Challenges and Opportunities in Adolescent Gynecology Patients with Surgically-Treated Congenital and Acquired Anomalies: Transition of Care from Pediatric to Adult Surgery
The transition from adolescence to young adulthood in patients with reproductive health care needs such as disorders of sexual development (DSDs) and congenital anomalies is a complex process occurring over several years. The transition process for these patients has is still poorly understood. The patients with DSDs and reproductive issues have specific and unique issues regarding timing of disclosure of diagnosis, genital examinations, gonadectomy, vaginal treatments, surgical procedures hormone replacement therapy, use of long term medication and potential cancer screening. (Source: Journal of Pediatric and Adolescent Gynecology)
Source: Journal of Pediatric and Adolescent Gynecology - December 5, 2018 Category: OBGYN Authors: S Paige Hertweck, David H. Rothstein Source Type: research

Maternal use of thyroid hormone replacement therapy before, during, and after pregnancy: agreement between self-report and prescription records and group-based trajectory modeling of prescription patterns
(Source: Clinical Epidemiology)
Source: Clinical Epidemiology - December 3, 2018 Category: Epidemiology Tags: Clinical Epidemiology Source Type: research

A Double-Blind Randomized Pilot Study Evaluating the Safety and Efficacy of Topical MEP in the Facial Appearance Improvement of Estrogen Deficient Females
Authors: Draelos ZD Abstract Facial skin aging is accelerated in postmenopausal females due to decreased collagen, reduced hydration, and loss of skin elasticity constituting the characteristics of estrogen deficient skin (EDS). The presence of estrogen receptors on dermal fibroblasts and epidermal keratinocytes confirms the role of estrogen in skin health. This research examined the efficacy and tolerability of topical methyl estradiolpropanoate (MEP) as an anti-aging cosmeceutical with estrogen like cutaneous effects in postmenopausal women who had never taken hormone replacement therapy (HRT). MEP was applied to...
Source: Journal of Drugs in Dermatology - December 1, 2018 Category: Dermatology Tags: J Drugs Dermatol Source Type: research

Neurokinin 3 receptor antagonism – a novel treatment for menopausal hot flushes
Menopause is associated with significant symptomatic burden, with approximately two thirds of post menopausal women suffering from vasomotor symptoms, hot flushes and night sweats. The mainstay of treatment for hot flushes continues to be hormone replacement therapy. However, as HRT is contraindicated in some cases, alternative, efficacious treatment options are also required. Hot flushes are thought to arise as a result of significant changes in the neuroendocrine circuitry underpinning the reproductive axis during menopause. This includes reduced circulating ovarian estrogens, hypersecretion of gonadotropins and increase...
Source: Neuroendocrinology - November 30, 2018 Category: Endocrinology Source Type: research

“When you hear hoofbeats, think of horses not zebras”: a case of bladder endometriosis in menopause
We report a case of a rectal-vaginal mass found during a routine pelvic exam in a 60-years-old asymptomatic menopausal woman, with no history of hormone replacement therapy, chronic pelvic pain, infertility or previous gynecological surgery. (Source: The Journal of Minimally Invasive Gynecology)
Source: The Journal of Minimally Invasive Gynecology - November 30, 2018 Category: OBGYN Authors: E Solima, I Pino, G Scagnelli, D Biasoni, M Vignali Tags: IMAGES IN Gynecological Surgery Source Type: research

No 366 - Prise en charge gyn écologique du cancer du sein et de l'ovaire héréditaire.
No 366 - Prise en charge gynécologique du cancer du sein et de l'ovaire héréditaire. J Obstet Gynaecol Can. 2018 Nov;40(11):1511-1527 Authors: Jacobson M, Bernardini M, Sobel ML, Kim RH, McCuaig J, Allen L Abstract OBJECTIF: La présente opinion de comité énumère les recommandations pour la prise en charge gynécologique des femmes ayant reçu un diagnostic de syndrome du cancer du sein et de l'ovaire héréditaire (CSOH) en ce qui a trait au dépistage, à la contraception, à la chimioprophylaxie, aux facteurs &...
Source: Journal of Obstetrics and Gynaecology Canada : JOGC - November 27, 2018 Category: OBGYN Tags: J Obstet Gynaecol Can Source Type: research

