Log in to search using one of your social media accounts:

 

Assessment of potential risk factors for breast cancer in a population in Southern Brazil
ConclusionThe risk prediction model indicates that the following variables should be assessed in this specific population: age, height, having had previous breast biopsies, number of pregnancies, and use of hormone replacement therapy. These findings may help to better understand the causal model of breast cancer in Southern Brazil. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - January 17, 2018 Category: Cancer & Oncology Source Type: research

Hormone replacement therapy may prevent depression in menopause
A study of 172 women suggests that HRT treatment is more effective than a placebo at preventing symptoms of depression from emerging during early menopause (Source: New Scientist - Health)
Source: New Scientist - Health - January 10, 2018 Category: Consumer Health News Source Type: research

Association of 100% fruit juice consumption and 3-year weight change among postmenopausal women in the in the Women's Health Initiative
In conclusion, an increase in 100% fruit juice consumption was associated with a small amount of long-term weight gain in postmenopausal women. (Source: Preventive Medicine)
Source: Preventive Medicine - January 10, 2018 Category: International Medicine & Public Health Source Type: research

Progesterone Receptor (PGR) Gene Variants Associated with Breast Cancer and Associated Features: a Case-Control Study.
Abstract Insofar as altered estrogen receptor-progesterone receptor (PR) expression contribute to breast cancer pathogenesis, previous studies examined the association of genetic variation in PR gene (PGR) with breast cancer, but with mixed outcome. We evaluated the association between PGR variants, and breast cancer and associated features. A retrospective case-control study involving 183 female breast cancer patients, and 222 control women. PGR genotyping was done by real-time PCR. Minor allele frequencies of rs1042838, rs590688, and rs10895068 PGR gene polymorphisms were significantly higher in breast cancer pa...
Source: Pathology Oncology Research - January 4, 2018 Category: Pathology Authors: Ghali RM, Al-Mutawa MA, Ebrahim BH, Jrah HH, Zaied S, Bhiri H, Hmila F, Mahjoub T, Almawi WY Tags: Pathol Oncol Res Source Type: research

Systemic review of hormone replacement therapy in the infertile man
Conclusions Exogenous testosterone inhibits spermatogenesis. Hypogonadal men wanting to preserve their fertility and at the same time benefiting from TRT effects can be prescribed selective oestrogen receptor modulators or testosterone plus low-dose human chorionic gonadotrophin (hCG). Patients treated for infertility with hypogonadotrophic hypogonadism can be prescribed hCG alone at first followed by or in combination from the start with follicle-stimulating hormone preparations. (Source: Arab Journal of Urology)
Source: Arab Journal of Urology - December 31, 2017 Category: Urology & Nephrology Source Type: research

Update on the effect of exogenous hormone use on glioma risk in women: a meta-analysis of case-control and cohort studies
AbstractVarious studies have confirmed the important roles of endogenous hormones in the development of gliomas, while the roles of exogenous hormones remain controversial. Based on case-control studies and cohort studies, a meta-analysis was exerted to explore the effect of two exogenous hormones use (HRT: hormone replacement therapy; OC: oral contraceptives) on glioma risk. 16 eligible studies, including 11 case-control studies and 5 cohort studies, containing 8055027 women, were included in our study. All included studies have reported the relative risks (RRs) or odds ratios (ORs), and 95% confidence intervals (CIs). We...
Source: Journal of Neuro-Oncology - December 26, 2017 Category: Cancer & Oncology Source Type: research

Systematic evaluation on the clinical efficacy of acupoint stimulation therapy for treatment of premature ovarian insufficiency on the basis of network Meta-analysis
Conclusion On the basis of current evidences, acupoint stimulation therapy has a better clinical efficacy and safety for treatment of POI when compared with HRT. The acupoint stimulation therapies ranking the top 3 have more significant curative effects, but the long-term efficacy and the effect on the ovarian function still need to be further explored. In addition, the conclusion of this study still needs to be verified through a large number of RCTs with reasonable designs and appropriate methods. (Source: World Journal of Acupuncture Moxibustion)
Source: World Journal of Acupuncture Moxibustion - December 24, 2017 Category: Complementary Medicine Source Type: research

