Current practices in deceased organ donor management.
Abstract PURPOSE OF REVIEW: Optimizing the management of deceased organ donors focuses on providing critical care that prevents, mitigates, or repairs the pathophysiologic sequelae of brain death. This review discusses protocol-based care; approaches to monitoring, resuscitation, hormone replacement therapy, and respiratory management; and the potential of various additional donor therapies. RECENT FINDINGS: Protocol-based critical care after the determination of brain death has the potential to substantially increase the quantity and improve the quality of organs available for transplantation. Close hemodyna...
Source: Current Opinion in Organ Transplantation - May 17, 2019 Category: Transplant Surgery Authors: Patel MS, Abt PL Tags: Curr Opin Organ Transplant Source Type: research

Current practices in deceased organ donor management
Purpose of review Optimizing the management of deceased organ donors focuses on providing critical care that prevents, mitigates, or repairs the pathophysiologic sequelae of brain death. This review discusses protocol-based care; approaches to monitoring, resuscitation, hormone replacement therapy, and respiratory management; and the potential of various additional donor therapies. Recent findings Protocol-based critical care after the determination of brain death has the potential to substantially increase the quantity and improve the quality of organs available for transplantation. Close hemodynamic monitoring with ...
Source: Current Opinion in Organ Transplantation - May 16, 2019 Category: Surgery Tags: ETHICAL CONSIDERATIONS OF ALLOCATION: Edited by David A. Axelrod Source Type: research

Problem-patients in HRT
Since the Women's Health Initiative (WHI) has been stopped 2002 due to increased risk of venous thromboembolism, myocardial infarction, stroke and breast cancer, safety issues have got great concern using hormone replacement therapy (HRT). However, using lower dosages, other hormonal components and/or transdermal instead of oral application can reduce those risks although not demonstrated in a placebo-controlled study comparable to WHI. However, this has been shown in large case/control- and cohort-studies reflecting more practical conditions in contrast to WHI. (Source: Maturitas)
Source: Maturitas - May 14, 2019 Category: Primary Care Authors: Alfred O. Mueck Tags: INV65 Source Type: research

Herbal medicine - when to use and what to expect (beurteilung pflanzlicher pr äparate in der menopausentherapie)
With the publication of adverse effects of a hormone replacement therapy in 2002 the wish of many women for a more natural and safer treatment method increased rapidly. Soy, soy preparations and black cohosh/cimicifuga racemosa became the most popular herbal remedies for the relief of hot flushes. Until today only a few randomised trials were published about herbal medicine. The results regarding efficacy and safety are still conflicting, although in recent years more promising outcomes have emerged. (Source: Maturitas)
Source: Maturitas - May 14, 2019 Category: Primary Care Authors: Bruno Imthurn Tags: INV59 Source Type: research

HRT for young women with premature ovarian insufficiency
Premature ovarian insufficiency (POI) is a condition characterized by sex-steroid deficiency, amenorrhea, infertility and elevated gonadotropins in women younger than 40 years of age. Women with POI need exogenous sex steroids to compensate for the decreased production by their ovaries and for these young women hormone replacement therapy is “true replacement” of ovarian hormones. Optimal hormone therapy depends on whether the patient has primary or secondary amenorrhea. Young women with primary amenorrhea in whom secondary sex characteristics have failed to develop initially should be given very low doses of e...
Source: Maturitas - May 14, 2019 Category: Primary Care Authors: Sophia Kalantaridou Tags: INV48 Source Type: research

Sexuality after menopause
is a major component of health and well-being, although it is often neglected by both patients and health care providers. Sexual dysfunction appears early after menopause due to both vaginal dryness/dyspareunia and decreased libido, as an effect of hypoestrogenism in the periphery as well as in the central nervous system. Systemic (hormone replacement therapy) and topical estrogens (in the form of vaginal creams/gels) represent the main available therapeutic interventions. (Source: Maturitas)
Source: Maturitas - May 14, 2019 Category: Primary Care Authors: Neoklis Georgopoulos Tags: INV47 Source Type: research

Minimize risk with “natural” hormone replacement therapy?
To this discuss this topic the meaning of “natural” in hormone replacement therapy (HRT) needs to be defined. What is “natural” to the women that seek advice from their gynecologist? Biological products, derived directly from nature, are in general associated with fewer side effects, low or even no risks, but is this feeling evidenc e based? To advice our patients based on actual knowledge these issues are thoroughly reviewed and compared to synthetic treatment options with regard to breast cancer, endometrial cancer, cardiovascular events, diabetes and others. (Source: Maturitas)
Source: Maturitas - May 14, 2019 Category: Primary Care Authors: May Ziller Tags: P76 Source Type: research

