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The relationship between the hormone levels before transplantation and outcomes of hormone replacement therapy-frozen embryo transfer.
Authors: Liu YF, Wang F, Huang GY, Mao XG Abstract OBJECTIVE: To analyze the relationship between outcomes of hormone replacement therapy-frozen embryo transfer (HRT-FET) and serum estradiol and progesterone levels on the day of endometrial transformation and before transplantation. METHODS: Clinical datas of patients who underwent 426 cycles of FET were retrospectively analyzed and were divided into groups according to estradiol and progesterone levels. Differences in embryo implantation rate and clinical pregnancy rate were compared, and relationship between estradiol levels and outcome of transplantation was...
Source: Minerva Endocrinologica - November 11, 2017 Category: Endocrinology Tags: Minerva Endocrinol Source Type: research

Novel effects of phytoestrogenic soy isoflavones on serum calcium and chloride in premenopausal women: a 2-year double-blind, randomized, placebo-controlled study
Soy phytoestrogens are potential alternatives to postmenopausal hormone replacement therapy (HRT). Adverse effects of HRT such as myocardial infarction, stroke, and pulmonary embolism are mediated by calcium-induced signaling (Source: Clinical Nutrition)
Source: Clinical Nutrition - November 11, 2017 Category: Nutrition Authors: Lee-Jane W. Lu, Nai-Wei Chen, Fatima Nayeem, Yong-Fang Kuo, V-M. Sadagopa Ramanujam, Donald G. Brunder, Manubai Nagamani, Karl E. Anderson Source Type: research

Proteomics in plasma of ovariectomized rats and those exposed to estradiol valerate
Publication date: Available online 18 October 2017 Source:The Journal of Steroid Biochemistry and Molecular Biology Author(s): Hai Jiang, Wenpei Bai, Wenjuan Wang, Ke Wang, Jing Jia, Jing Zhang, He Diao, Lihua Qin The menopausal period, an inevitable physiological process for women, is frequently associated with physiological and psychological dysfunction attributable to substantial fluctuation and gradual decrease in female hormones induced by ovarian failure, leading to corresponding symptoms and diseases that impact multiple systems in the body to varying degrees. As prior studies have focused primarily on menopausal s...
Source: The Journal of Steroid Biochemistry and Molecular Biology - November 6, 2017 Category: Biochemistry Source Type: research

Surgical and pharmacological reassignment: influence on transsexual cardiovascular risk profile
Abstract Background/AimTo evaluate and stratify early cardiovascular risk of transsexuals who underwent pharmacological and/or surgical gender reassignment. MethodsFifty‐six transsexuals were divided into two groups: group 1 – underwent gonadectomy (orchiectomy for transwomen and hystero‐annessiectomy for transmen); group 2 – hormone replacement therapy alone. All participants underwent carotid artery intima‐media thickness (C‐IMT) and flow‐mediated vasodilation (FMD) of brachial artery evaluations. ResultsFMD was lower in patients who had undergone gonadectomy compared with non‐surgically treated p...
Source: Internal Medicine Journal - November 5, 2017 Category: Internal Medicine Authors: Marco M. Ciccone, Giuseppe Loverro, Pietro Scicchitano, Matteo Loverro, Gabriella Ricci, Francesca Scaramuzzi, Michele Gesualdo, Annapaola Zito, Marcello Campagna, Michele Moncelli, Vittorio Nicolardi, Fabio Manca, Barbara Boninfante, Santa Carbonara, Fra Tags: Original Article Source Type: research

Characteristics of patients and patterns of chronic venous disease of the lower limbs in a referral hospital in Cameroon
Conclusions Patients have many risk factors and are young with a male predominance. Most patients are symptomatic with advanced disease. The etiology is primary in most patients, and reflux is more common. (Source: Journal of Vascular Surgery: Venous and Lymphatic Disorders)
Source: Journal of Vascular Surgery: Venous and Lymphatic Disorders - November 1, 2017 Category: Surgery Source Type: research

