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Yawning and cortisol levels in multiple sclerosis: potential new diagnostic tool
Publication date: Available online 2 May 2018 Source:Multiple Sclerosis and Related Disorders Author(s): Simon B N Thompson, Alister Coleman, Nicola Williams Yawning is a significant behavioural response and, together with cortisol, is potentially a new diagnostic marker of neurological diseases. Evidence of an association between yawning and cortisol was found which supports the Thompson Cortisol Hypothesis and thermoregulation hypotheses, indication that brain cooling occurs when yawning. 117 volunteers aged 18-69 years were randomly allocated to experimentally controlled conditions to provoke yawning. Thirty-three had ...
Source: Multiple Sclerosis and Related Disorders - May 15, 2018 Category: Neurology Source Type: research

Hormone replacement therapy for women previously treated for endometrial cancer.
CONCLUSIONS: Currently, there is insufficient high-quality evidence to inform women considering HRT after treatment for endometrial cancer. The available evidence (both the single RCT and non-randomised evidence) does not suggest significant harm, if HRT is used after surgical treatment for early-stage endometrial cancer. There is no information available regarding use of HRT in higher-stage endometrial cancer (FIGO stage II and above). The use of HRT after endometrial cancer treatment should be individualised, taking account of the woman's symptoms and preferences, and the uncertainty of evidence for and against HRT use. ...
Source: Cochrane Database of Systematic Reviews - May 15, 2018 Category: General Medicine Authors: Edey KA, Rundle S, Hickey M Tags: Cochrane Database Syst Rev Source Type: research

Hormone replacement therapy decreases the risk of tinnitus in menopausal women: a nationwide study.
We examined the medical records of menopausal women aged between 45 and 79 years from Taiwan's National Health Insurance Research Database of records between 1 January 2000 and 31 December 2010 to establish matched cohorts (13,920 HRT users and 41,760 nonusers). The incidence of tinnitus in HRT users and nonusers were matched 1:3 based on propensity-score matching over this ten year period. The Cox regression hazard model was used to identify risk factors of tinnitus, and results indicate that a significantly lower percentage of HRT users (P = 0.017) developed tinnitus in comparison with nonusers (0.43%, 60/13, 920 vs. 0.5...
Source: Oncotarget - May 9, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

Pharmacotherapy for the treatment of depression in patients with alzheimer's disease: a treatment-resistant depressive disorder.
Authors: Lozupone M, La Montagna M, D'Urso F, Piccininni C, Sardone R, Dibello V, Giannelli G, Solfrizzi V, Greco A, Daniele A, Quaranta N, Seripa D, Bellomo A, Logroscino G, Panza F Abstract INTRODUCTION: Pharmacotherapy for the treatment of depressive disorders in Alzheimer's Disease (AD) represents a clinical challenge. pharmacological options are often attempted after a period of watchful waiting (8-12 weeks). monoaminergic antidepressant drugs have shown only modest or null clinical benefits, maybe because the etiology of depressive symptoms in ad patients is fundamentally different from that of nondement...
Source: Expert Opinion on Pharmacotherapy - May 7, 2018 Category: Drugs & Pharmacology Tags: Expert Opin Pharmacother Source Type: research

Progressive Non-familial Adult onset Cerebellar Degeneration: An Unusual Occurrence with Hashimoto's Thyroiditis.
We report a case of cerebellar atrophy in a 31 year old female whose detailed evaluation had revealed sub-clinical hypothyroidism secondary to autoimmune thyroiditis with a very high anti-TPO (anti-thyroid peroxidase) antibody levels. MRI (Magnetic Resonanace Imaging) of brain showed diffuse bilateral cerebellar atrophy. She was treated with thyroid hormone supplementation and after one year of follow up, cerebellar signs had disappeared completely with significant reduction in anti-TPO antibody levels. Imaging of the brain post one year of follow-up revealed normal cerebellum. Hence, we opine that thyroid dysfunction shou...
Source: Psychopharmacology Bulletin - May 3, 2018 Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

Presentation, progression, and predictors of ovarian insufficiency in classic galactosemia
AbstractClassic galactosemia (CG) is an inherited metabolic disorder that affects about 1 in 50,000 live births in the United States and many other countries. With the benefit of early detection by newborn screening and rapid dietary restriction of galactose, generally achieved by removing dairy from the diet, most affected infants are spared the acute and potentially lethal symptoms of disease. Despite early detection and life-long dietary intervention, however, most patients grow to experience a constellation of long-term complications that include premature ovarian insufficiency in the vast majority of girls and young w...
Source: Journal of Inherited Metabolic Disease - May 2, 2018 Category: Internal Medicine Source Type: research