Effect of complementary alternative medicine on menopausal symptoms, among rural women of South India
Objectives: Women experience varying physical and psychological symptoms as they transit through post-reproducitve phase of life or Menopause. The commonly recommended Hormone Replacement Therapy (HRT)2 is losing its popularity among midlife women due to associated risks and side-effects. Hence the objective of this study was to develop and investigate the effect of a Complementary Alternative Medicine (CAM)3, which was holistic in nature. (Source: Maturitas)
Source: Maturitas - May 14, 2019 Category: Primary Care Authors: Sonia Sunny Tags: P05 Source Type: research

Acquired generalized lipodystrophy under immune checkpoint inhibition.
This article is protected by copyright. All rights reserved. PMID: 31077337 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - May 11, 2019 Category: Dermatology Authors: Haddad N, Vidal-Trecan T, Baroudjian B, Zagdanski AM, Arangalage D, Battistella M, Gautier JF, Lebbe C, Delyon J, PATIO group Tags: Br J Dermatol Source Type: research

The exercise timing hypothesis - Can exercise training compensate for the reduction in blood vessel function after menopause if timed right?
This article is protected by copyright. All rights reserved. PMID: 31077368 [PubMed - as supplied by publisher] (Source: The Journal of Physiology)
Source: The Journal of Physiology - May 11, 2019 Category: Physiology Authors: Gliemann L, Hellsten Y Tags: J Physiol Source Type: research

Adverse Effects in Skeletal Muscle Following the Medicinal Use of Nicotiana glauca.
Abstract Nicotiana glauca is a cosmopolitan shrub, used in medicine to treat swellings, wounds, sores and cancer. However, its users lack of knowledge of the adverse effects. We seek to evaluate the effects of lipid extracts from N. glauca on myoblasts, identifying the compounds which cause undesirable effects. Myoblasts are important in muscle homeostasis, thus a high death rate of them cause myopathies. We performed an ethanolic extraction from leaves of N. glauca and the extract was successively partitioned with hexane, chloroform and ethyl acetate. The effects of extracts in C2C12 cells were analysed by termin...
Source: Biological and Pharmaceutical Bulletin - May 8, 2019 Category: Drugs & Pharmacology Authors: Musso F, Lincor D, Vasconsuelo A, Pronsato L, Faraoni B, Milanesi L Tags: Biol Pharm Bull Source Type: research

Effects of Bariatric Surgery in Male Obesity-Associated Hypogonadism
AbstractIntroductionThe prevalence of obesity has grown exponentially over the last several decades. Research has linked male obesity to changes in the gonadal axis, which can induce functional hypogonadism. Bariatric surgery provides sustained weight loss and metabolic improvement. This was a retrospective cohort study to evaluate the male gonadal axis and metabolic profiles of obese individuals during the bariatric pre- and post-operative periods while comparing them to a normal body mass index (BMI) group.MethodsTwenty-nine obese men, who underwent bariatric surgery between 2012 and 2016 at the Federal University of San...
Source: Obesity Surgery - May 7, 2019 Category: Surgery Source Type: research

Does estrogen deprivation affect pelvic floor muscle contractility?
ConclusionsEstrogen deprivation may not be an independent predictor of pelvic floor muscle contractility. (Source: International Urogynecology Journal)
Source: International Urogynecology Journal - May 4, 2019 Category: OBGYN Source Type: research

Review of Hormone Replacement Therapy in Girls and Adolescents with Hypogonadism
Girls with either hypo- or hypergonadotropic hypogonadism need treatment with estrogens to initiate puberty and maintain normal hormonal mileau. The focus of this review is hormone replacement treatment in girls with hypogonadism, both to initiate and progress through puberty, and to maintain healthy hormonal mileau in women. It also addresses what is known in the literature regarding estrogen levels in girls and women, instructive cases, practical tables for reference and application, and thoughts on future directions in this area. (Source: Journal of Pediatric and Adolescent Gynecology)
Source: Journal of Pediatric and Adolescent Gynecology - May 3, 2019 Category: OBGYN Authors: Karen O. Klein, Susan A. Phillips Source Type: research