No. 366-Gynaecologic Management of Hereditary Breast and Ovarian Cancer.
Authors: Jacobson M, Bernardini M, Sobel ML, Kim RH, McCuaig J, Allen L Abstract OBJECTIVE: This Committee Opinion outlines the gynaecologic management recommendations for women diagnosed with hereditary breast and ovarian cancer syndrome (HBOC) with respect to screening, contraception, chemoprophylaxis, fertility considerations, risk-reducing surgery, and post-oophorectomy care. INTENDED USERS: This Committee Opinion is designed for gynaecologic oncologists, general gynaecologists, family physicians, genetic counsellors, registered nurses, nurse practitioners, residents, and health care providers. TARGET P...
Source: Journal of Obstetrics and Gynaecology Canada : JOGC - November 27, 2018 Category: OBGYN Tags: J Obstet Gynaecol Can Source Type: research

Enlargement of Langerhans cell histiocytosis of the hypothalamus with progression into the basal ganglia and white matter.
Conclusions: Definitive histopathological diagnosis and subsequent appropriate therapy, such as steroid administration, are required when LCH lesions in the hypothalamus become progressively enlarged and new lesions appear in the brain parenchyma. PMID: 30450262 [PubMed] (Source: Surgical Neurology International)
Source: Surgical Neurology International - November 21, 2018 Category: Neurosurgery Tags: Surg Neurol Int Source Type: research

Sex differences in the vascular function and related mechanisms: role of 17 β-estradiol.
Sex differences in the vascular function and related mechanisms: role of 17β-estradiol. Am J Physiol Heart Circ Physiol. 2018 Dec 01;315(6):H1499-H1518 Authors: Pabbidi MR, Kuppusamy M, Didion SP, Sanapureddy P, Reed JT, Sontakke SP Abstract The incidence of cardiovascular disease (CVD) is lower in premenopausal women but increases with age and menopause compared with similarly aged men. Based on the prevalence of CVD in postmenopausal women, sex hormone-dependent mechanisms have been postulated to be the primary factors responsible for the protection from CVD in premenopausal women. Recent Women...
Source: American Journal of Physiology. Heart and Circulatory Physiology - November 20, 2018 Category: Physiology Authors: Pabbidi MR, Kuppusamy M, Didion SP, Sanapureddy P, Reed JT, Sontakke SP Tags: Am J Physiol Heart Circ Physiol Source Type: research

Hypothyroidism is associated with worse outcomes of hepatocellular carcinoma patients after liver transplantation
ConclusionHypothyroidism is associated with poorer overall and recurrence ‐free survival of HCC patients receiving liver transplantation. These results require validation. (Source: Cancer Medicine)
Source: Cancer Medicine - November 19, 2018 Category: Cancer & Oncology Authors: Ning Zhang, Weidong Jin, Shuangnan Zhou, Ju Dong Yang, William S. Harmsen, Nasra H. Giama, Nicha Wongjarupong, Julie K. Heimbach, Kymberly D. Watt, Harmeet Malhi, Terry M. Therneau, Lewis R. Roberts Tags: ORIGINAL RESEARCH Source Type: research

Reproductive factors, obesity and risk of colorectal cancer in a cohort of Asian women
ConclusionsObesity is positively associated with CC but not RC, and abdominal obesity exerts an independent effect. Reproductive factors had at best a weak effect on CC and RC. (Source: Cancer Epidemiology)
Source: Cancer Epidemiology - November 16, 2018 Category: Cancer & Oncology Source Type: research

Estrogen receptor-alpha (ESR1) polymorphism rs1999805 associates with asthma
As adults, women have higher rates of asthma and allergic disease as well as increased asthma severity compared to men.1 Pre or peri-menstrual worsening of asthma symptoms (PMA) were reported in 17% of women enrolled in the severe asthma research program, with 52% of these women with PMA having severe asthma.2, 3 Further, use of birth control medications or hormone replacement therapy during peri or post-menopause was also linked to worsening of asthma in some women.2, 4 Mouse models of asthma showed estrogen signaling through estrogen receptor-alpha (ER- α), and not ER-β, increased allergic airway inflammation,...
Source: Annals of Allergy, Asthma and Immunology - November 15, 2018 Category: Allergy & Immunology Authors: Melissa H. Bloodworth, Mark Rusznak, Lisa Bastarache, Janey Wang, Dawn C. Newcomb Tags: Letters Source Type: research

