The physiology of endocrine systems with ageing
Publication date: Available online 17 July 2018Source: The Lancet Diabetes & EndocrinologyAuthor(s): Annewieke W van den Beld, Jean-Marc Kaufman, M Carola Zillikens, Steven W J Lamberts, Josephine M Egan, Aart J van der LelySummaryDuring ageing, the secretory patterns of the hormones produced by the hypothalamic–pituitary axis change, as does the sensitivity of the axis to negative feedback by end hormones. Additionally, glucose homoeostasis tends towards disequilibrium with increasing age. Along with these endocrine alterations, a loss of bone and muscle mass and strength occurs, coupled with an increase in fat ...
Source: The Lancet Diabetes and Endocrinology - July 18, 2018 Category: Endocrinology Source Type: research

Successful spontaneous pregnancy with acupuncture after premature ovarian failure
Publication date: Available online 17 July 2018Source: World Journal of Acupuncture - MoxibustionAuthor(s): YIN Yaqian, XU Huanfang, SHANG Jie, YANG Huisheng, FANG YigongABSTRACTIn this paper, a case of premature ovarian failure(POF), accompanied with amenorrhea for 2 years was reported. After 2 months of acupuncture, the patient's menstruation was resumed, and after 11 months of treatment, the patient had a spontaneous pregnancy. It is suggested that acupuncture should be used for the patient with POF as early as possible, and if necessary, hormone replacement therapy is still needed, and it is still expected to obtain sp...
Source: World Journal of Acupuncture Moxibustion - July 18, 2018 Category: Complementary Medicine Source Type: research

A novel role for estrogen-induced signaling in the colorectal cancer gender bias
AbstractColorectal cancer (CRC) is a malignancy whose incidence is increasing globally, and there is a gender difference in the increasing risk. Evidence from hormone replacement therapy studies points to a role for circulating estrogens in suppressing the development of CRC. Estrogen receptor- β has been identified as a tumor suppressor, but other actions of estrogen may also contribute to the difference in CRC incidence between men and women. The KCNQ1/KCNE3 potassium channel is regulated by estrogen in order to modulate chloride secretion during the menstrual cycle; the effect of estro gen on the colon is to promot...
Source: Irish Journal of Medical Science - July 17, 2018 Category: General Medicine Source Type: research

Sex hormones and venous thromboembolism - from contraception to hormone replacement therapy.
Abstract The use of sex hormones such as combined oral contraceptives (COC) or hormone replacement therapy (HRT) increases the risk for venous thromboembolism (VTE) considerably, especially in patients with an increased intrinsic risk for thromboembolic complications. Despite public and media attention and increasing scientific evidence, prescription patterns seem to be hard to change. It is well recognized that the patient's baseline risk is the most relevant factor in the absolute risk for developing VTE. The relative risk increase associated with sex hormones, depends on the type and dosage of hormones, the rou...
Source: VASA. Zeitschrift fur Gefasskrankheiten. Journal for Vascular Diseases - July 16, 2018 Category: Surgery Authors: Beyer-Westendorf J, Bauersachs R, Hach-Wunderle V, Zotz RB, Rott H Tags: Vasa Source Type: research

Natural hormone replacement therapy with a functioning ovary after the menopause: dream or reality?
Publication date: Available online 30 June 2018Source: Reproductive BioMedicine OnlineAuthor(s): Jacques Donnez, Marie-Madeleine DolmansAbstractAt the dawn of humanity, it was rare to live beyond the age of 35 years, so the ovary was intended to function for a woman's entire life. Nowadays, it is not unusual for women to live into their 80s. This means that many of them spend 30–40% of their lives in the menopause at increased risk of various conditions associated with an absence of oestrogens (cardiovascular disease, bone mineral density loss). Reimplantation of frozen–thawed ovarian tissue is able to restore ...
Source: Reproductive BioMedicine Online - July 11, 2018 Category: Reproduction Medicine Source Type: research

Identification of the first homozygous POLG mutation causing non-syndromic ovarian dysfunction.
CONCLUSIONS: Biallelic mutations in POLG may be associated with ovarian dysfunction. This study has improved our understanding of POLG-related genetic mutations in ovarian dysfunction, and the mode of inheritance of certain sequence variants. This information will assist genetic counseling and precision medicine in the future. PMID: 29992832 [PubMed - as supplied by publisher] (Source: Climacteric)
Source: Climacteric - July 11, 2018 Category: Geriatrics Authors: Chen B, Li L, Wang J, Zhou Y, Zhu J, Li T, Pan H, Liu B, Cao Y, Wang B Tags: Climacteric Source Type: research

