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Indoor Wood-Burning Stove and Fireplace Use and Breast Cancer in a Prospective Cohort Study
Conclusions: In this prospective study, using an indoor wood-burning stove/fireplace in the longest adult residence at least once a week and burning either wood or natural gas/propane was associated with a modestly higher risk of breast cancer. https://doi.org/10.1289/EHP827 Received: 18 July 2016 Revised: 16 November 2016 Accepted: 09 December 2016 Published: 18 July 2017 Address correspondence to A.J. White, Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709-2233 USA. Telephone: (919) 316-4867. Email: alexandra.white@nih.gov Supp...
Source: EHP Research - July 18, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Hormone factors play a favorable role in female head and neck cancer risk
Abstract Due to lower female incidence, estimates of exogenous and endogenous hormonal factors in head and neck cancers (HNCs, comprising cancers of the oral cavity, oropharynx, hypopharynx, and larynx) among women have been inconsistent and unable to account for key HNC risk factors. We pooled data from 11 studies from Europe, North America, and Japan. Analysis included 1572 HNC female cases and 4343 controls. Pooled odds ratios (ORs) estimates and their 95% confidence intervals (CIs) were calculated using multivariate logistic regression models adjusting for tobacco smoking and alcohol drinking. Lower risk was observed i...
Source: Cancer Medicine - July 14, 2017 Category: Cancer & Oncology Authors: Dana Hashim, Samantha Sartori, Carlo La Vecchia, Diego Serraino, Luigino Dal Maso, Eva Negri, Elaine Smith, Fabio Levi, Stefania Boccia, Gabriella Cadoni, Hung N. Luu, Yuan ‐Chin Amy Lee, Mia Hashibe, Paolo Boffetta Tags: Original Research Source Type: research

Are incident gallstones associated to sex ‐dependent changes with age? A cohort study
The objectives of this study were to determine if changes with age in physiology, lifestyle, or reproductive hormones were associated with incident gallstones. A cohort study of a general population random sample (N = 2366) aged 30–60 years was performed. Participants were ultrasound screened for gallstones in 1982–84 and again in 1993–94. Lifestyle data and blood samples were obtained and re‐analyzed in 2004. Changes with age in physiology (body mass index, blood pressure, blood lipids, self‐rated health), lifestyle (smoking, alcohol and coffee consumption, dietary habits, physical act...
Source: Andrology - July 13, 2017 Category: Urology & Nephrology Authors: D. M. Shabanzadeh, S. A. Holmboe, L. T. S ørensen, A. Linneberg, A.‐M. Andersson, T. Jørgensen Tags: Original Article Source Type: research

Radiation-associated breast cancer and gonadal hormone exposure: a report from the Childhood Cancer Survivor Study
n Leeuwen, Malcolm C Pike & Kevin C Oeffinger (Source: British Journal of Cancer)
Source: British Journal of Cancer - July 11, 2017 Category: Cancer & Oncology Authors: Chaya S Moskowitz Joanne F Chou Charles A Sklar Dana Barnea C écile M Ronckers Danielle Novetsky Friedman Joseph P Neglia Lucie Turcotte Rebecca M Howell Tara O Henderson Gregory T Armstrong Wendy M Leisenring Leslie L Robison Flora E van Leeuwen Malcolm Tags: hormone replacement therapy late effects pediatric malignancy second malignancies supradiaphragmatic radiotherapy Source Type: research

Age of menarche is associated with knee joint replacement due to primary osteoarthritis. (The HUNT Study and the Norwegian Arthroplasty Register)
To investigate whether parity, age at menarche, menopausal status, age at menopause, use of oral contraceptives or use of hormone replacement therapy (HRT) were associated with total knee replacement (TKR) or total hip replacement (THR) due to primary osteoarthritis. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - July 10, 2017 Category: Rheumatology Authors: Alf Inge Hellevik, Lars Nordsletten, Marianne Bakke Johnsen, Anne Marie Fenstad, Ove Furnes, Kjersti Storheim, John Anker Zwart, Gunnar Flugsrud, Arnulf Langhammer Source Type: research

Age of menarche is associated with knee joint replacement due to primary osteoarthritis (The HUNT Study and the Norwegian Arthroplasty Register)
To investigate whether parity, age at menarche, menopausal status, age at menopause, use of oral contraceptives (OC) or use of hormone replacement therapy (HRT) were associated with total knee replacement (TKR) or total hip replacement (THR) due to primary osteoarthritis. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - July 10, 2017 Category: Rheumatology Authors: A.I. Hellevik, L. Nordsletten, M.B. Johnsen, A.M. Fenstad, O. Furnes, K. Storheim, J.A. Zwart, G. Flugsrud, A. Langhammer Source Type: research