THERAPY OF ENDOCRINE DISEASE: Growth Hormone Replacement Therapy in Adults: Thirty Years of Personal Clinical Experience.
Abstract The acute metabolic actions of purified human GH was first documented in adult hypopituitary patients more than 50 years ago, and placebo controlled long term GH trials in GH-deficient adults (GHDA) surfaced in 1989 with the availability of biosynthetic human GH. Untreated GHDA is associated with excess morbidity and mortality from cardiovascular disease and the phenotype includes fatigue, reduced aerobic exercise capacity, abdominal obesity, reduced lean body mass, osteopenia, and elevated levels of circulating cardiovascular biomarkers. Several of these features reverse and normalize with GH replacement...
Source: European Journal of Endocrinology - May 1, 2018 Category: Endocrinology Authors: Jorgensen JOL, Juul A Tags: Eur J Endocrinol Source Type: research

Research Progress of Progesterone Preparations: a mini Review.
CONCLUSION: Although progesterone has first-pass effects, with these methods, the bioavailability and compliance can greatly increase. PMID: 29708071 [PubMed - as supplied by publisher] (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - April 27, 2018 Category: Drugs & Pharmacology Authors: Ye M, Pan W, Yang X, Zhang X Tags: Curr Drug Metab Source Type: research

Pharmacological interventions for the prevention of insufficiency fractures and avascular necrosis associated with pelvic radiotherapy in adults.
CONCLUSIONS: The evidence relating to interventions to prevent insufficiency fractures and avascular necrosis associated with pelvic radiotherapy in adults is of very low certainty. This review highlights the need for prospective clinical trials using interventions prior to and during radiotherapy to prevent radiation-related bone morbidity, insufficiency fractures and avascular necrosis. Future trials could involve prospective assessment of bone health including BMD and bone turnover markers prior to pelvic radiotherapy. The interventions for investigation could begin as radiotherapy commences and remain ongoing for 12 to...
Source: Cochrane Database of Systematic Reviews - April 23, 2018 Category: General Medicine Authors: van den Blink QU, Garcez K, Henson CC, Davidson SE, Higham CE Tags: Cochrane Database Syst Rev Source Type: research

Low dose of acacetin promotes breast cancer MCF-7 cells proliferation through the activation of ERK/ PI3K /AKT signaling pathway.
Conclusion Low dose of acacetin from 10^-3 μM to 1 μM promoted the proliferation of MCF-7 cells through the ERK/PI3K/AKT pathway and its downstream cyclin signaling, and this pathway is mainly mediated by the expression of ERα. PMID: 29676234 [PubMed - as supplied by publisher] (Source: Recent Patents on Anti-Cancer Drug Discovery)
Source: Recent Patents on Anti-Cancer Drug Discovery - April 22, 2018 Category: Cancer & Oncology Tags: Recent Pat Anticancer Drug Discov Source Type: research

Hormone replacement therapy, mammographic density, and breast cancer risk: a cohort study
ConclusionsMD partially mediates some of the association between HRT and breast cancer risk. The association between HRT and breast cancer seems to be stronger in women with dense breasts. (Source: Cancer Causes and Control)
Source: Cancer Causes and Control - April 18, 2018 Category: Cancer & Oncology Source Type: research

Levonorgestrel-releasing intra-uterine systems as female contraceptives.
Authors: Grandi G, Farulla A, Sileo FG, Facchinetti F Abstract INTRODUCTION: The availability and use of long-acting reversible contraceptives (LARCs), such as levonorgestrel intrauterine systems (LNG-IUSs), have increased in recent times. Areas covered: The authors provide a narrative review of the LNG-IUSs currently available worldwide as female contraceptives (LNG-IUS 13.5, 19.5 and 52 mg). Specific features of the devices and their parameters of efficacy and tolerability were considered as outcomes. Expert opinion: The one-handed 3.8-mm-diameter inserter of LNG-IUS 13.5 mg and 19.5 mg may be part...
Source: Expert Opinion on Pharmacotherapy - April 13, 2018 Category: Drugs & Pharmacology Tags: Expert Opin Pharmacother Source Type: research

