Fasting mimicking diet (ProLon) by Valter Longo, PhD
Interventions that promote longevity, remembered by mnemonic:DEEP purple - “eat colorful plant foods:Dietary modification,Exercise, activeEngagement,Purposeful living (click here toenlarge the image).Valter D. Longo (born October 9, 1967) is an Italian-American biogerontologist and cell biologist known for his studies on the role of fasting and nutrient response genes on cellular protection aging and diseases and for proposing that longevity is regulated by similar genes and mechanisms in many eukaryotes. He is currently a professor at the USC Davis School of Gerontology with a joint appointment in the department of Biol...
Source: Clinical Cases and Images - Blog - September 13, 2019 Category: Universities & Medical Training Tags: Diet Longevity Source Type: blogs
Fight Aging! Newsletter, July 15th 2019
In conclusion, we show here that sEVs are responsible for mediating paracrine senescence and speculate that they could be involved in inducing bystander senescence during therapy-induced senescence or aging. In fact, when compared to soluble factors, sEVs have different biophysical and biochemical properties as they have a longer lifespan than do soluble factors and they are more resistant to protease degradation. The idea that blocking sEV secretion could be a potential therapeutic approach to alleviate senescence "spreading" during chemotherapy-induced senescence or in aging tissues presents itself as a very attractive t...
Source: Fight Aging! - July 14, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
More Supporting Evidence for Pancreatic Fat to be the Cause of Type 2 Diabetes
Type 2 diabetes is, for the vast majority of patients, a condition caused by being significantly overweight. Age does has an influence on the risk of being overweight leading to metabolic syndrome and then type 2 diabetes; it is reasonable to say that type 2 diabetes is an age-related condition. In essence, the younger you are, the more fat tissue it requires to push your metabolism over the red line. A few years back, researchers demonstrated that it is specifically fat in the pancreas that causes type 2 diabetes. Of course the only way to put that fat into the pancreas in the normal course of affairs is to become very ov...
Source: Fight Aging! - July 9, 2019 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, June 24th 2019
This study sought to investigate what could be learned from how these men have fared. The men were born in 1925-1928 and similar health-related data from questionnaires, physical examination, and blood samples are available for all surveys. Survival curves over various variable strata were applied to evaluate the impact of individual risk factors and combinations of risk factors on all-cause deaths. At the end of 2018, 118 (16.0%) of the men had reached 90 years of age.
Smoking in 1974 was the strongest single risk factor associated with survival, with observed percentages of men reaching 90 years being 26.3, 25.7, ...
Source: Fight Aging! - June 23, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Reviewing the Role of Cellular Senescence in the Aging of the Heart
In this study, compared to young mice (4 months of age), aged mice (20-22 months of age) exhibited increased left ventricular weight and cardiomyocyte volume, and showed reduction in cardiomyocyte number, together with reduced ventricular function, indicating the pathological roles of cardiomyocyte senescence in the aged heart.
Heart failure can be characterized into two types depending on the level of systolic function. One is described as heart failure with reduced ejection fraction (HFrEF), another is classified as heart failure with preserved ejection fraction (HFpEF), and both types of heart failure are prevale...
Source: Fight Aging! - June 21, 2019 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Avocado Bacon Burger
Every once in a while, it’s nice to have a burger filled with plenty of high-fat fillings. I filled mine with sliced avocado, thinly-sliced onion, bacon, sliced goat cheese, and hamburger, topped with my favorite sriracha mayonnaise, but you can choose your own favorite fillings. (Sriracha mayonnaise = 1 part sriracha sauce to 4 parts mayonnaise.)
Unlike conventional burgers, burgers made without grains and with ingredients that are fat-rich make this sort of burger exceptionally filling. I dare you to completely finish just one.
Makes two hamburger buns for one burger
1/2 cup almond flour
1 tablespoon ground psylli...
Source: Wheat Belly Blog - June 13, 2019 Category: Cardiology Authors: Dr. Davis Tags: Recipes gluten-free grain-free wheat belly Source Type: blogs
Fight Aging! Newsletter, June 10th 2019
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more.
This content is...
Source: Fight Aging! - June 9, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
More Evidence for Cellular Senescence of β Cells to Drive Type 2 Diabetes
Recently, researchers have demonstrated that senescence of pancreatic β cells is important in both the autoimmunity of type 1 diabetes and the metabolic dysfunction of type 2 diabetes. This was very surprising in the first case, less so in the second, since type 2 diabetes emerges more readily in older individuals. The specific mechanisms by which increased cellular senescence arises in the pancreas is probably different in each case, but the use of senolytic treatments to clear senescent cells has produced significant benefits in animal models of both conditions. This adds to the many other conditions in which targeted r...
Source: Fight Aging! - June 4, 2019 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Foods for Sleep: A List of the Best and Worst Foods for Getting Sleep
You're reading Foods for Sleep: A List of the Best and Worst Foods for Getting Sleep, originally posted on Pick the Brain | Motivation and Self Improvement. If you're enjoying this, please visit our site for more inspirational articles.
