Evaluation of the Impact of a Multimodel Intervention on Prescribing Patterns of Sedative-Hypnotics in a Behavioral Health System.
Conclusions: Implementation of a multimodal intervention led to a significant decrease in rates of chronic sedative-hypnotic prescriptions in a large behavioral health system.
PMID: 29873949 [PubMed - in process] (Source: The Primary Care Companion for CNS Disorders)
Source: The Primary Care Companion for CNS Disorders - June 7, 2018 Category: Primary Care Tags: Prim Care Companion CNS Disord Source Type: research
Suppression of wheal and flare in histamine test by the main H1 antihistamines commercialized in Brazil
Conclusions: Brazilian commercial antihistamines presented different profiles of inhibition of wheal and flares in the histamine test, as well as adverse effects. Generic loratadine, fexofenadine and cetirizine presented larger flares than brand drugs. (Source: Anais Brasileiros de Dermatologia)
Source: Anais Brasileiros de Dermatologia - May 3, 2018 Category: Dermatology Source Type: research
Psychiatric comedication in patients with epilepsy.
Abstract
Psychiatric disorders are more common in patients with epilepsy than in the general population. The aims of the study were to assess the frequency and type of psychotropic drug usage in patients with epilepsy, to assess the risk factors for their use, and to assess their proconvulsive potential and the risk of interactions with antiepileptic drugs. This 20-month prospective study included patients treated at the university hospital outpatient clinic. Psychotropic drugs have been classified according to the Anatomical Therapeutic Chemical Classification System. Of the 621 patients (with a mean age ...
Source: Epilepsy and Behaviour - April 26, 2018 Category: Neurology Authors: Bosak M, Cyranka K, Dudek D, Kowalik M, Mołek P, Słowik A Tags: Epilepsy Behav Source Type: research
A fully validated method for the simultaneous determination of 11 antihistamines in breast milk by gas chromatography-mass spectrometry.
Abstract
Antihistamines are excreted into breast milk in small amounts; however, there are no adequate published studies or data concerning their effects on newborns and safety during breastfeeding. Thus, the development of sensitive and specific methodologies for the determination of antihistamines in breast milk is critical. A simple and sensitive GC-MS method for the simultaneous determination of eleven antihistamines (diphenhydramine, orphenadrine, chlorpheniramine, dimethindene, meclozine, hydroxyzine, loratadine, desloratadine, cetirizine, rupatadine and ebastine) in breast milk was developed and val...
Source: Biomedical Chromatography : BMC - April 12, 2018 Category: Biomedical Science Authors: Katselou M, Athanaselis S, Nikolaou P, Qammaz S, Dona A, Spiliopoulou C, Papoutsis I Tags: Biomed Chromatogr Source Type: research
Treatment with omalizumab or cyclosporine for resistant chronic spontaneous urticaria?
Koski and Kennedy1 review omalizumab and cyclosporine for the treatment of antihistamine-resistant chronic spontaneous (idiopathic) urticaria. Although appropriately indicating cetirizine to be used in up to 4 times the maximum recommended dose, they indicate adding a leukotriene receptor antagonist, diphenhydramine, or hydroxyzine as a second step. However, a systematic review concluded that leukotriene receptor antagonists were not effective as monotherapy or in combination with antihistamines. (Source: Annals of Allergy, Asthma and Immunology)
Source: Annals of Allergy, Asthma and Immunology - March 1, 2018 Category: Allergy & Immunology Authors: Miles Weinberger Source Type: research
Sensitive voltammetric determination of hydroxyzine and its main metabolite cetirizine and identification of oxidation products by nuclear magnetic resonance spectroscopy
Publication date: Available online 7 November 2017 Source:Journal of Electroanalytical Chemistry Author(s): Bruna Claudia Lourencao, Tiago Almeida Silva, Maiara da Silva Santos, Antonio Gilberto Ferreira, Orlando Fatibello-Filho The electrochemical detection and electrooxidation path of the first-generation antihistamine receptor hydroxyzine (HDZ) and its main metabolite cetirizine (CTZ) are addressed in this research. A carbon black-modified electrode to explore the electrochemical responsivity and electroanalytical detection of HDZ and CTZ was designed. Compared to the bare electrode, the irreversible anodic respo...