Age of menarche is associated with knee joint replacement due to  primary osteoarthritis (The HUNT Study and the Norwegian Arthroplasty Register)
To investigate whether parity, age at menarche, menopausal status, age at menopause, use of oral contraceptives (OC) or use of hormone replacement therapy (HRT) were associated with total knee replacement (TKR) or total hip replacement (THR) due to primary osteoarthritis. (Source: Osteoarthritis and Cartilage)
Source: Osteoarthritis and Cartilage - July 10, 2017 Category: Rheumatology Authors: A.I. Hellevik, L. Nordsletten, M.B. Johnsen, A.M. Fenstad, O. Furnes, K. Storheim, J.A. Zwart, G. Flugsrud, A. Langhammer Source Type: research

Factors associated with complementary and alternative medicine use among women at midlife.
Abstract Hormone replacement therapy (HRT) has been established as the first-line treatment for women experiencing menopausal symptoms. The use of complementary and alternative medicine (CAM), however, is becoming increasingly popular among women at midlife for management of such symptoms. Despite the equivocal evidence of CAM's efficacy in the reduction and alleviation of menopausal symptoms in placebo-controlled, randomized trials, 50% of women at midlife use CAM. To date, several large, population-based studies have focused upon CAM use amongst menopausal women and the factors associated with the adoption of su...
Source: Climacteric - July 8, 2017 Category: Geriatrics Authors: Costanian C, Christensen RAG, Edgell H, Ardern CI, Tamim H Tags: Climacteric Source Type: research

Impact of postoperative pituitary tumor adrenal insufficiency and hormone replacement therapy (HRT) on tumor recurrence.
CONCLUSIONS: The age, patient gender and the size of the tumor were not independent risk factors leading to postoperative pituitary tumor adrenal insufficiency. However, the occurrence rate of adrenal insufficiency of patients in high age group was higher than that of patients in low age group. Also, the occurrence rate of adrenal insufficiency of patients (whose one or several hormones dramatically decreased before the operation) was significantly higher than that of patients (whose hormone level did not decrease before the operation). So, the patients in high age group and whose one or several hormones dramatically decre...
Source: European Review for Medical and Pharmacological Sciences - July 7, 2017 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Models of cognitive functions with respect to selected parameters of functional state of the thyroid gland in post-menopausal women.
The objective of the study was the development of models of cognitive functions in a group of post-menopausal women, according to the concentration of the selected laboratory parameters evaluating the functional state of the thyroid gland. MATERIAL AND METHODS: The study was conducted during 2012-2014, and covered women aged 50-65 years, minimum two years after the last menstruation, without chronic diseases, cancerous diseases, mental disorders, addiction to drugs or alcohol, and who did not use hormone replacement therapy. At the stage of qualification, a brief MoCA test was performed; 383 women were qualified for t...
Source: Endokrynologia Polska - July 1, 2017 Category: Endocrinology Authors: Gujski M, Pinkas J, Witczak M, Owoc A, Bojar I Tags: Endokrynol Pol Source Type: research

The menopause: benefits and risks of available treatments
Menopausal symptoms affect many women, but debate continues over the role of hormone replacement therapy (HRT) in their management. This review provides a summary of the current treatment options for menopause management and considers their benefits and risks. (Source: Prescriber)
Source: Prescriber - June 30, 2017 Category: Primary Care Authors: Rosemary Cochrane, Heather Currie Tags: Drug Review Source Type: research

Mammographic breast density and breast cancer risk in a Mediterranean population: a nested case –control study in the EPIC Florence cohort
ConclusionsWe confirm in this Mediterranean population the association of increasing MBD, classified according to BI-RADS with BC risk also taking into account other well-known risk factors for this neoplasm. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - June 21, 2017 Category: Cancer & Oncology Source Type: research

Social, health and ocular factors associated with primary open angle glaucoma amongst Chinese Singaporeans
This study evaluated the association of primary open angle glaucoma with smoking, health and ocular factors among Chinese Singaporeans. DesignCase‐control study Participants711 primary open angle glaucoma patients from a Singapore hospital and 2788 population‐based controls. MethodsSubjects underwent clinical examination and completed a questionnaire with details on family history of glaucoma, comorbidities, smoking, alcohol consumption, age at menopause and use of hormone replacement therapy. Primary open angle glaucoma was sub‐classified as normal‐tension glaucoma and high‐tension glaucoma depending on the untr...
Source: Clinical and Experimental Ophthalmology - June 16, 2017 Category: Opthalmology Authors: Nathalie Chiam, Mani Baskaran, Zheng Li, Shamira Perera, David Goh, Rahat Husain, Chiea Chuen Khor, Ching ‐Yu Cheng, Tin Aung FRCOphth, Eranga N Vithana Tags: Original Article Source Type: research