Sleep is relatively flimsy to please – and it’s likely that at least once you found yourself staring at the dark walls, on a night where you could not sleep. Still, did you know that the food you eat could greatly affect the quality of your sleep? Here is what you should – or should not – consume in the hours before going to bed.
Foods Recommended for a Good Sleep
So, there are fo...
Source: PickTheBrain | Motivation and Self Improvement - April 9, 2019 Category: Consumer Health News Authors: maryjames Tags: diet featured health and fitness better sleep foods for sleep pickthebrain self improvement Source Type: blogs
A practical guide to the Mediterranean diet
The Mediterranean diet has received much attention as a healthy way to eat, and with good reason. The Mediterranean diet has been shown to reduce risk of heart disease, metabolic syndrome, diabetes, certain cancers, depression, and in older adults, a decreased risk of frailty, along with better mental and physical function. In January, US News and World Report named it the “best diet overall” for the second year running.
What is the Mediterranean diet?
The traditional Mediterranean diet is based on foods available in countries that border the Mediterranean Sea. The foundation for this healthy diet includes
an abundanc...
Source: Harvard Health Blog - March 21, 2019 Category: Consumer Health News Authors: Katherine D. McManus, MS, RD, LDN Tags: Health Healthy Eating Source Type: blogs
Fight Aging! Newsletter, March 18th 2019
This study provides a possible reason why genes carrying health risks have persisted in human populations. The second found evidence for multiple variants in genes related to ageing that exhibited antagonistic pleiotropic effects. They found higher risk allele frequencies with large effect sizes for late-onset diseases (relative to early-onset diseases) and an excess of variants with antagonistic effects expressed through early and late life diseases.
There also exists other recent tangible evidence of antagonistic pleiotropy in specific human genes. The SPATA31 gene has been found under strong positive genomic sele...
Source: Fight Aging! - March 17, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
SGLT-2 Inhibitors as Calorie Restriction Mimetics
SGLT-2 inhibitors, or gliflozins, are a newer and still expensive class of anti-diabetic drug. They work by interfering in the trafficking of glucose, preventing the kidney from reclaiming glucose and introducing it back into the bloodstream. The glucose is instead excreted. Analogously to metformin, another anti-diabetic drug, it is proposed that inhibition of SGLT-2 in some ways mimic the effects of calorie restriction, triggering beneficial cellular housekeeping mechanisms that usually only turn on during periods of fasting or low calorie intake. Size of effect and degree of side-effects are always the questions in thes...
Source: Fight Aging! - March 14, 2019 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
I don ’ t have a gallbladder – Can I still follow the Wheat Belly high-fat lifestyle?
People often misinterpret difficulty ingesting fats after gallbladder surgery as a lack of bile, but that is usually not the case: You have the same quantity of bile after as you did before.
The real problem is SIBO, small intestinal bacterial overgrowth, that causes bile and fat malabsorption. The solution is to address the SIBO, not to reduce fat.
The post I don’t have a gallbladder–Can I still follow the Wheat Belly high-fat lifestyle? appeared first on Dr. William Davis. (Source: Wheat Belly Blog)
Source: Wheat Belly Blog - March 13, 2019 Category: Cardiology Authors: Dr. Davis Tags: News & Updates dysbiosis grain-free grains prebiotic probiotic sibo small intestinal bacterial overgrowth undoctored wheat belly Source Type: blogs
Is the ketogenic diet dangerous?
Answer: No—unless you do it for more than a few months. After a few months, the upfront metabolic and weight benefits will begin to reverse and new health problems arise. We know this with confidence. I raise this question once again because more and more people are coming to me reporting problems. It may take months, even years, but the long-term consequences can be quite serious.
Achieving ketosis by engaging in a very low-carbohydrate, high-fat lifestyle is—without a doubt—an effective means of losing weight, breaking insulin and leptin resistance, reversing type 2 diabetes and fatty liver, redu...
Source: Wheat Belly Blog - March 12, 2019 Category: Cardiology Authors: Dr. Davis Tags: ketones bowel flora ketogenic ketotic undoctored wheat belly Source Type: blogs
Five Fabulous Fats
Happy Fat Tuesday!
On this day, celebrated in many countries with lavish parties and high-fat foods, we’re recognizing the importance of fats in the body.
You’ve probably heard about different types of fat, such as saturated, trans, monounsaturated, omega-3, and omega-6. But fats aren’t just ingredients in food. Along with similar molecules, they fall under the broad term lipids and serve critical roles in the body. Lipids protect your vital organs. They help cells communicate. They launch chemical reactions needed for growth, immune function, and reproduction. They serve as the building blocks of your ...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - March 5, 2019 Category: Research Authors: Susanne Hiller-Sturmhoefel and Alisa Zapp Machalek Tags: Cell Biology Chemistry and Biochemistry Pharmacology Cellular Processes Diseases Lipids Source Type: blogs