Menopause and Non-Alcoholic Fatty Liver Disease: A Review Focusing on Therapeutic Perspectives.
Abstract There is increasing evidence that menopause is associated with the progression and severity of non-alcoholic fatty liver disease (NAFLD). Estrogen deficiency worsens non-alcoholic steatohepatitis (NASH) in mice models with fatty liver. The prevalence of NAFLD seems to be higher in postmenopausal compared with premenopausal women. Although more data are needed, lower serum estradiol levels are associated with NASH in postmenopausal women. Apart from estrogen deficiency, relative androgen excess and decrease in sex hormone-binding protein are observed in postmenopausal women. These hormonal changes seem to ...
Source: Current Vascular Pharmacology - July 11, 2018 Category: Drugs & Pharmacology Authors: Venetsanaki V, Polyzos SA Tags: Curr Vasc Pharmacol Source Type: research

Systematic review of hormone replacement therapy in the infertile man
ConclusionsExogenous testosterone inhibits spermatogenesis. Hypogonadal men wanting to preserve their fertility and at the same time benefiting from TRT effects can be prescribed selective oestrogen receptor modulators or testosterone plus low-dose human chorionic gonadotrophin (hCG). Patients treated for infertility with hypogonadotrophic hypogonadism can be prescribed hCG alone at first followed by or in combination from the start with follicle-stimulating hormone preparations. (Source: Arab Journal of Urology)
Source: Arab Journal of Urology - July 10, 2018 Category: Urology & Nephrology Source Type: research

Understanding the role of environmental factors in the development of systemic lupus erythematosus
Publication date: June 2017Source: Best Practice & Research Clinical Rheumatology, Volume 31, Issue 3Author(s): Christine G. Parks, Aline de Souza Espindola Santos, Medha Barbhaiya, Karen H. CostenbaderAbstractSystemic lupus erythematosus (SLE) is a multisystem disease with a complex etiology. Its risk is higher among women, racial and ethnic minorities, and individuals with a family history of SLE or related autoimmune diseases. It is believed that genetic factors interact with environmental exposures throughout the lifespan to influence susceptibility to developing SLE. The strongest epidemiologic evidence exists for...
Source: Best Practice and Research Clinical Rheumatology - July 10, 2018 Category: Rheumatology Source Type: research

Enhanced estrogenic effects of biotransformed soy extracts
This study aimed to improve the process conditions for biotransformation of soymilk polyphenols by tannase to obtain higher amounts of isoflavone aglycones and metabolites such as equol. The estrogenic potential of the extracts was evaluated in in vitro assays. The results showed that the aglycones increased 36–46 times after reaction with tannase and proved that it is possible to produce equol in soymilk using an enzymatic bioprocess, without gut microbial intervention. Moreover, the soymilk biotransformed by tannase presented higher estrogenic action in the MCF-7 BUS cell line assay, making it a promising nutraceut...
Source: Journal of Functional Foods - July 10, 2018 Category: Nutrition Source Type: research

Yawning and cortisol levels in multiple sclerosis: Potential new diagnostic tool
Publication date: July 2018Source: Multiple Sclerosis and Related Disorders, Volume 23Author(s): Simon B.N. Thompson, Alister Coleman, Nicola WilliamsAbstractYawning is a significant behavioural response and, together with cortisol, is potentially a new diagnostic marker of neurological diseases. Evidence of an association between yawning and cortisol was found which supports the Thompson Cortisol Hypothesis and thermoregulation hypotheses, indication that brain cooling occurs when yawning. 117 volunteers aged 18–69 years were randomly allocated to experimentally controlled conditions to provoke yawning. Thirty-three...
Source: Multiple Sclerosis and Related Disorders - July 10, 2018 Category: Neurology Source Type: research

Primary adrenal insufficiency in children: Diagnosis and management
Publication date: Available online 6 June 2018Source: Best Practice & Research Clinical Endocrinology & MetabolismAuthor(s): Tarik Kirkgoz, Tulay GuranPrimary adrenal insufficiency (PAI) is a life-threatening disorder of adrenal cortex which is characterized by deficient biosynthesis of glucocorticoids, with or without deficiency in mineralocorticoids and adrenal androgens. Typical manifestations of primary adrenal insufficiency include hyperpigmentation, hypotension, hypoglycaemia, hyponatremia with or without hyperkalemia that are generally preceded by nonspecific symptoms at the onset. Recessively inherited mono...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - July 10, 2018 Category: Endocrinology Source Type: research