Hormone therapy and patients satisfaction with treatment, in a large cohort of diverse disorders of sex development (DSD)
ConclusionsMore than 50% in the total cohort had hormone replacement. Although adherence was generally good, this study shows that hormone replacement therapy may be improved. This may be achieved by better individualization of the treatment and by providing specific information to patients regarding both long term and short‐term hormonal effects and side effects.This article is protected by copyright. All rights reserved. (Source: Clinical Endocrinology)
Source: Clinical Endocrinology - November 1, 2017 Category: Endocrinology Authors: Anna Nordenstr öm, Robert Röhle, Ute Thyen, Claire Bouvattier, Jolanta Slowikowska‐Hilczer, Nicole Reisch, Hedi Claahsen van der Grinten, Aude Brac de la Perriere, Peggy T. Cohen‐Kettenis, Birgit Köhler, Tags: Original Article Source Type: research

Safety of vaginal oestrogen in hormone replacement therapy
Vaginal oestrogen not linked to invasive breast cancer or pulmonary embolism risk. (Source: Clinical Pharmacist)
Source: Clinical Pharmacist - October 31, 2017 Category: Drugs & Pharmacology Source Type: research

Effect of growth hormone replacement therapy on plasma diacron-reactive oxygen metabolites and endothelial function in Japanese patients: The GREAT clinical study.
This study examined the effect of growth hormone (GH) replacement therapy on diacron-reactive oxygen metabolites (d-ROMs) and endothelial function in Japanese patients with GHD, using peripheral arterial tonometry. This was an open-label, prospective, case-control study. Nine patients with GHD who had not previously received any GH replacement therapy were enrolled. The following parameters were evaluated at baseline (before treatment), and after 24 weeks of GH replacement therapy: endothelial function using the reactive hyperemia index (RHI; EndoPAT(®) system), d-ROMs, blood pressure, and fasting lipid levels. Plasma ...
Source: Endocrine Journal - October 27, 2017 Category: Endocrinology Tags: Endocr J Source Type: research

Masculine Voices Predict Well-Being in Female-to-Male Transgender Individuals.
Abstract Voices convey important social information about an individual's identity, including gender. This is especially relevant to transgender individuals, who cite voice alteration as a primary goal of the gender alignment process. Although the voice is a primary target of testosterone therapy among female-to-male (FTM) trans people, little research has explored the effects of such changes on their psychological well-being. Here, we investigated how FTMs' vocal gender related to their well-being. A total of 77 FTMs (M age = 25.45 years, SD = 6.77) provided voice samples and completed me...
Source: Archives of Sexual Behavior - October 25, 2017 Category: Psychiatry & Psychology Authors: Watt SO, Tskhay KO, Rule NO Tags: Arch Sex Behav Source Type: research

Environmental noise and breast cancer risk?
Breast cancer is the most frequent cancer among women especially in the Western world where, despite improved survival, it is one of the leading causes of death (1). Furthermore, for several decades there has been an increase in incidence, though recently there seems to be a stabilization in risk or even a small decline in typical high-risk areas such as Europe and the USA but at the same time a steep increase in typical low-risk societies such as Japan (2). Breast cancer is often regarded as a singular disease, but recent discoveries are pointing to a variety of types of potentially different etiology. Thus, the female...
Source: Scandinavian Journal of Work, Environment and Health - October 18, 2017 Category: Occupational Health Tags: Editorial Source Type: research

Effects of 1-year growth hormone replacement therapy on thyroid volume and function of the children and adolescents with idiopathic growth hormone deficiency
Journal Name: Journal of Pediatric Endocrinology and Metabolism Issue: Ahead of print (Source: Journal of Pediatric Endocrinology and Metabolism)
Source: Journal of Pediatric Endocrinology and Metabolism - October 17, 2017 Category: Endocrinology Source Type: research

Neurokinin 3 receptor antagonism - the magic bullet for hot flushes?
Abstract Hot flushes affect 70% of menopausal women and are reported as being the most bothersome symptom by the majority. Hormone replacement therapy and other currently available alternative therapies are not without side-effects and/or have variable efficacy, and so an effective novel therapy could be practice-changing. Over the last 20 years, numerous studies in animal and human models have implicated neurokinin B, a hypothalamic neuropeptide, together with its receptor (NK3R) in the etiology of menopausal hot flushes. Most recently, a randomized, placebo-controlled trial of an NK3R antagonist in symptomatic m...
Source: Climacteric - October 17, 2017 Category: Geriatrics Authors: Prague JK, Dhillo WS Tags: Climacteric Source Type: research

