Type 1 Segmental Darier Disease: Case Report and Discussion of the Treatment Options
Darier disease is a rare type of autosomal dominant genodermatosis, and it is caused by a mutation in the gene coding for the endoplasmic reticulum membrane calcium pump Ca2+-ATPase type 2, leading to compromised intercellular adhesion. Moreover, this condition is characterized by multiple keratotic greasy papules with a seborrheic distribution and is worsened by heat and sun exposure, sweating, and friction. Occasionally, it may be associated with nail abnormalities and may involve the mucosa. Unilateral segmental Darier disease is a rare variant characterized by unilateral eruption of erythematic keratotic papules not as...
Source: Case Reports in Dermatology - September 11, 2020 Category: Dermatology Source Type: research

A Case of Ofuji Disease Successfully Treated with the Combination of Low-Dose Indomethacin and Topical Tacrolimus
Eosinophilic pustular folliculitis (EPF) (Ofuji disease) is a chronic, noninfectious pruritic cutaneous disorder of unknown etiology. No official guidelines are available for its treatment. Herein we present the case of a 59-year-old Caucasian man admitted to our outpatient clinic due to a generalized itchy skin rash characterized by papulo-pustules involving the face, trunk, and limbs. Histological examination supported the clinical diagnosis of EPF (Ofuji disease). The combination of low-dose oral indomethacin and topical tacrolimus ointment once a day led to a complete resolution of the lesions as well as associated sym...
Source: Case Reports in Dermatology - August 18, 2020 Category: Dermatology Source Type: research

Improvement of Psoriasis, Psoriatic Arthritis, and Alopecia Universalis during Treatment with Tofacitinib: A Case Report
Alopecia areata (AA) is the most common immune-mediated hair loss disorder with a life-time prevalence of 2%. The pathogenesis of AA is not completely understood, but interferon gamma (INF- γ) and Janus kinases (JAK) may play a key role. Here, we present a case involving a male patient with psoriasis and psoriatic arthritis, who exhibited a rapid hair loss, diagnosed as AA, during ciclosporin treatment. As ciclosporin was unable to control his psoriasis, the treatment was changed to m ethotrexate injections, but the hair loss progressed into alopecia universalis. During treatment with the oral JAK inhibitor tofacitin...
Source: Case Reports in Dermatology - August 18, 2020 Category: Dermatology Source Type: research

Angiosarcoma of the Auricle in a Patient with Xeroderma Pigmentosum Variant
We report a 73-year-old Japanese man with angiosarcoma of the auricle and an XP-variant, which is a very rare condition. In this case, long-term physical stimulation due to auricular deformation after surgery may have been the cause. Angiosarcoma associated with XP has a better prognosis than common angiosarcoma, perhaps because of the smaller tumor size. As XP patients are at high risk of skin neoplasms, they consult dermatologists regularly, and therefore skin tumors are likely to be detected early.Case Rep Dermatol 2020;12:144 –149 (Source: Case Reports in Dermatology)
Source: Case Reports in Dermatology - August 18, 2020 Category: Dermatology Source Type: research

Primary Cutaneous Cryptococcosis: An Unusual Injection Site Infection
We describe an unusual case of PCC in an injection site of an immunocompromised patient. The specific case demonstrates a challenging treating dilemma with different alternative treatment choices. In the presented clinical setting, each choice concealed its risks and benefits. We highlight the importance of patient education for taking the appropriate measures for the disinfection of subcutaneous injection sites.Case Rep Dermatol 2020;12:138 –143 (Source: Case Reports in Dermatology)
Source: Case Reports in Dermatology - August 14, 2020 Category: Dermatology Source Type: research

Use of Anti-IL-17 Monoclonal Antibodies in HIV Patients with Erythrodermic Psoriasis
In conclusion, anti-IL-17 monoclonal antibodies are an effective and promising treatment option for HIV-infected patients with psoriasis.Case Rep Dermatol 2020;12:132 –137 (Source: Case Reports in Dermatology)
Source: Case Reports in Dermatology - August 12, 2020 Category: Dermatology Source Type: research

