Assessment of patient-reported outcomes (PROs): treatment satisfaction, medication adherence, and quality of life (QoL) and the associated factors in postmenopausal osteoporosis (PMO) patients in Korea
AbstractPatient-reported outcomes (PROs) provide practical guides for treatment; however, studies that have evaluated PROs of women in Korea with postmenopausal osteoporosis (PMO) are lacking. This cross-sectional, multi-center (29 nationwide hospitals) study, performed from March 2013 to July 2014, aimed to assess PROs related to treatment satisfaction, medication adherence, and quality of life (QoL) in Korean PMO women using osteoporosis medication for prevention/treatment. Patient demographics, clinical characteristics, treatment patterns, PROs, and experience using medication were collected. The 14-item Treatment Satis...
Source: Journal of Bone and Mineral Metabolism - September 20, 2018 Category: Orthopaedics Source Type: research

Estrogen in vascular smooth muscle cells: A friend or a foe?
Abstract Cardiovascular disease (CVD) continues to be the leading cause of death worldwide. The effect of estrogen on these diseases has been assessed in in vitro and in vivo models, as well as in observational studies. Collectively, these studies alluded to a cardiovasculo-protective effect of estrogen. However, comprehensive clinical investigation failed to produce concrete proof of a cardiovascular protective effect for hormone replacement therapy (HRT), let alone rule out potential harm. These seemingly paradoxical effects of estrogen were explained by the 'theory of timing and opportunity'. This theory states...
Source: Vascular Pharmacology - September 15, 2018 Category: Drugs & Pharmacology Authors: Dehaini H, Fardoun M, Saleh HA, El-Yazbi A, Eid AA, Eid AH Tags: Vascul Pharmacol Source Type: research

Ovarian survival after pelvic radiation: transposition until the age of 35  years
AbstractPurposeTo evaluate the effectiveness of ovarian transposition (OT) prior to radiation therapy (RT) and to evaluate the effect of age on ovarian survival (OS) after OT.MethodsWe performed a retrospective control study, with women (aged    40 IU/L and/or estradiol 
Source: Archives of Gynecology and Obstetrics - September 14, 2018 Category: OBGYN Source Type: research

Treatment outcomes of intracranial germinoma: a retrospective analysis of 170 patients from a single institution
ConclusionsWVI or WBRT+  primary boost (PB) is a sufficient irradiation field for localized intracranial germinoma, while patients with bifocal disease should undergo craniospinal irradiation (CSI), especially when treated with RT alone. CSF β-HCG is not a prognostic marker for intracranial germinomas. The treatment res ults of chemotherapy followed by reduced-dose RT are comparable to those of RT alone. IMRT is recommended for intracranial germinoma to improve the target volume accuracy and decrease the complications of RT. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - September 12, 2018 Category: Cancer & Oncology Source Type: research

Sex Differences in the Vascular Function and Related Mechanisms: Role of 17 βEstradiol.
Sex Differences in the Vascular Function and Related Mechanisms: Role of 17βEstradiol. Am J Physiol Heart Circ Physiol. 2018 Sep 07;: Authors: Pabbidi MR, Kuppusamy M, Didion SP, Sanapureddy P, Reed J, Sontakke SP Abstract The incidence of cardiovascular disease (CVD) is lower in pre-menopausal women but increases with age and menopause compared to similar-aged men. Based on the prevalence of CVD in the post-menopausal women, sex hormone-dependent mechanisms have been postulated to be the primary factors responsible for the protection from CVD in pre-menopausal women. Recent Women's Health Initia...
Source: American Journal of Physiology. Heart and Circulatory Physiology - September 7, 2018 Category: Physiology Authors: Pabbidi MR, Kuppusamy M, Didion SP, Sanapureddy P, Reed J, Sontakke SP Tags: Am J Physiol Heart Circ Physiol Source Type: research

Is lower low-density lipoprotein cholesterol associated with lower androgen and erectile dysfunction in men?
ConclusionLower LDL-C levels were significantly associated with lower free T and lower FAI in a general population of men. Moreover, both low and high levels of LDL-C might be risk factors for ED. (Source: Nutrition, Metabolism and Cardiovascular Diseases)
Source: Nutrition, Metabolism and Cardiovascular Diseases - September 2, 2018 Category: Nutrition Source Type: research

