Fight Aging! Newsletter, February 5th 2018
In this study, we tested the hypothesis that Gbp1 plays a role in regulating immunometabolism and senescence of macrophages. We found that Gbp1 was mainly expressed in macrophages, but not adipocytes in response to IFNγ/LPS stimulation; Gbp1 expression was significantly decreased in inguinal white adipose tissue (iWAT) of high-fat diet (HFD)-fed and aged mice. We also observed that downregulation of Gbp1 in macrophages resulted in M1 polarization and impairment of mitochondrial respiratory function possibly via disrupting mitophagy activity. Moreover, macrophages with downregulated Gbp1 displayed dampened glycolysis and e...
Source: Fight Aging! - February 4, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Be ketotic . . . but only sometime
Achieving ketosis by engaging in a very low-carbohydrate, high-fat lifestyle is an effective means of losing weight, breaking insulin and leptin resistance, reversing type 2 diabetes and fatty liver, reducing blood pressure, reversing the inflammation of visceral fat, and may even cause partial or total remission of selected cancers.
So what’s the problem?
The problem comes when people remain ketotic for extended periods. We know with confidence that long-term ketosis poses substantial risk for health complications because thousands of children have followed ketogenic diets over the years as a means of suppressing in...
Source: Wheat Belly Blog - February 2, 2018 Category: Cardiology Authors: Dr. Davis Tags: Undoctored Wheat Belly Lifestyle Source Type: blogs
Gbp1 Levels Fall with Age, Making Macrophages Less Helpful and More Harmful
In this study, we tested the hypothesis that Gbp1 plays a role in regulating immunometabolism and senescence of macrophages. We found that Gbp1 was mainly expressed in macrophages, but not adipocytes in response to IFNγ/LPS stimulation; Gbp1 expression was significantly decreased in inguinal white adipose tissue (iWAT) of high-fat diet (HFD)-fed and aged mice. We also observed that downregulation of Gbp1 in macrophages resulted in M1 polarization and impairment of mitochondrial respiratory function possibly via disrupting mitophagy activity. Moreover, macrophages with downregulated Gbp1 displayed dampened glycolysis and e...
Source: Fight Aging! - January 30, 2018 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Eat a Mediterranean Style Diet to Ward Off Alzheimer's
More American's--especially the baby boom generation--are learning the importance of eating healthy.By Bob DeMarcoAlzheimer's Reading RoomA new research study indicates that eating Mediterranean-style seems to reduces the risk of mild cognitive impairment, dementia, and Alzheimer's.There are numerous studies that indicate this style of eating helps reduce cardiovascular risk factors like high cholesterol, hypertension and diabetes.All of these are linked to Alzheimer's and I have written about them previously on this blog (use the search box for more information).Dementia Care TipsThe Mediterranean diet is a heart-healthy ...
Source: Alzheimer's Reading Room, The - January 7, 2018 Category: Neurology Tags: alzheimer's care alzheimer's risk alzheimers dementia care diet eating health help with dementia care lifestyle Mediterranean Diet Source Type: blogs
The Critical Role Nutrition Plays in Mental Health
One of the most unrecognized factors in the development of mental health is the role of nutrition. The link between diet and mental health is growing as the field of Nutritional Psychiatry/Psychology expands. This field is becoming more impactful as epidemics continue to make headlines surrounding the health of our country and world. We know nutrition has substantial physical impacts, but it is the mental impacts of nutrition that are gaining traction with additional research and heightening awareness around this topic.
Proper nutrition is what fuels our bodies and our bodies need a regular supply of fuel. Oxygen is part o...
Source: World of Psychology - December 10, 2017 Category: Psychiatry & Psychology Authors: Darren DeYoung Tags: Alternative and Nutritional Supplements Habits Health-related Diet dietary concerns Eating Habits eating healthy Mental Health Mood nutritional psychiatry sugar Source Type: blogs
Do You Know the Signs of Stress?
“Stress is an alarm clock that lets you know you’re attached to something that’s not true for you.” – Byron Katie
As a run up to the holidays, doesn’t it seem like everyone’s rushing around trying to cram too much into too little time? Crazed to find a parking space in an overcrowded lot, racing to get into the elevator before the door closes or hitting the door-close button so no one else can get in, exhibiting uncharitable, rude and potentially unhealthy behavior when trying to snatch the last sale item and so much more are all signs of stressed-out individuals.
Is it any wonder the commercials for antacid...
Source: World of Psychology - November 30, 2017 Category: Psychiatry & Psychology Authors: Suzanne Kane Tags: Brain and Behavior Creativity Happiness Holiday Coping LifeHelper Mental Health and Wellness Self-Help Stress Coping Mechanisms Coping Skills Relaxation stress reduction Source Type: blogs
Fight Aging! Newsletter, November 27th 2017
We examined associations between mortality and accelerometer-measured PA using age-relevant intensity cutpoints in older women of various ethnicities.
