Fight Aging! Newsletter, July 20th 2020

This study was the first to demonstrate a causal relationship between glial senescence and neurodegeneration. In this study, accumulations of senescent astrocytes and microglia were found in tau-associated neurodegenerative disease model mice. Elimination of these senescent cells via a genetic approach can reduce tau deposition and prevent the degeneration of cortical and hippocampal neurons. Most recently, it was shown that clearance of senescent oligodendrocyte progenitor cells in AD model mice with senolytic agents could lessen the Aβ plaque load, reduce neuroinflammation, and ameliorate cognitive deficits. This seno-therapeutic approach is currently being tested in neurodegenerative diseases and despite expected challenges and difficulties, more detailed investigation is warranted. Lipocalin 2 as a Link Between Metabolic Syndrome and Neuroinflammation https://www.fightaging.org/archives/2020/07/lipocalin-2-as-a-link-between-metabolic-syndrome-and-neuroinflammation/ Obesity and its immediate consequences, such as non-alcoholic fatty liver disease and type 2 diabetes, are associated with greater neuroinflammation and risk of dementia. Excess visceral fat tissue does its part to produce chronic inflammation throughout the body, but here researchers focus on a specific metabolic dysregulation in the liver that produces inflammation in the brain. That inflammation in turn drives a faster progression towards neurodegenerative conditions. The lesso...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs

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AbstractHuman trafficking is an egregious violation of basic human rights that has reached global proportions. Despite the gradual proliferation of social science research and policy endeavors, a contemporary understanding of state human trafficking statutes has received limited discussion. Existing commentary tends to underserve survivor experiences in the law. Using a database of 982 human trafficking state statutes, this study seeks to describe the landscape of how the law acknowledges survivors. In doing so, we found that states acknowledge survivors through 1. formal agency guidelines, 2. survivor rights and services,...
Source: Crime, Law and Social Change - Category: Criminology Source Type: research
Contributors : King L Hung ; Kathryn E Yost ; Liangqi Xie ; Quanming Shi ; Konstantin Helmsauer ; Jens Luebeck ; Robert Sch öpflin ; Joshua T Lange ; Rocio Chamorro ; Natasha E Weiser ; Celine Chen ; Maria E Valieva ; Ivy Tsz-Lo Wong ; Sihan Wu ; Siavash R Dehkordi ; Connor V Duffy ; Katerina Kraft ; Jun Tang ; Julia A Belk ; John C Rose ; M R Corces ; Jeffrey M Granja ; Utkrisht Rajkumar ; Jordan Friedlein ; An indya Bagchi ; Ansuman T Satpathy ; Robert Tijan ; Stefan Mundlos ; Vineet Bafna ; Anton G Henssen ; Paul S Mischel ; Zhe Liu ; Howard Y ChangSeries Type : Expression profiling by high throughput sequencingOrg...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Jeremy Farrar explains why we must expect new variants, and why he ’d like to give away his booster shot.Medscape
Source: Medscape Transplantation Headlines - Category: Transplant Surgery Tags: Internal Medicine Expert Interview Source Type: news
AbstractReproducibility of clinical output is important when investigating therapeutic efficacy in pre-clinical animal studies. Due to its physiological relevance, a swine myocardial infarction (MI) model has been widely used to evaluate the effectiveness of stem cells or tissue-engineered constructs for ischemic heart diseases. Several methods are used to induce MI in the swine model. However, it is difficult, using these approaches, to obtain a similar level of functional outcomes from a group of animals due to interpersonal variation, leading to increased experimental cost. Hence, in order to minimize human intervention...
Source: European Journal of Applied Physiology - Category: Physiology Source Type: research
The company has grown from about 20 people to 100 since CEO Andrei Floriou came aboard 18 months ago.
Source: bizjournals.com Health Care:Biotechnology headlines - Category: Biotechnology Authors: Source Type: news
J. Mater. Chem. A, 2021, Advance Article DOI: 10.1039/D1TA05586K, PaperWenhao Zhao, Dongzhi Zhang, Yan Yang, Chen Du, Bao Zhang This paper reports the excellent properties and multifunctional applications of a fast self-healing polyvinyl alcohol nano-organic composite hydrogel. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - J. Mater. Chem. latest articles - Category: Chemistry Authors: Source Type: research
New J. Chem., 2021, Advance Article DOI: 10.1039/D1NJ03038H, PaperMehmet Oguz, Berna Dogan, Serdar Durdagi, Asif Ali Bhatti, Serdar Karakurt, Mustafa Yilmaz Although quercetin is an effective bioactive compound preventing the progress of several human cancers, its impact is reduced due to low bioavailability. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - New J. Chem. latest articles - Category: Chemistry Authors: Source Type: research
This time around, it ’ll be a much smoother experience than the ones earlier this year when there wasn’t enough vaccine to meet demand.
Source: bizjournals.com Health Care:Biotechnology headlines - Category: Biotechnology Authors: Source Type: news
Environ. Sci.: Processes Impacts, 2021, Accepted Manuscript DOI: 10.1039/D1EM00202C, CommunicationMayomi Omebeyinje, Adewale Adeluyi, Chandrani Mitra, Paramita Chakraborty, Gregory Gandee, Nalit Patel, Bindhu Verghese, Christine Farrance, Matthew Hull, Paramita Basu, Kwonmoo Lee, Atin Adhikari, Burcu Adivar, Jennifer Horney, Anindya Chanda Indoor flooding is a leading contributor to indoor dampness and the associated mold infestations in the coastal United States. Whether the prevalent mold genera that infest the coastal flood-prone buildings... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - J. Environ. Monit. latest articles - Category: Environmental Health Authors: Source Type: research
Now that schools have welcomed students back to classrooms, they face a new challenge: a shortage of teachers and staff the likes of which some districts say they have never seen.Associated Press
Source: Medscape Critical Care Headlines - Category: Intensive Care Tags: Infectious Diseases News Source Type: news
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