Tolypocladium sinense Mycelium Polysaccharide Alleviates Obesity, Lipid Metabolism Disorder, and Inflammation Caused by High Fat Diet via Improving Intestinal Barrier and Modulating Gut Microbiota
ConclusionThe findings show that TSMP can inhibit obesity and alleviates obesity-related lipid metabolism disorders, inflammatory responses, and oxidative stress by modulating the gut microbiota and improving intestinal barrier. (Source: Molecular Nutrition and Food Research)
Source: Molecular Nutrition and Food Research - April 24, 2024 Category: Food Science Authors: Mingjian Bai,
Xiaolong Wang,
Dongyang Liu,
Aofeng Xu,
Hao Cheng,
Lin Li,
Chunjing Zhang Tags: Research Article Source Type: research
1,25(OH)2D3 inhibits pancreatic stellate cells activation and promotes insulin secretion in T2DM
ConclusionOur findings identify that PSCs activation contributes to islet fibrosis and β-cell dysfunction. 1,25(OH)2D3 exerts beneficial effects on T2DM potentially by inhibiting PSCs activation and inflammatory response, highlighting promising control strategies of T2DM by vitamin D.Graphical AbstractFig. 7 Molecular mechanism of 1,25(OH)2D3 in β cell damage following PSCs activation in T2DM mice. (Source: Endocrine)
Source: Endocrine - April 24, 2024 Category: Endocrinology Source Type: research
Mechano-sensor Piezo1 inhibits glucagon production in pancreatic α-cells
CONCLUSION: Our study uncovers the regulatory role of the Piezo1 ion channel in α cells. Piezo1 influences glucagon production by affecting mTOR signaling pathway.PMID:38653360 | DOI:10.1016/j.bbadis.2024.167185 (Source: Biochimica et Biophysica Acta)
Source: Biochimica et Biophysica Acta - April 23, 2024 Category: Biochemistry Authors: Wenying Guo Luyang Gao Haocong Mo Handan Deng Yawen Zhao Geyang Xu Source Type: research
GSE195829 miRNA seq mouse liver HFD, PCB126, Aroclor1260 exposure
Contributors : Belinda J Petri ; Kellianne M Piell ; Bandrida Wahlang ; Kimberly Z Head ; Kalina Andreeva ; Eric C Rouchka ; Jianmin Pan ; Shesh N Rai ; Matthew C Cave ; Carolyn M KlingeSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Mus musculusExposure to high fat diet (HFD) and persistent organic pollutants including polychlorinated biphenyls (PCBs) is associated with liver injury in human populations and with non-alcoholic fatty liver disease (NAFLD) and steatohepatitis (NASH) in animal models. Exposure of HFD-fed male mice to the non-dioxin-like (NDL) PCB mixture Aroclor1260 or to dio...
Source: GEO: Gene Expression Omnibus - April 23, 2024 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by high throughput sequencing Mus musculus Source Type: research
GSE176110 AOS10-FMT could rescure the adverse effects induced by high fat diet on the Spleen
We report the side-effects of High fat diet on the spleen, and foud that the AOS10-FMT could rescure the side-effect of High fat diet in many factors,such as inflammation (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 23, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
GSE175940 AOS10-FMT could rescure the adverse effects induced by high fat diet on the Colon
We report the side-effects of High fat diet on the colon, and foud that the AOS10-FMT could rescure the side-effect of High fat diet in many factors (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 23, 2024 Category: Genetics & Stem Cells Tags: Other Mus musculus Source Type: research
GSE175911 AOS10-FMT could rescure the adverse effects induced by high fat diet on the testis
We report the side-effects of High fat diet on the testis, and foud that the AOS10-FMT could rescure the side-effect of High fat diet in many factors,such as spermatogenesis,lipid metabolism and oxidative stress (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 23, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
GSE173566 AOS10-FMT could rescure the adverse effects induced by high fat diet on the kidney
We report the side-effects of High fat diet on the liver, and foud that the AOS10-FMT could rescure the side-effect of High fat diet in many factors,such as lipid metabolism and oxidative stress (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - April 23, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
GSE254105 Alternate high fat diet aggravates atherosclerosis through an IL1B- 2 dependent reprogramming of neutrophil progenitors
Contributors : Jean-R émi Lavillegrand ; Marc Diedisheim ; Hafid Ait-OufellaSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusSystemic immune responses induced by chronic hypercholesterolemia contribute to the initiation, progression and complications of atherosclerosis. However, it is common for individuals to change dietary habits over time. The consequences of an alternating high fat diet and the associated variations in plasma cholesterol levels on atherosclerosis are unknown. To address this relevant issue, we developed a novel protocol in atherosclerosis-prone mice that allowe...
