Macrophage-derived extracellular vesicles alter cardiac recovery and metabolism in a rat heart model of donation after circulatory death
J Cell Mol Med. 2024 Apr;28(8):e18281. doi: 10.1111/jcmm.18281.ABSTRACTConditions to which the cardiac graft is exposed during transplantation with donation after circulatory death (DCD) can trigger the recruitment of macrophages that are either unpolarized (M0) or pro-inflammatory (M1) as well as the release of extracellular vesicles (EV). We aimed to characterize the effects of M0 and M1 macrophage-derived EV administration on post-ischaemic functional recovery and glucose metabolism using an isolated rat heart model of DCD. Isolated rat hearts were subjected to 20 min aerobic perfusion, followed by 27 min global, warm i...
Source: J Cell Mol Med - April 23, 2024 Category: Molecular Biology Authors: Selianne Graf Vanessa Biemmi Maria Arnold Adrian Segiser Anja M üller Natalia M éndez-Carmona Manuel Egle Matthias Siepe Lucio Barile Sarah Longnus Source Type: research
Artificial intelligence-powered insights into high-risk, non-obstructive coronary atherosclerosis: a case report
DISCUSSION: The main clinical message of this case report is that advanced plaque analysis by cardiac CT, especially when performed with AI-based software, may provide important prognostic information leading to a personalized preventive approach. Moreover, AI-based software may contribute to promote a routine evaluation of these important data already included in traditional cardiac CT.PMID:38651080 | PMC:PMC11033843 | DOI:10.1093/ehjcr/ytae172 (Source: Atherosclerosis)
Source: Atherosclerosis - April 23, 2024 Category: Cardiology Authors: Andrea Provera Daniele Andreini Kersten Petersen Emanuele Gallinoro Edoardo Conte Source Type: research
Improvement in right heart function following kidney transplantation in esrd patients: insights from speckle tracking echocardiography analysis
This study aimed to evaluate the effects of KTx on the right heart chambers in ESRD patients. 57 adult KTx candidates were enrolled in this prospective longitudinal study, while 49 of them were included in the final assessment. Patients underwent a comprehensive cardiac assessment, including conventional echocardiography, speckle tracking echocardiography, and three-dimensional heart modeling both before and after surgery. Echocardiographic assessments showed significant increases in right ventricular (RV) ejection fraction, RV fractional area change (RVFAC), tricuspid annular plain systolic excursion, RV fractional shorte...
Source: Atherosclerosis - April 23, 2024 Category: Cardiology Authors: Mohammad Khani Amir Moradi Erfan Ghadirzadeh Seyed Pooria Salehi Mashhad Sari Tooba Akbari Source Type: research
Apixaban in bridge to transplant and destination LVAD ‐ rationale and study design: the ApixiVAD trial
ConclusionsA positive outcome in the ApixiVAD study would provide the basis for future, larger, pivotal anticoagulation trials in LVAD patients. (Source: ESC Heart Failure)
Source: ESC Heart Failure - April 23, 2024 Category: Cardiology Authors: Bruno Schnegg,
Ricardo Deveza,
Christopher Hayward Tags: Study Design Source Type: research
Surveillance Imaging and Management of Cardiac Sarcoidosis after Advanced Heart Failure Therapies
Cardiac sarcoidosis (CS), an inflammatory disorder characterized by granulomatous inflammation, can manifest as heart failure (HF), ventricular arrhythmias, and conduction disease (1). Despite immunosuppression and medical therapy for HF, a subset of CS patients will progress to end-stage HF requiring left ventricular assist device (LVAD) therapy and/or heart transplantation (HT) which are associated with excellent outcomes (2, 3). The optimal surveillance strategy for monitoring CS recrudescence after advanced heart failure therapies remains undefined. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - April 23, 2024 Category: Cardiology Authors: Richa Gupta, Francisca Bermudez, Tania Vora, Navid Homayouni, Gaby Weissman, Ajay Kadakkal, Nana Afari-Armah, Sriram Rao, Phillip H. Lam, Maria E. Rodrigo, Mark Hofmeyer, Mrinalini Krishnan, Keki Balsara, Samer S. Najjar, Farooq H. Sheikh Tags: Brief report Source Type: research
Improvement in right heart function following kidney transplantation in esrd patients: insights from speckle tracking echocardiography analysis
This study aimed to evaluate the effects of KTx on the right heart chambers in ESRD patients. 57 adult KTx candidates were enrolled in this prospective longitudinal study, while 49 of them were included in the final assessment. Patients underwent a comprehensive cardiac assessment, including conventional echocardiography, speckle tracking echocardiography, and three-dimensional heart modeling both before and after surgery. Echocardiographic assessments showed significant increases in right ventricular (RV) ejection fraction, RV fractional area change (RVFAC), tricuspid annular plain systolic excursion, RV fractional shorte...
