Fight Aging! Newsletter, February 8th 2021
This study was divided in two phases: CALERIE-1 and CALERIE-2. CALERIE-1 study was performed to assess the possible effects induced by a reduction of 10-30% of caloric intake on body composition parameters and lipid profile after 6 and 12 months in a population of middle-aged non-obese subjects. CALERIE-1 results showed an improvement in lipid and glycemic profile and a reduction in body weight (BW) and fat mass.
CALERIE-2 was the largest multi-center study on CRD. A total of 220 subjects were enrolled randomly with a 2:1 allocation into two subgroups: 145 in the CRD group and 75 in the ad libitum group. The CRD gro...
Source: Fight Aging! - February 7, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, January 11th 2021
This study demonstrates the potential of a natural (o-Vanillin) and a synthetic (RG-7112) senolytic compounds to remove senescent IVD cells, decrease SASP factors release, reduce the inflammatory environment and enhance the IVD matrix production. Removal of senescent cells, using senolytics drugs, could lead to improved therapeutic interventions and ultimately decrease pain and a provide a better quality of life of patients living with intervertebral disc degeneration and low back pain.
From Ying Ann Chiao of Oklahoma Medical Research Foundation: Mitochondrial dysfunction plays a central role in aging and cardiovasc...
Source: Fight Aging! - January 10, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Subset of Fat Tissue Cells is Largely Responsible for the Inflammation Generated by Excess Visceral Fat Tissue
Scientists here suggest that the chronic inflammation generated by visceral fat tissue, an important form of metabolic disarray that drives age-related disease and dysfunction, is not produced by all fat cells. Indeed, it may be primarily produced by a specific type of progenitor cell lining blood vessels in fat tissue. This is an interesting demonstration, but it remains the case that the best solution to excess visceral fat is never to obtain it in the first place. The effects of visceral fat on metabolism quite literally accelerate the progression of degenerative aging.
When a person consumes more calories than...
Source: Fight Aging! - January 5, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Buyer beware: The story of a pricey and “credentialled” program to end Alzheimer’s Disease
When her husband was diagnosed with early-stage Alzheimer’s disease in 2015, Elizabeth Pan was devastated by the lack of options to slow his inevitable decline. But she was encouraged when she discovered the work of a UCLA neurologist, Dr. Dale Bredesen, who offered a comprehensive lifestyle management program to halt or even reverse cognitive decline in patients like her husband.
After decades of research, Bredesen had concluded that more than 36 drivers of Alzheimer’s cumulatively contribute to the loss of mental acuity. They range from chronic conditions like heart disease and diabetes to vitamin and hormonal defi...
Source: SharpBrains - December 22, 2020 Category: Neuroscience Authors: Kaiser Health News Tags: Brain/ Mental Health aging Alzheimer’s Disease cognitive decline Dale Bredesen dementia end Alzheimer's Disease nutritional supplements Source Type: blogs
Weight Loss: This Technique Improves Eating Habits Automatically
It increases levels of the neurotransmitter dopamine, which reduces the desire for high-fat foods.
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Source: PsyBlog | Psychology Blog - December 19, 2020 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Weight Loss Source Type: blogs
Fight Aging! Newsletter, November 30th 2020
We examined specific aspects of metabolism in male PolG+/mut mice at 6 and 12 months of age under three dietary conditions: normal chow (NC) feeding, high-fat feeding (HFD), and 24-hr starvation. We performed mitochondrial proteomics and assessed dynamics and quality control signaling in muscle and liver to determine whether mitochondria respond to mtDNA point mutations by altering morphology and turnover. In the current study, we observed that the accumulation of mtDNA point mutations failed to disrupt metabolic homeostasis and insulin action in male mice, but with aging, metabolic health was likely preserved by counterme...
Source: Fight Aging! - November 29, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Excessive Mitochondrial Point Mutations Do Not Lead to Obvious Metabolic Dysfunction
We examined specific aspects of metabolism in male PolG+/mut mice at 6 and 12 months of age under three dietary conditions: normal chow (NC) feeding, high-fat feeding (HFD), and 24-hr starvation. We performed mitochondrial proteomics and assessed dynamics and quality control signaling in muscle and liver to determine whether mitochondria respond to mtDNA point mutations by altering morphology and turnover. In the current study, we observed that the accumulation of mtDNA point mutations failed to disrupt metabolic homeostasis and insulin action in male mice, but with aging, metabolic health was likely preserved by counterme...