The Epistemological Weight of Randomized-Controlled Trials Depends on Their Results.
Abstract When evaluating the internal validity of clinical trials, physicians and medical researchers place substantial importance on factors such as blinding and randomization. For a particular randomized-controlled trial (RCT), causal inference and explanation require additional contextual considerations, to which we assign the term "epistemological weight." We argue that one component of epistemological weight, epistemological function, depends on a trial's results. We further note that discordant RCTs often lead to hypothesis generation, an epistemological function that is rare among concordant studi...
Source: Perspectives in Biology and Medicine - August 28, 2018 Category: Medical Ethics Authors: Flanagan RF, Dammann O Tags: Perspect Biol Med Source Type: research

Exploratory Profiling of Urine MicroRNAs in the dy2J/dy2J Mouse Model of LAMA2-CMD: Relation to Disease Progression
In this study we aimed at profiling miRNA expression in urine from dy2J/dy2J mice to assess their potential for monitoring disease progression. Three distinct time points (three, four and six weeks of age) were chosen to represent asymptomatic, initial symptoms and established disease, respectively. Here we show that distinct sets of miRNA characterise each time point whilst CK fails to differentiate between them. MATERIALS AND METHODS Ethics Statement Wild-type and dy2J/dy2J (B6.WK-Lama2dy-2J/J) mice were purchased from Jackson laboratory and bred in the Biomedical Center according to institutional animal care guidel...
Source: PLOS Currents Muscular Dystrophy - August 27, 2018 Category: Neurology Authors: Bernardo Moreira Soares Oliveira Source Type: research

Long-term Effects of Growth Hormone Replacement Therapy in Childhood-onset Craniopharyngioma: Results of the German Craniopharyngioma Registry (HIT-Endo).
CONCLUSIONS: We conclude that GH substitution was safe with regard to risk of tumor progression/relapse in CP. Growth was improved by GH, whereas the development of obesity was not influenced by GH substitution. However, early initiation of GH substitution after CP diagnosis might have beneficial effects on weight development and neuropsychological outcome. PMID: 30139824 [PubMed - as supplied by publisher] (Source: European Journal of Endocrinology)
Source: European Journal of Endocrinology - August 23, 2018 Category: Endocrinology Authors: Boekhoff S, Bogusz A, Sterkenburg AS, Eveslage M, Müller HL Tags: Eur J Endocrinol Source Type: research

The role of inflammation and potential use of sex steroids in intracranial aneurysms and subarachnoid hemorrhage.
Conclusion: Inflammation may play a role in the pathogenesis of intracranial aneurysm formation and subarachnoid hemorrhage, and administration of sex hormones as anti-inflammatory agents has been associated with improved functional outcome in experimental models. Further studies are needed to determine the therapeutic role of these hormones in the intracranial aneurysms and aSAH. PMID: 30105144 [PubMed] (Source: Surgical Neurology International)
Source: Surgical Neurology International - August 16, 2018 Category: Neurosurgery Tags: Surg Neurol Int Source Type: research

Care of the adult woman with Turner syndrome.
Abstract Turner syndrome (TS) is the most common chromosomal abnormality in females, affecting up to 1/2000 live female births. TS is associated with partial or complete loss of the second X-chromosome in phenotypic females and is associated with increased morbidity and mortality. There are many challenges in providing optimal care for the adult TS women. This review highlights uncertainties that remain in hormone replacement therapy, bone health and cardiovascular optimization and discusses current management recommendations based on the recently published international guidelines and the experience at the TS cli...
Source: Climacteric - August 10, 2018 Category: Geriatrics Authors: Shah S, Nguyen HH, Vincent AJ Tags: Climacteric Source Type: research

Effects of endometrial preparations and transferred embryo types on pregnancy outcome from patients with advanced maternal age.
Abstract We explored the strategy of frozen-thawed embryo transfer (FET) in the women with advanced maternal age (AMA). We first determined the age cut-off point of AMA by retrospective analysis of pregnancy outcomes in the patients undergoing FET. The patients with AMA were divided into 3 groups including natural cycle (NC) group, controlled ovarian stimulation (COS) group, and hormone replacement therapy (HRT) group, and simultaneously were divided into 2 groups including cleavage-stage embryo transfer (CET) group and blastocyst-stage embryo transfer (BET) group. The clinical pregnancy, embryo implantation, abor...
Source: Systems Biology in Reproductive Medicine - August 9, 2018 Category: Reproduction Medicine Authors: Liu J, Zheng J, Lei YL, Wen XF Tags: Syst Biol Reprod Med Source Type: research