Unexpected Presentation of COVID-19 in a 38-Year-Old Male Patient: A Case Report
We presently report the case of COVID-19 in a 38-year-old male who had come to the primary health care clinic of Shahid Beheshti University of Medical Sciences, which specializes in the COVID-19 epidemic. He reported having fatigue, myalgia, fever, rash, and loss of taste and smell. The physical findings were maculopapular rash over his trunk, inguinal regions, and left arm, erythema of larynx with an aphthous lesion on left tonsil, he did not have a fever, and respiratory distress symptoms. There were no changes regarding COVID-19 in the spiral lung CT scan. However, the result of PCR for COVID-19 RNA was positive.Case Re...
Source: Case Reports in Dermatology - July 29, 2020 Category: Dermatology Source Type: research

Widespread Hypertrophic Lichen Planus following Programmed Cell Death Ligand 1 Blockade
Hypertrophic lichen planus (HLP) may not have the typical histological findings of lichen planus and often mimics squamous cell carcinoma (SCC). Distinguishing between the two can pose a diagnostic challenge. Here, we present a case of eruptive HLP mimicking SCC in the context of programmed cell death ligand 1 (PD-L1) immune checkpoint inhibition. A 73-year-old woman recently treated with durvalumab, an anti-PD-L1 antibody, presented to our clinic with diffuse hyperkeratotic papules and plaques previously thought to be eruptive SCC. The lesions did not respond to topical fluorouracil and continued to appear despite discont...
Source: Case Reports in Dermatology - June 18, 2020 Category: Dermatology Source Type: research

A Case of Pincer Nail Successfully Treated with Tazarotene 0.1% Gel
Pincer nail is a common condition characterized by excessive transverse nail curvature, progressively pinching the nail bed distally, resulting in cosmetic discomfort, pain and functional limitation. Treatment is difficult and often unsatisfactory. Surgical treatment performed by experienced physicians provides good outcomes. However, patients usually hesitate to undergo invasive procedures, preferring conservative treatments. Unfortunately, these mainly offer only temporary relief and recurrence rate is high. Topical tazarotene has been used in several nail conditions, but its potential remains not fully elucidated. We he...
Source: Case Reports in Dermatology - May 18, 2020 Category: Dermatology Source Type: research

Extramammary Paget ’s Disease and Melanoma: 2 Cases of Double Cancers
Extramammary Paget ’s disease (EMPD) is a rare intraepidermal neoplastic disease. There is a well-known relationship between EMPD and underlying malignancy. However, only a few cases of EMPD and cutaneous melanoma have been reported previously. In this case report we present 2 cases of such double cancers: one as a collision tumor, the other at separate sites. We discuss the pathogenesis, treatment, and importance of a thorough clinical and radiological examination and review the literature.Case Rep Dermatol 2020;12:107 –113 (Source: Case Reports in Dermatology)
Source: Case Reports in Dermatology - May 18, 2020 Category: Dermatology Source Type: research

Reflectance Confocal Microscopy of Pigmented Bowen ’s Disease: A Case Series of Difficult to Diagnose Lesions
Pigmented Bowen ’s disease is a rare variant of in situ squamous skin cell carcinoma. It mainly affects patients between 60 and 70 years of age. Its clinical features include well-demarcated, pigmented plaque arising in photo-exposed areas of the body. The best-characterized feature of the disease by histological examination is the presence of atypical keratinocytes, hyperpigmentation of the epidermis with trans-epidermal elimination of melanin and dermal melanophages. Precise diagnosis is often difficult, both clinically and dermoscopically, as Bowen’s disease is often mistaken with keratinocyte tumors s uch a...
Source: Case Reports in Dermatology - May 15, 2020 Category: Dermatology Source Type: research

A Case of Dermatomyositis Coexisting with Both Anti-Mi-2 and Anti-NXP-2 Antibodies
Myositis-specific autoantibodies (MSAs) including anti-Mi-2 and anti-nuclear matrix protein 2 (NXP-2) antibodies have been detected in the patients with dermatomyositis (DM), and are useful tools for identifying clinical subsets of DM. MSAs are exclusively found in DM patients. Anti-Mi-2 antibody-positive DM patients show the typical skin lesions and myositis and are rarely associated with internal malignancy and interstitial lung disease (ILD). On the other hand, adult DM patients with anti-NXP-2 antibody often show calcinosis and internal malignancy, but rarely ILD. In addition, anti-NXP-2 antibody-positive DM patients h...
Source: Case Reports in Dermatology - May 5, 2020 Category: Dermatology Source Type: research