Use of hormone replacement therapy improves the prognosis in patients with colorectal cancer: A population ‐based study in Sweden
This article is protected by copyright. All rights reserved. (Source: International Journal of Cancer)
Source: International Journal of Cancer - December 22, 2017 Category: Cancer & Oncology Authors: Jianguang Ji, Jan Sundquist, Kristina Sundquist Tags: Research Article Source Type: research

Progesterone concentrations and dosage with frozen embryo transfers – What's best?
BackgroundThere is a lack of consensus on the optimal dose and form of progesterone supplementation during frozen‐thawed embryo transfer with hormone replacement therapy. AimsWe aim to identify the serum progesterone concentration on day 16 most likely to result in positive pregnancy outcomes. Materials and methodsWe undertook a retrospective study of 4582 women who underwent frozen embryo transfer with hormone replacement therapy, or natural frozen embryo transfer, over 14 years at a multi‐site private in vitro fertilisation clinic. Embryos were 3–5 days of age at time of transfer. We extracted data on...
Source: The Australian and New Zealand Journal of Obstetrics and Gynaecology - December 22, 2017 Category: OBGYN Authors: Surabhi Kumble Basnayake, Michelle Volovsky, Luk Rombauts, Tiki Osianlis, Beverley Vollenhoven, Martin Healey Tags: Original Article Source Type: research

Impact of microbiota on the use and effects of isoflavones in the relief of climacteric symptoms in menopausal women – A review
Publication date: February 2018 Source:Journal of Functional Foods, Volume 41 Author(s): Naice E.S. Monteiro, Lívia D. Queirós, Danielle B. Lopes, Adriana O. Pedro, Gabriela A. Macedo Menopause is a natural event that occurs in women around the age of 50 years, causing irregularities in the menstrual cycle until its complete end, due to the hormonal deficit, especially estrogen, that causes several unpleasant urogenital and vasomotor symptoms. Hormone replacement therapy has many benefits, but should be prescribed with caution in women with a history of stroke, thromboembolic events, certain types of cance...
Source: Journal of Functional Foods - December 22, 2017 Category: Nutrition Source Type: research

Hormone therapy and patient satisfaction with treatment, in a large cohort of diverse disorders of sex development
ConclusionsMore than 50% in the total cohort had hormone replacement. Although adherence was generally good, this study shows that hormone replacement therapy may be improved. This may be achieved by better individualization of the treatment and by providing specific information to patients regarding both long‐term and short‐term hormonal effects and side effects. (Source: Clinical Endocrinology)
Source: Clinical Endocrinology - December 17, 2017 Category: Endocrinology Authors: Anna Nordenstr öm, Robert Röhle, Ute Thyen, Claire Bouvattier, Jolanta Slowikowska‐Hilczer, Nicole Reisch, Hedi Claahsen van der Grinten, Aude Brac de la Perriere, Peggy T. Cohen‐Kettenis, Birgit Köhler, Tags: ORIGINAL ARTICLE Source Type: research

Fall Risk Factors in Mid-Age Women: The Australian Longitudinal Study on Women ’s Health
Conclusions Identified fall risk factors varied over time, highlighting that falling involves a complex interplay of risk factors in mid-age women. (Source: American Journal of Preventive Medicine)
Source: American Journal of Preventive Medicine - December 15, 2017 Category: International Medicine & Public Health Source Type: research

Economy class syndrome: what is it and who are the individuals at risk?
Abstract The term 'economy class syndrome' refers to the occurrence of thrombotic events during long-haul flights that mainly occur in passengers in the economy class of the aircraft. This syndrome results from several factors related to the aircraft cabin (immobilization, hypobaric hypoxia and low humidity) and the passenger (body mass index, thrombophilia, oral contraceptives or hormone replacement therapy, cancer), acting together to predispose to excessive blood coagulation, which can result in venous thromboembolism. Several risk factors, both genetic and acquired, are associated with venous thromboembolism. The most ...
Source: Revista Brasileira de Hematologia e Hemoterapia - December 12, 2017 Category: Hematology Source Type: research