Computerized hybrid decision-making system for hormone replacement therapy in menopausal women.
CONCLUSIONS: We have developed a computerized hybrid decision-making system recommending HRT to peri- and post-menopausal women in order to assist and protect physicians. PMID: 30475776 [PubMed - as supplied by publisher] (Source: Technology and Health Care)
Source: Technology and Health Care - November 13, 2018 Category: Medical Devices Authors: Bacak HO, Leblebicioglu K, Tanacan A, Sinan Beksac M Tags: Technol Health Care Source Type: research

Effect of GnRHa on Th17/Treg cells in peripheral blood of patients with unexplained repeated implantation failure
ConclusionThere were an increase and a decrease in the number of Th17 and Treg cells, respectively, with Th17/Treg cells imbalanced in unexplained RIF. GnRHa downregulation may play a direct immunomodulatory role in disrupting the imbalance and then improve the endometrial receptivity. These effects did not depend on the E2 levels in peripheral blood, nor affect early embryonic development. (Source: Archives of Gynecology and Obstetrics)
Source: Archives of Gynecology and Obstetrics - November 12, 2018 Category: OBGYN Source Type: research

Sesquiterpenes from Cyperus rotundus and 4α,5α-oxidoeudesm-11-en-3-one as a potential selective estrogen receptor modulator
Publication date: January 2019Source: Biomedicine & Pharmacotherapy, Volume 109Author(s): Yong Joo Park, Hailing Zheng, Jong Hwan Kwak, Kyu Hyuck ChungAbstractEstrogenic activity-oriented fractionation and purification of methanol extract from the rhizome of Cyperus rotundus, a well-known traditional herbal medicine, led to the isolation of six sesquiterpenes. 4α,5α-Oxidoeudesm-11-en-3-one (2) and cyper-11-ene-3,4-dione (3) together with four known sesquiterpenes, cyperotundone (1), caryophyllene α-oxide (4), α-cyperone (5), and isocyperol (6) were obtained from the hexane and dichloromethane fr...
Source: Biomedicine and Pharmacotherapy - November 11, 2018 Category: Drugs & Pharmacology Source Type: research

Natural cycle versus hormone replacement therapy cycle in frozen-thawed embryo transfer.
Conclusion: This study showed no difference between the implantation rate, clinical pregnancy rate or live birth rate between the natural cycle group and HRT cycle group. These results may provide clinicians with more freedom to individualize patient treatment, particularly with respect to the selection of the endometrial preparation method, if these results are supported by large randomized controlled studies in the future. PMID: 30397709 [PubMed - in process] (Source: Saudi Medical Journal)
Source: Saudi Medical Journal - November 8, 2018 Category: Middle East Health Tags: Saudi Med J Source Type: research

Sodium Restriction in Heart Failure: Too Much Uncertainty
We have long treated the dictum to restrict sodium intake in heart failure as a pillar of best practices and a sacrosanct edict that populates the core database for all physicians treating cardiovascular disease. Guidelines have mandated empirical thresholds that are to be respected, and consensus statements from leading organizations further make the case for sodium restriction as a basic tenet of good cardiovascular care. However, like many other dogmatic statements that were fully embedded in cardiovascular medicine —for example, suppression of premature ventricular contractions, avoidance of β-blockers in le...
Source: JAMA Internal Medicine - November 5, 2018 Category: Internal Medicine Source Type: research

Differences in menopausal symptoms and coping strategies according to personality in Japanese nurses.
In conclusion, there were differences in the menopausal symptoms and coping strategies between the nurses who had a type A personality and the nurses who had a non-type A personality. Impact statement What is already known on this subject? Menopausal symptoms have been shown to be affected by lifestyle and by socioeconomic status as well as oestrogen deficiency, but there have been few studies on the associations of personality with menopausal symptoms and coping with the menopausal symptoms. The type A personality is associated with a greater risk for the development of several diseases. However, the association of a type...
Source: Journal of Obstetrics and Gynaecology - October 30, 2018 Category: OBGYN Tags: J Obstet Gynaecol Source Type: research