Evaluation of gonadotropin-replacement therapy in male patients with hypogonadotropic hypogonadism.
This study aimed to analyze the efficacy of hormone replacement therapy and determine predictive factors for successful spermatogenesis and spontaneous pregnancy in patients with idiopathic HH. A total of 112 patients with low testosterone (T), luteinizing hormone (LH) and follicle-stimulating hormone (FSH), and normal prolactin levels were diagnosed with HH and administered LH and FSH analogs as hormone replacement therapy. During treatment, 96 (85.7%) patients had sperm present in ejaculate samples. Among these patients, 72 were married and wanted a child. Of these 72 patients, 48 (66.7%) of couples had pregnancies from ...
Source: Asian Journal of Andrology - May 3, 2019 Category: Urology & Nephrology Authors: Ortac M, Hidir M, Salabas E, Boyuk A, Bese C, Pazir Y, Kadioglu A Tags: Asian J Androl Source Type: research

The Current Evidence on the Association Between the Urinary Microbiome and Urinary Incontinence in Women
This study also found that Proteus DNA, a genus with many uropathogenic species (Drzewiecka, 2016), was more prevalent in women with OAB compared to asymptomatic controls (Curtiss et al., 2017). IC A recent study by Abernethy et al. suggested that the microbiome may play a role in IC (Abernethy et al., 2017). In this study, 16S rRNA analysis determined the microbiome of catheterized urine from women (n = 40) with IC was not dominated by a single genus and was less likely to contain Lactobacillus compared to asymptomatic women. Abernethy et al. also showed that L. acidophilus was associated with less severe scores on the ...
Source: Frontiers in cellular and infection microbiology - May 1, 2019 Category: Microbiology Source Type: research

Identifying a disease specific renin-angiotensin-aldosterone system fingerprint in patients with primary adrenal insufficiency.
s M Abstract BACKGROUND: In patients suffering from primary adrenal insufficiency (AI) mortality is increased despite adequate glucocorticoid (GC) and mineralocorticoid (MC) replacement therapy, mainly due to an increased cardiovascular risk. Since activation of the renin-angiotensin-aldosterone system (RAAS) plays an important role in the modulation of cardiovascular risk factors we performed in depth characterization of the RAAS activity. METHODS: 8 patients with primary AI (female=5;age:56±21years;BMI:22.8±2kg/m2;mean blood pressure:140/83mmHg; hydrocortisone dose:21.9±5mg/day; fludroc...
Source: European Journal of Endocrinology - May 1, 2019 Category: Endocrinology Authors: Wolf P, Mayr J, Beiglböck H, Fellinger P, Winhofer Y, Poglitsch M, Gessl A, Kautzky-Willer A, Luger A, Krebs M Tags: Eur J Endocrinol Source Type: research

Autoimmune Disease in Women: Endocrine Transition and Risk Across the Lifespan
Maunil K. Desai1 and Roberta Diaz Brinton2,3* 1School of Pharmacy, University of Southern California, Los Angeles, CA, United States 2Center for Innovation in Brain Science, University of Arizona, Tucson, AZ, United States 3Departments of Pharmacology and Neurology, College of Medicine, University of Arizona, Tucson, AZ, United States Women have a higher incidence and prevalence of autoimmune diseases than men, and 85% or more patients of multiple autoimmune diseases are female. Women undergo sweeping endocrinological changes at least twice during their lifetime, puberty and menopause, with many women undergoin...
Source: Frontiers in Endocrinology - April 29, 2019 Category: Endocrinology Source Type: research

New Causes of Hypophysitis
Publication date: Available online 26 April 2019Source: Best Practice & Research Clinical Endocrinology & MetabolismAuthor(s): Kevin C.J. Yuen, Vera Popovic, Peter J. TrainerAbstractHypophysitis is a rare entity characterized by inflammation of the pituitary gland and its stalk that can cause hypopituitarism and/or mass effect. Etiology can be categorized as primary or secondary to systemic disease, but may also be classified according to anatomical and hispathological criteria. Newly recognized causes of hypophysits have been recently described, mainly secondary to immunomodulatory medications and IgG4-related dis...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - April 27, 2019 Category: Endocrinology Source Type: research