Estradiol mediates relaxation of porcine lower esophageal sphincter
Publication date: August 2018Source: Steroids, Volume 136Author(s): Ching-Chung Tsai, Shu-Leei Tey, Li-Ching Chang, Yu-Tsun Su, Kai-Jen Lin, Shih-Che HuangAbstractMost pregnant women have symptoms of gastroesophageal reflux disease (GERD) during pregnancy. Postmenopausal hormone replacement therapy is associated with GERD. The effects of estradiol on lower esophageal sphincter (LES) motility and GERD are not clearly known. The purpose of this study is to investigate the effects of estradiol on the motility of the porcine LES. Relaxations of clasp and sling strips of porcine LES caused by estradiol were measured using isome...
Source: Steroids - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Enhanced estrogenic effects of biotransformed soy extracts
This study aimed to improve the process conditions for biotransformation of soymilk polyphenols by tannase to obtain higher amounts of isoflavone aglycones and metabolites such as equol. The estrogenic potential of the extracts was evaluated in in vitro assays. The results showed that the aglycones increased 36–46 times after reaction with tannase and proved that it is possible to produce equol in soymilk using an enzymatic bioprocess, without gut microbial intervention. Moreover, the soymilk biotransformed by tannase presented higher estrogenic action in the MCF-7 BUS cell line assay, making it a promising nutraceut...
Source: Journal of Functional Foods - July 6, 2018 Category: Nutrition Source Type: research

Effect of low-normal and high-normal IGF-1 levels on memory and wellbeing during growth hormone replacement therapy: a randomized clinical trial in adult growth hormone deficiency
The aim of the present study was to investigate the effect of low-normal and high-normal levels of IGF-1 in growth hormone (GH) deficient adults on cognition and wellbeing during GH treatment. (Source: Health and Quality of Life Outcomes)
Source: Health and Quality of Life Outcomes - July 6, 2018 Category: International Medicine & Public Health Authors: Christa C. van Bunderen, Jan Berend Deijen and Madeleine L. Drent Tags: Research Source Type: research

Natural hormone replacement therapy with a functioning ovary after the menopause: dream or reality?
Publication date: Available online 30 June 2018Source: Reproductive BioMedicine OnlineAuthor(s): Jacques Donnez, Marie-Madeleine DolmansAbstractAt the dawn of humanity, it was rare to live beyond the age of 35 years, so the ovary was intended to function for a woman's entire life. Nowadays, it is not unusual for women to live into their 80s. This means that many of them spend 30–40% of their lives in the menopause at increased risk of various conditions associated with an absence of oestrogens (cardiovascular disease, bone mineral density loss). Reimplantation of frozen–thawed ovarian tissue is able to restore ...
Source: Reproductive BioMedicine Online - July 5, 2018 Category: Reproduction Medicine Source Type: research

Systematic review of hormone replacement therapy in the infertile man
ConclusionsExogenous testosterone inhibits spermatogenesis. Hypogonadal men wanting to preserve their fertility and at the same time benefiting from TRT effects can be prescribed selective oestrogen receptor modulators or testosterone plus low-dose human chorionic gonadotrophin (hCG). Patients treated for infertility with hypogonadotrophic hypogonadism can be prescribed hCG alone at first followed by or in combination from the start with follicle-stimulating hormone preparations. (Source: Arab Journal of Urology)
Source: Arab Journal of Urology - July 5, 2018 Category: Urology & Nephrology Source Type: research

Understanding the role of environmental factors in the development of systemic lupus erythematosus
Publication date: June 2017Source: Best Practice & Research Clinical Rheumatology, Volume 31, Issue 3Author(s): Christine G. Parks, Aline de Souza Espindola Santos, Medha Barbhaiya, Karen H. CostenbaderAbstractSystemic lupus erythematosus (SLE) is a multisystem disease with a complex etiology. Its risk is higher among women, racial and ethnic minorities, and individuals with a family history of SLE or related autoimmune diseases. It is believed that genetic factors interact with environmental exposures throughout the lifespan to influence susceptibility to developing SLE. The strongest epidemiologic evidence exists for...
Source: Best Practice and Research Clinical Rheumatology - July 5, 2018 Category: Rheumatology Source Type: research