NAMS-gallup survey on women's knowledge, information sources, and attitudes to menopause and hormone replacement therapy
The North American Menopause Society (NAMS) sponsored a Gallup Organization survey of 833 women aged 45-60 to determine attitudes and experience with menopause and various forms of hormone replacement therapy (HRT). The results of this survey are presented herein. (Source: Menopause)
Source: Menopause - October 25, 2018 Category: OBGYN Tags: Commemorative Papers Source Type: research

Progestin enhances vasoconstrictor responses in postmenopausal women receiving estrogen replacement therapy
Clinical and experimental evidence suggests that the cardioprotective effect of estrogen replacement is due to effects both on scrum lipids and on blood vessels. Current practice includes the use of a progestin in combination with estrogen if the patient still has her uterus: however, little is known about the effects of combination therapy on vascular reactivity. We therefore studied the effects of estrogen alone and with added progestin on forearm vascular resistance at rest, during reactive hyperemia, and after cold pressor stimulation using plethysmography in six healthy, postmenopausal women. Measurements were made be...
Source: Menopause - October 25, 2018 Category: OBGYN Tags: Commemorative Papers Source Type: research

Continuation of postmenopausal hormone replacement therapy: comparison of cyclic versus continuous combined schedules
Discontinuation of hormone replacement therapy (HRT) is much more common than what is reported in randomized, double-blind clinical trials. Our purpose in this retrospective study, using a prescription database, was to compare the continuation rate among women who took cyclic combination therapy adding progesterone to estrogen (CYC-PERT) or continuous combined estrogen progestin therapy (CC-PERT). The study subjects were 1,532 women, ≥45 years old, who initially filled index prescriptions for 0.625 mg conjugated estrogens. They were divided into two groups (CYC-PERT = 644, CC-PERT = 888) on the basis of copres...
Source: Menopause - October 25, 2018 Category: OBGYN Tags: Commemorative Papers Source Type: research

Breast cancer risk among women under 55 years of age by joint effects of usage of oral contraceptives and hormone replacement therapy
Conclusions: Although our results must be cautiously interpreted given small numbers within subgroups, they raise concern and emphasize the need for further evaluation on breast cancer risk of the increasingly common exposure to both oral contraceptives and hormone replacement therapy. (Source: Menopause)
Source: Menopause - October 25, 2018 Category: OBGYN Tags: Commemorative Papers Source Type: research

Comparison of the antioxidant effects of equine estrogens, red wine components, vitamin E, and probucol on low-density lipoprotein oxidation in postmenopausal women
Objective: Oxidized low-density lipoprotein (LDL) seems to play an important role in the etiology of atherosclerosis. To further study this, we performed two studies: (1) we determined the ability of 10 estrogen components of the drug, conjugated equine estrogen (CEE), trans-resveratrol (t-resveratrol) and quercetin (red wine components), trolox (vitamin E analog), and probucol (a serum cholesterol-lowering drug) to delay or prevent the oxidation of plasma LDL isolated from untreated postmenopausal women, and (2) we assessed the effect of long-term (>1 year) estrogen replacement therapy and hormone replacement therapy...
Source: Menopause - October 25, 2018 Category: OBGYN Tags: Commemorative Papers Source Type: research

Identification of Primary Medication Concerns Regarding Thyroid Hormone Replacement Therapy From Online Patient Medication Reviews: Text Mining of Social Network Data
Conclusions: Natural language processing of text content available on social media could identify different themes of patient medication concerns that can be validated in future studies to inform the design of tailored medication counseling for improved patient treatment satisfaction. (Source: Journal of Medical Internet Research)
Source: Journal of Medical Internet Research - October 24, 2018 Category: General Medicine Authors: So Hyun Park Song Hee Hong Source Type: research

Active Endometriosis in Postmenopausal Women: A Descriptive Case-Series
Objective: To identify a cohort of postmenopausal women with histologically confirmed endometriosis and to characterize them based on age, body mass index (BMI), age of menopause, anatomic location of lesions, use of hormone replacement therapy (HRT) and narcotics. (Source: The Journal of Minimally Invasive Gynecology)
Source: The Journal of Minimally Invasive Gynecology - October 22, 2018 Category: OBGYN Authors: S. Radtke, E. Scarbrough, J. Holcombe, N. Gupta, R. Furr Source Type: research