Recurrent thromboembolism after splenectomy in a patient with complex hemoglobin disease: a case report
Abstract The term 'economy class syndrome' refers to the occurrence of thrombotic events during long-haul flights that mainly occur in passengers in the economy class of the aircraft. This syndrome results from several factors related to the aircraft cabin (immobilization, hypobaric hypoxia and low humidity) and the passenger (body mass index, thrombophilia, oral contraceptives or hormone replacement therapy, cancer), acting together to predispose to excessive blood coagulation, which can result in venous thromboembolism. Several risk factors, both genetic and acquired, are associated with venous thromboembolism. The most ...
Source: Revista Brasileira de Hematologia e Hemoterapia - December 12, 2017 Category: Hematology Source Type: research

Autoimmune hemolytic anemia and hyperglobulinemia leading to the diagnosis of multiple myeloma
Abstract The term 'economy class syndrome' refers to the occurrence of thrombotic events during long-haul flights that mainly occur in passengers in the economy class of the aircraft. This syndrome results from several factors related to the aircraft cabin (immobilization, hypobaric hypoxia and low humidity) and the passenger (body mass index, thrombophilia, oral contraceptives or hormone replacement therapy, cancer), acting together to predispose to excessive blood coagulation, which can result in venous thromboembolism. Several risk factors, both genetic and acquired, are associated with venous thromboembolism. The most ...
Source: Revista Brasileira de Hematologia e Hemoterapia - December 12, 2017 Category: Hematology Source Type: research

Primary imatinib failure rescued by dasatinib and maintained by reintroduction of imatinib
Abstract The term 'economy class syndrome' refers to the occurrence of thrombotic events during long-haul flights that mainly occur in passengers in the economy class of the aircraft. This syndrome results from several factors related to the aircraft cabin (immobilization, hypobaric hypoxia and low humidity) and the passenger (body mass index, thrombophilia, oral contraceptives or hormone replacement therapy, cancer), acting together to predispose to excessive blood coagulation, which can result in venous thromboembolism. Several risk factors, both genetic and acquired, are associated with venous thromboembolism. The most ...
Source: Revista Brasileira de Hematologia e Hemoterapia - December 12, 2017 Category: Hematology Source Type: research

Passenger lymphocyte syndrome in liver transplantation
Abstract The term 'economy class syndrome' refers to the occurrence of thrombotic events during long-haul flights that mainly occur in passengers in the economy class of the aircraft. This syndrome results from several factors related to the aircraft cabin (immobilization, hypobaric hypoxia and low humidity) and the passenger (body mass index, thrombophilia, oral contraceptives or hormone replacement therapy, cancer), acting together to predispose to excessive blood coagulation, which can result in venous thromboembolism. Several risk factors, both genetic and acquired, are associated with venous thromboembolism. The most ...
Source: Revista Brasileira de Hematologia e Hemoterapia - December 12, 2017 Category: Hematology Source Type: research

DNA microarray expression profiling of a new t(8;13) AML case allows identification of possible leukemogenic transformation markers
Abstract The term 'economy class syndrome' refers to the occurrence of thrombotic events during long-haul flights that mainly occur in passengers in the economy class of the aircraft. This syndrome results from several factors related to the aircraft cabin (immobilization, hypobaric hypoxia and low humidity) and the passenger (body mass index, thrombophilia, oral contraceptives or hormone replacement therapy, cancer), acting together to predispose to excessive blood coagulation, which can result in venous thromboembolism. Several risk factors, both genetic and acquired, are associated with venous thromboembolism. The most ...
Source: Revista Brasileira de Hematologia e Hemoterapia - December 12, 2017 Category: Hematology Source Type: research

