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Congenital hypothyroidism due to ectopic sublingual thyroid gland in Prader-Willi Syndrome: a case report
ConclusionsIn this context PWS should be considered in obese children with CH who do not improve adequately with l-thyroxine therapy. Also, thyroid function in all PWS children should be assessed regularly in order to avoid delayed diagnosis of hypothyroidism. (Source: Italian Journal of Pediatrics)
Source: Italian Journal of Pediatrics - September 22, 2017 Category: Pediatrics Source Type: research

17 β-Estradiol induces proliferation of endometrial NK cells (CD56+) in postmenopausal women.
CONCLUSION: 17β-Estradiol induced the proliferation of endometrial uterine natural killer cells (CD56+) in postmenopausal women. PMID: 28933961 [PubMed - as supplied by publisher] (Source: Climacteric)
Source: Climacteric - September 21, 2017 Category: Geriatrics Authors: Sho T, Hachisuga T, Koi C, Kurita T, Kagami S, Kawagoe T, Matsuura Y, Yoshimura K, Hisaoka M Tags: Climacteric Source Type: research

A case-control study of hormonal exposures as etiologic factors for ALS in women: Euro-MOTOR
Conclusions: This large case-control study across 3 different countries has demonstrated an association between exogenous estrogens and progestogens and reduced odds of ALS in women. These results are at variance with previous findings, which may be partly explained by differential regulatory, social, and cultural attitudes toward pregnancy, birth control, and HRT across the countries included. Our results indicate that hormonal factors may be important etiologic factors in ALS; however, a full understanding requires further investigation. (Source: Neurology)
Source: Neurology - September 18, 2017 Category: Neurology Authors: Rooney, J. P. K., Visser, A. E., D'Ovidio, F., Vermeulen, R., Beghi, E., Chio, A., Veldink, J. H., Logroscino, G., van den Berg, L. H., Hardiman, O., For the Euro-MOTOR Consortium Tags: Amyotrophic lateral sclerosis, Case control studies, Risk factors in epidemiology ARTICLE Source Type: research

Growth hormone therapy for people with thalassaemia.
CONCLUSIONS: A small single trial contributed evidence of moderate quality that the use of growth hormone for a year may improve height velocity of children with thalassaemia although height SD score in the treatment group was similar to the control group. There are no randomised controlled trials in adults or trials that address the use of growth hormone therapy over a longer period and assess its effect on final height and quality of life. The optimal dosage of growth hormone and the ideal time to start this therapy remain uncertain. Large well-designed randomised controlled trials over a longer period with sufficient du...
Source: Cochrane Database of Systematic Reviews - September 18, 2017 Category: General Medicine Authors: Ngim CF, Lai NM, Hong JY, Tan SL, Ramadas A, Muthukumarasamy P, Thong MK Tags: Cochrane Database Syst Rev Source Type: research

Circulating dehydroepiandrosterone-sulphate decreases even with a slight change in oestradiol.
Authors: Matsui S, Yasui T, Kasai K, Yoshida K, Kato T, Uemura H, Kuwahara A, Matsuzaki T, Irahara M Abstract The aim of this study was to determine the effect of hormone replacement therapy (HRT) on changes in circulating dehydroepiandrosterone-sulphate (DHEA-S) with focus on the relationship between oestrogen level and change in DHEA-S. Forty-two women were enrolled in this longitudinal study. Nineteen women received oral oestradiol and twenty-three women received transdermal oestradiol continuously. Twenty women received progesterone continuously except for women who had undergone hysterectomy. Circulating oestr...
Source: Journal of Obstetrics and Gynaecology - September 16, 2017 Category: OBGYN Tags: J Obstet Gynaecol Source Type: research

Hormone replacement therapy after treatment for cervical cancer: Are we adhering to standard of care?
CONCLUSIONS: Fewer than half of all women received counseling and/or a prescription for HRT after diagnoses of iatrogenic menopause, and disparities were noted based on insurance status. These findings reflect a need for clearer guidelines on HRT during survivorship and improved efforts to reduce disparities in the distribution of survivorship care. PMID: 28923411 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - September 16, 2017 Category: Cancer & Oncology Authors: Rauh LA, Pannone AF, Cantrell LA Tags: Gynecol Oncol Source Type: research

Chinese and Indian women ’s experience with alternative medications for menopause related symptoms: A qualitative analysis
ConclusionsChinese and Indian women used alternative medicine in prevention and treatment of menopause-related problems even as they were avoiding HRT because of the fear of side effects. They believed that their supplements were effective, safe and cost-beneficial even with long-term use. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - September 15, 2017 Category: Internal Medicine Source Type: research