Yawning and cortisol levels in multiple sclerosis: Potential new diagnostic tool
Publication date: July 2018Source: Multiple Sclerosis and Related Disorders, Volume 23Author(s): Simon B.N. Thompson, Alister Coleman, Nicola WilliamsAbstractYawning is a significant behavioural response and, together with cortisol, is potentially a new diagnostic marker of neurological diseases. Evidence of an association between yawning and cortisol was found which supports the Thompson Cortisol Hypothesis and thermoregulation hypotheses, indication that brain cooling occurs when yawning. 117 volunteers aged 18–69 years were randomly allocated to experimentally controlled conditions to provoke yawning. Thirty-three...
Source: Multiple Sclerosis and Related Disorders - July 5, 2018 Category: Neurology Source Type: research

Primary adrenal insufficiency in children: Diagnosis and management
Publication date: Available online 6 June 2018Source: Best Practice & Research Clinical Endocrinology & MetabolismAuthor(s): Tarik Kirkgoz, Tulay GuranPrimary adrenal insufficiency (PAI) is a life-threatening disorder of adrenal cortex which is characterized by deficient biosynthesis of glucocorticoids, with or without deficiency in mineralocorticoids and adrenal androgens. Typical manifestations of primary adrenal insufficiency include hyperpigmentation, hypotension, hypoglycaemia, hyponatremia with or without hyperkalemia that are generally preceded by nonspecific symptoms at the onset. Recessively inherited mono...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - July 5, 2018 Category: Endocrinology Source Type: research

Estradiol mediates relaxation of porcine lower esophageal sphincter
Publication date: August 2018Source: Steroids, Volume 136Author(s): Ching-Chung Tsai, Shu-Leei Tey, Li-Ching Chang, Yu-Tsun Su, Kai-Jen Lin, Shih-Che HuangAbstractMost pregnant women have symptoms of gastroesophageal reflux disease (GERD) during pregnancy. Postmenopausal hormone replacement therapy is associated with GERD. The effects of estradiol on lower esophageal sphincter (LES) motility and GERD are not clearly known. The purpose of this study is to investigate the effects of estradiol on the motility of the porcine LES. Relaxations of clasp and sling strips of porcine LES caused by estradiol were measured using isome...
Source: Steroids - July 5, 2018 Category: Drugs & Pharmacology Source Type: research

Alpha-Lipoic Acid Protects Human Aortic Endothelial Cells Against H < sub > 2 < /sub > O < sub > 2 < /sub > -Induced Injury and Inhibits Atherosclerosis in Ovariectomized Low Density Lipoprotein Receptor Knock-Out Mice
Conclusions: ALA could provide a potential treatment for atherosclerosis in postmenopausal patients.Cell Physiol Biochem 2018;47:2261 –2277 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - July 5, 2018 Category: Cytology Source Type: research

Preoperative and Postoperative Considerations in Gender-Affirming Surgery
AbstractPurpose of ReviewThe review is aimed at determining critical factors in the preoperative and postoperative care of transgender patients undergoing gender-affirming surgery. General and procedure-specific considerations are summarized to improve the longitudinal perioperative care of transgender patients.Recent FindingsSurgical providers should follow World Professional Association for Transgender Health (WPATH) guidelines regarding eligibility for surgery. Important elements in preoperative evaluation include mental health screening, fertility discussion, and adjustment of hormone replacement therapy. Postoperative...
Source: Current Sexual Health Reports - July 2, 2018 Category: Sexual Medicine Source Type: research

Proteomic biomarkers of cognitive impairment in obstructive sleep apnea syndrome
ConclusionsProteomic biomarkers in participants with cognitive impairment suggest roles for insulin, and vascular signaling pathways, some of which are similar to findings in Alzheimer ’s disease. A better understanding of the pathogenic mechanisms of CI in OSAS will help focus clinical trials needed in this patient population. (Source: Sleep and Breathing)
Source: Sleep and Breathing - July 2, 2018 Category: Respiratory Medicine Source Type: research

Proteomic biomarkers of cognitive impairment in obstructive sleep apnea syndrome.
CONCLUSIONS: Proteomic biomarkers in participants with cognitive impairment suggest roles for insulin, and vascular signaling pathways, some of which are similar to findings in Alzheimer's disease. A better understanding of the pathogenic mechanisms of CI in OSAS will help focus clinical trials needed in this patient population. PMID: 29968150 [PubMed - as supplied by publisher] (Source: Genomics Proteomics ...)
Source: Genomics Proteomics ... - July 2, 2018 Category: Genetics & Stem Cells Authors: Lal C, Hardiman G, Kumbhare S, Strange C Tags: Sleep Breath Source Type: research

