Fight Aging! Newsletter, June 29th 2020
In conclusion, metabolomics is a promising approach for the assessment of biological age and appears complementary to established epigenetic clocks.
Sedentary Behavior Raises the Risk of Cancer Mortality
https://www.fightaging.org/archives/2020/06/sedentary-behavior-raises-the-risk-of-cancer-mortality/
Living a sedentary lifestyle is known to be harmful to long term health, raising the risk of age-related disease and mortality. Researchers here show that a sedentary life specifically increases cancer mortality, and does so independently of other factors. This is one of many, many reasons to maintain a r...
Source: Fight Aging! - June 28, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Cyclic Peptides to Remodel the Gut Microbiome by Suppressing Growth of Harmful Bacteria
Research into the effects of the gut microbiome on health and aging is presently flourishing. Scientists are identifying meaningful changes in microbial populations that take place with age, as well as metabolites generated by gut microbes that favorably influence health, such as indoles, butyrate, propionate, and so forth. With advancing age, the balance of microbial populations shifts from beneficial to harmful. The production of beneficial metabolites decreases. Microbes invade gut tissue to produce a state of chronic inflammation that spreads to accelerate the onset and progression of age-related disease throughout the...
Source: Fight Aging! - June 23, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
The Best Weight Loss Technique: Low-Fat Versus High-Fat Diets
Research reveals if low-fat diets are better for weight loss.
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The Anxiety Plan: 42 Strategies For Worry, Phobias, OCD and Panic
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Activate: How To Find Joy Again By Changing What You Do (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - May 31, 2020 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Weight Loss Source Type: blogs
Fight Aging! Newsletter, June 1st 2020
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
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Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - May 31, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Visceral Fat Behaves Differently in Long-Lived Dwarf Mice
A few varieties of dwarf mice exhibit considerable longevity. They are produced via forms of mutation that disable portions of growth hormone metabolism, such as via growth hormone receptor knockout. Most research has thus focused on insulin signaling, IGF-1, and other pathways closely tied to growth hormone. Here, scientists instead focus on the behavior of fat tissue in these long-lived mouse lineages, suggesting that the significant differences they observe in the metabolism of visceral fat may contribute to the impact on aging.
It is well known that visceral fat is metabolically active, and excess amounts create...
Source: Fight Aging! - May 29, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Vaccination as a Limited Option for Removal of Senescent Cells
In today's open access paper, the authors demonstrate a form of vaccination against a surface marker that appears on a subset of senescent T cells that reside in fat tissue, thus directing the rest of the immune system to attack and destroy these cells. There is good evidence for excess fat tissue to result in an increased burden of senescent cells, which disrupt metabolism via the generation of inflammatory signals. A novel branch of medicine is under construction, based on senolytic therapies capable of selectively destroying senescent cells in aged tissues. The growing numbers of senescent cells in older people (and eve...
Source: Fight Aging! - May 26, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, May 25th 2020
In conclusion, our results suggest a previously unknown mechanism whereby the canonical NF-κB cascade and a mitochondrial fission pathway interdependently regulate endothelial inflammation.
Lin28 as a Target for Nerve Regeneration
https://www.fightaging.org/archives/2020/05/lin28-as-a-target-for-nerve-regeneration/
Researchers here show that the gene Lin28 regulates axon regrowth. In mice, raised levels of Lin28 produce greater regeneration of nerve injuries. Past research has investigated Lin28 from the standpoint of producing a more general improvement in regenerative capacity. It improves mitochondr...
Source: Fight Aging! - May 24, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Follistatin Gene Therapy Doubles Muscle Mass in Mice
Follistatin is an inhibitor of myostatin. Blocking myostatin activity enhances muscle growth, with accompanying beneficial side-effects such as a loss of excess fat tissue. This is well proven. There are a good number of animal lineages (mice, dogs, cows, and so forth) resulting from natural or engineered myostatin loss of function mutations, and even a few well-muscled human individuals with similar mutations. A number of groups are at various stages in the development of therapies to either upregulate follistatin or inhibit myostatin. The latter is further along in the formal regulatory process: human trials have been co...
Source: Fight Aging! - May 18, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
The Breakfast That Boosts Weight Loss By 65%
The food lowers cravings for high-sugar and high-fat foods and suppresses appetite during the day.