Graves ’ disease thyrotoxicosis and propylthiouracil related agranulocytosis successfully treated with therapeutic plasma exchange and g-csf followed by total thyroidectomy.
We report the case of a 27-year-old woman who is 3 months post-partum, breastfeeding, and suffering from Graves ’ disease hyperthyroidism treated first with methimazole and then with propylthiouracil due to a methimazole allergy. She was admitted for urosepsis and agranulocytosis. The patient was diagnosed with propylthiouracil related agranulocytosis, diffuse toxic goiter, and thyro-gastric syndrome. Antit hyroid drug therapy was stopped resulting in a worsening of thyrotoxicosis. Agranulocytosis was treated with 8 doses of G-CSF with full recovery. To rapidly restore euthyroidism and to perform a thyroidectomy, the...
Source: Mediterranean Journal of Hematology and Infectious Diseases - October 15, 2017 Category: Hematology Source Type: research

Hypopituitarism presenting as congestive heart failure
We present an unusual case of SS in a young lady who continued to have normal menstruation after the index event, had two spontaneous pregnancies, and was diagnosed only 11 years later when she presented to us with acute heart failure. (Source: Journal of Postgraduate Medicine)
Source: Journal of Postgraduate Medicine - October 11, 2017 Category: Internal Medicine Authors: S Giri P Bansal S Malik R Bansal Source Type: research

Postoperative complications following primary penile inversion vaginoplasty among 330 male-to-female transgender patients
We describe postoperative complications after penile inversion vaginoplasty and evaluate age, BMI, and years on hormone replacement therapy (HRT) as risk factors for complications. (Source: The Journal of Urology)
Source: The Journal of Urology - October 11, 2017 Category: Urology & Nephrology Authors: Thomas W. Gaither, Mohannad A. Awad, E. Charles Osterberg, Gregory P. Murphy, Angelita Romero, Marci L. Bowers, Benjamin N. Breyer Source Type: research

Polipectomy with Integrated Bigatti Shaver ®
MN, 50 years old, BMI: 36. Menopause was 7 years ago. No hormone replacement therapy before. She was treated for breast cancer and stopped using tamoxifen two years ago. Asymptomatic. She underwent to a screening transvaginal ultrasound that showed an endometrial thickness of 0.6  cm. Diagnostic hysteroscopy visualized two endometrial polyps. Surgical hysteroscopy was performed with The Integrated Bigatti Shaver (IBS®). The IBS® consists in a 6° angle telescope with an integrated sheath and a working channel in which a rigid shaver system is inserted. (Source: The Journal of Minimally Invasive Gynecology)
Source: The Journal of Minimally Invasive Gynecology - October 7, 2017 Category: OBGYN Authors: D.V. Imperador, T. Moscovitz, M. Tcherniakovsky, E. Baracat, C.E. Fernandes, M. Wajman Source Type: research

Menopause and hormone replacement therapy. The 2017 recommendations of the Italian Menopause Society.
Authors: Gambacciani M, Biglia N, Cagnacci A, DI Carlo C, Caruso S, Cicinelli E, DE Leo V, Farris M, Gambera A, Guaschino S, Lanzone A, Paoletti AM, Russo N, Vicariotto F, Villa P, Volpe A Abstract In the last decade the risk benefits ratio of HRT has been reevaluated mainly in tens of cardiovascular risk. Present Consensus Statement is largely inspired by the Global Consensus on Menopausel Hormone Therapy in 2013 and 2016 by leading global menopause societies (The American Society for Reproductive Medicine, The Asia Pacific Menopause Federation, The Endocrine Society, The European Menopause and Andropause Society,...
Source: Minerva Ginecologica - October 5, 2017 Category: OBGYN Tags: Minerva Ginecol Source Type: research

Effects of estradiol and progesterone on the growth of HeLa cervical cancer cells.
CONCLUSIONS: Overall, these results suggest that the combined application of E2 and P can be a new effective strategy for hormone replacement therapy after treatment of cervical adenocarcinoma. PMID: 28975965 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - October 5, 2017 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