Hysteroscopic Endometrial Resection for Diagnosis and Treatment of Postmenopausal Bleeding in Women with and without Hormone Replacement Therapy
Objective: Postmenopausal bleeding (PMB), is associated with 5%-10% of endometrial cancer (EC) and/or atypical hyperplasia (AH). Office endometrial sampling fails in 11%, is inadequate in 31% and in 7% of women EC/AH is identified. Our objective was to determine the role of hysteroscopic endometrial resection (HER) for diagnosis and treatment of PMB in women with/without hormone replacement therapy (HRT). (Source: The Journal of Minimally Invasive Gynecology)
Source: The Journal of Minimally Invasive Gynecology - October 22, 2018 Category: OBGYN Authors: R. Aljasser, A. Vilos, A. Oraif, B. Abu-Rafea, G. Vilos Source Type: research

Emerging Research on the Implications of Hormone Replacement Therapy on Coronary Heart Disease
AbstractPurpose of ReviewCardiovascular disease (CVD) is known to be an increasing cause of mortality among women, particularly postmenopausal women. Hormone replacement therapy (HRT) is a topic that has been investigated over the past decade for its known impact on the cardiovascular system. This review summarizes the evidence and current opinion on the associations between HRT and CVD, evidence both supporting and against HRT use as a prevention to the development of coronary heart disease (CHD).Recent FindingsThe majority of the new data available suggests the use of HRT has the potential to be more beneficial in the pr...
Source: Current Atherosclerosis Reports - October 22, 2018 Category: Cardiology Source Type: research

Metabolic responses to walking in children with Prader ‐Willi syndrome on growth hormone replacement therapy
American Journal of Medical Genetics Part A, EarlyView. (Source: American Journal of Medical Genetics Part A)
Source: American Journal of Medical Genetics Part A - October 22, 2018 Category: Genetics & Stem Cells Authors: Adam M. Hyde, Frank A. Chavoya, Fabiano V. Silveira, William C. Beam, Daniela A. Rubin Source Type: research

Screening breast magnetic resonance imaging in women with hormone replacement therapy
The objective of this study was to compare the performance of screening mammography versus magnetic resonance imaging (MRI) in hormone replacement therapy (HRT) users.MethodsWe performed a retrospective review of 4628 women who had mammography or breast MRI screening from the beginning of HRT use at three institutions from April 2005 to December 2015. Information of demographics, number of biopsies performed and pathologic outcomes were collected. Sensitivity, specificity, negative predictive value (NPV) and positive predictive value (PPV) of screening mammography and MRI were compared.ResultsTotally 11,540 screening studi...
Source: European Journal of Medical Research - October 20, 2018 Category: Research Source Type: research

Comparative Efficacy of Alendronate upon Vertebral Bone Mineral Density and Fracture Rates in East Asians Versus Non-East Asians with Postmenopausal Osteoporosis: A Systematic Review and Meta-Analysis
Horm Metab Res 2018; 50: 738-746 DOI: 10.1055/a-0741-8300Bisphosphonates, such as alendronate, have become the most widely used and effective anti-resorptive therapy for postmenopausal osteoporosis. Previous genetic studies suggest that ethnicity may drive differing responses to bisphosphonate therapy in East Asians and non-East Asians. Therefore, the aim of this study was to comparatively evaluate the efficacy of alendronate upon lumbar spinal BMD and vertebral fracture rates in East Asians and non-East Asians with postmenopausal osteoporosis. MEDLINE, EMBASE, and Cochrane CENTRAL were searched for relevant randomized con...
Source: Hormone and Metabolic Research - October 12, 2018 Category: Endocrinology Authors: Wang, Yexin Jia, Gongwei Song, Jin Kong, Xiangqing Zhang, Weihong Meng, Chunyang Tags: Endocrine Care Source Type: research

Beyond contraception and hormone replacement therapy: advancing Nestorone to a neuroprotective drug in the clinic.
Abstract Neurological diseases such as ischemic stroke can be debilitating and have limited treatments available. The progestin Nestorone® (segesterone acetate) has been evaluated for use in birth control and hormone replacement therapy due to its potency and high affinity for the progesterone receptor. Interestingly, Nestorone also exerts neuroprotection in animals afflicted with various central nervous system diseases, including stroke, which implicates its potential for treating these maladies in clinical settings. In fact, a recent Brain Research paper by Tanaka and colleagues demonstrates Nestorone's abil...
Source: Brain Research - October 12, 2018 Category: Neurology Authors: Tuazon JP, Sitruk-Ware R, Borlongan CV Tags: Brain Res Source Type: research