HRT not linked to early death, study concludes
Hormone replacement therapy  is not associated with all-cause, cancer or cardiovascular death, according to the results of an 18-year follow-up study. (Source: The Pharmaceutical Journal)
Source: The Pharmaceutical Journal - September 14, 2017 Category: Drugs & Pharmacology Source Type: research

Does genetic testing for ER α gene polymorphisms provide new possibilities of treatment for cognitive function disorders in postmenopausal women?
Does genetic testing for ERα gene polymorphisms provide new possibilities of treatment for cognitive function disorders in postmenopausal women? Arch Med Sci. 2017 Aug;13(5):1224-1232 Authors: Gujski M, Pinkas J, Wierzbińska-Stępniak A, Owoc A, Bojar I Abstract It is commonly considered that cognitive abilities decrease with age, especially with respect to processing and psychomotor speed. It is an interesting issue whether, apart from the ageing process, the undergoing of menopause itself deteriorates cognitive functions, compared to women at reproductive age. Hopes for improvement of cognitiv...
Source: Archives of Medical Science - September 10, 2017 Category: General Medicine Tags: Arch Med Sci Source Type: research

Bone regenerative effect of aqueous Cynanchum wilfordii extract in receptor activator of nuclear factor- κB ligand-induced osteoclast differentiation and estrogen deficiency-induced osteoporosis
Osteoporosis increases with age, most frequently in postmenopausal women because of reduced ovarian hormone levels. Furthermore, estrogen deficiency impairs trabecular metaphyseal bone. Although efficacious, long-term hormone replacement therapy (HRT) has estrogen-like side effects including breast and endometrial cancers, and non-hormonal or herbal therapies may be safer alternatives. Therefore, the aim of this study was to investigate the effects of aqueous extracts ofCynanchum wilfordii (CWW) on receptor activator of nuclear factor- κ B (NF-κ B) ligand (RANKL)-induced osteoclast differentiationin vitro and o...
Source: International Journal of Phytomedicine - September 2, 2017 Category: Science Authors: Woojin Jun Source Type: research

Venous thromboembolism and hyperhomocysteinemia as first manifestation of pernicious anemia: a case series
ConclusionsThese reports demonstrate that pernicious anemia, on its own, can lead to hyperhomocysteinemia that is significant enough to lead to thrombosis. Understanding the molecular pathogenesis of the development of thrombosis in patients with hyperhomocysteinemia related to Biermer disease would help us to identify patients at risk and to treat them accordingly. The literature concerning the relationship between homocysteine and venous thrombosis is briefly reviewed. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - September 2, 2017 Category: General Medicine Source Type: research

Bone regenerative effect of aqueous < em > Cynanchum wilfordii < /em > extract in receptor activator of nuclear factor- κB ligand-induced osteoclast differentiation and estrogen deficiency-induced osteoporosis
Osteoporosis increases with age, most frequently in postmenopausal women because of reduced ovarian hormone levels. Furthermore, estrogen deficiency impairs trabecular metaphyseal bone. Although efficacious, long-term hormone replacement therapy (HRT) has estrogen-like side effects including breast and endometrial cancers, and non-hormonal or herbal therapies may be safer alternatives. Therefore, the aim of this study was to investigate the effects of aqueous extracts ofCynanchum wilfordii (CWW) on receptor activator of nuclear factor- κ B (NF-κ B) ligand (RANKL)-induced osteoclast differentiationin vitro and o...
Source: International Journal of Phytomedicine - September 2, 2017 Category: Science Authors: Woojin Jun Source Type: research

Combined bioavailable isoflavones and probiotics improve bone status and estrogen metabolism in postmenopausal osteopenic women: a randomized controlled trial [Bone metabolism]
In this study, we sought to determine the beneficial effects of a bioavailable isoflavone and probiotic treatment against postmenopausal osteopenia. Design: We used a novel red clover extract (RCE) rich in isoflavone aglycones and probiotics to concomitantly promote uptake and a favorable intestinal bacterial profile to enhance isoflavone bioavailability. This was a 12-mo, double-blind, parallel design, placebo-controlled, randomized controlled trial of 78 postmenopausal osteopenic women supplemented with calcium (1200 mg/d), magnesium (550 mg/d), and calcitriol (25 μg/d) given either RCE (60 mg isoflavone aglycones/d a...
Source: American Journal of Clinical Nutrition - September 1, 2017 Category: Nutrition Authors: Lambert, M. N. T., Thybo, C. B., Lykkeboe, S., Rasmussen, L. M., Frette, X., Christensen, L. P., Jeppesen, P. B. Tags: Dietary Bioactive Compounds Research Articles Bone metabolism Source Type: research