Atypical Clinical Presentation of Hidradenitis Suppurativa in a Patient with Severe Mannose-Binding Lectin Deficiency
Mannose-binding lectin (MBL) deficiency is associated with recurrent infections, autoimmune and inflammatory skin disease, and vascular complications. MBL deficiency is not a recognized comorbidity in hidradenitis suppurativa (HS); the latter is associated with the group of autoinflammatory disorders. A 32-year-old woman presented with a history of recurrent painful, deep-seated abscesses and pustular lesions since the age of 13 years. Lesions were noted predominantly in HS distribution, i.e., submammary, inguinal, and perianal areas were affected. However, unusual locations (jawlines, neck) were also affected. The patient...
Source: Case Reports in Dermatology - May 5, 2020 Category: Dermatology Source Type: research

Exfoliative Erythroderma: An Unusual Presentation of Paraneoplastic Pemphigus Associated with Castleman ’s Disease
We report a 23-year-old woman who presented with generalized scaly erythematous rash predominately on the upper trunk and hemorrhagic stomatitis. The histopathologic and immunopathologic findings were consistent with the diagnosis of paraneoplastic pemphigus. Castleman ’s tumor was diagnosed with computed tomography and exploratory laparotomy. A partial clinical improvement was observed after complete tumor removal and intravenous immunoglobulin administration. However, the patient died as a result of septicemia.Case Rep Dermatol 2020;12:76 –81 (Source: Case Reports in Dermatology)
Source: Case Reports in Dermatology - April 14, 2020 Category: Dermatology Source Type: research

Unusual Presentation of Cutaneous Spindle Cell Squamous Cell Carcinoma: A Case Report
We present a rare case of a patient with SpSCC in the gluteal region with regional lymph node metastasis. The patient was treated with wide excision of the tumor, inguinal lymph node dissection, and adjuvant radiotherapy. Cutaneous SpSCC is clinically similar to conventional SCC but can demonstrate more aggressive behavior. This case is rare since it was localized in the gluteal region of an otherwise healthy man.Case Rep Dermatol 2020;12:70 –75 (Source: Case Reports in Dermatology)
Source: Case Reports in Dermatology - April 8, 2020 Category: Dermatology Source Type: research

Netherton ’s Syndrome: A Case of Two Male Siblings Diagnosed in Adulthood
Netherton ’s syndrome (NS) is a rare autosomal recessive genetic disease caused by a germline mutation in the SPINK5 gene. It is most commonly diagnosed in neonates due to the presence of congenital ichthyosiform erythroderma. Affected individuals will typically also develop a hair shaft abnormality known a s trichorrhexis invaginata, severe atopy, and a migratory rash known as ichythyosis linearis circumflexa. The chronicity and severity of NS adversely affects a patient’s quality of life to a large extent. It Is therefore important that this condition is identified early, and treatment to reduce cu taneous in...
Source: Case Reports in Dermatology - April 8, 2020 Category: Dermatology Source Type: research

Prelims
Case Rep Dermatol 2019;11:I –IV (Source: Case Reports in Dermatology)
Source: Case Reports in Dermatology - March 26, 2020 Category: Dermatology Source Type: research

A Case of Loose Anagen Hair Syndrome in a Southeast Asian Boy
We report the case of a 13-year-old Thai boy who presented with a single patch of hair thinning on the frontal scalp with excessive shedding, and the hairs did not grow long. Microscopic examination showed naked anagen bulbs with ruffling of the cuticle, which is compatible with loose anagen hair syndrome. To our knowledge, there is no reported case in Southeast Asian children.Case Rep Dermatol 2019;11:204 –208 (Source: Case Reports in Dermatology)
Source: Case Reports in Dermatology - July 3, 2019 Category: Dermatology Source Type: research

< b > < i > Trichophyton erinacei < /i > < /b > Onychomycosis: The First to Evidence a Proximal Subungual Onychomycosis Pattern
We describe the case of a 23-year-old Thai female who had a history of systemic lupus erythematosus with lupus nephritis type III and who developed widespread skin and nail infections caused byT. erinacei that were most likely transmitted from a hedgehog. Although the patient did not demonstrate a clinical improvement or mycological cure following systemic itraconazole and fluconazole treatment, she achieved clinical and mycological cures after terbinafine therapy. A drug susceptibility test should be performed in patients withT. erinacei infections to facilitate decision-making about antifungal therapy. Here, we are the f...
Source: Case Reports in Dermatology - July 2, 2019 Category: Dermatology Source Type: research