Effects of the experimental administration of oral estrogen on prefrontal functions in healthy young women
Abstract17-Beta-estradiol (E2) stimulates neural plasticity and dopaminergic transmission in the prefrontal cortex, which is critically involved in attentional control, working memory, and other executive functions. Studies investigating E2 ’s actions on prefrontally mediated behavior in the course of the menstrual cycle or during hormone replacement therapy are inconclusive, with numerous null findings as well as beneficial and detrimental effects. The current study focused on the effect of E2 on attentional performance, as animal studies indicate that supraphysiological doses (i.e., above estrous cycle levels)...
Source: Psychopharmacology - October 10, 2018 Category: Psychiatry Source Type: research

Human versus non-human sex steroid use in hormone replacement therapies part 1: Preclinical data
Publication date: Available online 9 October 2018Source: Molecular and Cellular EndocrinologyAuthor(s): Craig S. Atwood, Samuel F. EksteinAbstractPrior to 2002, hormone replacement therapy (HRT) was considered to be an important component of postmenopausal healthcare. This was based on a plethora of basic, epidemiological and clinical studies demonstrating the health benefits of supplementation with human sex steroids. However, adverse findings from the Women's Health Initiative (WHI) studies that examined the 2 major forms of HRT in use in the US at that time - Premarin (conjugated equine estrogens; CEE) and Prempro (CEE&...
Source: Molecular and Cellular Endocrinology - October 9, 2018 Category: Endocrinology Source Type: research

Prospective Study of Endogenous Hormones and Incidence of Venous Thromboembolism: The Atherosclerosis Risk in Communities Study.
This study does not support the existence of an important association between plasma concentrations of endogenous testosterone, DHEAS or SHBG with risk of VTE in middle-aged to older men or post-menopausal women not using HRT. PMID: 30296818 [PubMed - as supplied by publisher] (Source: Thrombosis and Haemostasis)
Source: Thrombosis and Haemostasis - October 8, 2018 Category: Hematology Authors: Roetker NS, MacLehose RF, Hoogeveen RC, Ballantyne CM, Basu S, Cushman M, Folsom AR Tags: Thromb Haemost Source Type: research

Progesterone levels on pregnancy test day after hormone replacement therapy-cryopreserved embryo transfer cycles and related reproductive outcomes
Publication date: Available online 6 October 2018Source: Reproductive BioMedicine OnlineAuthor(s): Birgit Alsbjerg, Lise Thomsen, Helle O Elbaek, Rita Laursen, Betina B Povlsen, Thor Haahr, Peter HumaidanAbstract Research question: Do serum progesterone levels determine ongoing pregnancy rates (OPR) in hormone replacement therapy frozen–thawed embryo transfer (HRT–FET) cycles?Design: A cohort study of 244 HRT–FET cycles from a Danish public fertility centre. Data from patients undergoing HRT–FET from January 2016 to December 2017 were extracted from a clinical database. All patients had transfer in ...
Source: Reproductive BioMedicine Online - October 6, 2018 Category: Reproduction Medicine Source Type: research

Diet and Lifestyle Role in Homocysteine Metabolism in Turner ’s Syndrome.
Conclusion: Cardiovascular risk in Turner syndrome can be reduced using educational approaches to a healthy lifestyle with dietary guidelines. Besides this, we also recommend measuring HoloTC for the prompt detection of B12 defi ciency and to consider hormone replacement therapy in the biochemical assessment of homocysteine in TS. (Source: Medical Principles and Practice)
Source: Medical Principles and Practice - October 5, 2018 Category: Internal Medicine Source Type: research

Asymptomatic Complicated Cysts in Postmenopausal Women: Is Tissue Sampling Unnecessarily High?
ConclusionThis study supports the use of a probably benign assessment of asymptomatic complicated cysts irrespective of age. The sensitivity for malignancy was 100% in our cohort. (Source: Academic Radiology)
Source: Academic Radiology - October 5, 2018 Category: Radiology Source Type: research

