Evaluation of sulfated maltodextrin as a novel anionic chiral selector for the enantioseparation of basic chiral drugs by capillary electrophoresis
This article is protected by copyright. All rights reserved (Source: Electrophoresis)
Source: Electrophoresis - September 1, 2014 Category: Biochemistry Authors: Hadi Tabani, Mojtaba Mahyari, Ali Sahragard, Ali Reza Fakhari, Ahmad Shaabani Tags: Research Paper Source Type: research
Reducing Transcranial Direct Current Stimulation‐Induced Erythema With Skin Pretreatment: Considerations for Sham‐Controlled Clinical Trials
ConclusionsKetoprofen 2% topical pretreatment might be an interesting strategy to reduce tDCS‐induced erythema and might be useful for blinding improvement in further sham‐controlled tDCS trials. (Source: Neuromodulation)
Source: Neuromodulation - August 1, 2014 Category: Neurology Authors: Fabiana Guarienti, Wolnei Caumo, Pedro Shiozawa, Quirino Cordeiro, Paulo S. Boggio, Isabela M. Benseñor, Paulo A. Lotufo, Marom Bikson, André R. Brunoni Tags: Clinical Research Source Type: research
Benzhydrylpiperazine compounds inhibit cholesterol-dependent cellular entry of hepatitis C virus.
Abstract
Hepatitis C virus (HCV) remains a serious global health problem that lacks an effective cure. Although the introduction of protease inhibitors to the current standard-of-care interferon/ribavirin therapy for HCV infection has improved sustained virological response of genotype 1-infected patients, these inhibitors exacerbate already problematic side effects. Thus, new HCV antivirals are urgently needed. Using a cell-protection screen previously developed in our laboratory, we evaluated 30,426 compounds for inhibitors of potentially any stage of the HCV life cycle and identified 49 new HCV inhibito...
Source: Antiviral Research - July 11, 2014 Category: Virology Authors: Chamoun-Emanuelli AM, Pécheur EI, Chen Z Tags: Antiviral Res Source Type: research
Incidence and Management of Rash in Telaprevir-Treated Patients: Lessons for Simeprevir?
CONCLUSIONS: ABW and BMI appear to be related to rash development. This finding may have implications in the treatment of HCV with simeprevir, given its similarity to telaprevir.
PMID: 24939632 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)
Source: The Annals of Pharmacotherapy - June 17, 2014 Category: Drugs & Pharmacology Authors: Smith MA, Johnson HJ, Chopra KB, Dunn MA, Ulrich AM, Mohammad RA Tags: Ann Pharmacother Source Type: research
The Case Files: Disease Traveling by Plane
By Hirashima, Eva Tovar MD, MPH; Crucio, Ted MD
A 34-year-old woman presented to the ED complaining of nausea, vomiting, and body tingling. She had just returned from a one-week stay in Haiti. Four days prior to presentation, she had eaten red snapper in a local restaurant. A few hours after the ingestion, she had colicky abdominal pain, watery non-bloody diarrhea, and circumoral tingling, which later progressed to generalized itching, tingling, and intense burning.
The patient reported on arrival at our ED improvement of the diarrhea, but the generalized itching and tingling had worsened, and she complained of fatig...
Source: The Case Files - June 4, 2014 Category: Emergency Medicine Tags: Blog Posts Source Type: research
Histamine H1-receptor antagonists against Leishmania (L.) infantum: an in vitro and in vivo evaluation using phosphatidylserine-liposomes.
Abstract
Considering the limited and toxic therapeutic arsenal available for visceral leishmaniasis (VL), the drug repositioning approach could represent a promising tool to the introduction of alternative therapies. Histamine H1-receptor antagonists are drugs belonging to different therapeutic classes, including antiallergics and anxyolitics. In this work, we described for the first time the activity of H1-antagonists against L. (L.) infantum and their potential effectiveness in an experimental hamster model. The evaluation against promastigotes demonstrated that chlorpheniramine, cinnarizine, hydroxyzine...
Source: Acta Tropica - June 3, 2014 Category: Infectious Diseases Authors: Pinto EG, da Costa-Silva TA, Tempone AG Tags: Acta Trop Source Type: research
Repetitive injection field-amplified sample stacking for cationic compounds determination.
Abstract
The development of a field-amplified sample stacking technique is presented. Sensitivity enhancement in this technique was obtained by repetitive injections of a sample followed by steps of sample matrix removal through the application of counter-pressure. Under optimized conditions the background electrolyte (BGE) was composed of 80mM H3PO4 while the sample matrix contained 0.5mM H3PO4 and 30% (v/v) methanol. The elaborated method enabled a 4-fold effective injection of the sample (53s, 0.5psi). Each injection was followed by a focusing step during which the application of a voltage (2kV) and cou...
