Journals (General) Authors: Siemens W, Xander C, Meerpohl JJ, Buroh S, Antes G, Schwarzer G, Becker G Tags: Cochrane Database Syst Rev Source Type: research
Shortage of psychotropic medications in community pharmacies in Saudi Arabia: Causes and solutions
Conclusions The findings of this study should expedite the reform process in both the Ministry of Health and the Saudi Food and Drug Authority (SFDA) to publish and enforce an essential list of medications for retail community pharmacies, which should include the most commonly prescribed psychotropic medications. (Source: Saudi Pharmaceutical Journal)
Source: Saudi Pharmaceutical Journal - November 12, 2016 Category: Drugs & Pharmacology Source Type: research
[Wells syndrome mimicking facial cellulitis: Three cases].
DISCUSSION: These cases highlight the need to consider Wells syndrome in the differential diagnosis when evaluating a patient with facial cellulitis that does not respond to an initial antimicrobial regimen. In addition, our cases suggest that combined therapy with levocetirizine and hydroxyzine may be successfully used as first-line therapy or to prevent relapse after discontinuation of corticosteroid treatment.
PMID: 27839729 [PubMed - as supplied by publisher] (Source: Annales de Dermatologie et de Cenereologie)
Source: Annales de Dermatologie et de Cenereologie - November 9, 2016 Category: Dermatology Authors: Gallard C, Law-Ping-Man S, Darrieux L, Tisseau L, Safa G Tags: Ann Dermatol Venereol Source Type: research
Fixed drug eruption due to three antihistamines of a same chemical family: Cetirizine, levocetirizine, and hydroxyzine
(Source: Dermatologic Therapy)
Source: Dermatologic Therapy - September 8, 2016 Category: Dermatology Authors: Neetu Bhari, Rahul Mahajan, Sanjay Singh, Vinod Kumar Sharma Tags: Therapeutic Hotline: Letters Source Type: research
Psychogenic Itch Management.
Authors: Szepietowski JC, Reszke R
Abstract
Pruritus is a bothersome and prevalent symptom reported by patients suffering from both cutaneous and extracutaneous diseases. Psychogenic pruritus, also referred to as functional itch disorder, is a distinct clinical entity. According to the definition proposed by the French Psychodermatology Group (FPDG) in 2007, the disorder is characterized by pruritus which is the chief complaint and psychologic factors that contribute to eliciting, worsening, and sustaining the symptoms. Specific diagnostic criteria were proposed, including 3 compulsory and 7 optional, of w...
Source: Current Problems in Dermatology - September 1, 2016 Category: Dermatology Tags: Curr Probl Dermatol Source Type: research
Efficiency of Melatonin as Compared to Pentobarbital for Audiometry Brainstem Response in Children With Associated Disorders.
Conclusions: Melatonin is a drug widely used, particularly for electroencephalogram in children. Sleep duration allowed a success rate that was comparable to pentobarbital. Melatonin seems to be an efficient alternative to pentobarbital for pediatric ABR.
PMID: 27598454 [PubMed - as supplied by publisher] (Source: American Journal of Audiology)
Source: American Journal of Audiology - September 1, 2016 Category: Audiology Authors: Guerlain J, Paul A, Rouillon I, Parodi M, Garabedian EN, Loundon N Tags: Am J Audiol Source Type: research
Efficiency of Melatonin as Compared to Pentobarbital for Audiometry Brainstem Response in Children With Associated Disorders
Purpose Outpatient pediatric audiometry brainstem response (ABR) uses various techniques (no drug, hydroxyzine, pentobarbital, melatonin). The aim of this study was to evaluate the efficiency of melatonin as compared to pentobarbital in children with associated disorders.Method This was a retrospective study that took place in a tertiary care center. Eighty-three children (34 girls and 49 boys) had performed ABR under pentobarbital (GPent) or melatonin (GMel) between 2013 and 2014 and were included. All children had associated neurological or behavioral disorders or had failed a previous ABR using another technique. Succes...
Source: American Journal of Audiology - September 1, 2016 Category: Audiology Source Type: research
Patient/carers' recollection of medicines related information from an out-patient clinic appointment
Conclusion
Following an out-patient consultation, where a new medicine is prescribed, children and their parents/carers are usually able to recall the indication, dose regimen and duration of treatment. Few were able to recall, or were told about, possible adverse effects. This may include some important drug specific effects that require vigilance during treatment.