Over- and undertreatment of hypothyroidism is associated with excess mortality. A register-based cohort study.
Authors: Lillevang-Johansen M, Abrahamsen B, Jørgensen HL, Brix TH, Hegedus L Abstract Objective To investigate the association between hypothyroidism and mortality in both treated and untreated hypothyroid patients, and the consequences of over- and undertreatment with respect to mortality. Patients and methods Register-based cohort study of 235 168 individuals who had at least one serum TSH during 1995 to 2011 (median follow-up, 7.2 years). Hypothyroidism was defined as at least two measurements of TSH>4.0 mIU/L within a half year spaced by at least 14 days, or one measurement of TSH>4.0 mIU/L and tw...
Source: Thyroid : official journal of the American Thyroid Association - April 12, 2018 Category: Endocrinology Tags: Thyroid Source Type: research

Soy isoflavones improve cardiovascular disease risk markers in women during the early menopause
Conclusions Supplementation with soy protein with isoflavones for 6 months significantly improved CVR markers and calculated CVR at 6 months during early menopause compared to soy protein without isoflavones. ISRCTN registry ISRCTN34051237. (Source: Nutrition, Metabolism and Cardiovascular Diseases)
Source: Nutrition, Metabolism and Cardiovascular Diseases - April 10, 2018 Category: Nutrition Source Type: research

Soy isoflavones improve cardiovascular disease risk markers in women during the early menopause
Hormone replacement therapy may be beneficial for cardiovascular disease risk (CVR) in post-menopausal women. Soy isoflavones may act as selective estrogen receptor modulators. The aim of this study was to evaluate whether soy isoflavones had an effect on CVR markers. (Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD)
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - April 9, 2018 Category: Nutrition Authors: Thozhukat Sathyapalan, Myint Aye, Alan S. Rigby, Natalie J. Thatcher, Soha R. Dargham, Eric S. Kilpatrick, Stephen L. Atkin Source Type: research

Menopause Symptom Management in the United Kingdom
This article covers the main presenting complaints and treatments, from lifestyle to hormone replacement therapy, by drawing on guidelines from national bodies. (Source: Nursing Clinics of North America)
Source: Nursing Clinics of North America - April 6, 2018 Category: Nursing Authors: Debra Holloway Source Type: research

Autoimmune Addison's disease  - An update on pathogenesis.
Autoimmune Addison's disease - An update on pathogenesis. Ann Endocrinol (Paris). 2018 Apr 06;: Authors: Hellesen A, Bratland E, Husebye ES Abstract Autoimmunity against the adrenal cortex is the leading cause of Addison's disease in industrialized countries, with prevalence estimates ranging from 93-220 per million in Europe. The immune-mediated attack on adrenocortical cells cripples their ability to synthesize vital steroid hormones and necessitates life-long hormone replacement therapy. The autoimmune disease etiology is multifactorial involving variants in immune genes and environmental...
Source: Annales d'Endocrinologie - April 6, 2018 Category: Endocrinology Authors: Hellesen A, Bratland E, Husebye ES Tags: Ann Endocrinol (Paris) Source Type: research

Menopause Symptom Management in the United Kingdom
This article covers the main presenting complaints and treatments, from lifestyle to hormone replacement therapy, by drawing on guidelines from national bodies. (Source: Nursing Clinics of North America)
Source: Nursing Clinics of North America - April 6, 2018 Category: Nursing Authors: Debra Holloway Source Type: research

A high-affinity subtype-selective fluorescent probe for estrogen receptor β imaging in living cells.
A high-affinity subtype-selective fluorescent probe for estrogen receptor β imaging in living cells. Chem Commun (Camb). 2018 Apr 03;: Authors: Hu Z, Yang L, Ning W, Tang C, Meng Q, Zheng J, Dong C, Zhou HB Abstract Estrogen receptor β (ERβ) has recently been identified as a pharmaceutical target in hormone replacement therapy for breast cancers. However, the biological function of ERβ in disease progression remains unclear. A highly ERβ-selective fluorescent probe (FPNM) was discovered exhibiting nanomolar affinity for ERβ with an ERβ/ERα selectivity as high a...
Source: Chemical Communications - April 3, 2018 Category: Chemistry Authors: Hu Z, Yang L, Ning W, Tang C, Meng Q, Zheng J, Dong C, Zhou HB Tags: Chem Commun (Camb) Source Type: research