Oestrogen versus androgen in hormone-replacement therapy for complete androgen insensitivity syndrome: a multicentre, randomised, double-dummy, double-blind crossover trial
Publication date: Available online 31 July 2018Source: The Lancet Diabetes & EndocrinologyAuthor(s): Wiebke Birnbaum, Louise Marshall, Ralf Werner, Alexandra Kulle, Paul-Martin Holterhus, Katharina Rall, Birgit Köhler, Annette Richter-Unruh, Michaela F Hartmann, Stefan A Wudy, Matthias K Auer, Anke Lux, Siegfried Kropf, Olaf HiortSummaryBackgroundWomen with complete androgen insensitivity syndrome (CAIS) after gonadectomy have complained about reduced psychological wellbeing and sexual satisfaction. The aim of this study was to compare the effectiveness of hormone-replacement therapy with either androgen or oestro...
Source: The Lancet Diabetes and Endocrinology - August 1, 2018 Category: Endocrinology Source Type: research

Interaction study between antiplatelet agents, anticoagulants, thyroid replacement therapy and a bioavailable formulation of curcumin (Meriva ®).
CONCLUSIONS: Results from this non-interaction clinical study suggest that Meriva® does not interfere with the antiplatelet activity of the most common antiplatelet agents nor alters the INR values in stable patients assuming warfarin or dabigatran. Similarly, dosages of LT4 or metformin do not need to be adjusted in case of complementary treatment with Meriva®. PMID: 30070343 [PubMed - in process] (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - August 1, 2018 Category: Drugs & Pharmacology Authors: Hu S, Belcaro G, Dugall M, Peterzan P, Hosoi M, Ledda A, Riva A, Giacomelli L, Togni S, Eggenhoffner R, Cotellese R Tags: Eur Rev Med Pharmacol Sci Source Type: research

HRT not always linked with cognitive decline, study finds
Hormone replacement therapy may not always be associated with cognitive harm, a study has found. (Source: The Pharmaceutical Journal)
Source: The Pharmaceutical Journal - July 27, 2018 Category: Drugs & Pharmacology Source Type: research

Comorbidities in patients with non-functioning pituitary adenoma: influence of long-term growth hormone replacement.
Abstract BACKGROUND: Patients with hypopituitarism have an increased mortality. The aim of this study was to investigate comorbidities including cerebral infarction, type 2 diabetes mellitus (T2DM) and malignant tumours in patients with non-functioning pituitary adenomas (NFPA) with and without growth hormone replacement therapy (GHRT). METHOD: Observational cohort study in patients with NFPA within the western region of Sweden. Subjects were identified through the National Patient Registry and followed between 1987-2014. Patient records were reviewed and standardized incidence ratios (SIRs) with 95% confiden...
Source: European Journal of Endocrinology - July 26, 2018 Category: Endocrinology Authors: Hammarstrand C, Ragnarsson O, Bengtsson O, Bryngelsson IL, Johannsson G, Olsson DS Tags: Eur J Endocrinol Source Type: research

Mammographic Density and Circulating Sex Hormones: a Cross-Sectional Study in Postmenopausal Korean Women
AbstractMammographic density (MD) is a strong independent risk factor for breast cancer. It has been suggested that breast cancer is related to the exposure to circulating sex hormones. However, relations between MD and hormones have been inconsistent. In addition, such relations are mainly evaluated in Western populations. Therefore, we conducted a cross-sectional study in 396 cancer-free postmenopausal Korean women who had never used hormone replacement therapy. We assayed estradiol, testosterone, and sex hormone-binding globulin (SHBG) levels. We then calculated free testosterone (cFT) levels. Total and dense areas of d...
Source: Hormones and Cancer - July 24, 2018 Category: Cancer & Oncology Source Type: research

The Association between Female Reproductive Factors and Open-Angle Glaucoma in Korean Women: The Korean National Health and Nutrition Examination Survey V.
Conclusions: Only early menopause was associated with an increased risk of OAG in our study, in contrast to previous Western studies reporting both early menopause and late menarche as associated factors. PMID: 30026984 [PubMed] (Source: Journal of Ophthalmology)
Source: Journal of Ophthalmology - July 22, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

[Management guidelines for disorders / different sex development (SDS)].
e;nez Martínez L, Martínez-Urrutia MJ, Mora Palma C, Audí Parera L Abstract Disorders of Sex Development (DSD) include a wide range of anomalies among the chromosomal, gonadal, and phenotypic (genital) characteristics that define sexual differentiation. At present, a definition as Different Sexual Development (DSD) is currently preferred. They originate in the pre-natal stage, are classified according to the sex chromosomes present in the karyotype. The known genetic causes are numerous and heterogeneous, although, in some cases, they may be secondary to maternal factors and/or exposure to end...
Source: Anales de Pediatria - July 19, 2018 Category: Pediatrics Authors: Guerrero-Fernández J, Azcona San Julián C, Barreiro Conde J, Bermúdez de la Vega JA, Carcavilla Urquí A, Castaño González LA, Martos Tello JM, Rodríguez Estévez A, Yeste Fernández D, Martínez Martínez L, Martínez-Urrutia MJ, Mora Palma C, Aud Tags: An Pediatr (Barc) Source Type: research