Physiologic Growth Hormone Replacement Therapy and Craniopharyngioma Recurrence in Pediatric Patients: A Meta-Analysis
A systematic review and meta-analysis were conducted to examine the effect of growth hormone replacement therapy (GHRT) on the recurrence of craniopharyngioma in children. (Source: World Neurosurgery)
Source: World Neurosurgery - October 5, 2017 Category: Neurosurgery Authors: Nawaf M. Alotaibi, Nadia Noormohamed, David J. Cote, Salman Alharthi, Joanne Doucette, Hasan A. Zaidi, Rania A. Mekary, Timothy R. Smith Tags: Literature Reviews Source Type: research

Factor VII-activating protease: sex-related association with coronary artery calcification
Factor VII-activating protease (FSAP) may regulate development of cardiovascular disease (CVD). We evaluated sex differences in FSAP measures and examined the association between FSAP and coronary artery calcification (CAC) in a middle-aged population. Participants were randomly selected citizens aged 50 or 60 without CVD, diabetes mellitus, Marburg I polymorphism, or hormone replacement therapy (HRT). FSAP protein concentration (total FSAP), FSAP urokinase-activating capacity (FSAP GP), and FSAP GP/total FSAP (specific FSAP activity) were measured. Cardiac computed tomography (CT) determined the Agatston score, dividing t...
Source: Blood Coagulation and Fibrinolysis - October 1, 2017 Category: Hematology Tags: Original Articles Source Type: research

Comparative Trends in Hormone Replacement Therapy and Breast Cancer Incidence in the Unites States: Does Hormone Replacement Therapy Explain Declining Breast Cancer Rates?
The unprecedented decline in breast cancer (BC) incidence in the US between 1999 and 2004 has been attributed to decreases in combined hormone replacement therapy (CHT) after Women ’s Health Initiative (WHI) study results in 2002 suggesting increased BC risk with CHT use. Questions remain about the plausibility of this explanation given long-term WHI data suggesting an attenuated association. (Source: Journal of the American College of Surgeons)
Source: Journal of the American College of Surgeons - October 1, 2017 Category: Surgery Authors: Francys C. Verdial, Meghan R. Flanagan, Benjamin O. Anderson Tags: Scientific poster presentation Source Type: research

Annual report of the Women's Health Care Committee, Japan Society of Obstetrics and Gynecology, 2017
This report is based on the Japanese version of our annual report (Acta Obst Gynaec Jpn 2017;69(6):1480–1491), to publicize the activities of our committee. (Source: Journal of Obstetrics and Gynaecology Research)
Source: Journal of Obstetrics and Gynaecology Research - October 1, 2017 Category: OBGYN Authors: Kiyoshi Takamatsu, Jo Kitawaki Tags: JSOG Committee Report Source Type: research

Perioperative Management of Female Hormone Medications.
CONCLUSION: Until additional studies are performed, the risks and benefits must be weighed on an individual basis with consideration of prophylaxis when a decision is made to continue these medications in the perioperative period. Part of this decision making includes the risk of fetal harm in an unwanted pregnancy in preparation for nonobstetric surgery versus an increased risk of venous thromboembolism. PMID: 28969534 [PubMed - as supplied by publisher] (Source: Current Clinical Pharmacology)
Source: Current Clinical Pharmacology - September 26, 2017 Category: Drugs & Pharmacology Authors: Seim LA, Irizarry-Alvarado JM Tags: Curr Clin Pharmacol Source Type: research

Association Between Vitamin D and Carboxy-Terminal Cross-Linked Telopeptide of Type I Collagen in Children During Growth Hormone Replacement Therapy.
Authors: Witkowska-Sędek E, Stelmaszczyk-Emmel A, Kucharska A, Demkow U, Pyrżak B Abstract Growth hormone and insulin-like growth factor-1 (IGF-1) play a crucial role in the regulation of bone turnover. Adequate vitamin D status supports proper bone remodeling, leading to normal longitudinal bone growth and normal peak bone mass. The aim of this study was to evaluate the association between serum 25-hydroxyvitamin D [25(OH)D] and carboxy-terminal cross-linked telopeptide of type I collagen (ICTP) in children and adolescents with growth hormone deficiency at baseline and during recombinant human growth hormone (rh...
Source: Advances in Experimental Medicine and Biology - September 24, 2017 Category: Research Tags: Adv Exp Med Biol Source Type: research