Hormone replacement therapy and breast cancer survival: a systematic review and meta-analysis of observational studies.
In conclusion, the average effect of HRT use seems not harmful to breast cancer survival. Nevertheless, this effect of HRT use is needed for further assessment. PMID: 28601917 [PubMed - as supplied by publisher] (Source: Breast Cancer)
Source: Breast Cancer - June 10, 2017 Category: Cancer & Oncology Authors: Yu X, Zhou S, Wang J, Zhang Q, Hou J, Zhu L, He Y, Zhao J, Zhong S Tags: Breast Cancer Source Type: research

Obesity-associated Breast Cancer: Analysis of risk factors.
Authors: Engin A Abstract Several studies show that a significantly stronger association is obvious between increased body mass index (BMI) and higher breast cancer incidence. Furthermore, obese women are at higher risk of all-cause and breast cancer specific mortality when compared to non-obese women with breast cancer. In this context, increased levels of estrogens due to excessive aromatization activity of the adipose tissue, overexpression of pro-inflammatory cytokines, insulin resistance, hyperactivation of insulin-like growth factors (IGFs) pathways, adipocyte-derived adipokines, hypercholesterolemia and exce...
Source: Advances in Experimental Medicine and Biology - June 8, 2017 Category: Research Tags: Adv Exp Med Biol Source Type: research

Physiologic and exogenous hormone effects on the endometrium: important aspects for the surgical pathologist
The endometrium exhibits a unique physiology in its ability to cyclically respond to steroid hormones, resulting in morphologic changes that allow the pathologist's interpretation of proper endometrial function. Distinctive changes are also observed during times of physiologic hormonal changes, such as in pregnancy, or in pathologic and iatrogenic hormonal imbalances, as in certain functioning ovarian tumours and hormone therapy, respectively. The ubiquity of these states, in particular the widespread use of oral contraception, hormone replacement therapy, hormonal intrauterine devices, and nowadays frequent use of progest...
Source: Diagnostic Histopathology - June 7, 2017 Category: Pathology Authors: Mir Alikhan, Katja Gwin Tags: Gynaecological pathology Source Type: research

Xanthomatous Hypophysitis Presenting With Diabetes Insipidus Completely Cured Through Transsphenoidal Surgery: A Case Report and Literature Review
Xanthomatous hypophysitis (XH) is extremely rare. Only 27 cases have been reported in the literature. No XH patient presenting with diabetes insipidus (DI) has been completely cured through surgery. Here, we describe the first XH case of a DI patient whose pituitary function was normalized postoperatively, without hormone replacement therapy. (Source: World Neurosurgery)
Source: World Neurosurgery - June 2, 2017 Category: Neurosurgery Authors: Wei Lin, Lu Gao, Xiaopeng Guo, Wenze Wang, Bing Xing Tags: Case Report Source Type: research

Microscopic Transnasal Transsphenoidal Surgery for Pediatric Pituitary Adenomas
In conclusion, MTTS is a safe and effective surgical option for pediatric pituitary adenomas with minimal morbidity and excellent outcomes. (Source: Journal of Craniofacial Surgery)
Source: Journal of Craniofacial Surgery - June 1, 2017 Category: Surgery Tags: Clinical Studies Source Type: research

Congenital adrenal hyperplasia
Publication date: Available online 30 May 2017 Source:The Lancet Author(s): Diala El-Maouche, Wiebke Arlt, Deborah P Merke Congenital adrenal hyperplasia is a group of autosomal recessive disorders encompassing enzyme deficiencies in the adrenal steroidogenesis pathway that lead to impaired cortisol biosynthesis. Depending on the type and severity of steroid block, patients can have various alterations in glucocorticoid, mineralocorticoid, and sex steroid production that require hormone replacement therapy. Presentations vary from neonatal salt wasting and atypical genitalia, to adult presentation of hirsutism and irregul...
Source: The Lancet - May 31, 2017 Category: General Medicine Source Type: research

Impacts of Anti-dsDNA Antibody on In Vitro Fertilization-Embryo Transfer and Frozen-Thawed Embryo Transfer.
Authors: Fan J, Zhong Y, Chen C Abstract Our purpose is to explore whether anti-dsDNA antibody, which was demonstrated to enter living cells and induced apoptosis, could adversely affect reproductive outcomes. A total of 259 women receiving the in vitro fertilization-embryo transfer (IVF) cycle were enrolled in this study, including 52 women with positive ANA and anti-dsDNA (ANA+/anti-dsDNA+ group), 86 women with positive ANA and negative anti-dsDNA (ANA+/anti-dsDNA- group), and 121 women with negative ANA and anti-dsDNA (ANA-/anti-dsDNA- group). 136 nonpregnant women among 259 patients in the IVF-ET cycle were enr...
Source: Journal of Immunology Research - May 26, 2017 Category: Allergy & Immunology Tags: J Immunol Res Source Type: research