Sellar chondrosarcoma presenting with amenorrhea: A case report
Rationale: Intracranial chondrosarcomas are rare entities and most of which arise off the midline. Chondrosarcomas that occur in the sellar region are extremely rare, and to the best of our knowledge, there is no reporting about sellar chondrosarcoma with amenorrhea as the onset symptom. Patient concerns: A 45-year-old woman presented with a 7-month history of amenorrhea and a 3-month history of progressive visual loss in the left eye. Diagnosis: The patient was diagnosed with recurrent sellar chondrosarcoma arising from intrasellar with extensive tumor invasion into bilateral sphenoid sinuses. Interventions: Tw...
Source: Medicine - July 1, 2018 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Natural hormone replacement therapy with a functioning ovary after the menopause: dream or reality?
Publication date: Available online 30 June 2018 Source:Reproductive BioMedicine Online Author(s): Jacques Donnez, Marie-Madeleine Dolmans At the dawn of humanity, it was rare to live beyond the age of 35 years, so the ovary was intended to function for a woman's entire life. Nowadays, it is not unusual for women to live into their 80s. This means that many of them spend 30–40% of their lives in the menopause at increased risk of various conditions associated with an absence of oestrogens (cardiovascular disease, bone mineral density loss). Reimplantation of frozen–thawed ovarian tissue is able to restore long-...
Source: Reproductive BioMedicine Online - June 30, 2018 Category: Reproduction Medicine Source Type: research

Childhood Craniopharyngioma: A 22-Year Challenging Follow-Up in a Single Center
Horm Metab Res DOI: 10.1055/a-0641-5956Craniopharyngioma is a sellar/suprasellar benign tumor whose aggressiveness may imply in endocrine disturbances (hypothalamic obesity and hormone deficiencies). Fifty-seven patients were evaluated according to clinical characteristics, hypothalamic involvement, type of treatment, anthropometric variables, adiposity indexes (body mass index Z score category at diagnosis and post-treatment, total body fat, visceral adipose tissue, and metabolic syndrome components) and analyzed through multiple regression and logistic models. Patients were stratified according to growth hormone deficien...
Source: Hormone and Metabolic Research - June 29, 2018 Category: Endocrinology Authors: Tosta-Hernandez, Patr ícia Débora Cavalcanti Siviero-Miachon, Adriana Aparecida da Silva, Nasjla Saba Cappellano, Andrea Pinheiro, Marcelo de Medeiros Spinola-Castro, Angela Maria Tags: Endocrine Care Source Type: research

Japan Society of Obstetrics and Gynecology and Japan Society for Menopause and Women's Health 2017 guidelines for hormone replacement therapy
Journal of Obstetrics and Gynaecology Research, EarlyView. (Source: Journal of Obstetrics and Gynaecology Research)
Source: Journal of Obstetrics and Gynaecology Research - June 29, 2018 Category: OBGYN Authors: Hiroya Okano , Tsuyoshi Higuchi , Takumi Kurabayashi , Kazuya Makita , Hideki Mizunuma , Yoshiko Mochizuki , Satoshi Obayashi , Toshiyuki Yasui , Kiyoshi Takamatsu , Source Type: research

Menopausal hormone therapy and the risk of breast cancer by histological type and race: a meta-analysis of randomized controlled trials and cohort studies
ConclusionsAsian HRT users had a higher risk of breast cancer than western HRT users. Both ET and EPT were significantly associated with the risk of all breast cancer histological types and ER-positive breast cancer. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - June 28, 2018 Category: Cancer & Oncology Source Type: research

[Efficacy and safety of replacement treatment in isolated growth hormone deficiency].
te;pez-Siguero JP Abstract INTRODUCTION: Growth in patients with isolated growth hormone (GH) deficiency is heterogeneous despite treatment due to the low specificity of diagnostic tests, making it necessary to define efficacy variables. AIMS: To evaluate efficacy of hormone replacement therapy in children with isolated GH deficiency. METHODS: Observational-ambispective study of patients treated in our department in the last 14 years for isolated GH deficiency. This was defined as a GH level less than 7.4mg/dl in response to 2 stimulation tests in patients with height
Source: Anales de Pediatria - June 27, 2018 Category: Pediatrics Authors: Ariza Jiménez AB, Martínez-Aedo Ollero MJ, López-Siguero JP Tags: An Pediatr (Barc) Source Type: research

