Is the ketogenic diet dangerous?

  Answer: No—unless you do it for more than a few months. After a few months, the upfront metabolic and weight benefits will begin to reverse and new health problems arise. We know this with confidence. I raise this question once again because more and more people are coming to me reporting problems. It may take months, even years, but the long-term consequences can be quite serious. Achieving ketosis by engaging in a very low-carbohydrate, high-fat lifestyle is—without a doubt—an effective means of losing weight, breaking insulin and leptin resistance, reversing type 2 diabetes and fatty liver, reducing blood pressure, reversing the inflammation of visceral fat, and may even cause partial or total remission of selected cancers. It means taking advantage of a natural physiological response to accelerate benefits. So what’s the problem? The problem comes when people remain ketotic for extended periods. We know with confidence that long-term ketosis poses substantial risk for health complications because thousands of children have followed ketogenic diets over the years as a means of suppressing intractable grand mal seizures unresponsive to drugs, seizures that can lead to irreversible brain damage if not stopped. A ketogenic diet reduces seizures by approximately 55%. Because seizures are a chronic problem, these kids maintain ketosis for months to years. The health of these kids have been formally tracked. What happens to them beyond the reductio...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: ketones bowel flora ketogenic ketotic undoctored wheat belly Source Type: blogs

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This study compared the effects of different dietary energy contents (11.3, 12.0 and 12.7 MJ ME/ kg feed) fed ad libitum in a feedlot on the carcass quality characteristics (carcass yield, commercial yield, 3-rib cut) of goats introduced to feedlot at 22.2 ± 3.5 kg (18 weeks of age), and slaughtered at five week intervals. The energy content of the finisher diets had no effect (P > 0.05) on any of the traits measured. However, the time spent in the feedlot influenced (P 
Source: Small Ruminant Research - Category: Zoology Source Type: research
In this study, MHC-1 and PDL-1 score in primary and metastatic tumor cells was evaluated in 43 gastric cancer patients with lymph node metastasis. According to our results, the primary tumor PDL-1 score was correlated with the number of metastatic lymph nodes (r = 0.258; p = 0.024) and primary tumor size (r = 0.341; p = 0.045). A similar correlation was found between the primary tumor PDL-1 score and the metastatic tumor PDL-1 score (r = 0.213; p = 0.015). In our study, MHC-1 was found to be higher in primary tumors than metastatic tumors, although not statistically significant (p = 0.054). The results of our study showed ...
Source: Gastroenterology Research and Practice - Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research
Authors: McCarthy AJ, O'Reilly SM, Shanley J, Geraghty R, Ryan EJ, Cullen G, Sheahan K Abstract Background: As the malignant potential of sessile serrated lesions/polyps (SSL/Ps) and traditional serrated adenomas (TSAs) has been clearly demonstrated, it is important that serrated polyps are identified and correctly classified histologically. Aim: Our aim was to characterize the clinicopathological features of a series of SSL/Ps &TSAs, to assess the accuracy of the pathological diagnosis, the incidence, and the rate of dysplasia in SSL/Ps &TSAs. Methods: We identified all colorectal serrated polyps b...
Source: Gastroenterology Research and Practice - Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research
Publication date: Available online 18 March 2019Source: Veterinary MicrobiologyAuthor(s): Victoria E. Watson, Megan E. Jacob, José M. Bruno-Bárcena, Sophia Amirsultan, Stephen H. Stauffer, Victoria O. Píqueras, Rafael Frias, Jody L. GookinAbstractTypical enteropathogenic E. coli (tEPEC) carries the highest hazard of death in children with diarrhea and atypical EPEC (aEPEC) was recently identified as significantly associated with diarrheal mortality in kittens. In both children and kittens there is a significant association between aEPEC burden and diarrheal disease, however the infection can be found i...
Source: Veterinary Microbiology - Category: Veterinary Research Source Type: research
Conclusion: The monthly administration of IM NE represents a manageable and effective option, in terms of BMD and bone BM improvement, for the long-term treatment of postmenopausal OP women with gastric intolerance to BPs. This trial is registered with ClinicalTrials.gov Identifier: NCT03699150. PMID: 30881452 [PubMed]
Source: International Journal of Endocrinology - Category: Endocrinology Tags: Int J Endocrinol Source Type: research
Publication date: Available online 7 March 2019Source: Physics Letters AAuthor(s): Wenpo Yao, Wenli Yao, Jun WangAbstractThe association of equal heartbeat intervals with cardiac conditions and the effect of the equality on permutation-based time irreversibility are investigated in this paper. We measure the distributions of equal heartbeat intervals under three conditions, namely congestive heart failure (CHF), healthy young and elderly, whose time irreversibility is detected by measuring the probabilistic difference between permutations instead of raw vectors. We demonstrate that heartbeats contain high rates of equal st...
Source: Physics Letters A - Category: Physics Source Type: research
Claudio de Lucia, Celestino Sardu, Laurent Metzinger, Coert J. Zuurbier
Source: Frontiers in Physiology - Category: Physiology Source Type: research
Publication date: Available online 18 March 2019Source: Molecular Aspects of MedicineAuthor(s): Laura Valle, Richarda M. de Voer, Yael Goldberg, Wenche Sjursen, Asta Försti, Clara Ruiz-Ponte, Trinidad Caldés, Pilar Garré, Maren F. Olsen, Margareta Nordling, Sergi Castellvi-Bel, Kari HemminkiAbstractThe present article summarizes recent developments in the characterization of genetic predisposition to colorectal cancer (CRC). The main themes covered include new hereditary CRC and polyposis syndromes, non-CRC hereditary cancer genes found mutated in CRC patients, strategies used to identify novel causal ge...
Source: Molecular Aspects of Medicine - Category: Molecular Biology Source Type: research
Publication date: Available online 19 March 2019Source: Journal of Molecular StructureAuthor(s): Qianying Nie, Jun Qian, Chi ZhangAbstractA new 3D heterometallic coordination polymer (HCP), which formulated as {[Ca(H2O)2][LCo]·DMSO·2H2O}n (1) (DMSO = dimethyl sulfoxide), has been solvothermally synthesized from metalloligand LCo = [Co(2,4-pydca)2]2– (2,4-pydca = pyridine-2,4-dicarboxylate) and alkaline-earth ion CaII. HCP 1 has been well characterized by Fourier-transform infrared spectroscopy, elemental analysis and single-crystal X-ray diffraction analysis. The crystallographic analysis in...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
Publication date: Available online 18 March 2019Source: Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular BiologyAuthor(s): Yi Zhou, Xiaojin Zhang, Qian Xu, Jinpeng Yan, Fan Yu, Fenghua Wang, Jun Xiao, Yongju Luo, Huan ZhongAbstractHybrid Nile tilapia (Oreochromis niloticus, ♀) × blue tilapia (O. aureus, ♂) is a widely cultured tilapia variety due to its growth vigor compared to the parent species. As a peptide hormone, insulin-like growth factor 1 (IGF-1) plays a critical role in regulating somatic growth. The present study focuses on the expression characteristics of IGF-1 in hybrid...
Source: Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology - Category: Molecular Biology Source Type: research
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