Transdermal estrogens in the changing landscape of hormone replacement therapy.
Authors: Beck KL, Anderson MC, Kirk JK Abstract Views and clinical practice on hormone replacement therapy (HRT) for postmenopausal women have varied widely over the last several decades. The 1990s showed a dramatic decline in prescribing and only recently are prescription rates increasing again. Use of HRT is first line for women suffering from the symptoms of menopause. For a certain population of postmenopausal women, HRT is recommended for prevention of fracture. More consideration is being given to patient risk factors, side effects, and formulations available. Transdermal patch estrogen formulations have been...
Source: Postgraduate Medicine - May 26, 2017 Category: Internal Medicine Tags: Postgrad Med Source Type: research

Physiological and Normal Variations in FDG uptake: A pictorial review.
Conclusion: This pictorial review illustrates the physiological and normal variations in FDG uptake and will help in increasing the diagnostic accuracy of PET CT reports and thereby reducing the number of unnecessary follow-up studies/procedures. Research Support: Brain: greater uptake in the cerebral cortex, basal ganglia and thalami (grey matter), Variable uptake in the cord at C6-T1 and T12-L2 Head and Neck: wide spectrum of uptake pattern involving vocal cords, tonsils, waldeyer ring, parotid and submandibular glands. Thyroid: Focal and diffuse uptake patterns. Thymus: normal uptake in children, rebound thymic uptake B...
Source: Journal of Nuclear Medicine - May 24, 2017 Category: Nuclear Medicine Authors: SINGH, C., GUPTA, M., Prasad, R., Virmani, R., Virmani, S., Singh, J., Ali, A. Tags: Educational Exhibits Posters Source Type: research

Molecular imaging of tumor microenvironment to study synergistic effects of therapy with doxorubicin and CAMs
Conclusion: Although the treatment with black cohosh showed no therapeutic effect in our in vitro studies, we noticed significant changes in tumor metabolism and angiogenesis in vivo. The most intriguing finding was that the intake of BC alone was capable of changing the tumor microenvironment by increasing the metabolic rate and decreasing angiogenesis. More work remains to be done to further elucidate the therapeutic potential of BC and other CAMs with current chemotherapeutics. Research Support: Studies were funded by Arnold Beckman Foundation and the Ministry of Science and Higher Education Poland (Mobility Plus Progra...
Source: Journal of Nuclear Medicine - May 24, 2017 Category: Nuclear Medicine Authors: Hedhli, J., Konopka, C., Ploska, A., Schuh, S., Kalinowski, L., Dobrucka, I., Dobrucki, W. Tags: Oncology: Basic, Translational & amp; Therapy (Basic Science) Posters Source Type: research

A Comprehensive Method to Quantify Adaptations by Male and Female Mice with Hot Flashes Induced by the Neurokinin B Receptor Agonist, Senktide.
Abstract Vasomotor symptoms (VMS, or hot flashes) plague millions of reproductive age men and women who have natural or iatrogenic loss of sex steroid production. Many affected individuals are left without treatment options because of contraindications to hormone replacement therapy and the lack of equally effective non-hormonal alternatives. Moreover, development of safer, more effective therapies has been stymied by the lack of an animal model that recapitulates the hot flash phenomenon and enables direct testing of hypotheses regarding the pathophysiology underlying hot flashes. To address these problems, we de...
Source: Endocrinology - May 22, 2017 Category: Endocrinology Authors: Krull AA, Larsen SA, Clifton DK, Neal-Perry G, Steiner RA Tags: Endocrinology Source Type: research

Impact of risk-reducing salpingo-oophorectomy in premenopausal women.
CONCLUSIONS: The conclusions of this systematic review are limited by the absence of randomized, controlled trials. There is growing evidence from observational studies that RRSO may impact negatively on all-cause non-survival endpoints. PMID: 28509627 [PubMed - in process] (Source: Climacteric)
Source: Climacteric - May 18, 2017 Category: Geriatrics Authors: Vermeulen RFM, Beurden MV, Korse CM, Kenter GG Tags: Climacteric Source Type: research

[Cryptogenic stroke in a young patient with heart disease and kidney failure].
CONCLUSIONS: Fabry's disease must be suspected in young males with heart disease, stroke or peripheral neuropathy, skin lesions, kidney failure and a history of cases in the family. Hormone replacement therapy must be established at an early stage, as it can improve the prognosis. PMID: 28497441 [PubMed - in process] (Source: Revista de Neurologia)
Source: Revista de Neurologia - May 13, 2017 Category: Neurology Authors: Oyanguren B, Segoviano R, Alegria E, Besada E, Gonzalez-Salaices M, Eimil-Ortiz M, Lopez de Silanes C Tags: Rev Neurol Source Type: research