Access to Nutrition Counseling for Transgender Individuals on Hormone Replacement Therapy
Publication date: October 2018Source: Journal of the Academy of Nutrition and Dietetics, Volume 118, Issue 10Author(s): S. Zellers, R. Williams-Hooker, M. Levy, W. Maxey-Trotter (Source: Journal of the Academy of Nutrition and Dietetics)
Source: Journal of the Academy of Nutrition and Dietetics - October 5, 2018 Category: Nutrition Source Type: research

Japan Society of Gynecologic Oncology guidelines 2017 for the treatment of uterine cervical cancer
AbstractThe Japan Society of Gynecologic Oncology (JSGO) Guidelines 2017 for the Treatment of Uterine Cervical Cancer are for the purpose of providing standard treatment strategies for cervical cancer, indicating treatment methods currently considered appropriate for cervical cancer, minimizing variances in treatment methods among institutions, improving the safety of treatment and prognosis of diseases, reducing the economic and psychosomatic burden of patients by promoting performance of appropriate treatment, and enhancing mutual understanding between patients and healthcare professionals. The guidelines were prepared t...
Source: International Journal of Clinical Oncology - October 5, 2018 Category: Cancer & Oncology Source Type: research

Hormone replacement therapy after prophylactic risk-reducing salpingo-oophorectomy and breast cancer risk in BRCA1 and BRCA2 mutation carriers: a meta-analysis
Mutations in DNA repair pathways, including breast-cancer susceptibility gene 1 (BRCA1) and breast-cancer susceptibility gene 2 (BRCA2) mutation carries, predispose women to an elevated lifetime risk for ovarian cancer (OC) and breast cancer (BC) (National Comprehensive Cancer Network Guidelines, 2018). While the role of bilateral risk-reducing mastectomy is still controversial, risk-reducing salpingo-oophorectomy (RRSO) represents nowadays the main effective prophylactic OC risk measure that should be proposed to BRCA carries, especially once childbearing is complete (National Comprehensive Cancer Network Guidelines, 2018...
Source: Critical Reviews in Oncology Hematology - October 3, 2018 Category: Cancer & Oncology Authors: C. Marchetti, F. De Felice, S. Boccia, C. Sassu, V. Di Donato, G. Pergnola, I. Palaia, M. Monti, L. Muzii, V. Tombolini, P. Benedetti Panici Source Type: research

Primary hypothyroidism in a child leads to pituitary hyperplasia: A case report and literature review
Rationale: A sellar mass in children is most often seen in craniopharyngeal tumors, intracranial germ cell tumors, or pituitary adenomas. However, pituitary hyperplasia secondary to primary hypothyroidism (PHPH) is not commonly seen in children. Patient concerns: A 10-year-old girl was admitted due to growth retardation and obesity for 4 years. On physical examination, the patient had a height of 118 cm, body weight of 46 kg, body mass index (BMI) of 33.0 kg/m2. Diagnoses: After magnetic resonance imaging (MRI) and laboratory tests, her initial diagnosis was Hashimoto's thyroiditis, primary hypothyroidism, an...
Source: Medicine - October 1, 2018 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Access to Nutrition Counseling for Transgender Individuals on Hormone Replacement Therapy
Demonstrate an understanding of the lack of nutritional counseling by Registered Dietitian Nutritionists for transgender individuals undergoing hormone replacement therapy. (Source: Journal of the American Dietetic Association)
Source: Journal of the American Dietetic Association - October 1, 2018 Category: Nutrition Authors: S. Zellers, R. Williams-Hooker, M. Levy, W. Maxey-Trotter Tags: Tuesday, October 23 Source Type: research

Comorbidities in patients with non-functioning pituitary adenoma: influence of long-term growth hormone replacement
Abstract Background: Patients with hypopituitarism have an increased mortality. The aim of this study was to investigate comorbidities including cerebral infarction, type 2 diabetes mellitus (T2DM) and malignant tumors in patients with non-functioning pituitary adenomas (NFPA) with and without growth hormone replacement therapy (GHRT). Methods: Observational cohort study in patients with NFPA within the western region of Sweden. Subjects were identified through the National Patient Registry and followed between 1987 and 2014. Patient records were reviewed and standardized incidence ratios (SIRs) with 95% CIs ...
Source: European Journal of Endocrinology - October 1, 2018 Category: Endocrinology Authors: Hammarstrand C, Ragnarsson O, Bengtsson O, Bryngelsson IL, Johannsson G, Olsson DS Tags: Eur J Endocrinol Source Type: research