Congenital hypothyroidism due to ectopic sublingual thyroid gland in Prader-Willi Syndrome: a case report
ConclusionsIn this context PWS should be considered in obese children with CH who do not improve adequately with l-thyroxine therapy. Also, thyroid function in all PWS children should be assessed regularly in order to avoid delayed diagnosis of hypothyroidism. (Source: Italian Journal of Pediatrics)
Source: Italian Journal of Pediatrics - September 22, 2017 Category: Pediatrics Source Type: research

17 β-Estradiol induces proliferation of endometrial NK cells (CD56+) in postmenopausal women.
CONCLUSION: 17β-Estradiol induced the proliferation of endometrial uterine natural killer cells (CD56+) in postmenopausal women. PMID: 28933961 [PubMed - as supplied by publisher] (Source: Climacteric)
Source: Climacteric - September 21, 2017 Category: Geriatrics Authors: Sho T, Hachisuga T, Koi C, Kurita T, Kagami S, Kawagoe T, Matsuura Y, Yoshimura K, Hisaoka M Tags: Climacteric Source Type: research

A case-control study of hormonal exposures as etiologic factors for ALS in women: Euro-MOTOR
Conclusions: This large case-control study across 3 different countries has demonstrated an association between exogenous estrogens and progestogens and reduced odds of ALS in women. These results are at variance with previous findings, which may be partly explained by differential regulatory, social, and cultural attitudes toward pregnancy, birth control, and HRT across the countries included. Our results indicate that hormonal factors may be important etiologic factors in ALS; however, a full understanding requires further investigation. (Source: Neurology)
Source: Neurology - September 18, 2017 Category: Neurology Authors: Rooney, J. P. K., Visser, A. E., D'Ovidio, F., Vermeulen, R., Beghi, E., Chio, A., Veldink, J. H., Logroscino, G., van den Berg, L. H., Hardiman, O., For the Euro-MOTOR Consortium Tags: Amyotrophic lateral sclerosis, Case control studies, Risk factors in epidemiology ARTICLE Source Type: research

Growth hormone therapy for people with thalassaemia.
CONCLUSIONS: A small single trial contributed evidence of moderate quality that the use of growth hormone for a year may improve height velocity of children with thalassaemia although height SD score in the treatment group was similar to the control group. There are no randomised controlled trials in adults or trials that address the use of growth hormone therapy over a longer period and assess its effect on final height and quality of life. The optimal dosage of growth hormone and the ideal time to start this therapy remain uncertain. Large well-designed randomised controlled trials over a longer period with sufficient du...
Source: Cochrane Database of Systematic Reviews - September 18, 2017 Category: General Medicine Authors: Ngim CF, Lai NM, Hong JY, Tan SL, Ramadas A, Muthukumarasamy P, Thong MK Tags: Cochrane Database Syst Rev Source Type: research

Circulating dehydroepiandrosterone-sulphate decreases even with a slight change in oestradiol.
Authors: Matsui S, Yasui T, Kasai K, Yoshida K, Kato T, Uemura H, Kuwahara A, Matsuzaki T, Irahara M Abstract The aim of this study was to determine the effect of hormone replacement therapy (HRT) on changes in circulating dehydroepiandrosterone-sulphate (DHEA-S) with focus on the relationship between oestrogen level and change in DHEA-S. Forty-two women were enrolled in this longitudinal study. Nineteen women received oral oestradiol and twenty-three women received transdermal oestradiol continuously. Twenty women received progesterone continuously except for women who had undergone hysterectomy. Circulating oestr...
Source: Journal of Obstetrics and Gynaecology - September 16, 2017 Category: OBGYN Tags: J Obstet Gynaecol Source Type: research

Hormone replacement therapy after treatment for cervical cancer: Are we adhering to standard of care?
CONCLUSIONS: Fewer than half of all women received counseling and/or a prescription for HRT after diagnoses of iatrogenic menopause, and disparities were noted based on insurance status. These findings reflect a need for clearer guidelines on HRT during survivorship and improved efforts to reduce disparities in the distribution of survivorship care. PMID: 28923411 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - September 16, 2017 Category: Cancer & Oncology Authors: Rauh LA, Pannone AF, Cantrell LA Tags: Gynecol Oncol Source Type: research