Post-Menopausal Hormone Replacement Therapy Tied to Hearing Loss
(Source: The ASHA Leader Online)
Source: The ASHA Leader Online - September 1, 2017 Category: Speech-Language Pathology Source Type: research

Endometrial mirnome during the implantation windows can predict early miscarriage or live birth after fresh or frozen embryo transfer
The rates of miscarriages within the framework of the replacement of fresh or frozen-thawed embryos in patients under hormone replacement therapy remain a major problem in IVF/ICSI. By comparing the miRNome using the Affymetrix miRNA Array, we previously identified miRNAs signature during the implantation window in pregnant patients after embryo replacement achieving live birth versus a miscarriage. The aim of this study was to evaluate the miRNA expression profile in the prediction of early miscarriage or live birth after either fresh or frozen embryo replacement. (Source: Fertility and Sterility)
Source: Fertility and Sterility - September 1, 2017 Category: Reproduction Medicine Authors: L. Drissennek, F. Entezami, A. Gala, C. Vincens, D. Haouzi, S. Hamamah Tags: Poster session Source Type: research

Poster 300: Acute Onset of Psychotic Symptoms Following Abrupt Discontinuation of Hormone Replacement Therapy in a Trangendered Woman with Traumatic Brain Injury: A Case Report
Yu Chiu: I Have No Relevant Financial Relationships To Disclose (Source: PM and R)
Source: PM and R - September 1, 2017 Category: Rehabilitation Authors: Yu M. Chiu, Baruch Kim, Xuemue Qu, Prin X. Amorapanth Source Type: research

Epidemiology of Estrogen and Dementia in Women with Down Syndrome.
Abstract Several lines of investigation have shown a protective role for estrogen in Alzheimer's disease through a number of biological actions. This review examines studies of the role of estrogen-related factors in age at onset and risk for Alzheimer's disease in women with Down syndrome, a population at high risk for early onset of dementia. The studies are consistent in showing that early age at menopause and that low levels of endogenous bioavailable estradiol in postmenopausal women with Down syndrome are associated with earlier age at onset and overall risk for dementia. Polymorphisms in genes associated wi...
Source: Free Radical Biology and Medicine - August 23, 2017 Category: Biology Authors: Schupf N, Lee JH, Pang D, Zigman WB, Tycko B, Krinsky-McHale S, Silverman W Tags: Free Radic Biol Med Source Type: research

Influence of Tetrabromobisphenol A, with or without Concurrent Triclosan, upon Bisphenol A and Estradiol Concentrations in Mice
Conclusion: These data indicate that TBBPA, triclosan, and BPA interact in vivo, consistent with evidence that TBBPA and triclosan inhibit enzymes that are critical for BPA and E2 metabolism. https://doi.org/10.1289/EHP1329 Received: 04 November 2016 Revised: 11 April 2017 Accepted: 13 April 2017 Published: 21 August 2017 Address correspondence to D. deCatanzaro, Dept. of Psychology, Neuroscience & Behaviour, McMaster University, 1280 Main St. West, Hamilton ON L8S 4K1, Canada. Telephone: (905) 525-9140, ext. 23014. Email: decatanz@mcmaster.ca Supplemental Material is available online (https://doi.org/10.1289/EHP...
Source: EHP Research - August 21, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Association between Dietary Energy Density and Obesity-Associated Cancer: Results from the Women ’s Health Initiative
Conclusions Higher DED may be a contributing factor for obesity-related cancers, especially among normal-weight postmenopausal women and, as such, could serve as a modifiable behavior for dietary interventions to reduce obesity-associated cancer risk. (Source: Journal of the Academy of Nutrition and Dietetics)
Source: Journal of the Academy of Nutrition and Dietetics - August 17, 2017 Category: Nutrition Source Type: research

Breast cancer and exposure to aircraft, road, and railway-noise: a case –control study based on health insurance records
Conclusions The results indicate increased aircraft noise may be an etiologic factor for ER negative breast cancers. However, information regarding potential confounding factors was largely unattainable. Further research is required to understand how environmental noise may be involved in the pathogenesis of ER negative breast cancers.byHegewald J, Schubert M, Wagner M, Dr öge P, Prote U, Swart E, Möhler U, Zeeb H, Seidler A. doi:10.5271/sjweh.3664 (Source: Scandinavian Journal of Work, Environment and Health)
Source: Scandinavian Journal of Work, Environment and Health - August 16, 2017 Category: Occupational Health Tags: Original article Source Type: research