A high-affinity subtype-selective fluorescent probe for estrogen receptor [small beta] imaging in living cells
Chem. Commun., 2018, Accepted Manuscript DOI: 10.1039/C8CC00483H, CommunicationZhiye Hu, Lu Yang, Wentao Ning, chu tang, Qiuyu Meng, Jie Zheng, Chune Dong, Haibing Zhou Estrogen receptor [small beta] (ER[small beta]) has recently been identified as a pharmaceutical target in hormone replacement therapy for breast cancers. However, the biological function of ER[small beta] in disease progression remains unclear.... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Chem. Commun. latest articles)
Source: RSC - Chem. Commun. latest articles - March 23, 2018 Category: Chemistry Authors: Zhiye Hu Source Type: research

Mindfulness, cognitive behavioural and behaviour ‐based therapy for natural and treatment‐induced menopausal symptoms: a systematic review and meta‐analysis
BackgroundDuring menopause women experience vasomotor and psychosexual symptoms that cannot entirely be alleviated with hormone replacement therapy (HRT). Besides, HRT is contraindicated after breast cancer. ObjectivesTo review the evidence on the effectiveness of psychological interventions in reducing symptoms associated with menopause in natural or treatment‐induced menopausal women. Search strategyMedline/Pubmed, PsycINFO, EMBASE and AMED were searched until June 2017. Selection criteriaRandomised controlled trials (RCTs) concerning natural or treatment‐induced menopause, investigating mindfulness or (cognitive‐)...
Source: BJOG: An International Journal of Obstetrics and Gynaecology - March 15, 2018 Category: OBGYN Authors: CMG Driel, AS Stuursma, MJ Schroevers, MJE Mourits, GH Bock Tags: Systematic Review Source Type: research

Mindfulness, cognitive behavioural and behaviour-based therapy for natural and treatment-induced menopausal symptoms: a systematic review and meta-analysis.
Abstract BACKGROUND: During menopause women experience vasomotor and psychosexual symptoms that cannot entirely be alleviated with hormone replacement therapy (HRT). Besides, HRT is contraindicated after breast cancer. OBJECTIVES: To review the evidence on the effectiveness of psychological interventions in reducing symptoms associated with menopause in natural or treatment-induced menopausal women. SEARCH STRATEGY: Medline/Pubmed, PsycINFO, EMBASE and AMED were searched until June 2017. SELECTION CRITERIA: Randomised controlled trials (RCTs) concerning natural or treatment-induced menopause, invest...
Source: BJOG : An International Journal of Obstetrics and Gynaecology - March 15, 2018 Category: OBGYN Authors: van Driel C, Stuursma AS, Schroevers MJ, Mourits M, de Bock GH Tags: BJOG Source Type: research

Gender Differences in Radiation Therapy Effects in Male and Female Patients With Head and Neck Cancer
Previous studies have suggested lower risk of HNC incidence in women, and furthermore associated with a decreased risk in women who use exogenous hormone replacement therapy or have pregnancies under age 35. Other recent data suggest association with smoking, alcohol, and occupational history in women may have an effect on incidence. To date, few studies have discussed differences with regard to side effects, or measures of coping mechanisms with diagnosis and treatment in women with head and neck cancers undergoing radiation therapy. (Source: International Journal of Radiation Oncology * Biology * Physics)
Source: International Journal of Radiation Oncology * Biology * Physics - March 14, 2018 Category: Radiology Authors: B.R. Page, P. Han, L.C. Peng, Z. Cheng, J. Harkness, C. Shen, A. Choflet, E. Cecil, X. Hui, N.C. Schmitt, I. Shpitser, T.R. McNutt, H. Quon Source Type: research

Heterogeneity in caregiver population studies
In “Informal caregiving and metabolic markers in the UK Household Longitudinal Study”, Lacey et al. [1] state that “longitudinal studies investigating caregiving and metabolic markers have yet to account for potential modification by gender and caregiving intensity when investigating associations with health”. However, one study showed that longitudinal relationships between caregiver indicators, changes in psychological distress and metabolic markers, and new cases of ICD-9 coded Coronary Heart Disease, depend on gender and use of Hormone Replacement Therapy [2]. (Source: Maturitas)
Source: Maturitas - March 14, 2018 Category: Primary Care Authors: Peter P. Vitaliano Tags: Letter to the Editor Source Type: research