Frozen –thawed blastocyst transfer in natural cycle: feasibility in everyday clinical practice
AbstractPurposeTransfer of frozen –thawed embryos in natural cycle is gaining consensus but evidence on this approach is scanty. The aim of this study is reporting on the feasibility of this type of policy in everyday clinical practice.MethodsWe retrospectively selected all women undergoing the procedure between July 2013 and December 2014. During the study period, women were systematically scheduled for natural cycle if they referred regular menstrual cycles. Hormone replacement therapy (HRT) was conversely prescribed if the woman had irregular menstrual cycles or if the monitoring of the natural cycle failed. The a...
Source: Archives of Gynecology and Obstetrics - May 13, 2017 Category: OBGYN Source Type: research

Long-term breast cancer risk following ovarian stimulation in young egg donors: a call for follow-up, research and informed consent
Publication date: May 2017 Source:Reproductive BioMedicine Online, Volume 34, Issue 5 Author(s): Jennifer Schneider, Jennifer Lahl, Wendy Kramer In the USA and other countries, oocyte donation is gaining increasing importance. Although sufficient data exist on procedure-associated short-term risks for oocyte donors, such as ovarian hyperstimulation syndrome, long-term follow-up studies of egg donors are lacking and their health risks are unknown. The lack of information may be misleadingly interpreted as lack of risk. Long-term hormone replacement therapy is recognized as a risk factor for breast cancer; the breast cancer...
Source: Reproductive BioMedicine Online - May 11, 2017 Category: Reproduction Medicine Source Type: research

The management of menopause in women with a history of endometriosis: a systematic review
We present a synthesis of the existing case reports of endometriosis recurrence or malignant transformation in women undergoing treatment for menopausal symptoms. We highlight common presenting symptoms, potential risk factors and outcomes amongst the studies. Sparse high-quality evidence was identified, with few observational studies and only two randomized controlled trials. Given this paucity of data, no definitive conclusions can be drawn concerning risk.WIDER IMPLICATIONSDue to the lack of high-quality studies, it remains unclear how to advise women with a history of endometriosis regarding the management of menopausa...
Source: Human Reproduction Update - May 11, 2017 Category: OBGYN Source Type: research

Risk factors for cardiovascular disease in subclinical hypothyroidism
AbstractSubclinical hypothyroidism (SH), defined as an increased serum thyrotropin (TSH) level and normal plasma-free thyroid hormones ’ concentrations, is common in the general population, in particular, among elderly women. Its prevalence ranges from 4 to 15% and up to 20% among females aged >  60 year. Although SH has been associated with atherosclerotic cardiovascular disease (CVD), it is acknowledged that the high prevalence of dyslipidemia in elderly people is considered a common biochemical condition. Therefore, whether SH is associated with a higher risk for CVD is still controver sial. At t...
Source: Irish Journal of Medical Science - May 10, 2017 Category: General Medicine Source Type: research

Gender, Estrogen, and Obliterative Lesions in the Lung.
Authors: Assaggaf H, Felty Q Abstract Gender has been shown to impact the prevalence of several lung diseases such as cancer, asthma, chronic obstructive pulmonary disease, and pulmonary arterial hypertension (PAH). Controversy over the protective effects of estrogen on the cardiopulmonary system should be of no surprise as clinical trials of hormone replacement therapy have failed to show benefits observed in experimental models. Potential confounders to explain these inconsistent estrogenic effects include the dose, cellular context, and systemic versus local tissue levels of estrogen. Idiopathic PAH is dispropor...
Source: International Journal of Endocrinology - May 5, 2017 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Association of Catechol-O-methyltransferase polymorphism Val158Met and mammographic density: A meta-analysis.
CONCLUSIONS: COMT Val158Met polymorphism may be associated with mammographic density at least in healthy women. Menopausal status and HRT should be taken into account in future studies to avoid masking of the underlying effects. PMID: 28473194 [PubMed - as supplied by publisher] (Source: Gene)
Source: Gene - May 1, 2017 Category: Genetics & Stem Cells Authors: Kallionpää RA, Uusitalo E, Peltonen J Tags: Gene Source Type: research