The physiology of endocrine systems with ageing
Publication date: Available online 17 July 2018Source: The Lancet Diabetes & EndocrinologyAuthor(s): Annewieke W van den Beld, Jean-Marc Kaufman, M Carola Zillikens, Steven W J Lamberts, Josephine M Egan, Aart J van der LelySummaryDuring ageing, the secretory patterns of the hormones produced by the hypothalamic–pituitary axis change, as does the sensitivity of the axis to negative feedback by end hormones. Additionally, glucose homoeostasis tends towards disequilibrium with increasing age. Along with these endocrine alterations, a loss of bone and muscle mass and strength occurs, coupled with an increase in fat ...
Source: The Lancet Diabetes and Endocrinology - July 18, 2018 Category: Endocrinology Source Type: research

Successful spontaneous pregnancy with acupuncture after premature ovarian failure
Publication date: Available online 17 July 2018Source: World Journal of Acupuncture - MoxibustionAuthor(s): YIN Yaqian, XU Huanfang, SHANG Jie, YANG Huisheng, FANG YigongABSTRACTIn this paper, a case of premature ovarian failure(POF), accompanied with amenorrhea for 2 years was reported. After 2 months of acupuncture, the patient's menstruation was resumed, and after 11 months of treatment, the patient had a spontaneous pregnancy. It is suggested that acupuncture should be used for the patient with POF as early as possible, and if necessary, hormone replacement therapy is still needed, and it is still expected to obtain sp...
Source: World Journal of Acupuncture Moxibustion - July 18, 2018 Category: Complementary Medicine Source Type: research

A novel role for estrogen-induced signaling in the colorectal cancer gender bias
AbstractColorectal cancer (CRC) is a malignancy whose incidence is increasing globally, and there is a gender difference in the increasing risk. Evidence from hormone replacement therapy studies points to a role for circulating estrogens in suppressing the development of CRC. Estrogen receptor- β has been identified as a tumor suppressor, but other actions of estrogen may also contribute to the difference in CRC incidence between men and women. The KCNQ1/KCNE3 potassium channel is regulated by estrogen in order to modulate chloride secretion during the menstrual cycle; the effect of estro gen on the colon is to promot...
Source: Irish Journal of Medical Science - July 17, 2018 Category: General Medicine Source Type: research

Sex hormones and venous thromboembolism - from contraception to hormone replacement therapy.
Abstract The use of sex hormones such as combined oral contraceptives (COC) or hormone replacement therapy (HRT) increases the risk for venous thromboembolism (VTE) considerably, especially in patients with an increased intrinsic risk for thromboembolic complications. Despite public and media attention and increasing scientific evidence, prescription patterns seem to be hard to change. It is well recognized that the patient's baseline risk is the most relevant factor in the absolute risk for developing VTE. The relative risk increase associated with sex hormones, depends on the type and dosage of hormones, the rou...
Source: VASA. Zeitschrift fur Gefasskrankheiten. Journal for Vascular Diseases - July 16, 2018 Category: Surgery Authors: Beyer-Westendorf J, Bauersachs R, Hach-Wunderle V, Zotz RB, Rott H Tags: Vasa Source Type: research

Natural hormone replacement therapy with a functioning ovary after the menopause: dream or reality?
Publication date: Available online 30 June 2018Source: Reproductive BioMedicine OnlineAuthor(s): Jacques Donnez, Marie-Madeleine DolmansAbstractAt the dawn of humanity, it was rare to live beyond the age of 35 years, so the ovary was intended to function for a woman's entire life. Nowadays, it is not unusual for women to live into their 80s. This means that many of them spend 30–40% of their lives in the menopause at increased risk of various conditions associated with an absence of oestrogens (cardiovascular disease, bone mineral density loss). Reimplantation of frozen–thawed ovarian tissue is able to restore ...
Source: Reproductive BioMedicine Online - July 11, 2018 Category: Reproduction Medicine Source Type: research