Osteoporosis and Sarcopenia Increase Frailty Syndrome in the Elderly
Conclusions World population is aging and the increase in life expectancy is often unhealthy. In particular, musculoskeletal aging, which leads to sarcopenia and osteoporosis, has several causes such as changes in body composition, inflammation, and hormonal imbalance. Sarcopenia, osteoporosis, and more frequently, sarcopenic obesity are commonly associated with aging and frequently closely linked each other, often leading to the development of a frailty syndrome. Frailty syndrome favors an increased risk of loss function in daily activities, for cardiovascular diseases, cancers, falls, and mortality. As the number of eld...
Source: Frontiers in Endocrinology - April 24, 2019 Category: Endocrinology Source Type: research

Acupuncture May Reduce Menopausal Symptoms
A brief course of acupuncture may help ease menopausal symptoms and offer a treatment alternative to hormone replacement therapy, suggested astudy in BMJ Open. (Source: JAMA)
Source: JAMA - April 23, 2019 Category: General Medicine Source Type: research

GSE119497 XX sex chromosome complement promotes hyperlipidemia and atherosclerosis in mice
Contributors : Eric M Blalock ; Yasir AlSiraj ; Sean E Thatcher ; Ryan Temel ; Lei Cai ; Wendy Katz ; Heba M Ali ; Michael Petriello ; Andrew Morris ; Arthur P Arnold ; Karen Reue ; Patrick Tso ; Lisa CassisSeries Type : Expression profiling by arrayOrganism : Mus musculusIt is well recognized that men and women differ in circulating lipid profiles and consequently coronary artery disease (CAD). While sex hormones like estrogens are thought to protect women from CAD risk by promoting protective lipid profiles, hormone replacement therapy in women paradoxically increases CAD risk. Biological sex is determined by both sex ch...
Source: GEO: Gene Expression Omnibus - April 17, 2019 Category: Genetics & Stem Cells Tags: Expression profiling by array Mus musculus Source Type: research

Formulation and processability screening for the rational design of ethylene-vinyl acetate based intra-vaginal rings
Publication date: Available online 15 April 2019Source: International Journal of PharmaceuticsAuthor(s): I. Koutsamanis, S. Eder, M. Beretta, A. Witschnigg, A. Paudel, K. Nickisch, M. Friedrich, K. Eggenreich, E. RobleggAbstractThe application of ethylene-vinyl acetate (EVA) copolymers in reservoir-type intra-vaginal rings (IVRs) offers advantages over silicones including i) versatile properties, ii) absence of curing chemistry, and iii) continuous and flexible processing via co-extrusion. Thus, we investigated the capability of EVA based IVRs to deliver broad ranges of estradiol (E2) thereby, fulfilling the requirements o...
Source: International Journal of Pharmaceutics - April 17, 2019 Category: Drugs & Pharmacology Source Type: research

Functional survival of rat pituitary gland in hypothermic storage for pituitary transplantation
ConclusionsExtracted rat pituitary gland supplemented with special preservation solution could be preserved for 3  days under hypothermic condition. (Source: Pituitary)
Source: Pituitary - April 15, 2019 Category: Endocrinology Source Type: research

Tubal Remnant with Rectosigmoid Stricture in the Background of Endometriosis
A 49 year old surgically menopausal female on hormone replacement therapy presented to our clinic with persistent abdominal pain, pelvic pressure, nausea, and vomiting. She had history of severe endometriosis with prior total abdominal hysterectomy and bilateral salpingo-oophorectomy (BSO) performed at an outside facility. Significant bowel adhesions were encountered intra-operatively and the endometriosis was incompletely excised. A pelvic MRI at our institution demonstrated a nodular lesion in the sigmoid colon measuring 15  × 11mm impressing upon the wall of the colon resulting in luminal narrowing over a leng...
Source: The Journal of Minimally Invasive Gynecology - April 12, 2019 Category: OBGYN Authors: Mohammad Islam, Sadikah Behbehani, Paul Magtibay, Johnny Yi Tags: Original Article Source Type: research

Cardiovascular Programming During and After Diabetic Pregnancy: Role of Placental Dysfunction and IUGR
This study demonstrated that the incidence of ischemic heart disease and death were three times higher among men with low birth weight compared to men with high birth weight (5). Epidemiological investigations of adults born at the time of the Dutch famine between 1944 and 1945 revealed an association between maternal starvation and a low infant birth weight with a high incidence of hypertension and coronary heart disease in these adults (23). Furthermore, Painter et al. reported the incidence of early onset coronary heart disease among persons conceived during the Dutch famine (24). In that regard, Barker's findin...
Source: Frontiers in Endocrinology - April 9, 2019 Category: Endocrinology Source Type: research