Osteopetrosis in twin infants mimicking leukemia
Abstract The term 'economy class syndrome' refers to the occurrence of thrombotic events during long-haul flights that mainly occur in passengers in the economy class of the aircraft. This syndrome results from several factors related to the aircraft cabin (immobilization, hypobaric hypoxia and low humidity) and the passenger (body mass index, thrombophilia, oral contraceptives or hormone replacement therapy, cancer), acting together to predispose to excessive blood coagulation, which can result in venous thromboembolism. Several risk factors, both genetic and acquired, are associated with venous thromboembolism. The most ...
Source: Revista Brasileira de Hematologia e Hemoterapia - December 12, 2017 Category: Hematology Source Type: research

Role of daratumumab in transfusion medicine: a must know entity
Abstract The term 'economy class syndrome' refers to the occurrence of thrombotic events during long-haul flights that mainly occur in passengers in the economy class of the aircraft. This syndrome results from several factors related to the aircraft cabin (immobilization, hypobaric hypoxia and low humidity) and the passenger (body mass index, thrombophilia, oral contraceptives or hormone replacement therapy, cancer), acting together to predispose to excessive blood coagulation, which can result in venous thromboembolism. Several risk factors, both genetic and acquired, are associated with venous thromboembolism. The most ...
Source: Revista Brasileira de Hematologia e Hemoterapia - December 12, 2017 Category: Hematology Source Type: research

Acute myeloid leukemia with e1a2 BCR-ABL1 fusion gene: two cases with peculiar molecular and clinical presentations
Abstract The term 'economy class syndrome' refers to the occurrence of thrombotic events during long-haul flights that mainly occur in passengers in the economy class of the aircraft. This syndrome results from several factors related to the aircraft cabin (immobilization, hypobaric hypoxia and low humidity) and the passenger (body mass index, thrombophilia, oral contraceptives or hormone replacement therapy, cancer), acting together to predispose to excessive blood coagulation, which can result in venous thromboembolism. Several risk factors, both genetic and acquired, are associated with venous thromboembolism. The most ...
Source: Revista Brasileira de Hematologia e Hemoterapia - December 12, 2017 Category: Hematology Source Type: research

Molecular genetic techniques for gains and losses of genomic material in a case of acute myeloid leukemia
Abstract The term 'economy class syndrome' refers to the occurrence of thrombotic events during long-haul flights that mainly occur in passengers in the economy class of the aircraft. This syndrome results from several factors related to the aircraft cabin (immobilization, hypobaric hypoxia and low humidity) and the passenger (body mass index, thrombophilia, oral contraceptives or hormone replacement therapy, cancer), acting together to predispose to excessive blood coagulation, which can result in venous thromboembolism. Several risk factors, both genetic and acquired, are associated with venous thromboembolism. The most ...
Source: Revista Brasileira de Hematologia e Hemoterapia - December 12, 2017 Category: Hematology Source Type: research

Chromosomal aberrations detected by Fluorescence in situ hybridization in 344 Brazilian chronic lymphocytic leukemia patients
Abstract The term 'economy class syndrome' refers to the occurrence of thrombotic events during long-haul flights that mainly occur in passengers in the economy class of the aircraft. This syndrome results from several factors related to the aircraft cabin (immobilization, hypobaric hypoxia and low humidity) and the passenger (body mass index, thrombophilia, oral contraceptives or hormone replacement therapy, cancer), acting together to predispose to excessive blood coagulation, which can result in venous thromboembolism. Several risk factors, both genetic and acquired, are associated with venous thromboembolism. The most ...
Source: Revista Brasileira de Hematologia e Hemoterapia - December 12, 2017 Category: Hematology Source Type: research

Transgender venous thrombosis
A 53-year-old male-to-female transgender patient on cross-sex hormone replacement therapy (CSHT), estradiol 8 mg daily, presented to the emergency department (ED) with acute-onset headache and left visual field disturbances after a recent mechanical fall with head trauma. The medical history was notable for hyperlipidemia. There was no personal or family history of clotting disorders and no history of tobacco use. (Source: Neurology Clinical Practice)
Source: Neurology Clinical Practice - December 11, 2017 Category: Neurology Authors: Opaskar, A., Scharf, E. L., Chilungu, M. W., Kelly, A. G. Tags: All Cerebrovascular disease/Stroke, Cerebral venous thrombosis Case Source Type: research