Source: Journal of Electroanalytical Chemistry - November 7, 2017 Category: Chemistry Source Type: research
Treating Pediatric Anxiety: Initial Use of SSRIs and Other Antianxiety Prescription Medications.
CONCLUSIONS: SSRIs are the most commonly used first-line medication for pediatric anxiety disorders, with about half of SSRI initiators continuing treatment for 6 months. Still, a third began therapy on a non-SSRI medication, for which there is limited evidence of effectiveness for pediatric anxiety, and a notable proportion of children initiated with 2 antianxiety medication classes.
PMID: 29099547 [PubMed - as supplied by publisher] (Source: Journal of Clinical Psychiatry)
Source: Journal of Clinical Psychiatry - November 5, 2017 Category: Psychiatry Tags: J Clin Psychiatry Source Type: research
Chloral hydrate as a sedating agent for neurodiagnostic procedures in children.
CONCLUSIONS: The quality of evidence for the comparisons of oral chloral hydrate against several other methods of sedation was very variable. Oral chloral hydrate appears to have a lower sedation failure rate when compared with oral promethazine for children undergoing paediatric neurodiagnostic procedures. The sedation failure was similar for other comparisons such as oral dexmedetomidine, oral hydroxyzine hydrochloride, and oral midazolam. When compared with intravenous pentobarbital and music therapy, oral chloral hydrate had a higher sedation failure rate. However, it must be noted that the evidence for the outcomes fo...
Source: Cochrane Database of Systematic Reviews - November 3, 2017 Category: General Medicine Authors: Fong CY, Tay CG, Ong LC, Lai NM Tags: Cochrane Database Syst Rev Source Type: research
P378 A case of the nerves tiotropium for treatment of resistant anaphylaxis with vocal cord dysfunction
A 17-year-old girl with an allergy to house dust mites presented with recurrent and frequent episodes (2-3 per week) of acute lip/tongue angioedema, diffuse rash, and respiratory distress with inspiratory stridor. Most episodes were triggered by exposures to scents from perfumes and soaps. Despite prophylactic treatment with inhaled and nasal fluticasone propionate and an oral regimen of daily diphenhydramine, cetirizine, and hydroxyzine, as well as on demand intramuscular epinephrine and multiple courses of oral steroids, she experienced over fifteen episodes requiring emergency room visits and four hospital admissions. (...
Source: Annals of Allergy, Asthma and Immunology - October 27, 2017 Category: Allergy & Immunology Authors: J. Kepes, D. Bernstein, T. Atkinson Source Type: research
The Effect of Schinus terebinthifolius Raddi (Anacardiaceae) Bark Extract on Histamine-Induced Paw Edema and Ileum Smooth Muscle Contraction.
Authors: Nunes-Neto PA, Peixoto-Sobrinho TJDS, da Silva Júnior ED, Leopoldina da Silva J, Rodrigo da Silva Oliveira A, Pupo AS, Araújo AV, da Costa-Silva JH, Wanderley AG
Abstract
Schinus terebinthifolius Raddi (Anacardiaceae), popularly known as red aroeira, is used in traditional medicine to treat inflammatory, gastric, and respiratory disorders. The aim of this study was to evaluate the antihistaminic activity of S. terebinthifolius (St) bark extract by using in vivo and in vitro experimental models. The effects of St were investigated on contractions induced by histamine, carbachol, and potassium chl...
Source: Evidence-based Complementary and Alternative Medicine - September 22, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Contact Dermatitis Reaction to 2-Octyl Cyanoacrylate Following 3 Orthopedic Procedures.