The results support the hypothesis that higher levels of accelerometer-measured PA, even when below the moderate-intensity threshold recommended in current guidelines, are associated with lower all-cause and CVD mortality in women aged 63 to 99. Our findings expand on previous studies showing that higher self-reported PA reduces mortality in adults aged 60 and older, specifically in older women, and at less than recommended amounts. Moreover, our findings challenge th...
Source: Fight Aging! - November 26, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
My Husband Outlived His Brain Tumor Prognosis by 12 Years: How His Experience Could Help John McCain and Others
In conclusion, I would never advise John McCain and his family, or any other GBM patient, as to which of these treatments—or which combination of treatments—they should use. I hope they will learn about all of them, and decide on their own which one or ones they would like to try. I would also encourage them to do their own research, or to hire a researcher with experience in finding sensible, science-based, cutting-edge treatments.
I am very worried that they will not know about these treatments, and others like them, and will just use the standard of care. That would be a shame. It might also be a death sentence.
...
Source: HONEST MEDICINE: My Dream for the Future - November 21, 2017 Category: Consumer Health News Authors: JuliaS1573 at aol.com (Julia Schopick) Source Type: blogs
To What Extent are Gut Bacteria Involved in the Benefits of Fasting?
Calorie restriction improves health and extends life in most species and lineages tested, while both Protein restriction and intermittent fasting can provide similar but usually lesser packages of benefits. Once delving into the details of the biochemistry involved, however, the picture becomes very complex, and is still quite uncertain. These strategies probably work through overlapping collections of mechanisms that in turn interact with one another. Intermittent fasting and protein restriction still provide some benefits even when calorie level is kept constant, for example, and assays of epigenetic changes look fairly ...
Source: Fight Aging! - November 20, 2017 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Pharmacological PTB1B Inhibition Reduces Atherosclerotic Plaque
We present evidence that, in addition to its improvement in glucose homeostasis and adiposity, PTP1B inhibition results in activation of aortic Akt and AMPKα1, that is independent of the effects on the IR itself. Most importantly, for the first time, we demonstrate that inhibition of PTP1B results in a decrease in circulating serum cholesterol and triglyceride levels and protection against atherosclerotic plaque formation.
Atherosclerosis is now widely regarded as a chronic, low-grade inflammatory condition characterized by an increased pro-inflammatory environment and decreased anti-inflammation, pro-resolutionary...
Source: Fight Aging! - November 3, 2017 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Chocolate Frozen Yogurt
I took the super-duper thick yogurt that I made with added prebiotic fiber and made a really delicious and rich chocolate frozen yogurt.
Most store-bought yogurt, of course is the outdated and unhealthy low- or non-fat variety, often thickened with emulsifying agents to improve consistency, but damaging the mucous lining of your intestinal tract and encouraging dysbiosis, even if it contains probiotic microorganisms. We can make high-fat yogurt, prolong the fermentation process to further reduce lactose and denature the casein protein, and add a prebiotic fiber such as inulin to increase bacterial counts and increase butyr...
Source: Wheat Belly Blog - October 20, 2017 Category: Cardiology Authors: Dr. Davis Tags: Recipes Wheat Belly Lifestyle erythritol gluten-free low-carb monk fruit monkfruit natural sweetener stevia virtue Wheat Belly Total Health Source Type: blogs
Yogurt So Thick It Can Stand Up
I tried something new with making yogurt.
I made the Super-Duper High-Fat Wheat Belly Yogurt starting with organic half-and-half for richer fat content. This generally yields an end-product with great creamy mouthfeel, thicker than most store-bought full-fat yogurt, certainly far thicker, tastier, and more filling than the low- or non-fat garbage that fills most supermarket refrigerators.
Recall that, while dairy products undoubtedly have their problems, the process of lactate fermentation yielding yogurt reduces many of these problems. The lactose sugar is converted to lactic acid, reducing carb content, and potential for...
Source: Wheat Belly Blog - October 19, 2017 Category: Cardiology Authors: Dr. Davis Tags: Recipes Wheat Belly Lifestyle Fermentation gluten gluten-free grain-free grains high-fat lactate lactic Wheat Belly Total Health yogurt Source Type: blogs
Yogurt That Can Stand Up
I tried something new with making yogurt.
I made the Super-Duper High-Fat Wheat Belly Yogurt starting with organic half-and-half for richer fat content. This generally yields an end-product with great creamy mouthfeel, thicker than most store-bought full-fat yogurt, certainly far thicker, tastier, and more filling than the low- or non-fat garbage that fills most supermarket refrigerators.
Recall that, while dairy products undoubtedly have their problems, the process of lactate fermentation yielding yogurt reduces many of these problems. The lactose sugar is converted to lactic acid, reducing carb content, and potential for...
Source: Wheat Belly Blog - October 19, 2017 Category: Cardiology Authors: Dr. Davis Tags: Recipes Wheat Belly Lifestyle Fermentation gluten gluten-free grain-free grains high-fat lactate lactic Wheat Belly Total Health yogurt Source Type: blogs