Current practices in deceased organ donor management.
Abstract PURPOSE OF REVIEW: Optimizing the management of deceased organ donors focuses on providing critical care that prevents, mitigates, or repairs the pathophysiologic sequelae of brain death. This review discusses protocol-based care; approaches to monitoring, resuscitation, hormone replacement therapy, and respiratory management; and the potential of various additional donor therapies. RECENT FINDINGS: Protocol-based critical care after the determination of brain death has the potential to substantially increase the quantity and improve the quality of organs available for transplantation. Close hemodyna...
Source: Current Opinion in Organ Transplantation - April 5, 2019 Category: Transplant Surgery Authors: Patel MS, Abt PL Tags: Curr Opin Organ Transplant Source Type: research

HRT linked to increased Alzheimer ’s disease risk in women
Hormone replacement therapy is associated with a small but significantly increased risk of Alzheimer ’s disease, research published in The BMJ has found (Source: Clinical Pharmacist)
Source: Clinical Pharmacist - April 1, 2019 Category: Drugs & Pharmacology Source Type: research

Traumatic brain injury: neuropathological, neurocognitive and neurobehavioral sequelae
AbstractTraumatic brain injury (TBI) causes substantial neurological disabilities and mental distress. Annual TBI incidence is in magnitude of millions, making it a global health challenge. Categorization of TBI into severe, moderate and mild by scores on the Glasgow coma scale (GCS) is based on clinical grounds and standard brain imaging (CT). Recent research focused  on repeated mild TBI (sport and non-sport concussions) suggests that a considerable number of patients have long-term disabling neurocognitive and neurobehavioral sequelae. These relate to subtle neuronal injury (diffuse axonal injury) visible only by u...
Source: Pituitary - March 30, 2019 Category: Endocrinology Source Type: research

Hormone replacement therapy in brain-dead organ donors: a comprehensive review with an emphasis on traumatic brain injury
CONCLUSION Organ shortage remains a growing problem in the United States. Donor management including HRT has been proposed to combat the endocrine derangement associated with brain death and, in particular, TBI. While the existing literature reported compelling outcomes using HRT, there remains a need for further Level I and Level II evidence studies to define optimal practice. LEVEL OF EVIDENCE Review article, level IV. (Source: The Journal of Trauma: Injury, Infection, and Critical Care)
Source: The Journal of Trauma: Injury, Infection, and Critical Care - March 26, 2019 Category: Orthopaedics Tags: REVIEW ARTICLES Source Type: research

Isolated adrenocorticotropic hormone deficiency and thyroiditis associated with nivolumab therapy in a patient with advanced lung adenocarcinoma: a case report and review of the  literature
ConclusionsOur patient developed thyroiditis during cancer treatment with nivolumab and subsequently exhibited isolated adrenocorticotropic hormone deficiency 4  months after discontinuing the drug. Administration of nivolumab in combination with a genetic predisposition to polyglandular autoimmunity probably caused both the thyroiditis and hypophysitis, resulting in primary hypothyroidism and isolated adrenocorticotropic hormone deficiency, respectively, in our patient. The present case highlights the need for physicians to be aware that endocrine immune-related adverse events, including hypophysitis, can occur mor...
Source: Journal of Medical Case Reports - March 26, 2019 Category: General Medicine Source Type: research

Voiding Trial in Office after Unsuccessful Voiding Trial in Postoperative Unit: How Many More Days Is Enough?
Publication date: Available online 28 February 2019Source: Journal of Minimally Invasive GynecologyAuthor(s): Sadikah Behbehani, Tiffany Pham, Katie Kunze, Megan Wasson, Johnny YiABSTRACTStudy ObjectiveTo determine the incidence of a successful in-office voiding trial after minimally invasive hysterectomy.DesignA retrospective cohort study.SettingA tertiary care academic center.PatientsAll patients undergoing minimally invasive hysterectomies (vaginal, laparoscopic, or robotic) from January 2013 to July 2018 who have an unsuccessful voiding trial in the postoperative unit.InterventionsA voiding trial.Measurements and Main ...
Source: Journal of Minimally Invasive Gynecology - March 20, 2019 Category: OBGYN Source Type: research