Evaluation of thyroid function in pulmonary arterial hypertension
Conclusions: Prevalence of TP in our patients is similar to that described in the literature 100% of patients correspond to hypothyroidism. Patients with PAHwTP have better FC, greater distance walked and pulmonary hemodynamics (Source: European Respiratory Journal)
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Cueto Robledo, G., Gomez Lucas, S. A., Barragan Pola, G. Tags: Pulmonary Circulation and Pulmonary Vascular Disease Source Type: research

Hormone replacement therapy may preserve lung function during reproductive aging
Conclusions: Female sex hormones are important for the preservation of lung function in middle aged women. The accelerated lung function decline with menopause is likely caused by decreasing estrogen levels. (Source: European Respiratory Journal)
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Triebner, K., Accordini, S., Calciano, L., Johannessen, A., Benediktsdottir, B., Bifulco, E., Demoly, P., Dharmage, S., Franklin, K., Garcia-Aymerich, J., Gullon Blanco, J. A., Heinrich, J., Holm, M., Jarvis, D., Jogi, R., Lindberg, E., Moratalla Rovira, Tags: Epidemiology Source Type: research

Artificial ovary may fine-tune treatment for menopause symptoms
Many women experiencing menopause have mood swings, forgetfulness and weight gain. Could an implant be a safer alternative to hormone replacement therapy? (Source: New Scientist - Health)
Source: New Scientist - Health - December 5, 2017 Category: Consumer Health News Source Type: research

Understanding the role of environmental factors in the development of systemic lupus erythematosus
Publication date: Available online 21 October 2017 Source:Best Practice & Research Clinical Rheumatology Author(s): Christine G. Parks, Aline de Souza Espindola Santos, Medha Barbhaiya, Karen H. Costenbader Systemic lupus erythematosus (SLE) is a multisystem disease with a complex etiology. Its risk is higher among women, racial and ethnic minorities, and individuals with a family history of SLE or related autoimmune diseases. It is believed that genetic factors interact with environmental exposures throughout the lifespan to influence susceptibility to developing SLE. The strongest epidemiologic evidence exists f...
Source: Best Practice and Research Clinical Rheumatology - December 5, 2017 Category: Rheumatology Source Type: research

Rapid non ‐genomic modulation by neurosteroids of dendritic spines in the hippocampus: androgen, estrogen and corticosteroid
This article is protected by copyright. All rights reserved. (Source: Journal of Neuroendocrinology)
Source: Journal of Neuroendocrinology - December 1, 2017 Category: Endocrinology Authors: Gen Murakami, Yasushi Hojo, Asami Kato, Yoshimasa Komatsuzaki, Shigeo Horie, Mika Soma, Jonghyuk Kim, Suguru Kawato Tags: Review Article Source Type: research

Which drugs are risk factors for the development of gastroesophageal reflux disease?
Abstract Gastroesophageal reflux disease (GERD), which is common in many communities, is associated with structural factors, eating habits, and the use of certain drugs. The use of such drugs can lead to the emergence of GERD and can also exacerbate existing reflux symptoms. These drugs can contribute to GERD by directly causing mucosal damage, by reducing lower esophageal sphincter pressure (LESP), or by affecting esophagogastric motility. In this article, we report our investigation of the relationships between GERD and medications within the scope of the "Turkish GERD Consensus Group." For the medicat...
Source: The Turkish Journal of Gastroenterology - December 1, 2017 Category: Gastroenterology Authors: Mungan Z, Pınarbaşı Şimşek B Tags: Turk J Gastroenterol Source Type: research

