GSE262742 Redefining the molecular rejection states in 3230 heart transplant biopsies: relationships to parenchymal injury and graft survival
Contributor : Jessica ChangSeries Type : Expression profiling by arrayOrganism : Homo sapiensThe first-generation Molecular Microscope ® (MMDx) system for heart transplant endomyocardial biopsies used expression of rejection-associated transcripts (RATs) to diagnose T cell-mediated rejection (TCMR) and antibody-mediated rejection (ABMR) but also detected acute injury. However, the ideal system should detect rejection without being influenced by injury, to permit analysis of the relationship between rejection and parenchymal injury. To achieve this, we developed a new rejection classification in an expanded cohort of 323...
Source: GEO: Gene Expression Omnibus - April 2, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
Utah flouts FDA with law greenlighting placental stem cell therapies
The state of Utah is challenging the authority of the U.S. Food and Drug Administration (FDA) with a new, unusually bold law that allows patients to receive unapproved placental stem cell “therapies.” Observers predict that the law, which takes effect on 1 May, could significantly undermine FDA’s authority to regulate drugs and other treatments.
The
new statute
, passed almost unanimously by both houses of the Utah legislature in February and signed by Governor Spencer Cox (R) last month, declares that Utah health care providers “may perform a [placental] stem cell therapy that is not approved by [F...
Source: Science of Aging Knowledge Environment - April 1, 2024 Category: Geriatrics Source Type: research
From Blunt Cardiac Injury to Heart Transplant Following Motorcycle Collision
We present a case of a healthy 24-year-old man without significant past medical history who was in a motorcycle accident, resulting in sternal fracture and BCI. He was ultimately found to have thrombotic occlusion and dissection of his left anterior descending artery (LAD), requiring mechanical thrombectomy and drug-eluting stent, as well as subsequent hospitalizations and operations due to various complications. It was suspected that he went into ventricular fibrillation and had a second motorcycle collision, resulting in cardiogenic shock. Ultimately, his progression of ischemic cardiomyopathy and mitral regurgitation le...
Source: The American Surgeon - April 1, 2024 Category: Surgery Authors: Alexandra L Van Horn Jessica R Burgess Source Type: research
Author ’s Reply to Heart Transplant, CIED Implant and Mortality
We reported longer survival in orthotopic heart transplant patients receiving CIEDs, noting an early separation of survival curves which “suggest other confounding factors at play”. (Source: Heart Rhythm)
Source: Heart Rhythm - April 1, 2024 Category: Cardiology Authors: Zain Gowani, Michael R. Gold Source Type: research
Clinical Outcomes of Renal Transplant Recipients Undergoing Percutaneous Coronary Intervention
Clinical outcomes of patients with renal transplant (RT) undergoing percutaneous coronary intervention (PCI) remain poorly elucidated. (Source: Heart, Lung and Circulation)
Source: Heart, Lung and Circulation - April 1, 2024 Category: Cardiology Authors: Wayne C. Zheng, Nicole Evans, Diem Dinh, Jason E. Bloom, Angela L. Brennan, Jocasta Ball, Jeffrey Lefkovits, James A. Shaw, Christopher M. Reid, William Chan, Dion Stub Tags: Original Article Source Type: research
Management of incessant ventricular arrhythmias in a patient with left ventricular assist device: a case report
The implantation of left ventricular assist devices (LVADs) as a bridge to transplantation or as destination therapy in end-stage heart failure patients is frequently complicated by the emergence of ventricula... (Source: Journal of Cardiothoracic Surgery)
Source: Journal of Cardiothoracic Surgery - April 1, 2024 Category: Cardiovascular & Thoracic Surgery Authors: Chen Chen, Juan Du, Xianqiang Wang and Liang Zou Tags: Case Report Source Type: research
Impact of Diaphragmatic Plication on Lung Function Parameters and Long-Term Outcomes After Lung Transplantation
Purpose: A rare but important complication of lung transplantation (LTx) is postoperative phrenic nerve dysfunction (PND). Diaphragmatic plication (DP) represents an established treatment option for PND, however, the long-term effect of DP on lung function in lung transplant recipients is currently unknown. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , C. Hillebrand, T. Schweiger, S. Schwarz, S. Taghavi, C. Aigner, P. Jaksch, K. Hoetzenecker Source Type: research
Single Versus Double Lung Transplant in the Elderly: A Propensity-Matched Analysis
Purpose: Single lung transplantation (SLT) is considered for select candidates that may be at higher risk for bilateral lung transplantation (BLT), including older frail recipients. To optimize organ utilization, we compared the outcomes of BLT with SLT in older patients. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , A. Mehta, M. Budev, U. Ahmad, J. Yun, K. McCurry, H. Elgharably Source Type: research
Bronchial Artery Revascularization: Establishing the Bar Inlung Transplantation
Purpose: To determine short- and long-term outcomes of bronchial artery revascularization (BAR) for lung transplant when performed in a teaching and learning series. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , S. Unai, R. Mahboubi, G. Stockdale, L. Thuita, J. Yun, E. Blackstone, M. Machuzak, C. Koval, M. Budev, K. McCurry, G. Pettersson Source Type: research
Living-Donor Single-Lobe Lung Transplantation: A Single-Center Case Series
Purpose: Living donor lobar lung transplantation (LDLLT) has become a life saving option for severe patients in Japan. Single-lobe lung transplant procedure was required when small pediatric patients received oversized grafts or only one donor was available. The aim of this study was to evaluate posttransplant outcomes of LDLLT using a single lobar graft. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , S. Tanaka, M. Takahashi, S. Nishikawa, Y. Yutaka, A. Ohsumi, H. Date Source Type: research
Donor-Derived Cell-Free DNA for Early Detection of Rejection and Allograft Injury in Lung Transplant Recipients
This study aims to explore the potential utility of ddcfDNA as a non-invasive biomarker for detecting allograft function and acute rejection after lung transplantation. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , J. Walter, K. Hirv, O. Wachter, A. Dick, J. Kovacs, O. Gl ück, J. Zimmermann, S. Michel, M. Irlbeck, N. Kneidinger, R. Hatz, J. Behr, C. Schneider, T. Kauke Source Type: research
Withdrawn
NA (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Source Type: research
ECMO as Bridge to Lung Transplantation. Experience in a Center in a Country with Low Donor Supply. Cl ínica Santa María, Santiago De Chile
Purpose: The use of Extracorporeal Membrane Oxygenation (ECMO) as bridge therapy has improved the outcomes of patients requiring invasive mechanical ventilation prior to lung transplantation (LT). Our objective is to evaluate and describe the local experience of ECMO therapy as bridge to lung transplantation (EBLT) in the last 8 years. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , C. Paulsen, P. Salazar, C. Sepulveda, M. Santelices, D. Paredes, T. Regueira, R. Varas, S. Viacava, M. Fica Source Type: research
Factors Associated with Long Survival Following Single Lung Transplantation
This study identified the factors that are associated with long survival following SLTx. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , Z. Nauroz, J. Ruck, R. Riojas, J. Ha, A. Massie, D. Segev, C. Merlo, E. Bush Source Type: research
The Outcomes of Old Age Lung Transplantation: National Multi-Institutional Cohort Study
This study evaluated lung transplantation outcomes in old age and verified the proper cut-off value for old age with the prospectively collected nationwide multi-institutional cohort. (Source: The Journal of Heart and Lung Transplantation)
Source: The Journal of Heart and Lung Transplantation - April 1, 2024 Category: Transplant Surgery Authors: , B. Park, Y. Yang, A. Woo, M. Park, J. Lee Source Type: research