Thyroid-stimulating hormone levels in the normal range and incident type 2 diabetes mellitus
ConclusionThere is no apparent relation between plasma TSH levels in the normal range and incident T2DM in patients at high cardiovascular risk. (Source: Acta Diabetologica)
Source: Acta Diabetologica - March 16, 2019 Category: Endocrinology Source Type: research

Successful treatment of myxedema coma with a combination of levothyroxine and liothyronine.
Authors: Ueda K, Kiyota A, Tsuchida M, Okazaki M, Ozaki N Abstract Myxedema coma is a rare endocrine emergency resulting from the decompensation of severe hypothyroidism, which is associated with a high mortality rate. It is characterized by the deterioration of mental status, hypothermia, hypotension, hyponatremia, and hypoventilation. Early disease diagnosis and advancements in intensive supportive care have reduced the mortality rate. Besides intensive supportive care, appropriate management of the underlying thyroid hormone deficiency is essential. However, as the disease is rare and unrecognized, evidence-base...
Source: Endocrine Journal - March 13, 2019 Category: Endocrinology Tags: Endocr J Source Type: research

Thyroidectomy Versus Medical Management for Euthyroid Patients With Hashimoto Disease and Persisting Symptoms: A Randomized Trial.
Conclusion: Total thyroidectomy improved health-related quality of life and fatigue, whereas medical therapy did not. This improvement, along with concomitant elimination of serum anti-TPO antibodies, may elucidate disease mechanisms. Primary Funding Source: Telemark Hospital. PMID: 30856652 [PubMed - as supplied by publisher] (Source: Annals of Internal Medicine)
Source: Annals of Internal Medicine - March 12, 2019 Category: Internal Medicine Authors: Guldvog I, Reitsma LC, Johnsen L, Lauzike A, Gibbs C, Carlsen E, Lende TH, Narvestad JK, Omdal R, Kvaløy JT, Hoff G, Bernklev T, Søiland H Tags: Ann Intern Med Source Type: research

Improvements in body composition after 4 years of growth hormone treatment in adult-onset hypopituitarism compared to age-matched controls.
Conclusion: Four years of GHRT resulted in improvements in BMI and waist circumference in patients with adult-onset hypopituitarism compared to age-matched controls observed during the same follow-up time. Despite these beneficial effects on body composition, BMI and waist circumference remained higher in patients on GHRT compared to healthy controls. (Source: Neuroendocrinology)
Source: Neuroendocrinology - March 8, 2019 Category: Endocrinology Source Type: research

Voiding trial in office after unsuccessful voiding trial in postoperative unit. How many more days is enough?
Publication date: Available online 28 February 2019Source: Journal of Minimally Invasive GynecologyAuthor(s): Sadikah Behbehani, Tiffany Pham, Katie Kunze, Megan Wasson, Johnny YiAbstractStudy ObjectiveDetermine the incidence of successful in-office voiding trial after minimally invasive hysterectomy.DesignRetrospective cohort studySettingTertiary care academic centerPatients or ParticipantsAll patients undergoing minimally invasive hysterectomies (vaginal, laparoscopic, or robotic) from January 2013 to July 2018 who have unsuccessful voiding trial in the post-operative unitInterventionsVoiding trialMeasurements and Main R...
Source: Journal of Minimally Invasive Gynecology - February 28, 2019 Category: OBGYN Source Type: research

Estrogen and voluntary exercise attenuate cardiometabolic syndrome and hepatic steatosis in ovariectomized rats fed a high-fat high-fructose diet.
Abstract The prevalence of cardiometabolic syndrome (CMS) is increased in women after menopause. While hormone replacement therapy has been prescribed to relieve several components of CMS in postmenopausal women, some aspects of cardiometabolic dysfunction cannot be completely restored. The present study examined the effectiveness of estrogen replacement alone and in combination with exercise by voluntary wheel running (VWR) for alleviating the risks of CMS, insulin-mediated skeletal muscle glucose transport and hepatic fat accumulation in ovariectomized Sprague-Dawley rats fed a high-fat high-fructose diet (OHFFD...
Source: Am J Physiol Endocri... - February 26, 2019 Category: Endocrinology Authors: Buniam J, Chukijrungroat N, Khamphaya T, Weerachayaphorn J, Saengsirisuwan V Tags: Am J Physiol Endocrinol Metab Source Type: research