Identification of the first homozygous POLG mutation causing non-syndromic ovarian dysfunction.
CONCLUSIONS: Biallelic mutations in POLG may be associated with ovarian dysfunction. This study has improved our understanding of POLG-related genetic mutations in ovarian dysfunction, and the mode of inheritance of certain sequence variants. This information will assist genetic counseling and precision medicine in the future. PMID: 29992832 [PubMed - as supplied by publisher] (Source: Climacteric)
Source: Climacteric - July 11, 2018 Category: Geriatrics Authors: Chen B, Li L, Wang J, Zhou Y, Zhu J, Li T, Pan H, Liu B, Cao Y, Wang B Tags: Climacteric Source Type: research

Menopause and Non-Alcoholic Fatty Liver Disease: A Review Focusing on Therapeutic Perspectives.
Abstract There is increasing evidence that menopause is associated with the progression and severity of non-alcoholic fatty liver disease (NAFLD). Estrogen deficiency worsens non-alcoholic steatohepatitis (NASH) in mice models with fatty liver. The prevalence of NAFLD seems to be higher in postmenopausal compared with premenopausal women. Although more data are needed, lower serum estradiol levels are associated with NASH in postmenopausal women. Apart from estrogen deficiency, relative androgen excess and decrease in sex hormone-binding protein are observed in postmenopausal women. These hormonal changes seem to ...
Source: Current Vascular Pharmacology - July 11, 2018 Category: Drugs & Pharmacology Authors: Venetsanaki V, Polyzos SA Tags: Curr Vasc Pharmacol Source Type: research

Systematic review of hormone replacement therapy in the infertile man
ConclusionsExogenous testosterone inhibits spermatogenesis. Hypogonadal men wanting to preserve their fertility and at the same time benefiting from TRT effects can be prescribed selective oestrogen receptor modulators or testosterone plus low-dose human chorionic gonadotrophin (hCG). Patients treated for infertility with hypogonadotrophic hypogonadism can be prescribed hCG alone at first followed by or in combination from the start with follicle-stimulating hormone preparations. (Source: Arab Journal of Urology)
Source: Arab Journal of Urology - July 10, 2018 Category: Urology & Nephrology Source Type: research

Understanding the role of environmental factors in the development of systemic lupus erythematosus
Publication date: June 2017Source: Best Practice & Research Clinical Rheumatology, Volume 31, Issue 3Author(s): Christine G. Parks, Aline de Souza Espindola Santos, Medha Barbhaiya, Karen H. CostenbaderAbstractSystemic lupus erythematosus (SLE) is a multisystem disease with a complex etiology. Its risk is higher among women, racial and ethnic minorities, and individuals with a family history of SLE or related autoimmune diseases. It is believed that genetic factors interact with environmental exposures throughout the lifespan to influence susceptibility to developing SLE. The strongest epidemiologic evidence exists for...
Source: Best Practice and Research Clinical Rheumatology - July 10, 2018 Category: Rheumatology Source Type: research

Enhanced estrogenic effects of biotransformed soy extracts
This study aimed to improve the process conditions for biotransformation of soymilk polyphenols by tannase to obtain higher amounts of isoflavone aglycones and metabolites such as equol. The estrogenic potential of the extracts was evaluated in in vitro assays. The results showed that the aglycones increased 36–46 times after reaction with tannase and proved that it is possible to produce equol in soymilk using an enzymatic bioprocess, without gut microbial intervention. Moreover, the soymilk biotransformed by tannase presented higher estrogenic action in the MCF-7 BUS cell line assay, making it a promising nutraceut...
Source: Journal of Functional Foods - July 10, 2018 Category: Nutrition Source Type: research

Yawning and cortisol levels in multiple sclerosis: Potential new diagnostic tool
Publication date: July 2018Source: Multiple Sclerosis and Related Disorders, Volume 23Author(s): Simon B.N. Thompson, Alister Coleman, Nicola WilliamsAbstractYawning is a significant behavioural response and, together with cortisol, is potentially a new diagnostic marker of neurological diseases. Evidence of an association between yawning and cortisol was found which supports the Thompson Cortisol Hypothesis and thermoregulation hypotheses, indication that brain cooling occurs when yawning. 117 volunteers aged 18–69 years were randomly allocated to experimentally controlled conditions to provoke yawning. Thirty-three...
Source: Multiple Sclerosis and Related Disorders - July 10, 2018 Category: Neurology Source Type: research