Estradiol deficiency is a risk factor for idiopathic benign paroxysmal positional vertigo in postmenopausal female patients
Objectives/HypothesisAlthough it is generally considered that benign paroxysmal positional vertigo (BPPV) is associated with changes in female sex hormone levels, no direct data have been reported until now. The purpose of this article was to provide direct data showing the distinct relationship between female sex hormone fluctuations and BPPV in postmenopausal female patients. Study DesignProspective analysis in humans and basic research in animals. MethodsBlood samples were analyzed to determine the levels of estradiol, progesterone, follicle‐stimulating hormone, and luteinizing hormone in 50‐ to 80‐year‐old post...
Source: The Laryngoscope - May 1, 2017 Category: ENT & OMF Authors: Hualan Yang, Huanhuan Gu, Wenjing Sun, Yanpeng Li, Huijuan Wu, Molorerdene Burnee, Jianhua Zhuang Tags: Otology/Neurotology Source Type: research

016 –Treatment Adherence to Somavaratan (VRS-317), a Long-Acting Growth Hormone for Children with Growth Hormone Deficiency (GHD): the VISTA Trial
Background: Efficacy of growth hormone replacement therapy is compromised when patients fail to adhere to prescribed daily injections of recombinant human growth hormone (rhGH); noncompliance has been reported in up to 77% of patients with GHD. Somavaratan is a novel rhGH fusion protein with an extended half-life that allows less frequent dosing, compared to daily rhGH. Clinically meaningful improvements in height velocity and insulin-like growth factor (IGF)-I were previously demonstrated with weekly, twice-monthly, and monthly dosing of somavaratan in pre-pubertal children with GHD (VISTA Trial; NCT01718041). (Source: Jo...
Source: Journal of Pediatric Nursing - May 1, 2017 Category: Nursing Authors: Eric Humphriss, F. Naureen Sheikh, Morgan Seaman, David Ng, Kelly Di Trapani, Will Charlton Source Type: research

Oestrogen and progesterone receptors in melanoma and nevi: an immunohistochemical study
ConclusionSince our results represent preliminary findings, conclusions regarding a possible correlation between IVF therapy and melanoma occurrence cannot be ascertained. Larger laboratory studies should be performed to investigate reproductive hormone receptor expression in MM in women following IVF, pregnancy, prolonged contraceptive use, or hormone replacement therapy. (Source: European Journal of Dermatology)
Source: European Journal of Dermatology - May 1, 2017 Category: Dermatology Source Type: research

Abstract PR02: Validation of breast cancer risk prediction model using Nurses Health and Nurse Health II Studies
Background: Adding genetic and other biomarkers to breast cancer risk prediction models could markedly improve model discrimination; however, these expanded models have not been validated in a range of populations. In particular, the calibration of these new models how well the predicted absolute risks match observed risks has not been established. Good calibration is essential to confirm the utility of these risk models in precision prevention and treatment programs.Large cohort studies provide an ideal setting to validate risk models, as they can be used to validate both relative and absolute risks. However, in practice,...
Source: Cancer Epidemiology Biomarkers and Prevention - April 30, 2017 Category: Cancer & Oncology Authors: Gao, C., Choudhury, P. P., Maas, P., Tamimi, R., Eliassen, H., Chatterjee, N., Garcia-Closas, M., Kraft, P. Tags: Improving Cancer Risk Prediction for Prevention and Early Detection: Oral Presentations - Proffered Abstracts Source Type: research

Abstract PR05: Does a comprehensive family history of colorectal cancer improve risk prediction?
Conclusion: Our CRC prediction model that incorporates more comprehensive family history of CRC can provide improved calibration and discrimination of risks compared with the simple FH model, especially in populations with higher underlying risk. The models developed may potentially further improve screening decision making among subgroups with elevated CRC risk.References:1. Freedman AN, Slattery ML, Ballard-Barbash R, et al. Colorectal cancer risk prediction tool for white men and women without known susceptibility . J Clin Oncol 2009;27(5):686-693.2. Antoniou AC, Pharoah PDP, McMullan G, et al. A comprehensive model for...
Source: Cancer Epidemiology Biomarkers and Prevention - April 30, 2017 Category: Cancer & Oncology Authors: Zheng, Y., Hua, X., Win, A. K., Jenkins, M., Macinnis, R., Newcomb, P. Tags: Improving Cancer Risk Prediction for Prevention and Early Detection: Oral Presentations - Proffered Abstracts Source Type: research

Enhanced therapeutic benefit of quercetin-loaded phytosome nanoparticles in ovariectomized rats
Publication date: Available online 29 April 2017 Source:Chemico-Biological Interactions Author(s): Abeer I. Abd El-Fattah, Mohamed M. Fathy, Zeinab Y. Ali, Abd El-Rahman A. El-Garawany, Ehsan K. Mohamed Quercetin, a dietary flavonol phytoestrogen, has many health benefits but it is poorly absorbed when administered orally. To improve its bioavailability, we prepared quercetin-loaded phytosome nanoparticles (QP) using the thin film hydration method. The prepared nano-formulations were characterized using different techniques. Transmission electron microscopy revealed the homogeneously spherical, well and uniformly disperse...
Source: Chemico Biological Interactions - April 29, 2017 Category: Biochemistry Source Type: research