Source: Talanta - May 22, 2014 Category: Chemistry Authors: Dziomba S, Biernacki M, Olędzka I, Skrzydlewska E, Bączek T, Kowalski P Tags: Talanta Source Type: research
Bilateral Suprazygomatic Maxillary Nerve Block for Cleft Palate Repair in Children: A Prospective, Randomized, Double-blind Study versus Placebo
Conclusion: Bilateral SMB is an easy regional anesthesia technique that reduces total morphine consumption at 48 h after cleft palate repair in children and the use of continuous infusion of morphine and may decrease postoperative respiratory complications. (Source: Anesthesiology)
Source: Anesthesiology - May 20, 2014 Category: Anesthesiology Tags: Perioperative Medicine: Clinical Science Source Type: research
Bilastine vs. Hydroxyzine: Occupation of Brain Histamine H1 Receptors Evaluated by Positron Emission Tomography in Healthy Volunteers
ConclusionsA single oral dose of bilastine 20 mg had minimal H1RO, was not linked with subjective sedation or objective impairment of psychomotor performance, and was devoid of treatment‐related sedative AEs, thus satisfying relevant subjective, objective, and PET criteria as a nonsedating antihistamine. (Source: British Journal of Clinical Pharmacology)
Source: British Journal of Clinical Pharmacology - May 15, 2014 Category: Drugs & Pharmacology Authors: Magí Farré, Clara Pérez‐Mañá, Esther Papaseit, Esther Menoyo, Marta Pérez, Soraya Martin, Santiago Bullich, Santiago Rojas, José‐Raúl Herance, Carlos Trampal, Luis Labeaga, Román Valiente Tags: Main Paper Source Type: research
Selective inhibition of hepatitis c virus infection by hydroxyzine and benztropin.
In this study, we have used an unbiased screening cell culture assay to interrogate a chemical library of compounds approved for clinical use in humans. This system enables identifying non-toxic antiviral compounds targeting every aspect of the viral lifecycle, be the target viral or cellular. The aim of this study is to identify drugs approved for other therapeutic applications in humans that could be effective components of combination therapies against HCV. As a result of this analysis we identified twelve compounds with antiviral activity in cell culture, some of which had previously been identified as HCV inhibitors w...
Source: Antimicrobial Agents and Chemotherapy - April 7, 2014 Category: Microbiology Authors: Mingorance L, Friesland M, Coto-Llerena M, Pérez-Del-Pulgar S, Boix L, López-Oliva JM, Bruix J, Forns X, Gastaminza P Tags: Antimicrob Agents Chemother Source Type: research
Kansei biosensors to reproduce gustatory and olfactory senses.
Abstract
Anyone talks about the taste using different taste scale. Since how to feel the taste is different from one to other people, we sometimes lead to inconsistency when speaking about the taste of food. The present study aims at development of electronic tongue (taste sensor) and electronic nose (odor sensor). There are two important properties about the taste sensor. One, each sensor electrode (lipid/polymer membrane) is specific to each taste. Another is that the sensor can measure the aftertaste such as richness, which is the aftertaste of umami. In the case of, e.g., bitterness electrode (BT0)...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - March 9, 2014 Category: Drugs & Pharmacology Authors: Toko K Tags: Yakugaku Zasshi Source Type: research
Computational prediction and experimental selectivity coefficients for hydroxyzine and cetirizine molecularly imprinted polymer based potentiometric sensors.
Abstract
In spite of the increasing usages number of molecularly imprinted polymers (MIPs) in many scientific applications, the theoretical aspects of participating intra molecular forces are not fully understood. This work investigates effects of the electrostatic force, the Mulliken charge and the role of cavity's backbone atoms on the selectivity of MIPs. Moreover, charge distribution, which is a computational parameter, was proposed for the prediction of the selectivity coefficients of MIP-based sensors. In the computational approaches and experimental study, methacrylic acid (MAA) was chosen as the fu...
Source: Analytica Chimica Acta - February 8, 2014 Category: Chemistry Authors: Azimi A, Javanbakht M Tags: Anal Chim Acta Source Type: research
Night‐time sedating H1‐antihistamine increases daytime somnolence but not treatment efficacy in chronic spontaneous urticaria: a randomised controlled trial
ConclusionsThe widespread belief that sleep is aided by addition of a sedating first‐generation H1‐antihistamine, usually hydroxyzine, at night is not supported. These results are in line with the urticaria guidelines that first line treatment for urticaria should be new generation, non‐sedating H1‐antihistamines only.This article is protected by copyright. All rights reserved. (Source: British Journal of Dermatology)
Source: British Journal of Dermatology - January 28, 2014 Category: Dermatology Authors: M. Staevska, M. Gugutkova, C. Lazarova, T. Kralimarkova, V. Dimitrov, T. Zuberbier, M.K. Church, T.A. Popov Tags: Therapeutics Source Type: research
Night-time sedating H1 -antihistamine increases daytime somnolence but not treatment efficacy in chronic spontaneous urticaria: a randomised controlled trial.
CONCLUSIONS: The widespread belief that sleep is aided by addition of a sedating first-generation H1 -antihistamine, usually hydroxyzine, at night is not supported. These results are in line with the urticaria guidelines that first line treatment for urticaria should be new generation, non-sedating H1 -antihistamines only. This article is protected by copyright. All rights reserved.
PMID: 24472058 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - January 28, 2014 Category: Dermatology Authors: Staevska M, Gugutkova M, Lazarova C, Kralimarkova T, Dimitrov V, Zuberbier T, Church MK, Popov TA Tags: Br J Dermatol Source Type: research