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Accept Yourself: How to feel a profound sense of warmth and self-compassion
The Anxiety Plan: 42 Strategies For Worry, Phobias, OCD and Panic
Spark: 17 Steps That Will Boost Your Motivation For Anything
Activate: How To Find Joy Again By Changing What You Do (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - May 6, 2020 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Weight Loss Source Type: blogs
Fight Aging! Newsletter, March 30th 2020
This study, for the first time, shows that transplantation of non-autologous mitochondria from healthy skeletal muscle cells into normal cardiomyocytes leads to short-term improvement of bioenergetics indicating "supercharged" state. However, over time these improved effects disappear, which suggests transplantation of mitochondria may have a potential application in settings where there is an acute stress.
Outlining Some of the Science Behind Partial Reprogramming at Turn.bio
https://www.fightaging.org/archives/2020/03/outlining-some-of-the-science-behind-partial-reprogramming-at-turn-bio/
Turn.bio is ...
Source: Fight Aging! - March 29, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Age and Dietary Fat Result in Larger Inflammatory Populations of Gut Microbes
This study investigated the short-term responses of the gut microbiota composition to diets with different fat contents. Experimental animals were fed either a a normal diet (ND) or a high-fat diet (HFD) for 20 weeks and the microbial composition was evaluated at 10 and 20 weeks. In agreement with previous studies, body weight and the expression of colonic cytokines increased with higher dietary fat content. The diversity of the gut microbiota was significantly influenced by both age and diet, and two variable showed significant interactions.
At the phylum level, the proportion of Actinobacteria was significantl...
Source: Fight Aging! - March 27, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Reduced Calorie Intake and Periodic Fasting Independently Contribute to the Benefits of Calorie Restriction
Researchers here make the point that calorie restriction studies in animals are also introducing a strong component of time restricted feeding, as animals tend to be fed once a day. Studies of intermittent fasting without calorie reduction have shown that this can produce a similar set of metabolic responses to a reduced calorie intake. Intermittent fasting and calorie restriction have been shown to improve health and extend healthy life spans via two overlapping sets of mechanisms, as assessed by various omics approaches. Thus the details of the approach to feeding animals any given fixed amount of calories (delivery of f...
Source: Fight Aging! - March 19, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, March 9th 2020
In this study, we intravenously administrated the young mitochondria into aged mice to evaluate whether energy production increase in aged tissues or age-related behaviors improved after the mitochondrial transplantation. The results showed that heterozygous mitochondrial DNA of both aged and young mouse coexisted in tissues of aged mice after mitochondrial administration, and meanwhile, ATP content in tissues increased while reactive oxygen species (ROS) level reduced. Besides, the mitotherapy significantly improved cognitive and motor performance of aged mice. Our study, at the first report in aged animals, not only prov...
Source: Fight Aging! - March 8, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Delivery of Young Mitochondria to Old Mice Improves Cognitive and Motor Function
In this study, we intravenously administrated the young mitochondria into aged mice to evaluate whether energy production increase in aged tissues or age-related behaviors improved after the mitochondrial transplantation. The results showed that heterozygous mitochondrial DNA of both aged and young mouse coexisted in tissues of aged mice after mitochondrial administration, and meanwhile, ATP content in tissues increased while reactive oxygen species (ROS) level reduced. Besides, the mitotherapy significantly improved cognitive and motor performance of aged mice. Our study, at the first report in aged animals, not only prov...
Source: Fight Aging! - March 6, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, February 17th 2020
Discussion of the Evolutionary Genetics of Aging
Thymic Involution Contributes to Immunosenescence and Inflammaging
The Potential for Exosome Therapies to Treat Sarcopenia
Correlations of Mitochondrial DNA Copy Number and Epigenetic Age Measures
Evidence for PASK Deficiency to Reduce the Impact of Aging in Mice
The Aging Retina, a Mirror of the Aging Brain
Evidence for Loss of Capillary Density to be Important in Heart Disease
Aspects of Immune System Aging Proceed More Rapidly in Men
Deacetylation of the NLRP3 Inflammasome as a Way to Control Chronic Inflammation
Transplantation of Senescent Cel...
Source: Fight Aging! - February 16, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