Menopause in CKD
Publication date: Available online 9 March 2018 Source:American Journal of Kidney Diseases Author(s): Kavitha Vellanki, Susan Hou Most women with dialysis-dependent chronic kidney disease (CKD) stage 5 (CKD stage 5D) are in the postmenopausal age group. Early menopause is reported for all CKD stages (stages 3-5D). The traditional definition of menopause is not applicable in CKD stage 5(D) because menses can resume with hormone replacement therapy or kidney transplantation. Treatment of vasomotor symptoms continues to be the primary indication for hormone replacement therapy, with no dosing studies done specifically for CK...
Source: American Journal of Kidney Diseases - March 10, 2018 Category: Urology & Nephrology Source Type: research

A pituitary abscess with one year follow-up after conservative treatment: A case report.
We reported a case of a 58-year-old woman with a history of type 2 diabetes (T2DM) exhibited with headaches, nasal discharge, anosmia, diabetes insipidus and hypopituitarism due to PA, she was diagnosed based on clinical presentations, endocrine examination and MRI image features. She was treated with nasal wash and antibiotic therapy without surgical intervention. She has received hormone replacement therapy for one year and her condition has gradually become stabilized. Meanwhile, the lesion of MRI image didn't become serious after one year. Conservative treatment might be an option for the patients with PA, those reject...
Source: Neuroendocrinology Letters - March 7, 2018 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research

Vascular risk factors for male and female urgency urinary incontinence at age 68 years from a British birth cohort study
ConclusionMultifactorial mechanisms lead to UUI and vascular risk factors may contribute to the pathogenesis of bladder overactivity in addition to higher BMI. Severe UUI appears to be a distinct presentation with more specific contributory mechanisms than milder UUI. (Source: BJU International)
Source: BJU International - March 7, 2018 Category: Urology & Nephrology Authors: Alex Tsui, Diana Kuh, Linda Cardozo, Daniel Davis Tags: Original Article Source Type: research

Risk factors for discontinuation of thyroid hormone replacement therapy in early pregnancy: A study from the Norwegian Mother and Child Cohort Study and the Medical Birth Registry of Norway
ConclusionsIn Norway, around 13% of women with hypothyroidism discontinue THRT in early pregnancy. For discontinuers, non‐medicated mental comorbidity and non‐compliance with nutritional supplements presented increased risk, while having a medicated somatic disorder was protective. Health professionals advising women with hypothyroidism should be aware of risk factors associated with THRT discontinuation.This article is protected by copyright. All rights reserved. (Source: Acta Obstetricia et Gynecologica Scandinavica)
Source: Acta Obstetricia et Gynecologica Scandinavica - March 7, 2018 Category: OBGYN Authors: Anna Simone Frank, Angela Lupattelli, Hedvig Nordeng Tags: Original Research Article Source Type: research

Female reproductive and hormonal factors and incidence of primary total knee arthroplasty due to osteoarthritis
This study included 22,289 women in the Melbourne Collaborative Cohort Study. Data on age at menarche, pregnancy, parity, years of menstruation, oral contraceptive pill (OCP), menopausal status and hormone replacement therapy (HRT) were collected in 1990‐1994. Incidence of TKA during 2001‐2013 was determined by linking cohort records to the National Joint Replacement Registry. All analyses were adjusted for age, BMI at midlife, change in BMI (early reproductive age to midlife), country of birth, physical activity, smoking, and education. ResultsOver 12.7 years, 1,208 TKAs for osteoarthritis were identified. Ever pregna...
Source: Arthritis and Rheumatism - March 7, 2018 Category: Rheumatology Authors: Sultana Monira Hussain, Yuanyuan Wang, Graham G. Giles, Stephen Graves, Anita E. Wluka, Flavia M. Cicuttini Tags: Full Length Source Type: research

Ablation of prolactin receptor increases hepatic triglyceride accumulation.
Abstract Increasing prevalence of non-alcoholic fatty liver disease (NAFLD) worldwide has necessitated a more thorough understanding of it and expanded the scope of research in this field. Women are more resistant to NAFLD than men despite equal exposure to major risk factors, such as obesity or hyperlipidemia. Female resistance is hormone-dependent, as evidenced by the sharp increase in NAFLD incidence in post-menopausal women who do not take hormone replacement therapy. Here, we found that the estrogen-responsive pituitary hormone prolactin (PRL), through specific PRL receptor (PRLR), down-regulates hepatic trig...
Source: Biochemical and Biophysical Research communications - March 7, 2018 Category: Biochemistry Authors: Shao S, Yao Z, Lu J, Song Y, He Z, Yu C, Zhou X, Zhao L, Zhao J, Gao L Tags: Biochem Biophys Res Commun Source Type: research