Primary adrenal insufficiency in children: Diagnosis and management
Publication date: Available online 6 June 2018Source: Best Practice & Research Clinical Endocrinology & MetabolismAuthor(s): Tarik Kirkgoz, Tulay GuranPrimary adrenal insufficiency (PAI) is a life-threatening disorder of adrenal cortex which is characterized by deficient biosynthesis of glucocorticoids, with or without deficiency in mineralocorticoids and adrenal androgens. Typical manifestations of primary adrenal insufficiency include hyperpigmentation, hypotension, hypoglycaemia, hyponatremia with or without hyperkalemia that are generally preceded by nonspecific symptoms at the onset. Recessively inherited mono...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - July 10, 2018 Category: Endocrinology Source Type: research

Estradiol mediates relaxation of porcine lower esophageal sphincter
Publication date: August 2018Source: Steroids, Volume 136Author(s): Ching-Chung Tsai, Shu-Leei Tey, Li-Ching Chang, Yu-Tsun Su, Kai-Jen Lin, Shih-Che HuangAbstractMost pregnant women have symptoms of gastroesophageal reflux disease (GERD) during pregnancy. Postmenopausal hormone replacement therapy is associated with GERD. The effects of estradiol on lower esophageal sphincter (LES) motility and GERD are not clearly known. The purpose of this study is to investigate the effects of estradiol on the motility of the porcine LES. Relaxations of clasp and sling strips of porcine LES caused by estradiol were measured using isome...
Source: Steroids - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Enhanced estrogenic effects of biotransformed soy extracts
This study aimed to improve the process conditions for biotransformation of soymilk polyphenols by tannase to obtain higher amounts of isoflavone aglycones and metabolites such as equol. The estrogenic potential of the extracts was evaluated in in vitro assays. The results showed that the aglycones increased 36–46 times after reaction with tannase and proved that it is possible to produce equol in soymilk using an enzymatic bioprocess, without gut microbial intervention. Moreover, the soymilk biotransformed by tannase presented higher estrogenic action in the MCF-7 BUS cell line assay, making it a promising nutraceut...
Source: Journal of Functional Foods - July 6, 2018 Category: Nutrition Source Type: research

Effect of low-normal and high-normal IGF-1 levels on memory and wellbeing during growth hormone replacement therapy: a randomized clinical trial in adult growth hormone deficiency
The aim of the present study was to investigate the effect of low-normal and high-normal levels of IGF-1 in growth hormone (GH) deficient adults on cognition and wellbeing during GH treatment. (Source: Health and Quality of Life Outcomes)
Source: Health and Quality of Life Outcomes - July 6, 2018 Category: International Medicine & Public Health Authors: Christa C. van Bunderen, Jan Berend Deijen and Madeleine L. Drent Tags: Research Source Type: research

Natural hormone replacement therapy with a functioning ovary after the menopause: dream or reality?
Publication date: Available online 30 June 2018Source: Reproductive BioMedicine OnlineAuthor(s): Jacques Donnez, Marie-Madeleine DolmansAbstractAt the dawn of humanity, it was rare to live beyond the age of 35 years, so the ovary was intended to function for a woman's entire life. Nowadays, it is not unusual for women to live into their 80s. This means that many of them spend 30–40% of their lives in the menopause at increased risk of various conditions associated with an absence of oestrogens (cardiovascular disease, bone mineral density loss). Reimplantation of frozen–thawed ovarian tissue is able to restore ...
Source: Reproductive BioMedicine Online - July 5, 2018 Category: Reproduction Medicine Source Type: research

Systematic review of hormone replacement therapy in the infertile man
ConclusionsExogenous testosterone inhibits spermatogenesis. Hypogonadal men wanting to preserve their fertility and at the same time benefiting from TRT effects can be prescribed selective oestrogen receptor modulators or testosterone plus low-dose human chorionic gonadotrophin (hCG). Patients treated for infertility with hypogonadotrophic hypogonadism can be prescribed hCG alone at first followed by or in combination from the start with follicle-stimulating hormone preparations. (Source: Arab Journal of Urology)
Source: Arab Journal of Urology - July 5, 2018 Category: Urology & Nephrology Source Type: research

Understanding the role of environmental factors in the development of systemic lupus erythematosus
Publication date: June 2017Source: Best Practice & Research Clinical Rheumatology, Volume 31, Issue 3Author(s): Christine G. Parks, Aline de Souza Espindola Santos, Medha Barbhaiya, Karen H. CostenbaderAbstractSystemic lupus erythematosus (SLE) is a multisystem disease with a complex etiology. Its risk is higher among women, racial and ethnic minorities, and individuals with a family history of SLE or related autoimmune diseases. It is believed that genetic factors interact with environmental exposures throughout the lifespan to influence susceptibility to developing SLE. The strongest epidemiologic evidence exists for...
Source: Best Practice and Research Clinical Rheumatology - July 5, 2018 Category: Rheumatology Source Type: research