Enhanced therapeutic benefit of quercetin-loaded phytosome nanoparticles in ovariectomized rats.
Abstract Quercetin, a dietary flavonol phytoestrogen, has many health benefits but it is poorly absorbed when administered orally. To improve its bioavailability, we prepared quercetin-loaded phytosome nanoparticles (QP) using the thin film hydration method. The prepared nano-formulations were characterized using different techniques. Transmission electron microscopy revealed the homogeneously spherical, well and uniformly dispersed, nano-sized nature of QP. Dynamic light scattering measurements of QP (70 ± 7.44 nm) also confirmed this. Stability of the formed nanoparticles was established vi...
Source: Chemico-Biological Interactions - April 28, 2017 Category: Molecular Biology Authors: Abd El-Fattah AI, Fathy MM, Ali ZY, El-Garawany AEA, Mohamed EK Tags: Chem Biol Interact Source Type: research

Estradiol-loaded PLGA nanoparticles for improving low bone mineral density of cancellous bone caused by osteoporosis: Application of enhanced charged nanoparticles with iontophoresis
In this study, we have prepared E2-loaded poly(DL-lactide-co-glycolide) (PLGA) nanoparticles for osteoporosis by using a combination of an antisolvent diffusion method with preferential solvation. The average particle diameter of the nanoparticles was 110.0±41.0nm and the surface charge number density was 82 times higher than that of conventional E2-loaded PLGA nanoparticles. Therapeutic evaluation of E2-loaded PLGA nanoparticles was carried out using ovariectomized female rats. Therapeutic efficacy was evaluated to measure bone mineral density of cancellous bone using an X-ray CT system. When the E2-loaded PLGA nan...
Source: Colloids and Surfaces B: Biointerfaces - April 24, 2017 Category: Biochemistry Source Type: research

Effects of hormone replacement therapy on ambulatory blood pressure and vascular responses in normotensive women.
Authors: Paul Manwaring Litsa Morfis Terence Diamond Laurence G Howes Abstract The effects of chronic oestrogen replacement therapy (ERT) (conjugated equine oestrogen 0.625 mg/day) and combined oestrogen and progestogen replacement therapy (HRT) (ERT plus continuous medroxyprogesterone acetate 5 mg/day) on 24-h ambulatory blood pressure recordings, forearm vascular resistance (FVR) and FVR responses to noradrenaline, angiotensin II, acetylcholine and nitroprusside were studied in 17 normotensive postmenopausal women in a 3-month randomized, double-blind, placebo-controlled crossover trial with 1 month of therapy in...
Source: Blood Pressure - April 23, 2017 Category: Hematology Tags: Blood Press Source Type: research

Reproductive endocrinology: Potential new therapy for hot flushes
Nature Reviews Endocrinology 13, 314 (2017). doi:10.1038/nrendo.2017.49 Author: Claire Greenhill Hormone-replacement therapy (HRT) can effectively treat menopausal hot flushes, but is contraindicated in many women. A new study has now demonstrated that a neurokinin 3 receptor (NK3R) antagonist reduces the incidence and severity of hot flushes, and should be safe for use in most women. (Source: Nature Reviews Endocrinology)
Source: Nature Reviews Endocrinology - April 21, 2017 Category: Endocrinology Authors: Claire Greenhill Tags: Research Highlight Source Type: research

Use of Hormone Replacement in Females with Endocrine Disorders
Hormone replacement therapy (HRT) is necessary in adolescents with primary ovarian insufficiency (POI) in order to avoid estrogen deficiency. The goal of this minirewiew is to present the different types of estrogens (17 β-estradiol, estradiol valerate, ethinyl estradiol, and combined equine estrogens) as well as the different types of progestins available. In order to choose among the different types of HRTs, the features of each regimen are being discussed as well as their risks and their respective benefits. The differences between oral combined contraceptive pills and a dissociated regimen containing estrogen and ...
Source: Hormone Research in Paediatrics - April 19, 2017 Category: Endocrinology Source Type: research

An unexpected diagnosis of primary omental endometrial stromal sarcoma in a patient with acute right abdominal pain: A case report and review of literature
Conclusion EESS can occur without endometriosis and HRT may be an aetiological factor. The condition can mimic a chronic or acute abdominal pathology and laparoscopic core biopsy is the best way to achieve a diagnosis and formulate management. (Source: International Journal of Surgery Case Reports)
Source: International Journal of Surgery Case Reports - April 19, 2017 Category: Surgery Source Type: research