The Proliferative Response to p27 Down-Regulation in Estrogen Plus Progestin Hormonal Therapy is Lost in Breast Tumors.
Abstract Increased proliferation and breast cancer risk has been observed in postmenopausal women receiving estrogen (E) + progestin hormone replacement therapy (HRT). Progestin action is mediated through two progesterone receptor (PR) isoforms, PRA and PRB, with unique transcriptional activity and function. The current study examines hormonal regulation of PR isoforms in the normal postmenopausal human breast and the mechanism by which progestins increase proliferation and breast cancer risk. Archival benign breast biopsies from postmenopausal and premenopausal women, and luminal breast tumor biopsies from postme...
Source: Translational Oncology - March 7, 2018 Category: Cancer & Oncology Authors: Aupperlee MD, Kariagina A, Zaremba N, Basson MD, Schwartz RC, Haslam SZ Tags: Transl Oncol Source Type: research

The effects of the botanical estrogen, isoliquiritigenin on delayed spatial alternation
Publication date: March–April 2018 Source:Neurotoxicology and Teratology, Volume 66 Author(s): Payel Kundu, Steven L. Neese, Suren Bandara, Supida Monaikul, William G. Helferich, Daniel R. Doerge, Ikhlas A. Khan, Susan L. Schantz Age-related declines in cognitive function can impair working memory, reduce speed of processing, and alter attentional resources. In particular, menopausal women may show an acceleration in the rate of cognitive decline as well as an increased vulnerability to brain diseases as estrogens may play a neuroprotective and neurotrophic role in the brain. To treat menopausal symptoms, many women...
Source: Neurotoxicology and Teratology - March 4, 2018 Category: Toxicology Source Type: research

Transient Secondary Hypothyroidism and Thyroid Hormone Replacement Therapy in Pediatric Postoperative Cardiopulmonary Bypass.
CONCLUSIONS: There is a general lack of uniformity in the evaluation, diagnosis and treatment of transient secondary hypothyroidism in pediatric postoperative CPB patients. PMID: 29485000 [PubMed - as supplied by publisher] (Source: Current Cardiology Reviews)
Source: Current Cardiology Reviews - March 1, 2018 Category: Cardiology Tags: Curr Cardiol Rev Source Type: research

The Top Five Women ’s Health Issues in Preventive Cardiology
AbstractPurpose of ReviewThis review elucidates gender-based determinants of cardiovascular disease in an effort to answer common questions that arise for practitioners as they provide preventive care to women.Recent FindingsFive key topics are at the forefront of recent and ongoing research: (1) coronary microvascular dysfunction, (2) hormone replacement therapy, (3) breast arterial calcification, (4) calcium and vitamin D supplementation, and (5) metabolic considerations during pregnancy.SummaryMicrovascular dysfunction is a common cause of angina in women, and should be treated with the same rigor as macrovascular coron...
Source: Current Cardiovascular Risk Reports - February 28, 2018 Category: Cardiology Source Type: research

Association of translocator protein total distribution volume with duration of untreated major depressive disorder: a cross-sectional study
We examined the relationship of translocator protein (TSPO) total distribution volume (VT), a marker of microglial activation, with duration of untreated major depressive disorder, and with total illness duration and antidepressant exposure. Methods In this cross-sectional study, we recruited participants aged 18–75 years from the Toronto area and the Centre for Addiction and Mental Health (Toronto, ON, Canada). Participants either had major depressive episodes secondary to major depressive disorder or were healthy, as confirmed with a structured clinical interview and consultation with a study psychiatrist. To be en...
Source: The Lancet Psychiatry - February 27, 2018 Category: Psychiatry Source Type: research