Mosquito Bite-Induced Localized NK/T-Cell Lymphoma Relapsed in a Patient with Complete Remission of Extranodal NK/T-Cell Lymphoma, Nasal Type
We report a rare case of localized NK/T-cell lymphoma following a mosquito bite after achieving complete response of extranodal NK/T-cell lymphoma, nasal type (ENKL). T cells and NK cells infected by Epstein-Barr virus (EBV) lead to NK/T-cell lymphoma, including ENKL. Lymphoma related to mosquito bites usually requires a prolonged treatment course, and the disease onset of hypersensitivity begins in early childhood. In the current case, the patient had no history of hypersensitivity to mosquito bites. We speculate that the latently EBV-infected NK/T cells in the blood were reactivated by mosquito gland antigens, expanded a...
Source: Case Reports in Dermatology - June 26, 2019 Category: Dermatology Source Type: research

Severe Infantile Bullous Pemphigoid Treated with Dapsone after Bridging with Systemic Glucocorticoid
We present a case of severe and treatment-refractory bullous pemphigoid in a 3-month-old child. After topical and systemic corticoid treatment proved inefficient, dapsone 0.75 mg/kg was added initially without success. Disease control was reached with dapsone 1.5 mg/kg in addition to both topical and systemic glucocorticoid treatment, leaving the child with several side effects of the glucocorticoid treatment.Case Rep Dermatol 2019;11:187 –193 (Source: Case Reports in Dermatology)
Source: Case Reports in Dermatology - June 26, 2019 Category: Dermatology Source Type: research

Localized Hypertrichosis with Traumatic Panniculitis: A Case Report and Literature Review
Localized hypertrichosis with traumatic panniculitis is considered a rare condition. Previous articles have reported occurrence in females aged between 20 and 35 years. Possible mechanisms of trauma-induced localized hypertrichosis include hyperemia and angiogenesis induced by local inflammation, which can alter the hair growth cycle. The presence of inflammatory cells and lipomembranous changes on histopathology can support the diagnosis. We herein present a 35-year-old female patient with localized hypertrichosis following blunt trauma.Case Rep Dermatol 2019;11:180 –186 (Source: Case Reports in Dermatology)
Source: Case Reports in Dermatology - June 26, 2019 Category: Dermatology Source Type: research

Nail Lichen Planus in a Patient with Cogan Syndrome: Report of a Case and Discussion
Cogan syndrome and lichen planus represent two autoimmune disorders. Cogan syndrome is a very rare type of ANCA-negative vasculitis affecting the eyes and vestibulocochlear system. It has been associated with other autoimmune disorders, none of them showing any lichenoid inflammation. We herein report the first case of a patient that suffered from Cogan disease and developed isolated lichen planus on all nails a few years after the first diagnosis. The combination of two autoimmune disorders is not unusual and raises the question of common immunogenetic pathomechanisms.Case Rep Dermatol 2019;11:175 –179 (Source: Case...
Source: Case Reports in Dermatology - June 26, 2019 Category: Dermatology Source Type: research

Severe Cutaneous Adverse Reactions during Tapering of High-Dose Systemic Steroid Therapy for Autoimmune Diseases: Implications for Non-HIV Immune Reconstitution Inflammatory Syndrome
We present 2 cases of severe cutaneous adverse reactions (SCARs) during the tapering of corticosteroids, following several courses of high-dose pulse therapy for Vogt-Koyanagi-Harada disease. Their general symptoms and mucous membrane lesions, including those of the eye, were milder than those usually seen in Stevens-Johnson syndrome/toxic epidermal necrolysis. Based on their initial presentation, these cases were not initially identified as SCARs, but continued to progress over the course of a few days. The mechanism underlying the paradoxical response to steroid administration seen in these patients can be interpreted as...
Source: Case Reports in Dermatology - June 13, 2019 Category: Dermatology Source Type: research

Linear and Annular Lupus Panniculitis of the Scalp: Case Report with Emphasis on Trichoscopic Findings and Review of the Literature
Linear and annular lupus panniculitis of the scalp (LALPS) is a unique subset of lupus panniculitis, which results in non-scarring alopecia along the Blaschko line of the scalp in an otherwise healthy young patient. Numerous cases have been reported around the world, but data on their trichoscopic findings and correlations with the underlying pathology is sparse. We hereby present a case of 23-year-old male with LALPS and further describe his trichoscopic findings as well as their correlations with histopathological features.Case Rep Dermatol 2019;11:157 –165 (Source: Case Reports in Dermatology)
Source: Case Reports in Dermatology - June 6, 2019 Category: Dermatology Source Type: research