[Differential diagnosis and treatment of pituitary adenomas].
Authors: Hlaváč M, Sommer F, Karpel-Massler G, Wirtz R, Hoffmann T, Paľa A Abstract Pituitary adenomas are among the most common primary brain tumors. These tumors can produce all hormones of the anterior pituitary and thus cause endocrine diseases. Compression of the pituitary gland, the surrounding cranial nerves, or brain structures can lead to hypopituitarism, cranial nerve deficits, or diverse neurological symptoms. Visual impairment, typically with bitemporal hemianopsia, is the most common cardinal symptom. The diagnostic workup requires broad interdisciplinary cooperation. With the exception of pro...
Source: HNO - February 24, 2019 Category: ENT & OMF Tags: HNO Source Type: research

Can wearing high heels influence anal canal pressure and the severity of fecal incontinence?
ConclusionsIn this retrospective cohort of women with fecal incontinence, no clinical or manometric differences were observed between women who wore high heels versus those who did not. Because there is limited knowledge on this potential link and because the pelvic tilt may vary according to age and the habit of walking with high heels, further studies are necessary. (Source: International Urogynecology Journal)
Source: International Urogynecology Journal - February 22, 2019 Category: OBGYN Source Type: research

Inflammatory hepatocellular adenoma in a patient with Turner’s syndrome: a case report
CONCLUSIONWith the use of the contraceptive pill as a long-term female hormone replacement therapy for Turner’s syndrome, careful attention is required for HCA. (Source: International Journal of Surgery Case Reports)
Source: International Journal of Surgery Case Reports - February 16, 2019 Category: Surgery Source Type: research

Pituitary-directed medical treatment of Cushing's disease.
Authors: Arnaldi G, Cardinaletti M, Trementino L, Tirabassi G, Boscaro M Abstract The treatment of Cushing's disease is very complex and represents a challenge for clinicians. Transphenoidal surgical excision of adrenocorticotropic hormone (ACTH)-secreting pituitary adenoma remains the treatment of choice but, unfortunately, the rate of cure at long-term follow-up is suboptimal and recurrences are high, even in the hands of skilled neurosurgeons. Other treatment options, such as bilateral adrenalectomy and pituitary radiotherapy, are currently in use but no treatment has proven fully satisfactory during the lengthy...
Source: Expert Review of Endocrinology and Metabolism - February 15, 2019 Category: Endocrinology Tags: Expert Rev Endocrinol Metab Source Type: research

Management of the brain-dead donor in the ICU: general and specific therapy to improve transplantable organ quality
AbstractPurposeTo provide a practical overview of the management of the potential organ donor in the intensive care unit.MethodsSeven areas of donor management were considered for this review: hemodynamic management; fluids and electrolytes; respiratory management; endocrine management; temperature management; anaemia and coagulation; infection management. For each subchapter, a narrative review was conducted.Results and conclusionsMost elements in the current recommendations and guidelines are based on pathophysiological reasoning, epidemiological observations, or extrapolations from general ICU management strategies, and...
Source: Intensive Care Medicine - February 11, 2019 Category: Intensive Care Source Type: research

Predictors of Initiating Hormone Replacement Therapy in Postmenopausal Women: A Cross-Sectional Study.
Conclusion: This study suggests that although the results do not demonstrate an exhaustive list of factors affecting the HRT process, they nonetheless provide evidence that the location participants applied for, physicians' counselling and involvement, participant employment status, and knowledge surrounding HRT may affect a woman's intent to receive HRT. Therefore, these results indicate that health professional influence and HRT awareness are important for HRT use. Suggestions for health care include informing women of the advantages and disadvantages of HRT to encourage popularity. PMID: 30728754 [PubMed - in proces...
Source: The Scientific World Journal - February 10, 2019 Category: Science Tags: ScientificWorldJournal Source Type: research

Effects of Lespedeza Cuneata aqueous extract on testosterone-induced prostatic hyperplasia.
CONCLUSIONS: Based on the results, LCW is a potential pharmacological candidate for the treatment of prostatic hyperplasia. PMID: 30724641 [PubMed - in process] (Source: Pharmaceutical Biology)
Source: Pharmaceutical Biology - February 8, 2019 Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research