Breast cancer and exposure to aircraft, road, and railway-noise: a case-control study based on health insurance records.
Conclusions The results indicate increased aircraft noise may be an etiologic factor for ER negative breast cancers. However, information regarding potential confounding factors was largely unattainable. Further research is required to understand how environmental noise may be involved in the pathogenesis of ER negative breast cancers. PMID: 28813586 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Work, Environment and Health)
Source: Scandinavian Journal of Work, Environment and Health - August 16, 2017 Category: Occupational Health Authors: Hegewald J, Schubert M, Wagner M, Dröge P, Prote U, Swart E, Möhler U, Zeeb H, Seidler A Tags: Scand J Work Environ Health Source Type: research

Hormone replacement therapy after risk-reducing salpingo-oophorectomy minimises endocrine and sexual problems: A prospective study
There has been some doubts raised in earlier studies about the efficacy of hormone replacement therapy (HRT) in reducing endocrine and sexual problems in women who have undergone a risk-reducing salpingo-oophorectomy (RRSO). (Source: European Journal of Cancer)
Source: European Journal of Cancer - August 14, 2017 Category: Cancer & Oncology Authors: Ravi F.M. Vermeulen, Marc van Beurden, Jacobien M. Kieffer, Eveline M.A. Bleiker, Heiddis B. Valdimarsdottir, Leon F.A.G. Massuger, Marian J.E. Mourits, Katja N. Gaarenstroom, Eleonora B.L. van Dorst, Hans W.H.M. van der Putten, Neil K. Aaronson Tags: Original Research Source Type: research

Initial patient choice of a growth hormone device improves child and adolescent adherence to and therapeutic effects of growth hormone replacement therapy
Journal Name: Journal of Pediatric Endocrinology and Metabolism Issue: Ahead of print (Source: Journal of Pediatric Endocrinology and Metabolism)
Source: Journal of Pediatric Endocrinology and Metabolism - August 5, 2017 Category: Endocrinology Source Type: research

Age at menopause and hormone replacement therapy as risk factors for head and neck and oesophageal cancer  (Review).
Age at menopause and hormone replacement therapy as risk factors for head and neck and oesophageal cancer (Review). Oncol Rep. 2017 Aug 01;: Authors: McCarthy CE, Field JK, Marcus MW Abstract There were ~986,000 cases of head and neck cancer (HNC) and oesophageal cancer diagnosed worldwide in 2012. The incidence of these types of cancer is much higher in males than females, although this disparity decreases in the elderly population, suggesting a role for hormones as a risk factor. This systematic review investigates the potential role of female hormones [age at menopause and use of hormone r...
Source: Oncology Reports - August 4, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Initial patient choice of a growth hormone device improves child and adolescent adherence to and therapeutic effects of growth hormone replacement therapy
Journal Name: Journal of Pediatric Endocrinology and Metabolism Volume: 30 Issue: 9 Pages: 989-993 (Source: Journal of Pediatric Endocrinology and Metabolism)
Source: Journal of Pediatric Endocrinology and Metabolism - August 3, 2017 Category: Endocrinology Source Type: research

Combined bioavailable isoflavones and probiotics improve bone status and estrogen metabolism in postmenopausal osteopenic women: a randomized controlled trial.
In this study, we sought to determine the beneficial effects of a bioavailable isoflavone and probiotic treatment against postmenopausal osteopenia.Design: We used a novel red clover extract (RCE) rich in isoflavone aglycones and probiotics to concomitantly promote uptake and a favorable intestinal bacterial profile to enhance isoflavone bioavailability. This was a 12-mo, double-blind, parallel design, placebo-controlled, randomized controlled trial of 78 postmenopausal osteopenic women supplemented with calcium (1200 mg/d), magnesium (550 mg/d), and calcitriol (25 μg/d) given either RCE (60 mg isoflavone aglycones/d an...
Source: The American Journal of Clinical Nutrition - August 2, 2017 Category: Nutrition Authors: Lambert MNT, Thybo CB, Lykkeboe S, Rasmussen LM, Frette X, Christensen LP, Jeppesen PB Tags: Am J Clin Nutr Source Type: research