Chinese and Indian women ’s experience with alternative medications for menopause related symptoms: A qualitative analysis
ConclusionsChinese and Indian women used alternative medicine in prevention and treatment of menopause-related problems even as they were avoiding HRT because of the fear of side effects. They believed that their supplements were effective, safe and cost-beneficial even with long-term use. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - September 15, 2017 Category: Internal Medicine Source Type: research

HRT not linked to early death, study concludes
Hormone replacement therapy  is not associated with all-cause, cancer or cardiovascular death, according to the results of an 18-year follow-up study. (Source: The Pharmaceutical Journal)
Source: The Pharmaceutical Journal - September 14, 2017 Category: Drugs & Pharmacology Source Type: research

Does genetic testing for ER α gene polymorphisms provide new possibilities of treatment for cognitive function disorders in postmenopausal women?
Does genetic testing for ERα gene polymorphisms provide new possibilities of treatment for cognitive function disorders in postmenopausal women? Arch Med Sci. 2017 Aug;13(5):1224-1232 Authors: Gujski M, Pinkas J, Wierzbińska-Stępniak A, Owoc A, Bojar I Abstract It is commonly considered that cognitive abilities decrease with age, especially with respect to processing and psychomotor speed. It is an interesting issue whether, apart from the ageing process, the undergoing of menopause itself deteriorates cognitive functions, compared to women at reproductive age. Hopes for improvement of cognitiv...
Source: Archives of Medical Science - September 10, 2017 Category: General Medicine Tags: Arch Med Sci Source Type: research

Bone regenerative effect of aqueous Cynanchum wilfordii extract in receptor activator of nuclear factor- κB ligand-induced osteoclast differentiation and estrogen deficiency-induced osteoporosis
Osteoporosis increases with age, most frequently in postmenopausal women because of reduced ovarian hormone levels. Furthermore, estrogen deficiency impairs trabecular metaphyseal bone. Although efficacious, long-term hormone replacement therapy (HRT) has estrogen-like side effects including breast and endometrial cancers, and non-hormonal or herbal therapies may be safer alternatives. Therefore, the aim of this study was to investigate the effects of aqueous extracts ofCynanchum wilfordii (CWW) on receptor activator of nuclear factor- κ B (NF-κ B) ligand (RANKL)-induced osteoclast differentiationin vitro and o...
Source: International Journal of Phytomedicine - September 2, 2017 Category: Science Authors: Woojin Jun Source Type: research

Venous thromboembolism and hyperhomocysteinemia as first manifestation of pernicious anemia: a case series
ConclusionsThese reports demonstrate that pernicious anemia, on its own, can lead to hyperhomocysteinemia that is significant enough to lead to thrombosis. Understanding the molecular pathogenesis of the development of thrombosis in patients with hyperhomocysteinemia related to Biermer disease would help us to identify patients at risk and to treat them accordingly. The literature concerning the relationship between homocysteine and venous thrombosis is briefly reviewed. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - September 2, 2017 Category: General Medicine Source Type: research

Bone regenerative effect of aqueous < em > Cynanchum wilfordii < /em > extract in receptor activator of nuclear factor- κB ligand-induced osteoclast differentiation and estrogen deficiency-induced osteoporosis
Osteoporosis increases with age, most frequently in postmenopausal women because of reduced ovarian hormone levels. Furthermore, estrogen deficiency impairs trabecular metaphyseal bone. Although efficacious, long-term hormone replacement therapy (HRT) has estrogen-like side effects including breast and endometrial cancers, and non-hormonal or herbal therapies may be safer alternatives. Therefore, the aim of this study was to investigate the effects of aqueous extracts ofCynanchum wilfordii (CWW) on receptor activator of nuclear factor- κ B (NF-κ B) ligand (RANKL)-induced osteoclast differentiationin vitro and o...
Source: International Journal of Phytomedicine - September 2, 2017 Category: Science Authors: Woojin Jun Source Type: research

