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Adrenal crisis mainly manifested as recurrent syncope secondary to tislelizumab: a case report and literature review
We report this case to improve our understanding of this situation, identify this kind of disease, and prevent adrenal crisis in time. Eventually, limiting toxicities reduces the interruption of immunotherapy. Since irAEs are multisystem damage with more non-specific symptoms, except for oncologists, general practitioners who endorse the need for taking a holistic approach to the patient should play a vital role in the management of cancer treatment. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - January 16, 2024 Category: Allergy & Immunology Source Type: research

Elinzanetant: a phase III therapy for postmenopausal patients with vasomotor symptoms
Expert Opin Investig Drugs. 2024 Jan;33(1):19-26. doi: 10.1080/13543784.2024.2305122. Epub 2024 Feb 12.ABSTRACTINTRODUCTION: Menopausal vasomotor symptoms (VMS) are experienced by most women and are often debilitating and can last for years. While hormone replacement therapy is effective, it carries risks that have impacted its wider use, and it can be contraindicated. There is a large unmet need for a safe, effective non-hormonal therapy.AREAS COVERED: The importance of the neurokinin (NK) system in the hypothalamic regulation of the vasomotor center has become clear. NK antagonists, previously developed for other indicat...
Source: Expert Opinion on Investigational Drugs - January 15, 2024 Category: Drugs & Pharmacology Authors: Jenifer Sassarini Richard A Anderson Source Type: research

Case Report: From epilepsy and uterus didelphys to Turner syndrome-associated dysgerminoma
We present a unique case of a 33-year-old nulliparous Chinese woman with intermittent epilepsy and Mullerian anomalies carrying a double uterus, cervix, and vagina. The patient is also characterized as having Turner syndrome accompanied by 46,X, del(Xp22.33-11.23) and del(2)(q11.1-11.2). MRI exhibited a 17.0 cm × 20.0 cm × 10.5 cm solid ovarian lesion. Radical surgery and pathology revealed dysgerminoma at stage IIIc with lymphatic metastases and a KIT gene mutation identified in exon 13. Furthermore, the tumor microenvironment (TME) displayed robust expression of CD4+ T lymphocytes and PD-1, whereas the distribution ...
Source: Frontiers in Genetics - January 11, 2024 Category: Genetics & Stem Cells Source Type: research

Refining the role of reproductive factors on heart health
Ischaemic heart disease (IHD) is the leading cause of death worldwide in both women and men. Yet, the first manifestation of IHD is typically 5 to 10 years later in women than in men.1 The reasons for these sex differences in the age at onset of IHD are not fully understood. Female sex hormones, especially oestrogen, however, are often thought to explain the lower age-standardised incidence of IHD in women. In experimental studies, oestrogen has shown to have multiple cardioprotective properties, including reduced fibrosis and oxidative stress, stimulation of angiogenesis and vasodilation, and improved mitochondrial functi...
Source: Heart - January 10, 2024 Category: Cardiology Authors: Peters, S. A. E. Tags: Editorials Source Type: research

Effects of Hormone Replacement Therapy on Bone Mineral Density in Korean Adults With Turner Syndrome
CONCLUSION: Early onset and appropriate duration of hormone replacement therapy is important for increasing bone mineral density in patients with Turner syndrome. Also, ERT affects differently to TS patients according to mosaicism.PMID:38193328 | DOI:10.3346/jkms.2024.39.e9 (Source: J Korean Med Sci)
Source: J Korean Med Sci - January 9, 2024 Category: General Medicine Authors: SunYoung Kim Heeyon Kim Inha Lee Euna Choi JinKyung Baek Jaekyung Lee Hae-Rim Kim Bo Hyon Yun Young Sik Choi Seok Kyo Seo Source Type: research

Effects of Hormone Replacement Therapy on Bone Mineral Density in Korean Adults With Turner Syndrome
CONCLUSION: Early onset and appropriate duration of hormone replacement therapy is important for increasing bone mineral density in patients with Turner syndrome. Also, ERT affects differently to TS patients according to mosaicism.PMID:38193328 | DOI:10.3346/jkms.2024.39.e9 (Source: Journal of Korean Medical Science)
Source: Journal of Korean Medical Science - January 9, 2024 Category: Biomedical Science Authors: SunYoung Kim Heeyon Kim Inha Lee Euna Choi JinKyung Baek Jaekyung Lee Hae-Rim Kim Bo Hyon Yun Young Sik Choi Seok Kyo Seo Source Type: research

Effects of Hormone Replacement Therapy on Bone Mineral Density in Korean Adults With Turner Syndrome
CONCLUSION: Early onset and appropriate duration of hormone replacement therapy is important for increasing bone mineral density in patients with Turner syndrome. Also, ERT affects differently to TS patients according to mosaicism.PMID:38193328 | PMC:PMC10782041 | DOI:10.3346/jkms.2024.39.e9 (Source: J Korean Med Sci)
Source: J Korean Med Sci - January 9, 2024 Category: General Medicine Authors: SunYoung Kim Heeyon Kim Inha Lee Euna Choi JinKyung Baek Jaekyung Lee Hae-Rim Kim Bo Hyon Yun Young Sik Choi Seok Kyo Seo Source Type: research