Acute pituitary disease in pregnancy: how to handle hypophysitis and Sheehan's syndrome?
Authors: Honegger J, Giese S Abstract Pregnancy-related hypophysitis (PR-Hy) that typically occurs during late pregnancy and the early postpartum period is considered an autoimmune disorder. Knowledge and awareness of characteristic clinical symptoms and specific endocrine and neuroradiological features mostly enables a correct diagnosis and guarantees best possible management. In the presence of mild clinical symptoms, a "wait and watch" policy is recommended. Transsphenoidal surgery or glucocorticoid therapy is indicated if progressive clinical signs or severe visual symptoms are observed. Reported case...
Source: Minerva Endocrinologica - February 26, 2018 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Magnetic resonance imaging and spectroscopy evidence of efficacy for adrenal and gonadal hormone replacement therapy in anorexia nervosa
Dehydroepiandrosterone (DHEA)  + estrogen/progestin therapy for adolescent girls with anorexia nervosa (AN) has the potential to arrest bone loss. The primary aim of this study was to test the effects of DHEA + estrogen/progestin therapy in adolescent girls with AN on bone marrow in the distal femur using magnetic resona nce imaging (MRI) and spectroscopy. (Source: Bone)
Source: Bone - February 26, 2018 Category: Orthopaedics Authors: Sridhar Vajapeyam, Kirsten Ecklund, Robert V. Mulkern, Henry A. Feldman, Jennifer M. O'Donnell, Amy D. DiVasta, Clifford J. Rosen, Catherine M. Gordon Tags: Full Length Article Source Type: research

Is Hormone Replacement Therapy Safe in Women With a BRCA Mutation?: A Systematic Review of the Contemporary Literature
Conclusions: Decisions regarding the use of HT in women who undergo BSO after detection of a BRCA mutation must be individualized based on careful consideration of the risks and benefits. However, the risks of a subsequent cancer diagnosis appear small, particularly in regards to the benefits of treatment afforded by HT. (Source: American Journal of Clinical Oncology)
Source: American Journal of Clinical Oncology - February 23, 2018 Category: Cancer & Oncology Tags: Original Articles: Breast Source Type: research

Trajectories of plasma IGF-1, IGFBP-3, and their ratio in the Mayo Clinic Study of Aging.
We examined baseline and serial measures of plasma total IGF-1, IGF binding protein (IGFBP)-3, and their ratio, which is a proxy for bioavailable IGF-1, among 1618 adults, aged 50-95, enrolled in the Mayo Clinic Study of Aging. At baseline, IGF-1 and IGFBP-3 were strongly correlated (r = 0.62, p 
Source: Experimental Gerontology - February 20, 2018 Category: Geriatrics Authors: Wennberg AMV, Hagen CE, Petersen RC, Mielke MM Tags: Exp Gerontol Source Type: research

Rapid nongenomic modulation by neurosteroids of dendritic spines in the hippocampus: Androgen, oestrogen and corticosteroid
Abstract Memories are stored in synapses that consist of axon terminals and dendritic spines. Dendritic spines are postsynaptic structures of synapses and are essential for synaptic plasticity and cognition. Therefore, extensive investigations concerning the functions and structures of spines have been performed. Sex steroids and stress steroids have been shown to modulate hippocampal synapses. Although the rapid modulatory action of sex steroids on synapses has been studied in hippocampal neurones over several decades, the essential molecular mechanisms have not been fully understood. Here, a description of kinase‐depen...
Source: Journal of Neuroendocrinology - February 18, 2018 Category: Endocrinology Authors: G. Murakami, Y. Hojo, A. Kato, Y. Komatsuzaki, S. Horie, M. Soma, J. Kim, S. Kawato Tags: REVIEW ARTICLE Source Type: research

Systematic review of hormone replacement therapy in the infertile man
Conclusions Exogenous testosterone inhibits spermatogenesis. Hypogonadal men wanting to preserve their fertility and at the same time benefiting from TRT effects can be prescribed selective oestrogen receptor modulators or testosterone plus low-dose human chorionic gonadotrophin (hCG). Patients treated for infertility with hypogonadotrophic hypogonadism can be prescribed hCG alone at first followed by or in combination from the start with follicle-stimulating hormone preparations. (Source: Arab Journal of Urology)
Source: Arab Journal of Urology - February 10, 2018 Category: Urology & Nephrology Source Type: research

Hormonal factors and pancreatic cancer risk in women: The Malm ö Diet and Cancer Study
This article is protected by copyright. All rights reserved. (Source: International Journal of Cancer)
Source: International Journal of Cancer - February 9, 2018 Category: Cancer & Oncology Authors: Gustav Andersson, Signe Borgquist, Karin Jirstr öm Tags: Research Article Source Type: research