Thrombotic and hemorrhagic burden in women: Gender-related issues in the response to antithrombotic therapies
Thrombotic and bleeding risks, as well as the incidence and presentation of cardiovascular events and related outcomes, appear to differ between genders, partly in relation to variability in age, comorbidities and body size.Women experience frequent fluctuations of pro-thrombotic activity during their lifetime, related to menstrual cycles, the use of oral contraceptives, pregnancy, menopause, and hormone replacement therapy, all with potential impact on the clinical manifestations of atherosclerotic disease. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - February 8, 2019 Category: Cardiology Authors: Giulia Renda, Giuseppe Patti, Irene Marthe Lang, Jolanta M. Siller-Matula, Elaine M. Hylek, Giuseppe Ambrosio, Sylvia Haas, Raffaele De Caterina, Working Group on Thrombosis of the Italian Society of Cardiology Tags: Review Source Type: research

Efficacy of a Homeopathic Medicine of Capsicum frutescens L. (Solanaceae) in the Treatment of Hot Flashes in Menopausal Women: A Phase-2 Randomized Controlled Trial.
Abstract BACKGROUND:  Hot flashes are common in women during menopause, and are an important cause of discomfort, increasing the number of medical appointments. Hormone replacement therapy is an effective treatment, but it can bring undesirable consequences. Alternative treatments exist but they are not universally accepted or effective. The ingestion of malagueta peppers (popular name for fruits of Capsicum frutescens L., Solanaceae) causes sensations similar to those experienced by women during hot flashes. Using the homeopathic law of similars (let like be cured by like), we hypothesized that a homeopathic...
Source: Homeopathy - February 8, 2019 Category: Complementary Medicine Authors: Andrade DCDS, Carmona F, Angelucci MA, Martinez EZ, Pereira AMS Tags: Homeopathy Source Type: research

Climacteric status at the age of 46: impact on metabolic outcomes in population-based study.
mäki M Abstract Context: Menopausal transition is associated with increased cardiovascular risks. Available data on the effect of earlier climacterium on these risks is limited. Objective: To compare cardiovascular risk-associated parameters at the ages of 14, 31 and 46 in relation to climacteric status at the age of 46. Design, Setting and Participants: A prospective cohort study including 2685 women from the Northern Finland Birth Cohort 1966. Main Outcome Measures: Follicle-stimulating hormone (FSH), body mass index (BMI), waist circumference, waist-to-hip ratio (WHR), blood pressure (BP), b...
Source: The Journal of Clinical Endocrinology and Metabolism - February 8, 2019 Category: Endocrinology Authors: Susanna S, Mäkelä H, Auvinen J, Jokelainen J, Puukka K, Ebeling T, Suvanto E, Niinimäki M Tags: J Clin Endocrinol Metab Source Type: research

Estradiol Replacement Timing and Obesogenic Diet Effects on Body Composition and Metabolism in Post-menopausal Macaques.
In this study, we determined the effects of immediate E (ImE) or delayed E treatment on weight and metabolism parameters in old ovo-hysterectomized rhesus macaques consuming a WSD over a 30-month period. The placebo and ImE groups exhibited progressive gains in weight and fat mass, which ImE initially attenuated but did not prevent. Progression of insulin resistance was lessened by ImE compared to placebo under both fasting and IV glucose-stimulated conditions, plateauing in all groups between 24 and 30 months. Consequently, relative euglycemia was maintained through lower stimulated insulin levels with ImE than with place...
Source: Endocrinology - February 7, 2019 Category: Endocrinology Authors: Purnell JQ, Urbanski HF, Kievit P, Roberts CT, Bethea CL Tags: Endocrinology Source Type: research

Two Chinese Xia ‐Gibbs syndrome patients with partial growth hormone deficiency
ConclusionThis is the first report of Xia ‐Gibbs syndrome patients to be treated with growth hormone. Review of previously reported Xia‐Gibbs syndrome patient indicated that short stature is a frequent feature of this condition, but its underlying cause needs to be further investigated. (Source: Molecular Genetics & Genomic Medicine)
Source: Molecular Genetics & Genomic Medicine - February 6, 2019 Category: Genetics & Stem Cells Authors: Xinran Cheng, Fang Tang, Xuyun Hu, Hongduo Li, Mengting Li, Yiyong Fu, Li Yan, Zhonghui Li, Peng Gou, Na Su, Chunzhu Gong, Weilan He, Rong Xiang, Dongmei Bu, Yiping Shen Tags: CLINICAL REPORT Source Type: research