Effects of Hormone Replacement Therapy on Bone Mineral Density in Korean Adults With Turner Syndrome
CONCLUSION: Early onset and appropriate duration of hormone replacement therapy is important for increasing bone mineral density in patients with Turner syndrome. Also, ERT affects differently to TS patients according to mosaicism.PMID:38193328 | PMC:PMC10782041 | DOI:10.3346/jkms.2024.39.e9 (Source: Journal of Korean Medical Science)
Source: Journal of Korean Medical Science - January 9, 2024 Category: Biomedical Science Authors: SunYoung Kim Heeyon Kim Inha Lee Euna Choi JinKyung Baek Jaekyung Lee Hae-Rim Kim Bo Hyon Yun Young Sik Choi Seok Kyo Seo Source Type: research

The Intriguing Effects of Hormone Replacement Therapy on Cardiac Structure and Function
The acute and chronic cardiac adaptations to exercise in humans have been a subject of research for over a century since Henschen published his monograph in 1899 including a careful examination of cross-country ski racers before and after races.1,2 He was limited by the technology of the time, estimating cardiac size by percussion, for example. Despite the limitations of his approach, he correctly concluded that chronic exercise resulted in both dilation and hypertrophy of the heart and that was a positive adaptation. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - January 9, 2024 Category: Cardiology Authors: David T. Linker Tags: Editorial Source Type: research

Could setmelanotide be the game-changer for acquired hypothalamic obesity?
Children with acquired hypothalamic obesity, e.g. following treatment for pediatric craniopharyngioma are at great risk for metabolic syndrome, cardiovascular health problems and premature mortality. Treatment for acquired hypothalamic obesity has thus far been disappointing. Several interventions were reported to be partially successful, including dextro-amphetamine and GLP-1R agonists, although results in acquired hypothalamic obesity are conflicting. Disruption of signaling through the melanocortin-4 receptor (MC4R) pathway results in hyperphagia and severe early-onset hypothalamic obesity. Recently, the MC4R agonist se...
Source: Frontiers in Endocrinology - January 4, 2024 Category: Endocrinology Source Type: research

GSE252280 Endometrial transcriptome profiling of patients with recurrent implantation failure (RIF) during hormone replacement therapy (HRT) cycles
This study aims to explore the transcriptomic signatures of endometrium with normal and displaced WOIs during HRT cycles and to identify the causes of endometrial receptivity (ER) abnormalities and WOI displacement in RIF patients. 40 RIF patients were recruited and underwent personalized embryo transfer (pET) guided by the predicted results of endometrial receptivity diagnosis (ERD) model. Transcriptome analysis of endometrium from patients with clinical pregnancies after pET was performed to identify differentially expressed genes (DEGs) associated with WOI displacement. The ERD results indicated that 67.5% of RIF patien...
Source: GEO: Gene Expression Omnibus - January 3, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

The Outcome Of Acute Heart Failure In Patients On Hormone Replacement Therapy: A Nationwide Analysis
Heart Failure is a major public health issue that is associated with increased mortality. Recent studies suggest that replacement therapy in patients with coexisting congestive heart failure (CHF) and hormone deficiency can lead to the slowing of disease progression. Our study sought to estimate the impact of hormone replacement therapy on the clinical outcome of patients hospitalized for acute Heart Failure. (Source: Journal of Cardiac Failure)
Source: Journal of Cardiac Failure - January 1, 2024 Category: Cardiology Authors: Joseph Amoah, Sara Noureldin, Brittany Smith, Samir Dekowski, Michael Fatuyi, Francisco Somoza-Cano, Alero Arueyingho, Catherine Illah, Henry Egbuchiem Tags: 420 Source Type: research

Post cancer care in women with an increased risk of malignancy or previous malignancy: The use of hormone replacement therapy and alternative treatments
Best Pract Res Clin Endocrinol Metab. 2023 Dec 15:101854. doi: 10.1016/j.beem.2023.101854. Online ahead of print.NO ABSTRACTPMID:38160182 | DOI:10.1016/j.beem.2023.101854 (Source: Clinical Genitourinary Cancer)
Source: Clinical Genitourinary Cancer - December 30, 2023 Category: Cancer & Oncology Authors: Jenifer Sassarini Mary Ann Lumsden Source Type: research

Post cancer care in women with an increased risk of malignancy or previous malignancy: The use of hormone replacement therapy and alternative treatments
Best Pract Res Clin Endocrinol Metab. 2023 Dec 15:101854. doi: 10.1016/j.beem.2023.101854. Online ahead of print.NO ABSTRACTPMID:38160182 | DOI:10.1016/j.beem.2023.101854 (Source: Clinical Breast Cancer)
Source: Clinical Breast Cancer - December 30, 2023 Category: Cancer & Oncology Authors: Jenifer Sassarini Mary Ann Lumsden Source Type: research