[Phytoestrogens in the treatment of menopause].
ics A Abstract In previous centuries many women did not even live until their menopause years due to poor economic conditions, deficiencies of medicine, epidemics and wars. Nowadays in the developed countries, people live until they are 75-80 years old, and with the expansion of average age, the number of people affected by menopause and the years spent in that state increase. Nowadays women spend one third of their lives in the menopausal stage. The only effective way to treat unpleasant symptoms for centuries was with the use of herbs, and the knowledge about them spread through oral tradition. In the 20th centu...
Source: Orvosi Hetilap - August 1, 2017 Category: General Medicine Authors: Remport J, Blázovics A Tags: Orv Hetil Source Type: research

Surgical and pharmacological reassignment: influence on transsexuals cardiovascular risk profile
ABSTRACT IntroductionThe aim was to evaluate and stratify early cardiovascular risk of transsexuals undergone pharmacological and/or surgical gender reassignment. MethodsFifty‐six transsexuals were divided into two groups: 1‐ undergone gonadectomy (orchiectomy for trans women and hystero‐annessiectomy for trans men); group 2‐ hormone replacement therapy alone. All underwent carotid artery intima‐media thickness (C‐IMT) and flow‐mediated vasodilation (FMD) of brachial artery evaluations. ResultsFMD was lower in patients undergone gonadectomy as compared to not‐ surgically treated patients (Group 1: 5.711 vs ...
Source: Internal Medicine Journal - August 1, 2017 Category: Internal Medicine Authors: Marco Matteo Ciccone, Giuseppe Loverro, Pietro Scicchitano, Matteo Loverro, Gabriella Ricci, Francesca Scaramuzzi, Michele Gesualdo, Annapaola Zito, Marcello Campagna, Michele Moncelli, Vittorio Nicolardi, Fabio Manca, Barbara Boninfante, Santa Carbonara, Tags: Original Article Source Type: research

Estrogenic regulation of skeletal muscle proteome: a study of premenopausal women and postmenopausal MZ cotwins discordant for hormonal therapy
Summary Female middle age is characterized by a decline in skeletal muscle mass and performance, predisposing women to sarcopenia, functional limitations, and metabolic dysfunction as they age. Menopausal loss of ovarian function leading to low circulating level of 17β‐estradiol has been suggested as a contributing factor to aging‐related muscle deterioration. However, the underlying molecular mechanisms remain largely unknown and thus far androgens have been considered as a major anabolic hormone for skeletal muscle. We utilized muscle samples from 24 pre‐ and postmenopausal women to establish proteome‐wide p...
Source: Aging Cell - August 1, 2017 Category: Cytology Authors: Eija K. Laakkonen, Rabah Soliymani, Sira Karvinen, Jaakko Kaprio, Urho M. Kujala, Marc Baumann, Sarianna Sipil ä, Vuokko Kovanen, Maciej Lalowski Tags: Original Article Source Type: research

The association between serum ferritin and 25-hydroxyvitamin D and metabolic syndrome in Korean women: the Korea National Health and Nutrition Examination Survey 2010-2012.
Authors: Yoon H, Young Bae N, Young Gi M, Yeon Park B, Min Seong J Abstract The present study was conducted to assess the association between serum ferritin and 25-hydroxyvitamin D [25(OH)D] and metabolic syndrome (MetS) in Korean women. The data of a total of 9,256 adults (6,960 women without MetS and 2,296 women with MetS) aged ≥20 years from the Fifth Korean National Health and Nutrition Examination Survey (KNHANES V) (2010-2012) were analyzed. A covariance test adjusted for covariates was performed for serum ferritin levels in relation to vitamin D (vitamin D deficiency, 25(OH)D
Source: Journal of Clinical Biochemistry and Nutrition - July 29, 2017 Category: Nutrition Tags: J Clin Biochem Nutr Source Type: research

In vitro fertilization and pregnancy management in a woman with acquired idiopathic chylous ascites
Abstract Acquired idiopathic chylous ascites is extremely rare in women of reproductive age. This is the first report describing successful infertility and pregnancy management in a patient with idiopathic chylous ascites. A 23‐year‐old woman presented with abdominal distention and was diagnosed with idiopathic fluid collection. A lymphogram revealed lymphatic leakage from the right renal hilum. Lymphatic‐venous anastomosis of the thoracic duct was performed thrice, but the chylous ascites persisted. In vitro fertilization was performed because natural conception was not possible. Just prior to oocyte retrieval, tran...
Source: Journal of Obstetrics and Gynaecology Research - July 24, 2017 Category: OBGYN Authors: Ai Sakamoto, Yasuhiko Kamada, Sayoko Kotani, Kiyoshi Yamada, Yoshihiro Kimata, Yuji Hiramatsu Tags: Case Report Source Type: research