Combined bioavailable isoflavones and probiotics improve bone status and estrogen metabolism in postmenopausal osteopenic women: a randomized controlled trial [Bone metabolism]
In this study, we sought to determine the beneficial effects of a bioavailable isoflavone and probiotic treatment against postmenopausal osteopenia. Design: We used a novel red clover extract (RCE) rich in isoflavone aglycones and probiotics to concomitantly promote uptake and a favorable intestinal bacterial profile to enhance isoflavone bioavailability. This was a 12-mo, double-blind, parallel design, placebo-controlled, randomized controlled trial of 78 postmenopausal osteopenic women supplemented with calcium (1200 mg/d), magnesium (550 mg/d), and calcitriol (25 μg/d) given either RCE (60 mg isoflavone aglycones/d a...
Source: American Journal of Clinical Nutrition - September 1, 2017 Category: Nutrition Authors: Lambert, M. N. T., Thybo, C. B., Lykkeboe, S., Rasmussen, L. M., Frette, X., Christensen, L. P., Jeppesen, P. B. Tags: Dietary Bioactive Compounds Research Articles Bone metabolism Source Type: research

Post-Menopausal Hormone Replacement Therapy Tied to Hearing Loss
(Source: The ASHA Leader Online)
Source: The ASHA Leader Online - September 1, 2017 Category: Speech-Language Pathology Source Type: research

Endometrial mirnome during the implantation windows can predict early miscarriage or live birth after fresh or frozen embryo transfer
The rates of miscarriages within the framework of the replacement of fresh or frozen-thawed embryos in patients under hormone replacement therapy remain a major problem in IVF/ICSI. By comparing the miRNome using the Affymetrix miRNA Array, we previously identified miRNAs signature during the implantation window in pregnant patients after embryo replacement achieving live birth versus a miscarriage. The aim of this study was to evaluate the miRNA expression profile in the prediction of early miscarriage or live birth after either fresh or frozen embryo replacement. (Source: Fertility and Sterility)
Source: Fertility and Sterility - September 1, 2017 Category: Reproduction Medicine Authors: L. Drissennek, F. Entezami, A. Gala, C. Vincens, D. Haouzi, S. Hamamah Tags: Poster session Source Type: research

Poster 300: Acute Onset of Psychotic Symptoms Following Abrupt Discontinuation of Hormone Replacement Therapy in a Trangendered Woman with Traumatic Brain Injury: A Case Report
Yu Chiu: I Have No Relevant Financial Relationships To Disclose (Source: PM and R)
Source: PM and R - September 1, 2017 Category: Rehabilitation Authors: Yu M. Chiu, Baruch Kim, Xuemue Qu, Prin X. Amorapanth Source Type: research

Epidemiology of Estrogen and Dementia in Women with Down Syndrome.
Abstract Several lines of investigation have shown a protective role for estrogen in Alzheimer's disease through a number of biological actions. This review examines studies of the role of estrogen-related factors in age at onset and risk for Alzheimer's disease in women with Down syndrome, a population at high risk for early onset of dementia. The studies are consistent in showing that early age at menopause and that low levels of endogenous bioavailable estradiol in postmenopausal women with Down syndrome are associated with earlier age at onset and overall risk for dementia. Polymorphisms in genes associated wi...
Source: Free Radical Biology and Medicine - August 23, 2017 Category: Biology Authors: Schupf N, Lee JH, Pang D, Zigman WB, Tycko B, Krinsky-McHale S, Silverman W Tags: Free Radic Biol Med Source Type: research

Influence of Tetrabromobisphenol A, with or without Concurrent Triclosan, upon Bisphenol A and Estradiol Concentrations in Mice
Conclusion: These data indicate that TBBPA, triclosan, and BPA interact in vivo, consistent with evidence that TBBPA and triclosan inhibit enzymes that are critical for BPA and E2 metabolism. https://doi.org/10.1289/EHP1329 Received: 04 November 2016 Revised: 11 April 2017 Accepted: 13 April 2017 Published: 21 August 2017 Address correspondence to D. deCatanzaro, Dept. of Psychology, Neuroscience & Behaviour, McMaster University, 1280 Main St. West, Hamilton ON L8S 4K1, Canada. Telephone: (905) 525-9140, ext. 23014. Email: decatanz@mcmaster.ca Supplemental Material is available online (https://doi.org/10.1289/EHP...
Source: EHP Research - August 21, 2017 Category: Environmental Health Authors: Daniil Lyalko Tags: Research Source Type: research