Alopecia Induced by Autologous Fat Injection into the Temporal Area: Case Report and Review of the Literature
Alopecia secondary to facial filler injections is a highly unusual sequela. Only 2 cases of hyaluronic acid-induced alopecia have been reported to date. Accumulating evidence suggests vascular compromise as its etiology, which can be accidental intravascular injection or external compression by overfilled materials. We hereby present, to the best of our knowledge, the first case of localized nonscarring and scarring alopecia secondary to autologous fat grafting and review the literature regarding filler-induced alopecia.Case Rep Dermatol 2019;11:150 –156 (Source: Case Reports in Dermatology)
Source: Case Reports in Dermatology - June 5, 2019 Category: Dermatology Source Type: research

Spontaneous Regression of Annular Basal Cell Carcinoma: A Case Report
We herein present a case of annular basal cell carcinoma (BCC) with spontaneous regression on the right temporal region of a 56-year-old Japanese male. Histopathological examination revealed that the central section had no tumor cells. The sweat glands, follicles, and other cutaneous appendages were also absent. This pattern of spontaneous regression is quite uncommon, and understanding the histopathology may be important for future approaches to BCC.Case Rep Dermatol 2019;11:145 –149 (Source: Case Reports in Dermatology)
Source: Case Reports in Dermatology - June 4, 2019 Category: Dermatology Source Type: research

Original Method to Repigment Achromic Laser Tattoo Removal Scars
Laser tattoo removal is expensive, painful, and time-consuming. Even with the use of the right laser equipment, it is often impossible to eliminate all pigments. Incomplete tattoo removal, one of the undesired effects of laser treatment, is widely disseminated in the media and accepted by most patients. However, few patients know that laser tattoo removal can cause permanent scars. Some patients who develop achromic scars can feel disappointed with the results of laser tattoo removal and take legal action against the physician responsible for the treatment. This paper describes our experience with a drug delivery treatment...
Source: Case Reports in Dermatology - May 23, 2019 Category: Dermatology Source Type: research

Successful Treatment with Topical Diphenylcyclopropenone for Three Cases of Anogenital Warts in Children
Anogenital warts are caused by human papillomavirus types 6 and 11. They are rare in children, and treatment is difficult since conventional treatments are generally painful and require the patient to be anesthetized. Topical diphenylcyclopropenone (DPCP) is a contact immunotherapy used for treatments of recalcitrant warts and alopecia areata. We herein report 3 cases of anogenital warts in children successfully treated with topical DPCP. Our results suggest that topical DPCP may be a valuable option for the treatment of anogenital warts in children who have difficulty with painful destructive therapy.Case Rep Dermatol 201...
Source: Case Reports in Dermatology - May 22, 2019 Category: Dermatology Source Type: research

Bullous Pemphigoid Associated with Acquired Hemophilia A: A Case Report and Review of the Literature
We report a 68-year-old Thai woman diagnosed and treated for bullous pemphigoid (BP) for 11 months who recently presented with a 3-day history of extensive hemorrhagic bullae and large intra-oral buccal hematoma. Laboratory investigations confirmed a prolonged activated partial thromboplastin time, a low factor VIII level, a high factor VIII inhibitor level, and elevated anti-BPAG180 and anti-BPAG230 titers, confirming the diagnosis of BP associated with AHA. Immunosuppressive therapy with systemic corticosteroids and cyclophosphamide combined with bypassing agents for bleeding control resulted in significant clinical impr...
Source: Case Reports in Dermatology - May 22, 2019 Category: Dermatology Source Type: research

Merkel Cell Carcinoma of the Head in a Young African Albino Woman with HIV/HTLV-1 Coinfection Associated with Multiple Squamous Cell Carcinomas
We report a case of MCC of the head in a young albino woman with a HIV/HTLV-1 coinfection. The patient also suffered from multiple squamous cell carcinomas of the scalp, face, lip, and ears, suggesting an UV carcinogenesis of MCC. The purpose of this case report is to emphasize the relationship between immunosuppression (HIV/HTLV-1 coinfection, chronic sun exposure, ocular-cutaneous albinism, pregnancy) and MCC. It highlights the importance of early diagnosis, dermatological screening with a risk-stratified surveillance, particularly in immunosuppressed albino patients in sub-Saharan Africa, and multidisciplinary managemen...
Source: Case Reports in Dermatology - May 5, 2019 Category: Dermatology Source Type: research