Thyroid-stimulating hormone levels in the normal range and incident type 2 diabetes mellitus
ConclusionThere is no apparent relation between plasma TSH levels in the normal range and incident T2DM in patients at high cardiovascular risk. (Source: Acta Diabetologica)
Source: Acta Diabetologica - September 27, 2018 Category: Endocrinology Source Type: research

Assessment of patient-reported outcomes (PROs): treatment satisfaction, medication adherence, and quality of life (QoL) and the associated factors in postmenopausal osteoporosis (PMO) patients in Korea
AbstractPatient-reported outcomes (PROs) provide practical guides for treatment; however, studies that have evaluated PROs of women in Korea with postmenopausal osteoporosis (PMO) are lacking. This cross-sectional, multi-center (29 nationwide hospitals) study, performed from March 2013 to July 2014, aimed to assess PROs related to treatment satisfaction, medication adherence, and quality of life (QoL) in Korean PMO women using osteoporosis medication for prevention/treatment. Patient demographics, clinical characteristics, treatment patterns, PROs, and experience using medication were collected. The 14-item Treatment Satis...
Source: Journal of Bone and Mineral Metabolism - September 20, 2018 Category: Orthopaedics Source Type: research

Estrogen in vascular smooth muscle cells: A friend or a foe?
Abstract Cardiovascular disease (CVD) continues to be the leading cause of death worldwide. The effect of estrogen on these diseases has been assessed in in vitro and in vivo models, as well as in observational studies. Collectively, these studies alluded to a cardiovasculo-protective effect of estrogen. However, comprehensive clinical investigation failed to produce concrete proof of a cardiovascular protective effect for hormone replacement therapy (HRT), let alone rule out potential harm. These seemingly paradoxical effects of estrogen were explained by the 'theory of timing and opportunity'. This theory states...
Source: Vascular Pharmacology - September 15, 2018 Category: Drugs & Pharmacology Authors: Dehaini H, Fardoun M, Saleh HA, El-Yazbi A, Eid AA, Eid AH Tags: Vascul Pharmacol Source Type: research

Ovarian survival after pelvic radiation: transposition until the age of 35  years
AbstractPurposeTo evaluate the effectiveness of ovarian transposition (OT) prior to radiation therapy (RT) and to evaluate the effect of age on ovarian survival (OS) after OT.MethodsWe performed a retrospective control study, with women (aged    40 IU/L and/or estradiol 
Source: Archives of Gynecology and Obstetrics - September 14, 2018 Category: OBGYN Source Type: research

Treatment outcomes of intracranial germinoma: a retrospective analysis of 170 patients from a single institution
ConclusionsWVI or WBRT+  primary boost (PB) is a sufficient irradiation field for localized intracranial germinoma, while patients with bifocal disease should undergo craniospinal irradiation (CSI), especially when treated with RT alone. CSF β-HCG is not a prognostic marker for intracranial germinomas. The treatment res ults of chemotherapy followed by reduced-dose RT are comparable to those of RT alone. IMRT is recommended for intracranial germinoma to improve the target volume accuracy and decrease the complications of RT. (Source: Journal of Cancer Research and Clinical Oncology)
Source: Journal of Cancer Research and Clinical Oncology - September 12, 2018 Category: Cancer & Oncology Source Type: research

Sex Differences in the Vascular Function and Related Mechanisms: Role of 17 βEstradiol.
Sex Differences in the Vascular Function and Related Mechanisms: Role of 17βEstradiol. Am J Physiol Heart Circ Physiol. 2018 Sep 07;: Authors: Pabbidi MR, Kuppusamy M, Didion SP, Sanapureddy P, Reed J, Sontakke SP Abstract The incidence of cardiovascular disease (CVD) is lower in pre-menopausal women but increases with age and menopause compared to similar-aged men. Based on the prevalence of CVD in the post-menopausal women, sex hormone-dependent mechanisms have been postulated to be the primary factors responsible for the protection from CVD in pre-menopausal women. Recent Women's Health Initia...
Source: American Journal of Physiology. Heart and Circulatory Physiology - September 7, 2018 Category: Physiology Authors: Pabbidi MR, Kuppusamy M, Didion SP, Sanapureddy P, Reed J, Sontakke SP Tags: Am J Physiol Heart Circ Physiol Source Type: research