Fight Aging! Newsletter, December 19th 2022
In conclusion, p16 deletion or p16 positive cell clearance could be a novel strategy preventing long term HFD-induced skin aging.
Association of LDL-Cholesterol with Mortality
https://www.fightaging.org/archives/2022/12/association-of-ldl-cholesterol-with-mortality/
Researchers here report on a study of LDL-cholesterol and mortality risk in older people. As they note, data on this topic is conflicted once one moves beyond the matter of cardiovascular disease. Over a lifetime, higher LDL-cholesterol makes it easier to reach the tipping point at which cholesterol deposited in blood vessel walls produces e...
Source: Fight Aging! - December 18, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A High Fat Diet Promotes Cellular Senescence in Skin
In conclusion, p16 deletion or p16 positive cell clearance could be a novel strategy preventing long term HFD-induced skin aging.
Link: https://doi.org/10.1155/2022/3415528 (Source: Fight Aging!)
Source: Fight Aging! - December 12, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, October 10th 2022
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - October 9, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Targeting the Gut Microbiome to Treat Aging
The distribution of microbial populations making up the gut microbiome changes with age in ways that are harmful to health, causing a reduction in production of beneficial metabolites and an increase in chronic inflammation. Animal studies make it clear that some approaches to restoring a more youthful gut microbiome, such as fecal microbiota transplantation from young donors, can produce a sustained rejuvenation of the gut microbiome and consequent improvement in later life health. Given the comparatively simplicity of this approach, and that the state of the gut microbiome can accurately measured via low-cost assays, thi...
Source: Fight Aging! - October 3, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
This High-Fat Diet Protects Against Dementia, Research Suggests
Foods included in the diet include seafood, low-carb vegetables, cheese, eggs, coconut oil and olive oil. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - August 28, 2022 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Dementia Nutrition Source Type: blogs
Fight Aging! Newsletter, August 1st 2022
In this study, we used the recently released Infinium Mouse Methylation BeadChip to compare such epigenetic modifications in C57BL/6 (B6) and DBA/2J (DBA) mice. We observed marked differences in age-associated DNA methylation in these commonly used inbred mouse strains, indicating that epigenetic clocks for one strain cannot be simply applied to other strains without further verification. Interestingly, the CpGs with highest age-correlation were still overlapping in B6 and DBA mice and included the genes Hsf4, Prima1, Aspa, and Wnt3a. Furthermore, Hsf4, Aspa, and Wnt3a revealed highly significant age-associated DNA methyla...
Source: Fight Aging! - July 31, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Reviewing What is Known of the Longevity Gene INDY
INDY was one of the earlier longevity-related genes to be robustly identified, a discovery made 20 years ago now. Much of the exploratory work on INDY was carried out in flies, though more than enough time has now passed for mouse data to have also emerged. The authors of today's review paper characterize the benefits resulting from a reduced expression of INDY as a calorie restriction mimetic effect, more or less. That is a fair enough shorthand for any approach that improves cellular maintenance processes in a way that modestly slows the aging process, resisting the accumulation of damage, dysfunctional cells, and chroni...
Source: Fight Aging! - July 26, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, June 27th 2022
In conclusion, this study confirms that innate immune training can be induced in aging healthy individuals as well as critically ill sepsis patients. We found that innate immune training can be induced regardless of age and there was no substantive difference in the immune trained phenotype as a function of age. We employed β-glucan as our immune training stimulus. The ability of glucan to induce the trained phenotype suggests that it may be possible to pharmacologically induce the immune trained phenotype in aging human immunocytes.
Sitting Time Correlates with Mortality Risk
https://www.fightaging.org/archi...
Source: Fight Aging! - June 26, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Excess Cholesterol Provokes PERK Expression in Vascular Smooth Muscle Cells in Atherosclerosis
Atherosclerosis is a condition of localized excesses of cholesterol in blood vessel walls, leading to fatty plaques that narrow and weaken those vessels, ultimately leading to stroke or heart attack. A lot of attention is given to the way in which excess cholesterol induces dysfunction in the macrophage cells responsible for clearing that cholesterol from blood vessel walls, thereby creating a feedback loop in which atherosclerotic plaques grow. Researchers here instead look at the effects of excess cholesterol on smooth muscle cells, and how it draws them into making the problem worse.