Indoor Wood-Burning Stove and Fireplace Use and Breast Cancer in a Prospective Cohort Study
Conclusions: In this prospective study, using an indoor wood-burning stove/fireplace in the longest adult residence at least once a week and burning either wood or natural gas/propane was associated with a modestly higher risk of breast cancer. https://doi.org/10.1289/EHP827 Received: 18 July 2016 Revised: 16 November 2016 Accepted: 09 December 2016 Published: 18 July 2017 Address correspondence to A.J. White, Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709-2233 USA. Telephone: (919) 316-4867. Email: alexandra.white@nih.gov Supp...
Source: EHP Research - July 18, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Hormone factors play a favorable role in female head and neck cancer risk
Abstract Due to lower female incidence, estimates of exogenous and endogenous hormonal factors in head and neck cancers (HNCs, comprising cancers of the oral cavity, oropharynx, hypopharynx, and larynx) among women have been inconsistent and unable to account for key HNC risk factors. We pooled data from 11 studies from Europe, North America, and Japan. Analysis included 1572 HNC female cases and 4343 controls. Pooled odds ratios (ORs) estimates and their 95% confidence intervals (CIs) were calculated using multivariate logistic regression models adjusting for tobacco smoking and alcohol drinking. Lower risk was observed i...
Source: Cancer Medicine - July 14, 2017 Category: Cancer & Oncology Authors: Dana Hashim, Samantha Sartori, Carlo La Vecchia, Diego Serraino, Luigino Dal Maso, Eva Negri, Elaine Smith, Fabio Levi, Stefania Boccia, Gabriella Cadoni, Hung N. Luu, Yuan ‐Chin Amy Lee, Mia Hashibe, Paolo Boffetta Tags: Original Research Source Type: research

Are incident gallstones associated to sex ‐dependent changes with age? A cohort study
The objectives of this study were to determine if changes with age in physiology, lifestyle, or reproductive hormones were associated with incident gallstones. A cohort study of a general population random sample (N = 2366) aged 30–60 years was performed. Participants were ultrasound screened for gallstones in 1982–84 and again in 1993–94. Lifestyle data and blood samples were obtained and re‐analyzed in 2004. Changes with age in physiology (body mass index, blood pressure, blood lipids, self‐rated health), lifestyle (smoking, alcohol and coffee consumption, dietary habits, physical act...
Source: Andrology - July 13, 2017 Category: Urology & Nephrology Authors: D. M. Shabanzadeh, S. A. Holmboe, L. T. S ørensen, A. Linneberg, A.‐M. Andersson, T. Jørgensen Tags: Original Article Source Type: research

Radiation-associated breast cancer and gonadal hormone exposure: a report from the Childhood Cancer Survivor Study
n Leeuwen, Malcolm C Pike & Kevin C Oeffinger (Source: British Journal of Cancer)
Source: British Journal of Cancer - July 11, 2017 Category: Cancer & Oncology Authors: Chaya S Moskowitz Joanne F Chou Charles A Sklar Dana Barnea C écile M Ronckers Danielle Novetsky Friedman Joseph P Neglia Lucie Turcotte Rebecca M Howell Tara O Henderson Gregory T Armstrong Wendy M Leisenring Leslie L Robison Flora E van Leeuwen Malcolm Tags: hormone replacement therapy late effects pediatric malignancy second malignancies supradiaphragmatic radiotherapy Source Type: research

Age of menarche is associated with knee joint replacement due to primary osteoarthritis. (The HUNT Study and the Norwegian Arthroplasty Register)
To investigate whether parity, age at menarche, menopausal status, age at menopause, use of oral contraceptives or use of hormone replacement therapy (HRT) were associated with total knee replacement (TKR) or total hip replacement (THR) due to primary osteoarthritis. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - July 10, 2017 Category: Rheumatology Authors: Alf Inge Hellevik, Lars Nordsletten, Marianne Bakke Johnsen, Anne Marie Fenstad, Ove Furnes, Kjersti Storheim, John Anker Zwart, Gunnar Flugsrud, Arnulf Langhammer Source Type: research