Source: Fight Aging! - November 25, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, September 21st 2020
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - September 20, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Metformin Found to Reduce Liver Inflammation
Metformin produces a modest and unreliable extension of life in animal models, and human data shows a small increase in life span in diabetic patients. This is thought to work as a calorie restriction mimetic drug, triggering one slice of the beneficial response to a reduced nutrient intake. Researchers here dig further in the biochemistry of the drug, and find that it reduces liver inflammation in addition to other, known effects. This is interesting, and suggestive that any benefits it produces are going to be much smaller in healthier older adults with lower levels of chronic inflammation. It doesn't change the fact tha...
Source: Fight Aging! - September 17, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Does diet really matter when it comes to adult acne?
When I was a teenager, the advice I got about acne was clear and consistent:
Avoid oily foods and chocolate because they trigger breakouts and make existing acne worse
Wash your face often
Try a topical, over-the-counter remedy such as those containing benzoyl peroxide (Clearasil) or salicylic acid (Stridex).
By the time I got to medical school, the message had changed. I learned that the diet-acne connection was considered a myth, and that what we eat has little to do with making acne better or worse.
But a new study has once again turned the tables. It suggests that diet might contribute to acne — at least in adults....
Source: Harvard Health Blog - August 19, 2020 Category: Consumer Health News Authors: Robert H. Shmerling, MD Tags: Healthy Eating Skin and Hair Care Source Type: blogs
A High-Fat Food That Reduces Blood Pressure
Two servings a day of this high-fat food could lower diabetes risk and reduce high blood pressure.
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→ Explore PsyBlog's ebooks, all written by Dr Jeremy Dean:
Accept Yourself: How to feel a profound sense of warmth and self-compassion
The Anxiety Plan: 42 Strategies For Worry, Phobias, OCD and Panic
Spark: 17 Steps That Will Boost Your Motivation For Anything
Activate: How To Find Joy Again By Changing What You Do (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - August 9, 2020 Category: Psychiatry & Psychology Authors: Mina Dean Tags: Blood Pressure Diabetes Source Type: blogs
Fight Aging! Newsletter, August 3rd 2020
In this study, we examined the effects of oxytocin on the Aβ-induced impairment of synaptic plasticity in mice.
To investigate the effect of oxytocin on synaptic plasticity, we prepared acute hippocampal slices for extracellular recording and assessed long-term potentiation (LTP) with perfusion of the Aβ active fragment (Aβ25-35) in the absence and presence of oxytocin. We found that oxytocin reversed the impairment of LTP induced by Aβ25-35 perfusion in the mouse hippocampus. These effects were blocked by pretreatment with the selective oxytocin receptor antagonist L-368,899. Furthermore, the treatment with the...
Source: Fight Aging! - August 2, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Long Term Low Dose Ethanol Intake Modestly Extends Life in Mice
In this study, we use ethanol, the common substance in all kinds of alcoholic beverages, as a single variable to explore its effects in vivo. Our data showed that the long-term 3.5% ethanol substitution for drinking water had beneficial effects in mice, the daily performance of ethanol-fed mice was enhanced, the athletic ability and healthspan of ethanol-fed mice drastically improved. Furthermore, the ethanol-fed mice showed the resistance to high-fat diet (HFD). When supplemented with 3.5% ethanol, the HFD mice showed reduced multiple organ pathogenicity, increased insulin sensitivity, and decreased NF-kB activation and i...
Source: Fight Aging! - July 29, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, July 20th 2020
This study was the first to demonstrate a causal relationship between glial senescence and neurodegeneration. In this study, accumulations of senescent astrocytes and microglia were found in tau-associated neurodegenerative disease model mice. Elimination of these senescent cells via a genetic approach can reduce tau deposition and prevent the degeneration of cortical and hippocampal neurons.
Most recently, it was shown that clearance of senescent oligodendrocyte progenitor cells in AD model mice with senolytic agents could lessen the Aβ plaque load, reduce neuroinflammation, and ameliorate cognitive deficits. This...
Source: Fight Aging! - July 19, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Repetitive Element Activity is Reduced in Mice Subject to Interventions that Modestly Slow Aging
Today's open access paper is a companion piece to a recent discussion of repetitive element activity as a potential biomarker of biological aging. In today's paper, the authors note that a number of interventions that modestly slow aging in mice also reduce the activity of repetitive elements in the genome. Many forms of repetitive element are the remnants of ancient viruses, sequences that are capable of copying themselves into new locations in the genome, but are normally suppressed. A fair amount of attention has been given to retrotransposons, one category of repetitive elements, in the context of aging in recent years...
Source: Fight Aging! - July 14, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