Lifestyle factors and risk of sporadic colorectal cancer by microsatellite instability status: A systematic review and meta-analyses.
Conclusions: Lifestyle factors, such as HRT and smoking are differentially associated with the risk of MSI-H and MSS CRC. Further research on associations of lifestyle factors and CRC subtypes is necessary to provide a better understanding of the CRC disease pathway. PMID: 29438474 [PubMed - as supplied by publisher] (Source: Ann Oncol)
Source: Ann Oncol - February 9, 2018 Category: Cancer & Oncology Authors: Carr PR, Alwers E, Bienert S, Weberpals J, Kloor M, Brenner H, Hoffmeister M Tags: Ann Oncol Source Type: research

Lifestyle factors and risk of sporadic colorectal cancer by microsatellite instability status: a systematic review and meta-analyses
ConclusionsLifestyle factors, such as HRT and smoking are differentially associated with the risk of MSI-H and MSS CRC. Further research on associations of lifestyle factors and CRC subtypes is necessary to provide a better understanding of the CRC disease pathway. (Source: Annals of Oncology)
Source: Annals of Oncology - February 9, 2018 Category: Cancer & Oncology Source Type: research

Hormone replacement therapy in cancer survivors: Utopia?
(Source: Critical Reviews in Oncology Hematology)
Source: Critical Reviews in Oncology Hematology - February 8, 2018 Category: Cancer & Oncology Authors: Angioli Roberto, Daniela Luvero, Armento Grazia, Capriglione Stella, Plotti Francesco, Scaletta Giuseppe, Lopez Salvatore, Montera Roberto, Gatti Alessandra, Serra Giovan Battista, Benedetti Panici Pierluigi, Terranova Corrado Source Type: research

New determinants for gallstone disease? 
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New determinants for gallstone disease?
. Dan Med J. 2018 Feb;65(2): Authors: Shabanzadeh DM Abstract Gallstone disease is highly prevalent in Denmark and other countries of northern Europe, and cholecystectomy for the treatment of clinical gallstone disease is one the most frequently performed surgical procedures. Research efforts for the identification of mechanisms involved in gallstone formation have a long history and the most established include bile cholesterol saturation, gallbladder motor function, and the enterohepatic circulation of secondary bile salts produced by fecal microbiota. A smal...
Source: Danish Medical Journal - February 3, 2018 Category: General Medicine Tags: Dan Med J Source Type: research

Telangiectatic Matting is Associated with Hypersensitivity and a Bleeding Tendency.
CONCLUSION: TM is associated with both hypersensitivity and a bleeding tendency. This study revealed no significant increase in the incidence of haemostatic abnormalities in patients with TM compared with the control group. Given the significant association with hypersensitivity disorders, the underlying mast cell hyper-reactivity may contribute to both hypersensitivity and a bleeding tendency and predispose patients to TM. PMID: 29409702 [PubMed - as supplied by publisher] (Source: PubMed: Eur J Vasc Endovasc ...)
Source: PubMed: Eur J Vasc Endovasc ... - February 3, 2018 Category: Surgery Authors: Kadam P, Lim J, Paver I, Connor DE, Parsi K Tags: Eur J Vasc Endovasc Surg Source Type: research

Argininemia as a cause of severe chronic stunting and partial growth hormone deficiency (PGHD): A case report
AbstractRationale:Argininemia is an autosomal recessive inherited disorder of the urea cycle. Because of its atypical symptoms in early age, diagnosis can be delayed until the typical chronic manifestations – including spastic diplegia, deterioration in cognitive function, and epilepsy – appear in later childhood.Patient concerns:A Chinese boy initially presented with severe stunting and partial growth hormone deficiency (PGHD) at 3 years old and was initially treated with growth hormone replacement therapy. Seven years later (at 10 years old), he presented with spastic diplegia, cognitive function lesions, epi...
Source: Medicine - February 1, 2018 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

I Ching Balance Acupuncture Treatment of Migraines, Insomnia, and Depression in a Post-Ovariectomy Patient Receiving Hormone Replacement Therapy.
Conclusions: This patient reported a considerable improvement in all the outcome measures. She completed the treatment after experiencing great improvement in her QoL. Additional, larger-scale studies are warranted to investigate the effects of ICBA. PMID: 29410721 [PubMed] (Source: Acupuncture in Medicine)
Source: Acupuncture in Medicine - February 1, 2018 Category: Complementary Medicine Authors: Kotlyar A Tags: Med Acupunct Source Type: research