Age of menarche is associated with knee joint replacement due to primary osteoarthritis (The HUNT Study and the Norwegian Arthroplasty Register)
To investigate whether parity, age at menarche, menopausal status, age at menopause, use of oral contraceptives (OC) or use of hormone replacement therapy (HRT) were associated with total knee replacement (TKR) or total hip replacement (THR) due to primary osteoarthritis. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - July 10, 2017 Category: Rheumatology Authors: A.I. Hellevik, L. Nordsletten, M.B. Johnsen, A.M. Fenstad, O. Furnes, K. Storheim, J.A. Zwart, G. Flugsrud, A. Langhammer Source Type: research

Age of menarche is associated with knee joint replacement due to  primary osteoarthritis (The HUNT Study and the Norwegian Arthroplasty Register)
To investigate whether parity, age at menarche, menopausal status, age at menopause, use of oral contraceptives (OC) or use of hormone replacement therapy (HRT) were associated with total knee replacement (TKR) or total hip replacement (THR) due to primary osteoarthritis. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - July 10, 2017 Category: Rheumatology Authors: A.I. Hellevik, L. Nordsletten, M.B. Johnsen, A.M. Fenstad, O. Furnes, K. Storheim, J.A. Zwart, G. Flugsrud, A. Langhammer Source Type: research

Factors associated with complementary and alternative medicine use among women at midlife.
Abstract Hormone replacement therapy (HRT) has been established as the first-line treatment for women experiencing menopausal symptoms. The use of complementary and alternative medicine (CAM), however, is becoming increasingly popular among women at midlife for management of such symptoms. Despite the equivocal evidence of CAM's efficacy in the reduction and alleviation of menopausal symptoms in placebo-controlled, randomized trials, 50% of women at midlife use CAM. To date, several large, population-based studies have focused upon CAM use amongst menopausal women and the factors associated with the adoption of su...
Source: Climacteric - July 8, 2017 Category: Geriatrics Authors: Costanian C, Christensen RAG, Edgell H, Ardern CI, Tamim H Tags: Climacteric Source Type: research

Impact of postoperative pituitary tumor adrenal insufficiency and hormone replacement therapy (HRT) on tumor recurrence.
CONCLUSIONS: The age, patient gender and the size of the tumor were not independent risk factors leading to postoperative pituitary tumor adrenal insufficiency. However, the occurrence rate of adrenal insufficiency of patients in high age group was higher than that of patients in low age group. Also, the occurrence rate of adrenal insufficiency of patients (whose one or several hormones dramatically decreased before the operation) was significantly higher than that of patients (whose hormone level did not decrease before the operation). So, the patients in high age group and whose one or several hormones dramatically decre...
Source: European Review for Medical and Pharmacological Sciences - July 7, 2017 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Models of cognitive functions with respect to selected parameters of functional state of the thyroid gland in post-menopausal women.
The objective of the study was the development of models of cognitive functions in a group of post-menopausal women, according to the concentration of the selected laboratory parameters evaluating the functional state of the thyroid gland. MATERIAL AND METHODS: The study was conducted during 2012-2014, and covered women aged 50-65 years, minimum two years after the last menstruation, without chronic diseases, cancerous diseases, mental disorders, addiction to drugs or alcohol, and who did not use hormone replacement therapy. At the stage of qualification, a brief MoCA test was performed; 383 women were qualified for t...
Source: Endokrynologia Polska - July 1, 2017 Category: Endocrinology Authors: Gujski M, Pinkas J, Witczak M, Owoc A, Bojar I Tags: Endokrynol Pol Source Type: research

The menopause: benefits and risks of available treatments
Menopausal symptoms affect many women, but debate continues over the role of hormone replacement therapy (HRT) in their management. This review provides a summary of the current treatment options for menopause management and considers their benefits and risks. (Source: Prescriber)
Source: Prescriber - June 30, 2017 Category: Primary Care Authors: Rosemary Cochrane, Heather Currie Tags: Drug Review Source Type: research

Mammographic breast density and breast cancer risk in a Mediterranean population: a nested case –control study in the EPIC Florence cohort
ConclusionsWe confirm in this Mediterranean population the association of increasing MBD, classified according to BI-RADS with BC risk also taking into account other well-known risk factors for this neoplasm. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - June 21, 2017 Category: Cancer & Oncology Source Type: research