Does hormone replacement therapy promote better quality of sleep in women? Results from a large cross-sectional norwegian study (Hunt 3)
Introduction: Hormone replacement therapy (HRT) is commonly prescribed to alleviate some of the symptoms of the menopause, which often are associated with higher frequency of sleep problems (Ameratunga, Goldin,& Hickey, 2012). The effect of use of HRT on sleep quality is, however, controversial. Therefore, the aim of this study was to investigate possible associations between HRT and good quality sleep in Norwegian women. Other factors, as satisfaction with life, neuroticism, frequency of night sweats and selected life style factors as smoking, frequency of exercise, and marital status (co-habiting or not) were also in...
Source: Sleep Medicine - December 1, 2017 Category: Sleep Medicine Authors: M. Cvancarova Sm åstuen, L. Ribu, S. Helseth, N. Misvær, R. Andenæs Tags: Pharmacology Source Type: research

Awareness of hormone replacement therapy in medical care personnel in Jiaxing, China: a questionnaire survey
. (Source: Gynecological Endocrinology)
Source: Gynecological Endocrinology - November 23, 2017 Category: Endocrinology Authors: Lihong Gao Xiaojie Wu Xia Liu Qinglan Pu Meiguang Zhang Yingru Cai Lizhong Wang Wei Zhao Jiming Chen Source Type: research

Effect of Thyroid Hormone Replacement Therapy on Ovarian Volume and Androgen Hormones in Patients with Untreated Primary Hypothyroidism
CONCLUSION: Severe longstanding hypothyroidism leads to increased ovarian volume and/or cyst formation. A decrease in ovarian volume, resolution of ovarian cysts and reversal of the polycystic ovary syndrome-like appearance, together with improvement in serum hormone levels, occurred after euthyroidism was achieved. Ann Saudi Med 2011; 31(2): 145-151PMID: 21403408 DOI: 10.4103/0256-4947.77500 (Source: Annals of Saudi Medicine)
Source: Annals of Saudi Medicine - November 21, 2017 Category: General Medicine Tags: ISSUE 2 Source Type: research

The effects of progesterones on blood lipids in hormone replacement therapy
The safety of progestogens as a class has drawn much attention after the publication of data from the Women ’s Health Initiative (WHI) trial, particularly with respect to cardiovascular disease. Depending on th... (Source: Lipids in Health and Disease)
Source: Lipids in Health and Disease - November 21, 2017 Category: Lipidology Authors: Yifan Jiang and Weijie Tian Tags: Review Source Type: research

The relationship between the hormone levels before transplantation and outcomes of hormone replacement therapy-frozen embryo transfer.
Authors: Liu YF, Wang F, Huang GY, Mao XG Abstract OBJECTIVE: To analyze the relationship between outcomes of hormone replacement therapy-frozen embryo transfer (HRT-FET) and serum estradiol and progesterone levels on the day of endometrial transformation and before transplantation. METHODS: Clinical datas of patients who underwent 426 cycles of FET were retrospectively analyzed and were divided into groups according to estradiol and progesterone levels. Differences in embryo implantation rate and clinical pregnancy rate were compared, and relationship between estradiol levels and outcome of transplantation was...
Source: Minerva Endocrinologica - November 11, 2017 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Novel effects of phytoestrogenic soy isoflavones on serum calcium and chloride in premenopausal women: a 2-year double-blind, randomized, placebo-controlled study
Soy phytoestrogens are potential alternatives to postmenopausal hormone replacement therapy (HRT). Adverse effects of HRT such as myocardial infarction, stroke, and pulmonary embolism are mediated by calcium-induced signaling (Source: Clinical Nutrition)
Source: Clinical Nutrition - November 11, 2017 Category: Nutrition Authors: Lee-Jane W. Lu, Nai-Wei Chen, Fatima Nayeem, Yong-Fang Kuo, V-M. Sadagopa Ramanujam, Donald G. Brunder, Manubai Nagamani, Karl E. Anderson Source Type: research