Clinical accuracy of preoperative breast MRI for breast cancer
ConclusionsBreast MRI provides greater accuracy for a third of patients undergoing preoperative MGM and U/S. Mammographic calcifications were associated with MRI clinical accuracy for patients with invasive cancer. (Source: Journal of Surgical Oncology)
Source: Journal of Surgical Oncology - April 13, 2017 Category: Cancer & Oncology Authors: Jennifer Tseng, Alexandra Kyrillos, Erik Liederbach, Georgia G. Spear, Jacob Ecanow, Chi ‐Hsiung Wang, Tom Czechura, Olga Kantor, Megan Miller, David J. Winchester, Catherine E. Pesce, Sarah Rabbitt, Katharine Yao Tags: RESEARCH ARTICLE Source Type: research

240 The effect of female hormonal changes on psoriasis
While studies have noted improvement of psoriasis in most women during pregnancy with subsequent postpartum deterioration, there is little data on the impact of other hormonal events. Moreover, there have been changes in hormonally-based therapies in the last 20 years. We surveyed a large number and diversity of women on the effect that hormonal variations (menarche, menses, exposure to hormonal contraception, infertility therapy, pregnancy, menopause, and hormone replacement therapy) have had on their psoriasis. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - April 12, 2017 Category: Dermatology Authors: S. Feldstein, S. Admani, J. Proudfoot, W. Tom Tags: Clinical Research: Epidemiology of Skin Diseases Source Type: research

Menopause and Rheumatic Disease
Menopause occurs naturally in women at about 50 years of age. There is a wealth of data concerning the relationship of menopause to systemic lupus erythematosus, rheumatoid arthritis, and osteoarthritis; there are limited data concerning other rheumatic diseases. Age at menopause may affect the risk and course of rheumatic diseases. Osteoporosis, an integral part of inflammatory rheumatic diseases, is made worse by menopause. Hormone replacement therapy has been studied; its effects vary depending on the disease and even different manifestations within the same disease. Cyclophosphamide can induce early menopause, but ther...
Source: Rheumatic Disease Clinics of North America - April 11, 2017 Category: Rheumatology Authors: Mitali Talsania, Robert Hal Scofield Source Type: research

Common Causes of Postmenopausal Bleeding in Korean Women: 10-Year Outcomes from a Single Medical Center.
Abstract The common causes of postmenopausal bleeding (PMB), according to the data from the western world, are atrophy, hormone replacement therapy (HRT), endometrial cancer, etc. We conducted a retrospective study to assess whether the causes of PMB in Korean postmenopausal women are similar to those already known. This retrospective study used 10-year medical records (March 2005 to December 2014) of 792 PMB women in the Yonsei University Health System. The data were divided into 2 categories by 5-year intervals to compare the differences between the 2 periods. The most common cause of PMB in Korean women was atr...
Source: J Korean Med Sci - April 6, 2017 Category: Journals (General) Authors: Kim MK, Jung YS, Chon SJ, Yun BH, Cho S, Choi YS, Lee BS, Seo SK Tags: J Korean Med Sci Source Type: research

Lost in menopausal transition: the timing of atherosclerosis prevention in women.
Abstract Advanced atherosclerotic changes can often resist even to very aggressive treatment. Although basic mechanisms of its origin and development are known, some important steps in this process are still waiting for more detailed explanation. Therefore, in addition to already proved aggressive lowering of LDL cholesterol, appropriate timing of atherosclerosis treatment is of the essence. Revealing different stages of atherosclerotic process, less or more sensitive to treatment is of primary importance; however, its detection is complicated by several facts including not exactly identifiable periods of quiescen...
Source: Physiological Research - April 5, 2017 Category: Physiology Authors: Piťha J Tags: Physiol Res Source Type: research

Neurokinin 3 receptor antagonism as a novel treatment for menopausal hot flushes: a phase 2, randomised, double-blind, placebo-controlled trial
Publication date: Available online 3 April 2017 Source:The Lancet Author(s): Julia K Prague, Rachel E Roberts, Alexander N Comninos, Sophie Clarke, Channa N Jayasena, Zachary Nash, Chedie Doyle, Deborah A Papadopoulou, Stephen R Bloom, Pharis Mohideen, Nicholas Panay, Myra S Hunter, Johannes D Veldhuis, Lorraine C Webber, Les Huson, Waljit S Dhillo Background Hot flushes affect 70% of menopausal women and often severely impact physical, psychosocial, sexual, and overall wellbeing. Hormone replacement therapy is effective but is not without risk. Neurokinin B signalling is increased in menopausal women, and has been implic...
Source: The Lancet - April 4, 2017 Category: Journals (General) Source Type: research