Yawning and cortisol levels in multiple sclerosis: Potential new diagnostic tool
Publication date: July 2018Source: Multiple Sclerosis and Related Disorders, Volume 23Author(s): Simon B.N. Thompson, Alister Coleman, Nicola WilliamsAbstractYawning is a significant behavioural response and, together with cortisol, is potentially a new diagnostic marker of neurological diseases. Evidence of an association between yawning and cortisol was found which supports the Thompson Cortisol Hypothesis and thermoregulation hypotheses, indication that brain cooling occurs when yawning. 117 volunteers aged 18–69 years were randomly allocated to experimentally controlled conditions to provoke yawning. Thirty-three...
Source: Multiple Sclerosis and Related Disorders - July 5, 2018 Category: Neurology Source Type: research

Primary adrenal insufficiency in children: Diagnosis and management
Publication date: Available online 6 June 2018Source: Best Practice & Research Clinical Endocrinology & MetabolismAuthor(s): Tarik Kirkgoz, Tulay GuranPrimary adrenal insufficiency (PAI) is a life-threatening disorder of adrenal cortex which is characterized by deficient biosynthesis of glucocorticoids, with or without deficiency in mineralocorticoids and adrenal androgens. Typical manifestations of primary adrenal insufficiency include hyperpigmentation, hypotension, hypoglycaemia, hyponatremia with or without hyperkalemia that are generally preceded by nonspecific symptoms at the onset. Recessively inherited mono...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - July 5, 2018 Category: Endocrinology Source Type: research

Estradiol mediates relaxation of porcine lower esophageal sphincter
Publication date: August 2018Source: Steroids, Volume 136Author(s): Ching-Chung Tsai, Shu-Leei Tey, Li-Ching Chang, Yu-Tsun Su, Kai-Jen Lin, Shih-Che HuangAbstractMost pregnant women have symptoms of gastroesophageal reflux disease (GERD) during pregnancy. Postmenopausal hormone replacement therapy is associated with GERD. The effects of estradiol on lower esophageal sphincter (LES) motility and GERD are not clearly known. The purpose of this study is to investigate the effects of estradiol on the motility of the porcine LES. Relaxations of clasp and sling strips of porcine LES caused by estradiol were measured using isome...
Source: Steroids - July 5, 2018 Category: Drugs & Pharmacology Source Type: research

Alpha-Lipoic Acid Protects Human Aortic Endothelial Cells Against H < sub > 2 < /sub > O < sub > 2 < /sub > -Induced Injury and Inhibits Atherosclerosis in Ovariectomized Low Density Lipoprotein Receptor Knock-Out Mice
Conclusions: ALA could provide a potential treatment for atherosclerosis in postmenopausal patients.Cell Physiol Biochem 2018;47:2261 –2277 (Source: Cellular Physiology and Biochemistry)
Source: Cellular Physiology and Biochemistry - July 5, 2018 Category: Cytology Source Type: research

Preoperative and Postoperative Considerations in Gender-Affirming Surgery
AbstractPurpose of ReviewThe review is aimed at determining critical factors in the preoperative and postoperative care of transgender patients undergoing gender-affirming surgery. General and procedure-specific considerations are summarized to improve the longitudinal perioperative care of transgender patients.Recent FindingsSurgical providers should follow World Professional Association for Transgender Health (WPATH) guidelines regarding eligibility for surgery. Important elements in preoperative evaluation include mental health screening, fertility discussion, and adjustment of hormone replacement therapy. Postoperative...
Source: Current Sexual Health Reports - July 2, 2018 Category: Sexual Medicine Source Type: research

Proteomic biomarkers of cognitive impairment in obstructive sleep apnea syndrome
ConclusionsProteomic biomarkers in participants with cognitive impairment suggest roles for insulin, and vascular signaling pathways, some of which are similar to findings in Alzheimer ’s disease. A better understanding of the pathogenic mechanisms of CI in OSAS will help focus clinical trials needed in this patient population. (Source: Sleep and Breathing)
Source: Sleep and Breathing - July 2, 2018 Category: Respiratory Medicine Source Type: research

Proteomic biomarkers of cognitive impairment in obstructive sleep apnea syndrome.
CONCLUSIONS: Proteomic biomarkers in participants with cognitive impairment suggest roles for insulin, and vascular signaling pathways, some of which are similar to findings in Alzheimer's disease. A better understanding of the pathogenic mechanisms of CI in OSAS will help focus clinical trials needed in this patient population. PMID: 29968150 [PubMed - as supplied by publisher] (Source: Genomics Proteomics ...)
Source: Genomics Proteomics ... - July 2, 2018 Category: Genetics & Stem Cells Authors: Lal C, Hardiman G, Kumbhare S, Strange C Tags: Sleep Breath Source Type: research

