A Non-Inferiority Study on Endometrial Preparation Prior to FET-Letrozole Versus Hormone Replacement Therapy
ConclusionLetrozole FET could be a better alternative to the conventional HRT cycles, in selected population of patients, in terms of reproductive outcomes and patient satisfaction. (Source: The Journal of Obstetrics and Gynecology of India)
Source: The Journal of Obstetrics and Gynecology of India - February 6, 2024 Category: OBGYN Source Type: research

Risks and benefits of hormone replacement therapy in reproductive age women after hematopoietic stem cell transplants: a narrative review
Introduction and aims of the study: Haematopoietic stem cell transplantation increases survival for hematologic malignancies, but increasing numbers of survivors struggle with the side effects. For women with established primary ovarian failure, the question of whether menopausal or contraceptive hormone treatments are more beneficial remains unanswered because no comparative studies have been conducted. The aim of this study was to summarise the main benefits and risks of menopausal hormone therapy for patients who have undergone haematopoietic stem cell transplantation. (Source: European Journal of Obstetrics, Gynecology...
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - February 1, 2024 Category: OBGYN Authors: El żbieta Bumbul-Mazurek, Zana Bumbuliene, Gabija Raziunaite Source Type: research

Endometrial transcriptome profiling of patients with recurrent implantation failure during hormone replacement therapy cycles
ConclusionOur study shows that ER-related genes share similar gene expression patterns during WOI in both natural and HRT cycles, and their aberrant expression is associated with WOI displacements. The improvement of pregnancy outcomes in RIF patients by adjusting ET timing according to ERD results demonstrates the importance of transcriptome-based endometrial receptivity assessment and the clinical efficiency of ERD model. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - January 30, 2024 Category: Endocrinology Source Type: research