Terra Firme-Forme Dermatosis Diagnostic Sign and Treatment: A Case Report
Terra firma-forme dermatosis (TFFD) is a little-known disease of unknown etiology that clinically presents with asymptomatic brown to black plaques and resembles dirty skin. Here, we report the case of a 38-year-old woman with skin changes on her areolae that were mistakenly diagnosed as “dermatitis neglecta” by several physicians. Cleansing with water and soap had no impact on the skin appearance. But a swab of 70% isopropyl alcohol removed the plaques immediately, which confirmed the diagnosis of TFFD. Only a few cases of TFFD have been published, and this skin condition is no t mentioned in many textbooks. G...
Source: Case Reports in Dermatology - April 24, 2019 Category: Dermatology Source Type: research

Granulomatous Reactions from Tattoos Following BRAF Inhibitor Therapy
BRAF inhibitors may present several cutaneous adverse effects, including actinic keratosis, squamous cell carcinoma, keratoacanthoma, rashes, increased photosensitivity, panniculitis, palmoplantar and capillary involvement, pruritus and xerosis as well as granulomatous reactions. A 30-year-old patient with multiple tattoos received dabrafenib and trametinib for metastatic melanoma. After 4 months, he developed an induration and thickening strictly limited to several tattoos. Histopathology revealed nonnecrotizing granulomas in the dermis. Topical steroids relieved pruritus but not the granulomatous aspect of the tattoos. A...
Source: Case Reports in Dermatology - April 18, 2019 Category: Dermatology Source Type: research

< b > < i > Vibrio parahaemolyticus < /i > < /b > Induced Cellulitis and Septic Shock after a Sea Beach Holiday in a Patient with Leg Ulcers
We report the case of an 85-year-old patient who developed lower limb cellulitis caused byV. parahaemolyticus, originating from leg ulcers and complicated by septicaemia and septic shock, after a sea beach holiday. We discuss the epidemiology, pathogenesis, clinical manifestations and treatment ofV. parahaemolyticus infections.Case Rep Dermatol 2019;11:94 –100 (Source: Case Reports in Dermatology)
Source: Case Reports in Dermatology - April 17, 2019 Category: Dermatology Source Type: research

Hidradenitis Suppurativa is a Diagnosis to be Discussed
One of the values of case reports is that they foster communication between the involved parties. The cases included in this mini-review all underline different aspects of communication: between peers but also between physicians and patients. Few things, if any, can equal the concrete occasion to discuss empirical data. Among physicians, communication can not only create awareness but just as importantly provide solutions or suggest perspective to problems, while communication with patients is at the very core of medicine. These aspects are demonstrated in four cases dealing with the disease hidradenitis suppurativa.Case R...
Source: Case Reports in Dermatology - April 15, 2019 Category: Dermatology Source Type: research

Acral Amelanotic Melanoma Mimicking a Non-Healing Arterial Ulcer
Acral melanomas contribute to approximately 2 –3% of melanomas but are commonly misdiagnosed due to their rarity, subtlety at onset and tendency to display amelanotic features. This case report describes a 70-year-old male with an amelanotic melanoma misdiagnosed as a non-healing arterial ulcer. Histopathology demonstrated a Breslow 2.3 mm, C lark level IV acral lentiginous melanoma, which was definitively managed with surgical intervention. This case report highlights the importance of considering melanoma in the differential diagnosis of non-healing ulcers.Case Rep Dermatol 2019;11:77 –81 (Source: Case Reports in Dermatology)
Source: Case Reports in Dermatology - March 31, 2019 Category: Dermatology Source Type: research

Alopecia Diffusa while Using Interleukin-17 Inhibitors against Psoriasis Vulgaris
We report two cases of alopecia diffusa during the treatment of psoriasis vulgaris with interleukin (IL)-17 inhibitors. Psoriasis is one of the most common immune-mediated chronic skin diseases, strongly associated with IL-17A. Clinically, the monoclonal antibodies to IL-17A or its receptor, IL-17R, show a dramatic effect against psoriasis. Alopecia is also an IL-17-mediated autoimmune disease, and IL-17 inhibitors have been expected to be the gold standard for the treatment of alopecia; therefore, the complication of alopecia while using IL-17 may be regarded as an unexpected “paradoxical reaction.” T helper (...
Source: Case Reports in Dermatology - March 31, 2019 Category: Dermatology Source Type: research