Association between Dietary Energy Density and Obesity-Associated Cancer: Results from the Women ’s Health Initiative
Conclusions Higher DED may be a contributing factor for obesity-related cancers, especially among normal-weight postmenopausal women and, as such, could serve as a modifiable behavior for dietary interventions to reduce obesity-associated cancer risk. (Source: Journal of the Academy of Nutrition and Dietetics)
Source: Journal of the Academy of Nutrition and Dietetics - August 17, 2017 Category: Nutrition Source Type: research

Breast cancer and exposure to aircraft, road, and railway-noise: a case –control study based on health insurance records
Conclusions The results indicate increased aircraft noise may be an etiologic factor for ER negative breast cancers. However, information regarding potential confounding factors was largely unattainable. Further research is required to understand how environmental noise may be involved in the pathogenesis of ER negative breast cancers.byHegewald J, Schubert M, Wagner M, Dr öge P, Prote U, Swart E, Möhler U, Zeeb H, Seidler A. doi:10.5271/sjweh.3664 (Source: Scandinavian Journal of Work, Environment and Health)
Source: Scandinavian Journal of Work, Environment and Health - August 16, 2017 Category: Occupational Health Tags: Original article Source Type: research

Breast cancer and exposure to aircraft, road, and railway-noise: a case-control study based on health insurance records.
Conclusions The results indicate increased aircraft noise may be an etiologic factor for ER negative breast cancers. However, information regarding potential confounding factors was largely unattainable. Further research is required to understand how environmental noise may be involved in the pathogenesis of ER negative breast cancers. PMID: 28813586 [PubMed - as supplied by publisher] (Source: Scandinavian Journal of Work, Environment and Health)
Source: Scandinavian Journal of Work, Environment and Health - August 16, 2017 Category: Occupational Health Authors: Hegewald J, Schubert M, Wagner M, Dröge P, Prote U, Swart E, Möhler U, Zeeb H, Seidler A Tags: Scand J Work Environ Health Source Type: research

Hormone replacement therapy after risk-reducing salpingo-oophorectomy minimises endocrine and sexual problems: A prospective study
There has been some doubts raised in earlier studies about the efficacy of hormone replacement therapy (HRT) in reducing endocrine and sexual problems in women who have undergone a risk-reducing salpingo-oophorectomy (RRSO). (Source: European Journal of Cancer)
Source: European Journal of Cancer - August 14, 2017 Category: Cancer & Oncology Authors: Ravi F.M. Vermeulen, Marc van Beurden, Jacobien M. Kieffer, Eveline M.A. Bleiker, Heiddis B. Valdimarsdottir, Leon F.A.G. Massuger, Marian J.E. Mourits, Katja N. Gaarenstroom, Eleonora B.L. van Dorst, Hans W.H.M. van der Putten, Neil K. Aaronson Tags: Original Research Source Type: research

Initial patient choice of a growth hormone device improves child and adolescent adherence to and therapeutic effects of growth hormone replacement therapy
Journal Name: Journal of Pediatric Endocrinology and Metabolism Issue: Ahead of print (Source: Journal of Pediatric Endocrinology and Metabolism)
Source: Journal of Pediatric Endocrinology and Metabolism - August 5, 2017 Category: Endocrinology Source Type: research

Age at menopause and hormone replacement therapy as risk factors for head and neck and oesophageal cancer  (Review).
Age at menopause and hormone replacement therapy as risk factors for head and neck and oesophageal cancer (Review). Oncol Rep. 2017 Aug 01;: Authors: McCarthy CE, Field JK, Marcus MW Abstract There were ~986,000 cases of head and neck cancer (HNC) and oesophageal cancer diagnosed worldwide in 2012. The incidence of these types of cancer is much higher in males than females, although this disparity decreases in the elderly population, suggesting a role for hormones as a risk factor. This systematic review investigates the potential role of female hormones [age at menopause and use of hormone r...
Source: Oncology Reports - August 4, 2017 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Initial patient choice of a growth hormone device improves child and adolescent adherence to and therapeutic effects of growth hormone replacement therapy
Journal Name: Journal of Pediatric Endocrinology and Metabolism Volume: 30 Issue: 9 Pages: 989-993 (Source: Journal of Pediatric Endocrinology and Metabolism)
Source: Journal of Pediatric Endocrinology and Metabolism - August 3, 2017 Category: Endocrinology Source Type: research