Source: GEO: Gene Expression Omnibus - April 23, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
The potential molecular mechanism underlying gypenoside amelioration of atherosclerosis in ApoE(-/-) mice: A multi-omics investigation
In conclusion, Gyp appeared to have complex effects on atherosclerosis, most of which were positive. These results support the use of Gyp in the treatment of atherosclerosis.PMID:38644881 | PMC:PMC11031777 | DOI:10.1016/j.heliyon.2024.e29164 (Source: Atherosclerosis)
Source: Atherosclerosis - April 22, 2024 Category: Cardiology Authors: Xing Ju Yufeng Liu Ying Wang Guoyuan Sui Yixin Ma Huimin Cao Yuan Cao Jin Wu Ying Du Xue Leng Lianqun Jia Guanlin Yang Source Type: research
Disturbed flow impairs MerTK-mediated efferocytosis in aortic endothelial cells during atherosclerosis
Conclusions: Our data suggests that blood flow patterns play an important role in regulating MerTK-mediated efferocytosis in aortic ECs, revealing a new promising therapeutic strategy with EC efferocytosis restoration to against atherosclerosis.PMID:38646649 | PMC:PMC11024847 | DOI:10.7150/thno.93036 (Source: Atherosclerosis)
Source: Atherosclerosis - April 22, 2024 Category: Cardiology Authors: Jinzi Wu Shijie Liu Oishani Banerjee Hang Shi Bingzhong Xue Zufeng Ding Source Type: research
Effect of moxibustion on the SIRT1/FOXO3a signaling pathway in ApoE(-/-) mice with atherosclerosis
CONCLUSIONS: Moxibustion can reduce the body weight of AS model mice, regulate lipid levels, repair vascular intima, and alleviate endothelial damage. Its mechanism of action may be related to the regulation of the SIRT1/FOXO3a signaling pathway to improve oxidative damage.PMID:38649205 | DOI:10.13702/j.1000-0607.20230578 (Source: Atherosclerosis)
Source: Atherosclerosis - April 22, 2024 Category: Cardiology Authors: Zhao-Bo Yan Xian-Ming Wu Ning Zhang Zhi-Hong Yang Zhou Zhu Hua-Mei Yu Xiao-Qi Jia Xiao-Fang Yang Source Type: research
Serum testosterone levels and oxidative stress in type 1 diabetes, type 2 diabetes, and obesity
CONCLUSIONS: Increased oxidative stress in diabetes may be an important factor that decreases serum testosterone levels.PMID:38646988 | DOI:10.5603/ep.98190 (Source: Endokrynologia Polska)
Source: Endokrynologia Polska - April 22, 2024 Category: Endocrinology Authors: Hamit Yasar Ellidag Rahime Aslanko ç Mehmet K ök G üzin Aykal Özgür Aydın Özlem Özmen Remzi Can Çakır U ğur Doğan Source Type: research
Total flavonoids of Broussonetia papyrifera alleviate non-alcohol fatty liver disease via regulating Nrf2/AMPK/mTOR signaling pathways
CONCLUSION: Our experiments proved that TFBP has the therapeutic effect in NAFLD, and the activation of Nrf2 and AMPK signaling pathways should make sense.PMID:38649009 | DOI:10.1016/j.bbalip.2024.159497 (Source: Biochimica et Biophysica Acta)
Source: Biochimica et Biophysica Acta - April 22, 2024 Category: Biochemistry Authors: Qi Wang Yunfei Wei Yeling Wang Ziyang Yu Haiyan Qin Lilei Zhao Jiaqi Cheng Bingyu Shen Meiyu Jin Haihua Feng Source Type: research
Caffeic acid combined with arabinoxylan or β-glucan attenuates diet-induced obesity in mice via modulation of gut microbiota and metabolites
Int J Biol Macromol. 2024 Apr 20:131683. doi: 10.1016/j.ijbiomac.2024.131683. Online ahead of print.ABSTRACTPolyphenols and dietary fibers in whole grains are important bioactive compounds to reduce risks for obesity. However, whether the combination of the two components exhibits a stronger anti-obesity effect remains unclear. Caffeic acid is a major phenolic acid in cereals, and arabinoxylan and β-glucan are biological macromolecules with numerous health benefits. Here, we investigated the effect of caffeic acid combined with arabinoxylan or β-glucan on glucose and lipid metabolism, gut microbiota, and metabolites in m...
Source: International Journal of Biological Macromolecules - April 22, 2024 Category: Biochemistry Authors: Wei Fang Mingyu Jin Wentao Qi Chunli Kong Ge Song Wenting Peng Yong Wang Source Type: research