Source: The International Journal of Cardiovascular Imaging - April 23, 2024 Category: Radiology Source Type: research
Leukotriene B4: A Potential Mediator and Biomarker for Cardiac Allograft Vasculopathy
Cardiac allograft vasculopathy (CAV) remains the leading cause of long-term graft failure and mortality after heart transplantation. Effective preventive and treatment options are not available to-date, largely because underlying mechanisms remain poorly understood. We studied the potential role of leukotriene B4 (LTB4), an inflammatory lipid mediator, in development of CAV. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 23, 2024 Category: Transplant Surgery Authors: Dong Wang, Grigol Tediashvili, Daniel Kim, Xiaomeng Hu, Helen Luikart, Thomas Renne, Amy Tian, Kari C. Nadeau, Joachim Velden, Sonja Schrepfer, Kiran K. Khush Source Type: research
Fetal Echocardiographic Evaluation of Tricuspid Valve and Right Ventricular Function Including Global Longitudinal Strain in Hypoplastic Left Heart Syndrome and Association with Postnatal Outcomes
AbstractDespite significant advancements in the care of patients with hypoplastic left heart syndrome (HLHS) morbidity and mortality remain high. Postnatal right ventricular dysfunction and tricuspid regurgitation (TR) are associated with worse outcomes in HLHS. We aim to determine if right ventricle functional parameters and TR on fetal echocardiogram are associated with postnatal outcomes in HLHS patients. Retrospective review was performed on all fetuses with HLHS from 2014 to 2022 at our institution. Initial and follow up fetal echocardiogram measurements of right ventricular myocardial performance index (MPI), fractio...
Source: Mammalian Genome - April 22, 2024 Category: Genetics & Stem Cells Source Type: research
CD8+ T cell-mediated rejection of allogenic human induced pluripotent stem cell-derived cardiomyocyte sheets in human PBMC-transferred NOG MHC double knockout mice
Transplantation of human induced pluripotent stem cell-derived cardiomyocytes (hiPS-CMs) has emerged as a promising therapy to treat end-stage heart failure. However, immunogenicity of hiPS-CMs in transplanted patients has not been fully elucidated. Thus, in vivo models are required to estimate immune responses against hiPS-CMs in transplant recipients. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 22, 2024 Category: Transplant Surgery Authors: Ryu Matsumoto, Yin Enzhi, Kazuyoshi Takeda, Kodai Morimoto, Kyoko Yogo, Masaki Harada, Koji Tokushige, Yui Maehara, Saori Hirota, Yuko Kojima, Mamoru Ito, Nagako Sougawa, Shigeru Miyagawa, Yoshiki Sawa, Ko Okumura, Koichiro Uchida Tags: Original Translational Science Source Type: research
Evolving Applications of Echocardiography in the Evaluation of Left Atrial and Right Ventricular Strain
AbstractPurpose of ReviewSpeckle-tracking echocardiography (STE) can assess myocardial motion in non-LV chambers —including assessment of left atrial (LA) and right ventricular (RV) strain. This review seeks to highlight the diagnostic, prognostic, and clinical significance of these parameters in heart failure, atrial fibrillation (AF), diastolic dysfunction, pulmonary hypertension (PH), tricuspid regurgitat ion, and heart transplant recipients.Recent FindingsImpaired LA strain reflects worse LV diastolic function in individuals with and without HF, and this is associated with decreased exercise capacity. Initiating trea...