Multiple meningiomas in two male-to-female transsexual patients with hormone replacement therapy: A report of two cases and a brief literature review.
Conclusion: Radiological screening may be justifiable for transsexual patients with a history of long-standing HRT and special focus should be paid to transsexual patients displaying new neurological symptoms or those already diagnosed with a meningioma. PMID: 29930875 [PubMed] (Source: Surgical Neurology International)
Source: Surgical Neurology International - June 24, 2018 Category: Neurosurgery Tags: Surg Neurol Int Source Type: research

Thyroid function in healthy and unhealthy preterm newborns
This study sought to investigate thyroid hormone levels of healthy and unhealthy pre-term infants.Methods: The prospective study included 53 consecutive premature infants admitted to the neonatal intensive care unit within a duration of one year. Of these preterm babies, 20 were healthy, while 33 had problems such as asphyxia or RDS. Venous blood samples were collected at baseline 0-24 hours, 7 and 14 days and FT3, FT4, and TSH levels were determined. Other data recorded included demographic characteristics of the patients and clinical variables.Results: The most frequent health problems were RDS (87.9%), sepsis (30.3%), a...
Source: African Health Sciences - June 21, 2018 Category: African Health Source Type: research

Estradiol mediates relaxation of porcine lower esophageal sphincter
Publication date: August 2018 Source:Steroids, Volume 136 Author(s): Ching-Chung Tsai, Shu-Leei Tey, Li-Ching Chang, Yu-Tsun Su, Kai-Jen Lin, Shih-Che Huang Most pregnant women have symptoms of gastroesophageal reflux disease (GERD) during pregnancy. Postmenopausal hormone replacement therapy is associated with GERD. The effects of estradiol on lower esophageal sphincter (LES) motility and GERD are not clearly known. The purpose of this study is to investigate the effects of estradiol on the motility of the porcine LES. Relaxations of clasp and sling strips of porcine LES caused by estradiol were measured using isometric ...
Source: Steroids - June 21, 2018 Category: Drugs & Pharmacology Source Type: research

Hormone-replacement Therapy for Hepatopulmonary Syndrome and NASH Associated with Hypopituitarism.
Authors: Torii N, Ichihara A, Mizuguchi Y, Seki Y, Hashimoto E, Tokushige K Abstract The patient was a 23-year-old man who was diagnosed with severe hypoxemia and liver dysfunction after suffering from sudden difficulty breathing. At 2 years of age, he had been diagnosed with hypopituitarism, and had received hormone-replacement until he was 18 years of age. Echocardiography using micro bubbles and pulmonary scintigraphy indicated intrapulmonary shunt and a liver biopsy showed steatohepatitis. He was diagnosed with hepatopulmonary syndrome associated with nonalcoholic steatohepatitis. Hormone-replacement therapy wa...
Source: Internal Medicine - June 20, 2018 Category: Internal Medicine Tags: Intern Med Source Type: research

Postoperative growth hormone dynamics in clinically nonfunctioning pituitary adenoma.
In this study, we analyzed patients with NFPAs that underwent transsphenoidal surgery. Postoperatively, GH secretion was evaluated in response to GH-releasing peptide-2 (GHRP2) infusion. We also investigated how several factors affected GH dynamics. Of 119 patients analyzed, 94 (79.0%) had peak GH levels less than 9.0 ng/mL and were diagnosed with severe GHD (sGHD) immediately after surgery. Of those patients, 27 (28.7%) recovered from sGHD within 1-2 years after surgery. Univariate analyses confirmed that sGHD recovery improved significantly in patients that were younger, had only undergone a single primary surgery, had n...
Source: Endocrine Journal - June 20, 2018 Category: Endocrinology Tags: Endocr J Source Type: research

Transition in Pediatric and Adolescent Hypogonadal Girls: Gynecological Aspects, Estrogen Replacement Therapy, and Contraception.
uul A Abstract Hypogonadism may be suspected if puberty is delayed. Pubertal delay may be caused by a normal physiological variant, by primary ovarian insufficiency (Turner syndrome), or reflect congenital hypogonadotropic hypogonadism (HH; genetic) or acquired HH (brain lesions). Any underlying chronic disease like inflammatory bowel disease, celiac disease, malnutrition (anorexia or orthorexia), or excessive physical activity may also result in functional HH. Thus, girls with delayed puberty should be evaluated for an underlying pathology before any treatment, including oral contraception, is initiated. Estrogen...
Source: Endocrine Development - June 14, 2018 Category: Endocrinology Authors: Tønnes Pedersen A, Cleemann L, Main KM, Juul A Tags: Endocr Dev Source Type: research