Abstract
Two-octyl cyanoacrylate is a popular skin adhesive used for closing surgical incisions. Since Food and Drug Administration approval in 1998, the few reports of adverse reactions following its use have primarily been limited to the nonorthopedic literature. The authors present a case series of contact dermatitis associated with 2-octyl cyanoacrylate following orthopedic surgery and a review of the literature on the diagnosis and treatment of this complication. All 3 patients presented with blistering around their incisions within 2 weeks of surgery and responded to treatment involving removal of th...
Source: Orthopedics - September 21, 2017 Category: Orthopaedics Authors: Lake NH, Barlow BT, Toledano JE, Valentine J, McDonald LS Tags: Orthopedics Source Type: research
Practitioner Review: Treatment of chronic insomnia in children and adolescents with neurodevelopmental disabilities
ConclusionsHere, we provided a tentative guide for the use of drugs for insomnia in children with NDDs. Well‐controlled studies employing both objective polysomnography and subjective sleep measures are needed to determine the efficacy, effectiveness, and safety of the currently prescribed pediatric sleep medicines in children with NDDs. (Source: Journal of Child Psychology and Psychiatry)
Source: Journal of Child Psychology and Psychiatry - September 18, 2017 Category: Psychiatry Authors: Oliviero Bruni, Marco Angriman, Fabrizio Calisti, Alessandro Comandini, Giovanna Esposito, Samuele Cortese, Raffaele Ferri Tags: Practitioner Review Source Type: research
Chronic Spontaneous Urticaria: Pathogenesis and Treatment Considerations.
Authors: Kaplan AP
Abstract
The treatment of chronic spontaneous urticaria begins with antihistamines; however, the dose required typically exceeds that recommended for allergic rhinitis. Second-generation, relatively non-sedating H₁-receptor blockers are typically employed up to 4 times a day. First-generation antihistamines, such as hydroxyzine or diphenhydramine (Atarax or Benadryl), were employed similarly in the past. Should high-dose antihistamines fail to control symptoms (at least 50%), omalizumab at 300 mg/month is the next step. This is effective in 70% of antihistamine-refractory patients. H...
Source: Allergy, Asthma and Immunology Research - September 17, 2017 Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research
Extrapyramidal Side Effects in a Blue and Gold Macaw (Ara ararauna) Treated with Amitriptyline
Extrapyramidal side effects were observed in a 17-year-old female blue and gold macaw (Ara ararauna) that presented with an acute onset of dystonic reactions (repetitive and abnormal motions, head bobbing) and akathisia (restlessness, pacing) a few hours following a single partial dose of amitriptyline (5 mg/kg) orally. The patient was concurrently being treated with meloxicam (1 mg/kg PO q12h) and had previously been treated with hydroxyzine, prednisolone, leuprolide acetate, and deslorelin acetate, for chronic feather damaging behaviour. (Source: Journal of Veterinary Behavior: Clinical Applications and Research)
Source: Journal of Veterinary Behavior: Clinical Applications and Research - September 15, 2017 Category: Veterinary Research Authors: Trinita Barboza, Hugues Beaufrere Source Type: research
Direct coupling of electromembrane extraction to mass spectrometry - Advancing the probe functionality toward measurements of zwitterionic drug metabolites.
Abstract
A triple-flow electromembrane extraction (EME) probe was developed and coupled directly to electrospray-ionization mass spectrometry (ESI-MS). Metabolic reaction mixtures (pH 7.4) containing drug substances and related metabolites were continuously drawn (20 μL/min) into the EME probe in one flow channel, and mixed inside the probe with 7.5 μL min(-1) of 1 M formic acid as make-up flow from a second flow channel. Following this acidification, the drug substances and their related metabolites were continuously extracted by EME at 400 V, across a supported liquid membrane (SLM) comprising 2-n...
Source: Analytica Chimica Acta - August 18, 2017 Category: Chemistry Authors: Rye TK, Fuchs D, Pedersen-Bjergaard S, Petersen NJ Tags: Anal Chim Acta Source Type: research