Sellar chondrosarcoma presenting with amenorrhea: A case report
Rationale: Intracranial chondrosarcomas are rare entities and most of which arise off the midline. Chondrosarcomas that occur in the sellar region are extremely rare, and to the best of our knowledge, there is no reporting about sellar chondrosarcoma with amenorrhea as the onset symptom. Patient concerns: A 45-year-old woman presented with a 7-month history of amenorrhea and a 3-month history of progressive visual loss in the left eye. Diagnosis: The patient was diagnosed with recurrent sellar chondrosarcoma arising from intrasellar with extensive tumor invasion into bilateral sphenoid sinuses. Interventions: Tw...
Source: Medicine - July 1, 2018 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Natural hormone replacement therapy with a functioning ovary after the menopause: dream or reality?
Publication date: Available online 30 June 2018 Source:Reproductive BioMedicine Online Author(s): Jacques Donnez, Marie-Madeleine Dolmans At the dawn of humanity, it was rare to live beyond the age of 35 years, so the ovary was intended to function for a woman's entire life. Nowadays, it is not unusual for women to live into their 80s. This means that many of them spend 30–40% of their lives in the menopause at increased risk of various conditions associated with an absence of oestrogens (cardiovascular disease, bone mineral density loss). Reimplantation of frozen–thawed ovarian tissue is able to restore long-...
Source: Reproductive BioMedicine Online - June 30, 2018 Category: Reproduction Medicine Source Type: research

Childhood Craniopharyngioma: A 22-Year Challenging Follow-Up in a Single Center
Horm Metab Res DOI: 10.1055/a-0641-5956Craniopharyngioma is a sellar/suprasellar benign tumor whose aggressiveness may imply in endocrine disturbances (hypothalamic obesity and hormone deficiencies). Fifty-seven patients were evaluated according to clinical characteristics, hypothalamic involvement, type of treatment, anthropometric variables, adiposity indexes (body mass index Z score category at diagnosis and post-treatment, total body fat, visceral adipose tissue, and metabolic syndrome components) and analyzed through multiple regression and logistic models. Patients were stratified according to growth hormone deficien...
Source: Hormone and Metabolic Research - June 29, 2018 Category: Endocrinology Authors: Tosta-Hernandez, Patr ícia Débora Cavalcanti Siviero-Miachon, Adriana Aparecida da Silva, Nasjla Saba Cappellano, Andrea Pinheiro, Marcelo de Medeiros Spinola-Castro, Angela Maria Tags: Endocrine Care Source Type: research

Japan Society of Obstetrics and Gynecology and Japan Society for Menopause and Women's Health 2017 guidelines for hormone replacement therapy
Journal of Obstetrics and Gynaecology Research, EarlyView. (Source: Journal of Obstetrics and Gynaecology Research)
Source: Journal of Obstetrics and Gynaecology Research - June 29, 2018 Category: OBGYN Authors: Hiroya Okano , Tsuyoshi Higuchi , Takumi Kurabayashi , Kazuya Makita , Hideki Mizunuma , Yoshiko Mochizuki , Satoshi Obayashi , Toshiyuki Yasui , Kiyoshi Takamatsu , Source Type: research

Japan Society of Obstetrics and Gynecology and Japan Society for Menopause and Women's Health 2017 guidelines for hormone replacement therapy
Journal of Obstetrics and Gynaecology Research,Volume 44, Issue 8, Page 1355-1368, August 2018. (Source: Journal of Obstetrics and Gynaecology Research)
Source: Journal of Obstetrics and Gynaecology Research - June 29, 2018 Category: OBGYN Authors: Hiroya Okano , Tsuyoshi Higuchi , Takumi Kurabayashi , Kazuya Makita , Hideki Mizunuma , Yoshiko Mochizuki , Satoshi Obayashi , Toshiyuki Yasui , Kiyoshi Takamatsu , Source Type: research

Menopausal hormone therapy and the risk of breast cancer by histological type and race: a meta-analysis of randomized controlled trials and cohort studies
ConclusionsAsian HRT users had a higher risk of breast cancer than western HRT users. Both ET and EPT were significantly associated with the risk of all breast cancer histological types and ER-positive breast cancer. (Source: Breast Cancer Research and Treatment)
Source: Breast Cancer Research and Treatment - June 28, 2018 Category: Cancer & Oncology Source Type: research