Metabolic Complications in Adrenal Insufficiency.
Authors: Ueland GA, Husebye ES Abstract Pharmacological glucocorticoid treatment is associated with adverse metabolic consequences such as hypertension, overweight, reduced glucose tolerance, diabetes mellitus and ultimately increased mortality in cardiovascular disease. Here we review the evidence of detrimental effects of hormone replacement therapy in adrenal insufficiency (AI). Registry studies indicate increased cardiovascular mortality, hypertension, diabetes, and dyslipidemia in both primary and secondary AI, but when cohorts with carefully characterized patients are studied the picture is less clear, and re...
Source: Frontiers of Hormone Research - June 13, 2018 Category: Endocrinology Tags: Front Horm Res Source Type: research

P1 ‐067: Efficacy and safety of elbasvir/grazoprevir in women infected with hepatitis C virus genotype 1 or 4 and co‐administered oral contraceptives or hormone replacement therapy
Journal of Viral Hepatitis,Volume 25, Issue S2, Page 56-57, June 2018. (Source: Journal of Viral Hepatitis)
Source: Journal of Viral Hepatitis - June 13, 2018 Category: Infectious Diseases Source Type: research

Adherence to thyroid hormone replacement therapy: a retrospective, claims database analysis.
CONCLUSIONS: This large, retrospective real-world study demonstrated that adherence to levothyroxine remains a concern among patients with hypothyroidism and that differences in adherence may exist across levothyroxine formulations. PMID: 29874941 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - June 8, 2018 Category: Research Tags: Curr Med Res Opin Source Type: research

Dose-dependent effect of mammographic breast density on the risk of contralateral breast cancer
ConclusionBreast density is an independent and significant risk factor for development of contralateral breast cancer. This risk factor should contribute to clinical decision making. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - June 8, 2018 Category: Cancer & Oncology Source Type: research

Positive Effects of Bisphosphonates on Osteogenic Differentiation in Patient-Derived Mesenchymal Stem Cells for the Treatment of Osteoporosis
CONCLUSION:Our study using a clinically relevantin vitro model suggests that bisphosphonate treatment is more effective for patients with osteoporosis than its preventive effect for healthy person. In addition, patient-specific responses to bisphosphonates should be considered rather than bisphosphonate type prior to prescription. Further investigations are needed to determine how bisphosphonates influence hBMSCs function to mediate bone quality and turnover in osteoporotic patients. Such studies can generate novel approaches to treat age-related osteoporotic bone loss. (Source: Tissue Engineering and Regenerative Medicine)
Source: Tissue Engineering and Regenerative Medicine - June 8, 2018 Category: Biotechnology Source Type: research

Management of Hypothalamic Obesity during Transition from Childhood to Adulthood.
Abstract Hypothalamic obesity (HO) is a rare and serious disease of various origins: tumor, traumatism, radiotherapy, vascular, genetic, or even psychotropic drug use. HO usually begins in childhood with eating disorders and progresses with an aggregate of severe comorbidities. Transition from pediatric to adult health care is a critical period to assure weight stability and a good management of comorbidities. In case of loss to follow-up, there is an increased risk of major weight gain and long-term complications with severe obesity. To minimize this risk, pediatric and adult specialists must work together to pre...
Source: Endocrine Development - June 8, 2018 Category: Endocrinology Authors: Bretault M, Carette C, Barsamian C, Czernichow S Tags: Endocr Dev Source Type: research

Transition of Care from Childhood to Adulthood: Congenital Adrenal Hyperplasia.
Abstract Deficiency of the 21-hydroxylase enzyme is the most common form of congenital adrenal hyperplasia (CAH), accounting for more than 95% of the cases. With the advent of newborn screening and hormone replacement therapy, most children with CAH survive into adulthood. Adolescents and adults with CAH experience a number of complications, including short stature, obesity, infertility, impaired bone mineral density, and reduced quality of life. Transition from pediatric to adult care and management of long-term complications are challenging for both patients and practitioners. In adulthood, the aims of the medic...
Source: Endocrine Development - June 8, 2018 Category: Endocrinology Authors: Bachelot A Tags: Endocr Dev Source Type: research