Proteomics in plasma of ovariectomized rats and those exposed to estradiol valerate
Publication date: Available online 18 October 2017 Source:The Journal of Steroid Biochemistry and Molecular Biology Author(s): Hai Jiang, Wenpei Bai, Wenjuan Wang, Ke Wang, Jing Jia, Jing Zhang, He Diao, Lihua Qin The menopausal period, an inevitable physiological process for women, is frequently associated with physiological and psychological dysfunction attributable to substantial fluctuation and gradual decrease in female hormones induced by ovarian failure, leading to corresponding symptoms and diseases that impact multiple systems in the body to varying degrees. As prior studies have focused primarily on menopausal s...
Source: The Journal of Steroid Biochemistry and Molecular Biology - November 6, 2017 Category: Biochemistry Source Type: research

Surgical and pharmacological reassignment: influence on transsexual cardiovascular risk profile
Abstract Background/AimTo evaluate and stratify early cardiovascular risk of transsexuals who underwent pharmacological and/or surgical gender reassignment. MethodsFifty‐six transsexuals were divided into two groups: group 1 – underwent gonadectomy (orchiectomy for transwomen and hystero‐annessiectomy for transmen); group 2 – hormone replacement therapy alone. All participants underwent carotid artery intima‐media thickness (C‐IMT) and flow‐mediated vasodilation (FMD) of brachial artery evaluations. ResultsFMD was lower in patients who had undergone gonadectomy compared with non‐surgically treated p...
Source: Internal Medicine Journal - November 5, 2017 Category: Internal Medicine Authors: Marco M. Ciccone, Giuseppe Loverro, Pietro Scicchitano, Matteo Loverro, Gabriella Ricci, Francesca Scaramuzzi, Michele Gesualdo, Annapaola Zito, Marcello Campagna, Michele Moncelli, Vittorio Nicolardi, Fabio Manca, Barbara Boninfante, Santa Carbonara, Fra Tags: Original Article Source Type: research

Characteristics of patients and patterns of chronic venous disease of the lower limbs in a referral hospital in Cameroon
Conclusions Patients have many risk factors and are young with a male predominance. Most patients are symptomatic with advanced disease. The etiology is primary in most patients, and reflux is more common. (Source: Journal of Vascular Surgery: Venous and Lymphatic Disorders)
Source: Journal of Vascular Surgery: Venous and Lymphatic Disorders - November 1, 2017 Category: Surgery Source Type: research

Hormone therapy and patients satisfaction with treatment, in a large cohort of diverse disorders of sex development (DSD)
ConclusionsMore than 50% in the total cohort had hormone replacement. Although adherence was generally good, this study shows that hormone replacement therapy may be improved. This may be achieved by better individualization of the treatment and by providing specific information to patients regarding both long term and short‐term hormonal effects and side effects.This article is protected by copyright. All rights reserved. (Source: Clinical Endocrinology)
Source: Clinical Endocrinology - November 1, 2017 Category: Endocrinology Authors: Anna Nordenstr öm, Robert Röhle, Ute Thyen, Claire Bouvattier, Jolanta Slowikowska‐Hilczer, Nicole Reisch, Hedi Claahsen van der Grinten, Aude Brac de la Perriere, Peggy T. Cohen‐Kettenis, Birgit Köhler, Tags: Original Article Source Type: research

Safety of vaginal oestrogen in hormone replacement therapy
Vaginal oestrogen not linked to invasive breast cancer or pulmonary embolism risk. (Source: Clinical Pharmacist)
Source: Clinical Pharmacist - October 31, 2017 Category: Drugs & Pharmacology Source Type: research

Effect of growth hormone replacement therapy on plasma diacron-reactive oxygen metabolites and endothelial function in Japanese patients: The GREAT clinical study.
This study examined the effect of growth hormone (GH) replacement therapy on diacron-reactive oxygen metabolites (d-ROMs) and endothelial function in Japanese patients with GHD, using peripheral arterial tonometry. This was an open-label, prospective, case-control study. Nine patients with GHD who had not previously received any GH replacement therapy were enrolled. The following parameters were evaluated at baseline (before treatment), and after 24 weeks of GH replacement therapy: endothelial function using the reactive hyperemia index (RHI; EndoPAT(®) system), d-ROMs, blood pressure, and fasting lipid levels. Plasma ...
Source: Endocrine Journal - October 27, 2017 Category: Endocrinology Tags: Endocr J Source Type: research