An Extremely Rare Case of Leukoderma Induced by Cosmetics Containing Ascorbic Acid
We report the case of a 73-year-old woman with leukoderma induced by cosmetics containing ascorbic acid. She had noticed the sudden appearance of a hypopigmented macule on the cheek within 1 month after use of the cosmetics with the brand name Obaji C Serum. No history of use of rhododenol-containing cosmetics was declared. Histopathological analysis revealed that the number of matured melanocytes was apparently decreased, and T lymphocytes abundantly infiltrated mainly the perifollicular region. In addition to the discontinuation of using Obaji C Serum, phototherapy by excimer light was noticeably effective for repigmenta...
Source: Case Reports in Dermatology - March 31, 2019 Category: Dermatology Source Type: research

Discrete Papular Lichen Myxedematosus and Scleromyxedema with Hypothyroidism: A Report of Two Cases
Scleromyxedema and lichen myxedematosus (LM) are rare disorders that fall along the spectrum of primary cutaneous mucinoses. Scleromyxedema is a systemic form that classically presents with generalized waxy papules, sclerodermoid eruption, and monoclonal gammopathy; LM is a localized form limited to the skin that classically presents with white, firm, waxy papules and lacks monoclonal gammopathy. According to diagnostic criteria established in 2001, the diagnosis of both conditions requires absence of thyroid disease. However, atypical cases that lack monoclonal gammopathy and that present with hypothyroidism have been rep...
Source: Case Reports in Dermatology - March 20, 2019 Category: Dermatology Source Type: research

Steatocystoma Multiplex Suppurativa: A Case with Unusual Giant Cysts over the Scalp and Neck
We describe herein a 28-year-old male with SMS who presented with extensive giant cysts on his neck, face, and scalp.Case Rep Dermatol 2019;11:71 –76 (Source: Case Reports in Dermatology)
Source: Case Reports in Dermatology - March 20, 2019 Category: Dermatology Source Type: research

Localized Cutaneous Adverse Event Induced by Anastrozole as Adjuvant Treatment for Breast Cancer: A Case Report
We describe a rare case of a cutaneous adverse event that developed in a cancer-affected breast after aromatase inhibitor treatment. A 72-year-old postmenopausal female patient who was diagnosed with stage IA breast cancer received anastrozole as adjuvant treatment. Six months after the initiation of anastrozole, she developed an irregularly shaped purpuric plaque with several purpuric papules surrounding the postoperative scar on her left breast. Histological findings revealed capillary vessel proliferation and expansion, with hemorrhage in the superficial dermis. Immunohistochemistry of the skin biopsy specimen revealed ...
Source: Case Reports in Dermatology - March 7, 2019 Category: Dermatology Source Type: research

Generalized Molluscum Contagiosum Successfully Treated with Interferon-Alpha in a Patient with Folliculotropic Mycosis Fungoides
We present the case of a 50-year-old patient with folliculotropic mycosis fungoides (FMF) unresponsive to retinoids and the chemotherapeutic regimens CHOP, gemcitabine, and brentuximab-vedotin. During immunosuppressive therapy, the patient developed extensive progressive molluscum contagiosum. The mollusca did not respond to topical imiquimod but showed a swift complete response to interferon-alpha 2a (IFNa). Recently, the patient started with alemtuzumab as induction therapy for an allogenic stem cell transplantation and simultaneously continued IFNa therapy.Case Rep Dermatol 2019;11:52 –56 (Source: Case Reports in Dermatology)
Source: Case Reports in Dermatology - February 26, 2019 Category: Dermatology Source Type: research

A Rare Case of Localized Argyria on the Face
Due to its antibacterial actions, silver sulfadiazine is widely used as a topical agent in the treatment of wounds, including burns. Widespread or prolonged topical application of silver sulfadiazine dressings can lead to argyria including systemic symptoms due to the resorption of silver. Here, we report a patient experiencing localized argyria due to sunlight exposure after topical use of silver sulfadiazine cream on his face.Case Rep Dermatol 2019;11:23 –27 (Source: Case Reports in Dermatology)
Source: Case Reports in Dermatology - February 14, 2019 Category: Dermatology Source Type: research