Primary Adrenal Insufficiency in Children: Diagnosis and Management
Publication date: Available online 6 June 2018 Source:Best Practice &amp; Research Clinical Endocrinology &amp; Metabolism Author(s): Tarik Kirkgoz, Tulay Guran Primary adrenal insufficiency (PAI) is a life-threatening disorder of adrenal cortex which is characterized by deficient biosynthesis of glucocorticoids, with or without deficiency in mineralocorticoids and adrenal androgens. Typical manifestations of primary adrenal insufficiency include hyperpigmentation, hypotension, hypoglycaemia, hyponatremia with or without hyperkalemia that are generally preceded by nonspecific symptoms at the onset. Recessively inh...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - June 7, 2018 Category: Endocrinology Source Type: research

Volumetric bone mineral density of the spine predicts mortality in African-American men with type 2 diabetes
ConclusionsLower vBMD was associated with increased all-cause mortality in African-American men with T2D, independent of other risk factors for mortality including subclinical atherosclerosis. (Source: Osteoporosis International)
Source: Osteoporosis International - May 31, 2018 Category: Orthopaedics Source Type: research

Mayer-Rokitansky-Kuster-Hauser syndrome accompanied by invasive ductal carcinoma: a case report.
Authors: Kasap E, Gene M, Sahin N, Sivrikoz ON Abstract Milllerian agenesis and the absence of organs of Millerian canal origin are referred to as Mayer-Rokitansky-Kuster-Hauser (MRKH) syndrome. Invasive ductal carcinoma constitutes 47-75% of all breast carcinomas and is the most common type. The authors report the first case of invasive ductal carcinoma associated with MRKH syndrome in the literature to their knowledge. A 25-year-old woman with a palpable mass in her right breast for three months presented to the presented clinic. On physical examination a mobile, firm mass measuring 2x2 cm was detected in right b...
Source: European Journal of Gynaecological Oncology - May 24, 2018 Category: OBGYN Tags: Eur J Gynaecol Oncol Source Type: research

Massive pericardial effusion without cardiac tamponade due to subclinical hypothyroidism (Hashimoto's disease).
Authors: Papakonstantinou PE, Gourniezakis N, Skiadas C, Patrianakos A, Gikas A Abstract CONTEXT: Hypothyroidism is a significant cause of pericardial effusion. However, large pericardial effusions due to hypothyroidism are extremely rare. Hormone replacement therapy is the cornerstone of treatment for hypothyroidism and regular follow-up of patients after initiation of the therapy is indicated. Herein, the case of a 70-year-old woman with a massive pericardial effusion due to Hashimoto's disease is presented. ISSUES: A 70-year-old female from a rural village on the island of Crete, Greece, was admitted to our ...
Source: Rural and Remote Health - May 22, 2018 Category: Rural Health Tags: Rural Remote Health Source Type: research

Endocrinopathy-induced euvolemic hyponatremia
AbstractEuvolemic hyponatremia results from either the syndrome of inappropriate antidiuretic hormone secretion (SIADH), hypothyroidism, or adrenal insufficiency. Furthermore, the criteria for diagnosis of SIADH entail the exclusion of hypothyroidism and hypoadrenalism. We aim to assess the yield of euvolemic hyponatremia workup focusing on underlying endocrinopathies in a real-world setting. A single-center retrospective study includes all patients diagnosed with euvolemic hyponatremia in a tertiary hospital between 1.1.2007 and 1.1.2013. Demographic, clinical, and laboratory data were collected from medical charts. Euvol...
Source: Internal and Emergency Medicine - May 22, 2018 Category: Emergency Medicine Source Type: research

[Effect of serum estradiol level before progesterone administration on pregnancy outcomes of frozen-thawed embryo transfer cycles].
Abstract OBJECTIVE: To explore whether a high serum estradiol (E2) level before progesterone administration adversely affects the pregnancy outcomes of frozen-thawed embryo transfer (FET) cycles. METHODS: We retrospectively analyzed 205 hormone replacement therapy (HRT)-FET cycles in our Center between February, 2017 and August, 2017. With a cutoff value of serum E2 level of 600 pg/mL before progesterone administration, the cases were divided into high E2 level group and control group with normal E2 level, and the clinical characteristics and pregnancy outcomes were compared between the two groups. RESUL...
Source: Journal of Southern Medical University - May 20, 2018 Category: Universities & Medical Training Authors: Deng L, Chen X, Ye DS, Chen SL Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research