Masculine Voices Predict Well-Being in Female-to-Male Transgender Individuals.
Abstract Voices convey important social information about an individual's identity, including gender. This is especially relevant to transgender individuals, who cite voice alteration as a primary goal of the gender alignment process. Although the voice is a primary target of testosterone therapy among female-to-male (FTM) trans people, little research has explored the effects of such changes on their psychological well-being. Here, we investigated how FTMs' vocal gender related to their well-being. A total of 77 FTMs (M age = 25.45 years, SD = 6.77) provided voice samples and completed me...
Source: Archives of Sexual Behavior - October 25, 2017 Category: Psychiatry & Psychology Authors: Watt SO, Tskhay KO, Rule NO Tags: Arch Sex Behav Source Type: research

Environmental noise and breast cancer risk?
Breast cancer is the most frequent cancer among women especially in the Western world where, despite improved survival, it is one of the leading causes of death (1). Furthermore, for several decades there has been an increase in incidence, though recently there seems to be a stabilization in risk or even a small decline in typical high-risk areas such as Europe and the USA but at the same time a steep increase in typical low-risk societies such as Japan (2). Breast cancer is often regarded as a singular disease, but recent discoveries are pointing to a variety of types of potentially different etiology. Thus, the female...
Source: Scandinavian Journal of Work, Environment and Health - October 18, 2017 Category: Occupational Health Tags: Editorial Source Type: research

Effects of 1-year growth hormone replacement therapy on thyroid volume and function of the children and adolescents with idiopathic growth hormone deficiency
Journal Name: Journal of Pediatric Endocrinology and Metabolism Issue: Ahead of print (Source: Journal of Pediatric Endocrinology and Metabolism)
Source: Journal of Pediatric Endocrinology and Metabolism - October 17, 2017 Category: Endocrinology Source Type: research

Neurokinin 3 receptor antagonism - the magic bullet for hot flushes?
Abstract Hot flushes affect 70% of menopausal women and are reported as being the most bothersome symptom by the majority. Hormone replacement therapy and other currently available alternative therapies are not without side-effects and/or have variable efficacy, and so an effective novel therapy could be practice-changing. Over the last 20 years, numerous studies in animal and human models have implicated neurokinin B, a hypothalamic neuropeptide, together with its receptor (NK3R) in the etiology of menopausal hot flushes. Most recently, a randomized, placebo-controlled trial of an NK3R antagonist in symptomatic m...
Source: Climacteric - October 17, 2017 Category: Geriatrics Authors: Prague JK, Dhillo WS Tags: Climacteric Source Type: research

Graves ’ disease thyrotoxicosis and propylthiouracil related agranulocytosis successfully treated with therapeutic plasma exchange and g-csf followed by total thyroidectomy.
We report the case of a 27-year-old woman who is 3 months post-partum, breastfeeding, and suffering from Graves ’ disease hyperthyroidism treated first with methimazole and then with propylthiouracil due to a methimazole allergy. She was admitted for urosepsis and agranulocytosis. The patient was diagnosed with propylthiouracil related agranulocytosis, diffuse toxic goiter, and thyro-gastric syndrome. Antit hyroid drug therapy was stopped resulting in a worsening of thyrotoxicosis. Agranulocytosis was treated with 8 doses of G-CSF with full recovery. To rapidly restore euthyroidism and to perform a thyroidectomy, the...
Source: Mediterranean Journal of Hematology and Infectious Diseases - October 15, 2017 Category: Hematology Source Type: research

Hypopituitarism presenting as congestive heart failure
We present an unusual case of SS in a young lady who continued to have normal menstruation after the index event, had two spontaneous pregnancies, and was diagnosed only 11 years later when she presented to us with acute heart failure. (Source: Journal of Postgraduate Medicine)
Source: Journal of Postgraduate Medicine - October 11, 2017 Category: Internal Medicine Authors: S Giri P Bansal S Malik R Bansal Source Type: research