Social, health and ocular factors associated with primary open angle glaucoma amongst Chinese Singaporeans
This study evaluated the association of primary open angle glaucoma with smoking, health and ocular factors among Chinese Singaporeans. DesignCase‐control study Participants711 primary open angle glaucoma patients from a Singapore hospital and 2788 population‐based controls. MethodsSubjects underwent clinical examination and completed a questionnaire with details on family history of glaucoma, comorbidities, smoking, alcohol consumption, age at menopause and use of hormone replacement therapy. Primary open angle glaucoma was sub‐classified as normal‐tension glaucoma and high‐tension glaucoma depending on the untr...
Source: Clinical and Experimental Ophthalmology - June 16, 2017 Category: Opthalmology Authors: Nathalie Chiam, Mani Baskaran, Zheng Li, Shamira Perera, David Goh, Rahat Husain, Chiea Chuen Khor, Ching ‐Yu Cheng, Tin Aung FRCOphth, Eranga N Vithana Tags: Original Article Source Type: research

Hormone replacement therapy and breast cancer survival: a systematic review and meta-analysis of observational studies.
In conclusion, the average effect of HRT use seems not harmful to breast cancer survival. Nevertheless, this effect of HRT use is needed for further assessment. PMID: 28601917 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - June 10, 2017 Category: Cancer & Oncology Authors: Yu X, Zhou S, Wang J, Zhang Q, Hou J, Zhu L, He Y, Zhao J, Zhong S Tags: Breast Cancer Source Type: research

Obesity-associated Breast Cancer: Analysis of risk factors.
Authors: Engin A Abstract Several studies show that a significantly stronger association is obvious between increased body mass index (BMI) and higher breast cancer incidence. Furthermore, obese women are at higher risk of all-cause and breast cancer specific mortality when compared to non-obese women with breast cancer. In this context, increased levels of estrogens due to excessive aromatization activity of the adipose tissue, overexpression of pro-inflammatory cytokines, insulin resistance, hyperactivation of insulin-like growth factors (IGFs) pathways, adipocyte-derived adipokines, hypercholesterolemia and exce...
Source: Advances in Experimental Medicine and Biology - June 8, 2017 Category: Research Tags: Adv Exp Med Biol Source Type: research

Physiologic and exogenous hormone effects on the endometrium: important aspects for the surgical pathologist
The endometrium exhibits a unique physiology in its ability to cyclically respond to steroid hormones, resulting in morphologic changes that allow the pathologist's interpretation of proper endometrial function. Distinctive changes are also observed during times of physiologic hormonal changes, such as in pregnancy, or in pathologic and iatrogenic hormonal imbalances, as in certain functioning ovarian tumours and hormone therapy, respectively. The ubiquity of these states, in particular the widespread use of oral contraception, hormone replacement therapy, hormonal intrauterine devices, and nowadays frequent use of progest...
Source: Diagnostic Histopathology - June 7, 2017 Category: Pathology Authors: Mir Alikhan, Katja Gwin Tags: Gynaecological pathology Source Type: research

Xanthomatous Hypophysitis Presenting With Diabetes Insipidus Completely Cured Through Transsphenoidal Surgery: A Case Report and Literature Review
Xanthomatous hypophysitis (XH) is extremely rare. Only 27 cases have been reported in the literature. No XH patient presenting with diabetes insipidus (DI) has been completely cured through surgery. Here, we describe the first XH case of a DI patient whose pituitary function was normalized postoperatively, without hormone replacement therapy. (Source: World Neurosurgery)
Source: World Neurosurgery - June 2, 2017 Category: Neurosurgery Authors: Wei Lin, Lu Gao, Xiaopeng Guo, Wenze Wang, Bing Xing Tags: Case Report Source Type: research

Microscopic Transnasal Transsphenoidal Surgery for Pediatric Pituitary Adenomas
In conclusion, MTTS is a safe and effective surgical option for pediatric pituitary adenomas with minimal morbidity and excellent outcomes. (Source: Journal of Craniofacial Surgery)
Source: Journal of Craniofacial Surgery - June 1, 2017 Category: Surgery Tags: Clinical Studies Source Type: research

Congenital adrenal hyperplasia
Publication date: Available online 30 May 2017 Source:The Lancet Author(s): Diala El-Maouche, Wiebke Arlt, Deborah P Merke Congenital adrenal hyperplasia is a group of autosomal recessive disorders encompassing enzyme deficiencies in the adrenal steroidogenesis pathway that lead to impaired cortisol biosynthesis. Depending on the type and severity of steroid block, patients can have various alterations in glucocorticoid, mineralocorticoid, and sex steroid production that require hormone replacement therapy. Presentations vary from neonatal salt wasting and atypical genitalia, to adult presentation of hirsutism and irregul...
Source: The Lancet - May 31, 2017 Category: General Medicine Source Type: research