"We are trying to identify ...
Source: Fight Aging! - June 23, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
N-lactoyl-phenylalanine as a Link Between Exercise and Appetite Regulation
Exercise helps to downregulate appetite, among its many other beneficial outcomes. Researchers here point to raised levels of N-lactoyl-phenylalanine as an important part of this connection, one of a family of compounds formed as a result of exercise. In the present environment of prevalent obesity, a sizable amount of research into the biochemistry of exercise is directed towards its effects on consumption of food.
"Regular exercise has been proven to help weight loss, regulate appetite, and improve the metabolic profile, especially for people who are overweight and obese. If we can understand the mechanism by wh...
Source: Fight Aging! - June 23, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, April 18th 2022
In conclusion, our results suggest that SAH extends lifespan by inducing MetR or mimicking its downstream effects. Since the lifespan-extending effects of SAH are conserved in yeast and nematodes, and MetR extends the lifespan of many species, exposure to SAH is expected to have multiple benefits across evolutionary boundaries. Our findings offer the enticing possibility that in humans the benefits of a MetR diet can be achieved by promoting Met reduction with SAH. The use of endogenous metabolites, such as SAH, is considered safer than drugs and other substances, suggesting that it may be one of the most feasible ways to ...
Source: Fight Aging! - April 17, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
More on the Safe Mitochondrial Uncoupling Compound BAM15
In this study, the aged mice increased their muscle mass by an average of 8 percent, their strength by 40 percent, while they lost more than 20 percent of their fat."
BAM15 improves many of the key determinants of health and aging, including: (a) removing damaged mitochondria, the power plants of the cell; (b) making more healthy mitochondria, and; (c) reducing "inflammaging," or age-related inflammation, linked to muscle loss.
Mitochondrial uncoupling attenuates sarcopenic obesity by enhancing skeletal muscle mitophagy and quality control
Sarcopenic obesity is a highly prevalent disease with poor ...
Source: Fight Aging! - April 13, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Chaperone Mediated Autophagy as a Target for the Treatment of Atherosclerosis
Forms of autophagy function to remove unwanted, excess, or damaged structures and other molecules in the cell. These materials are delivered to a lysosome, a membrane packed with enzymes capable of dismantling near every macromolecule a cell will encounter, producing raw materials for reuse. Autophagy is quite clearly connected to tissue function and aging in a number of ways. It appears to decline in quality with age, leading to downstream problems in cell and tissue function as worn and damaged component parts accumulate. Upregulation of autophagy for long periods of time is a feature of numerous interventions, such as c...
Source: Fight Aging! - April 11, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
This High-Fat Diet Protects Against Dementia, Research Suggests
Foods included in the diet include seafood, low-carb vegetables, cheese, eggs, coconut oil and olive oil. (Source: PsyBlog | Psychology Blog)
Source: PsyBlog | Psychology Blog - January 19, 2022 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Dementia Nutrition Source Type: blogs
Eating Raw in 2021 (Recap)
Happy New Year!
Since I ate mostly raw for 2021 – so many salads! – I can go back to eating more cooked food today.
Oddly I feel less motivated to do that than I expected. I fell into some very simple eating habits centered around fruit and salads, and that worked well for me. I’m sure I ate more greens this year than in any previous year. I got really good at making salads that I like.
There are a lot of foods that I haven’t eaten since 2020, such as pizza. I look forward to trying them again, but that feels more like intellectual curiosity than any sort of craving. I feel like my cravings for ce...
Source: Steve Pavlina's Personal Development Blog - January 1, 2022 Category: Psychiatry & Psychology Authors: Steve Pavlina Tags: Health Lifestyle Source Type: blogs