Source: Current Cardiology Reports - April 22, 2024 Category: Cardiology Source Type: research
Spectrum of chronic lung allograft dysfunction pathology in human lung transplantation
Long-term survival after lung transplantation (LTx) remains limited by Chronic Lung Allograft Dysfunction (CLAD), which includes two main phenotypes: bronchiolitis obliterans syndrome (BOS) and restrictive allograft syndrome (RAS), with possible overlap. We aimed to detail and quantify pathological features of these CLAD sub-types. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 22, 2024 Category: Transplant Surgery Authors: Benjamin Renaud-Picard, Gregory Berra, David Hwang, Ella Huszti, Ei Miyamoto, Gerald J Berry, Prodipto Pal, Stephen Juvet, Shaf Keshavjee, Tereza Martinu Tags: Original Clinical Science Source Type: research
Cancers, Vol. 16, Pages 1592: Outcomes of Modified Mayo Stage IIIa and IIIb Cardiac Light-Chain Amyloidosis: Real-World Experience in Clinical Characteristics and Treatment & mdash;67 Patients Multicenter Analysis
Cancers, Vol. 16, Pages 1592: Outcomes of Modified Mayo Stage IIIa and IIIb Cardiac Light-Chain Amyloidosis: Real-World Experience in Clinical Characteristics and Treatment—67 Patients Multicenter Analysis
Cancers doi: 10.3390/cancers16081592
Authors:
Grzegorz Charliński
Maximilian Steinhardt
Leo Rasche
Veronica Gonzalez-Calle
Camila Peña
Harsh Parmar
Katarzyna Wiśniewska-Piąty
Julio Dávila Valls
Magdalena Olszewska-Szopa
Lidia Usnarska-Zubkiewicz
Alessandro Gozzetti
Sara Ciofini
Massimo Gentile
Elena Zamagni
Michał Kurlapski
Wojciech Legieć
David H. Vesole
Artur Jurcz...
Source: Cancers - April 21, 2024 Category: Cancer & Oncology Authors: Grzegorz Charli ński Maximilian Steinhardt Leo Rasche Veronica Gonzalez-Calle Camila Pe ña Harsh Parmar Katarzyna Wi śniewska-Piąty Julio D ávila Valls Magdalena Olszewska-Szopa Lidia Usnarska-Zubkiewicz Alessandro Gozzetti Sara Ciofini Massimo Genti Tags: Article Source Type: research
Bridge to Transplantation: Policies Impact Practices
Ann Thorac Surg. 2024 Apr 18:S0003-4975(24)00290-X. doi: 10.1016/j.athoracsur.2024.03.041. Online ahead of print.ABSTRACTSince the development of the first heart allocation system in 1988 to the most recent heart allocation system in 2018, the road to heart transplantation has continued to evolve. Policies were shaped with advances in temporary and durable left ventricular assist devices as well as prioritization of patients based on degree of illness. Herein, we review the changes in the heart allocation system over the past several decades and the impact of practice patterns across the United States.PMID:38642820 | DOI:1...
Source: The Annals of Thoracic Surgery - April 20, 2024 Category: Cardiovascular & Thoracic Surgery Authors: Akshay Kumar Amit Alam Erin Flattery Michael Dorsey Camille Yongue Allan Massie Suhani Patel Alex Reyentovich Nader Moazami Deane Smith Source Type: research
Analysis of the role of perfusion, mechanical, and electrical stimulation in bioreactors for cardiac tissue engineering
Bioprocess Biosyst Eng. 2024 Apr 20. doi: 10.1007/s00449-024-03004-5. Online ahead of print.ABSTRACTSince cardiovascular diseases (CVDs) are globally one of the leading causes of death, of which myocardial infarction (MI) can cause irreversible damage and decrease survivors' quality of life, novel therapeutics are needed. Current approaches such as organ transplantation do not fully restore cardiac function or are limited. As a valuable strategy, tissue engineering seeks to obtain constructs that resemble myocardial tissue, vessels, and heart valves using cells, biomaterials as scaffolds, biochemical and physical stimuli. ...
Source: Bioprocess and Biosystems Engineering - April 20, 2024 Category: Biomedical Engineering Authors: Jorge Bravo-Ol ín Sabina A Mart ínez-Carreón Emmanuel Francisco-Solano Alvaro R Lara Nohra E Beltran-Vargas Source Type: research
Bridge to Transplantation: Policies Impact Practices
Ann Thorac Surg. 2024 Apr 18:S0003-4975(24)00290-X. doi: 10.1016/j.athoracsur.2024.03.041. Online ahead of print.ABSTRACTSince the development of the first heart allocation system in 1988 to the most recent heart allocation system in 2018, the road to heart transplantation has continued to evolve. Policies were shaped with advances in temporary and durable left ventricular assist devices as well as prioritization of patients based on degree of illness. Herein, we review the changes in the heart allocation system over the past several decades and the impact of practice patterns across the United States.PMID:38642820 | DOI:1...
Source: The Annals of Thoracic Surgery - April 20, 2024 Category: Cardiovascular & Thoracic Surgery Authors: Akshay Kumar Amit Alam Erin Flattery Michael Dorsey Camille Yongue Allan Massie Suhani Patel Alex Reyentovich Nader Moazami Deane Smith Source Type: research