Patients, along with families and carers, should be involved in the decision to prescribe a medicine.2 This includes a discussion about the benefits of the medicine on the patient's condition and possible adverse effects.2 Treatment side effects have been shown...
Source: Archives of Disease in Childhood - August 16, 2016 Category: Pediatrics Authors: Aston, J., Patel, N., Smuels, J., Aujla, T., Malesi, G., Huynh, C., Wilson, K., Terry, D. Tags: Poster presentations Source Type: research
Premedication prevents infusion reactions and improves retention rate during infliximab treatment
Abstract
Infliximab (IFX) is an anti-tumor necrosis factor-alpha antibody used to treat inflammatory joint diseases. Infusion reactions (IR) can occur during and after intravenous administration and often require discontinuation of IFX therapy. This retrospective study aimed at evaluating the incidence of IR in patients with joint inflammatory diseases receiving IFX with and without premedication. Clinical charts of rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis patients receiving IFX from January 2002 to December 2014 were reviewed. Patients receiving only one premedication protoco...
Source: Clinical Rheumatology - July 18, 2016 Category: Rheumatology Source Type: research
The Psychopharmacology Algorithm Project at the Harvard South Shore Program: An Algorithm for Generalized Anxiety Disorder
Abstract: This revision of previous algorithms for the pharmacotherapy of generalized anxiety disorder was developed by the Psychopharmacology Algorithm Project at the Harvard South Shore Program. Algorithms from 1999 and 2010 and associated references were reevaluated. Newer studies and reviews published from 2008–14 were obtained from PubMed and analyzed with a focus on their potential to justify changes in the recommendations. Exceptions to the main algorithm for special patient populations, such as women of childbearing potential, pregnant women, the elderly, and those with common medical and psychiatric comorbiditie...
Source: Harvard Review of Psychiatry - July 1, 2016 Category: Psychiatry Tags: Review Source Type: research
Pharmaceutical Approach for the Diagnosis and Treatment of Malignant Syndrome: A Case Study.
Abstract
Since 2012, Matsudo City Hospital has increased the number of pharmacists stationed in the ward on weekday mornings at the emergency care center, the intensive care unit (ICU) and the high care unit (HCU). Multidisciplinary joint meetings and joint conferences are conducted in the emergency care center, and patient and drug information is shared. A 20-year-old man was transferred to our hospital after a traffic accident. He was diagnosed with subarachnoid hemorrhage and brain contusion. He exhibited violent movement and intense restlessness. He was sedated with a continuous intravenous infusion of...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - June 4, 2016 Category: Drugs & Pharmacology Authors: Kameda K, Watarai K, Takahashi K, Shoko T, Koinuma M, Ikushima G Tags: Yakugaku Zasshi Source Type: research
Dispersive liquid-liquid microextraction based on solidification of floating organic drop and high-performance liquid chromatography to the analysis of cocaine's major adulterants in human urine.
Abstract
A simple method has been proposed for the determination of cocaine's major adulterants (caffeine, levamisole, lidocaine, phenacetin, diltiazem, and hydroxyzine) in human urine by dispersive liquid-liquid microextraction based on solidification of floating organic drop (DLLME-SFO) in combination with high-performance liquid chromatography - photodiode array detector (HPLC-PDA). The reversed-phase chromatographic separation was obtained with a column C18 extended (250×4.6mm; 5μm; 80Å) in gradient elution mode using acetonitrile-trifluoroacetic acid 0.026% (v,v) (pH=2.5) at 1mLmin(-1) as mobile ph...
Source: Toxicology - April 29, 2016 Category: Toxicology Authors: Sena LC, Matos HR, Dórea HS, Pimentel MF, de Santana DC, de Santana FJ Tags: Toxicology Source Type: research
A Case Report of Kratom Addiction and Withdrawal.
This report describes a case of kratom addiction in a 37-year-old woman with a severe oploid-like withdrawal syndrome that was managed successfully with symptom-triggered clonidine therapy and scheduled hydroxyzine. A review of other case reports of kratom toxicity, the herb's addiction potential, and the kratom withdrawal syndrome is discussed. Physicians in the United States should be aware of the growing availability and abuse of kratom and the herb's potential adverse health effects, with particular attention to kratom's toxicity, addictive potential, and associated withdrawal syndrome.
PMID: 27057581 [PubMed -...
Source: WMJ - January 31, 2016 Category: Journals (General) Authors: Galbis-Reig D Tags: WMJ Source Type: research