Eosinophilic Granulomatosis with Polyangiitis Manifesting as Recurrent Nasal Polyps and Hemorrhagic Necrotic Bullae: A Rare Disease Successfully Treated with Azathioprine
This report represents one of the possible presentations of EGPA according to the antineutrophil cytoplasmic antibody status – which in our case was negative, with a low prognostic Five-Factor Score – that was successfully treated with oral steroids and azathioprine as a steroid-sparing agent. Our objective was to add a case report to the scarce existing literature in order to learn more about therapeutic options for EGPA. This case report demonstrates that oral steroids, as induction treatment, and azathioprine, as maintenance treatment, are effective in elderly patients with EGPA without involvement of any ot...
Source: Case Reports in Dermatology - February 14, 2019 Category: Dermatology Source Type: research

Syringocystadenoma Papilliferum: A Case Report and Review of the Literature
Syringocystadenoma papilliferum is a very rare, benign adnexal tumor that originates from the apocrine sweat glands. Herein, we report a 25-year-old male who presented with a 10-year history of an asymptomatic slowly growing skin lesion on his face. Skin examination revealed a solitary rounded 3 × 3 cm erythematous plaque with central crustation on the right side of his face. Punch skin biopsy was taken from the lesion. The epidermis showed downward papillomatous extensions. The dermis showed multiple epithelial sheets and dilated ducts that were lined by columnar cells. On the basis of th e above clinicopathological...
Source: Case Reports in Dermatology - February 14, 2019 Category: Dermatology Source Type: research

Serum Sickness after Equine Rabies Immunoglobulin in Identical Male Twins: Two Case Reports
We, hereby, report two cases of serum sickness in adult male identical twins who had received equine rabies immunoglobulin as a postexposure rabies treatment after cat scratches. The younger brother developed low-grade fever, polyarthritis, and multiple erythematous maculopapular eruptions, whereas low-grade fever and urticaria-like eruptions were detected in the elder brother. Both patients received a 7-day course of low-dose prednisolone and achieved good responses without recurrent attacks.Case Rep Dermatol 2019;11:40 –47 (Source: Case Reports in Dermatology)
Source: Case Reports in Dermatology - February 14, 2019 Category: Dermatology Source Type: research

Occult Basal Cell Carcinoma Arising in Seborrheic Keratosis
In this report, we present a case of occult microscopic basal cell carcinoma arising in a lesion of seborrheic keratosis. This case indicates that the basal cell carcinoma could arise from seborrheic keratosis and might help to clarify the origin of basal cell carcinoma.Case Rep Dermatol 2019;11:48 –51 (Source: Case Reports in Dermatology)
Source: Case Reports in Dermatology - February 14, 2019 Category: Dermatology Source Type: research

Lipedematous Alopecia: Clinical, Histopathological, and Trichoscopic Findings of a Single Case and Review of the Literature
A 66-year-old African woman suffered from a boggy thickening of the scalp in the frontoparietal area and the vertex accompanied by headache since infancy. In her thirties, she developed diffuse hair loss in the same area. Clinical and trichoscopic examination were unhelpful, but the histopathological and radiologic findings led to a diagnosis by demonstrating thick subcutaneous adipose tissue. First described in 1935 by Cornbleet [Arch Dermatol Syphilol. 1935; 32: 688], lipedematous scalp is a rare scalp disease marked by a soft thickening of the scalp. A similar clinicopathologic entity associated with nonscarring but per...
Source: Case Reports in Dermatology - January 27, 2019 Category: Dermatology Source Type: research

Treatment of Actinic Keratoses Facilitates Dermatoscopic Diagnosis of Early Basal Cell Carcinoma: A Case Report and Review
We report a case where the presence of BCC was dermatoscopically detected after an overlying AK was treated with topical chemotherapy, thus indicating that treatment of AK allows better visualization of other underlying malignancies.Case Rep Dermatol 2019;11:16 –22 (Source: Case Reports in Dermatology)
Source: Case Reports in Dermatology - January 27, 2019 Category: Dermatology Source Type: research

Malignant Melanoma Treated with Topical Imiquimod: A Bespoke Treatment That Spared the Amputation
We report the case of a 77-year-old female with a large, invasive, malignant melanoma of the malleolar area. Due to the size of the lesion, its location, and the patient ’s general condition, neither surgery nor radiotherapy were indicated. We offered topical treatment with 5% imiquimod to be applied once/day continuously over a 3-month period, pausing only when intense inflammation on the area of application occurred. Complete clinical and histological resolution of the lesion were observed. This case adds further merit to the growing body of evidence that imiquimod can be used to successfully treat malignant melano...
Source: Case Reports in Dermatology - January 13, 2019 Category: Dermatology Source Type: research