Prediction of adverse cardiovascular events in children using artificial intelligence-based electrocardiogram
This study aimed to develop and validate an ECG-derived marker of pediatric HF that reflects the risk of future cardiovascular events. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - April 3, 2024 Category: Cardiology Authors: Yoshitsugu Nogimori, Kaname Sato, Koichi Takamizawa, Yosuke Ogawa, Yu Tanaka, Kazuhiro Shiraga, Hitomi Masuda, Hikoro Matsui, Motohiro Kato, Masao Daimon, Katsuhito Fujiu, Ryo Inuzuka Source Type: research
Donation After Circulatory Death Heart Transplantation: A Narrative Review
Heart transplantation is the definitive treatment for refractory, end-stage heart failure. The number of patients awaiting transplantation far exceeds available organs. In an effort to expand the donor pool, donation after circulatory death (DCD) heart transplantation has garnered renewed interest. Unlike, donation after brain death, DCD donors do not meet criteria for brain death and are dependent on life-sustaining therapies. Procurement can include a direct strategy or normothermic regional perfusion, whereby there is restoration of perfusion to the organ prior to explantation. (Source: Journal of Cardiothoracic and Vascular Anesthesia)
Source: Journal of Cardiothoracic and Vascular Anesthesia - April 3, 2024 Category: Anesthesiology Authors: Dr. Kristin Constantine Trela, Dr. Christopher T. Salerno, Dr. Emuejevoke Chuba, Dr. Richa Dhawan Tags: Review Article Source Type: research
Renal Replacement Therapy After Heart Transplantation: Symptom or Syndromic?
To the Editor: (Source: Journal of Cardiothoracic and Vascular Anesthesia)
Source: Journal of Cardiothoracic and Vascular Anesthesia - April 3, 2024 Category: Anesthesiology Authors: Nicolas Kumar, Michael G. Fitzsimons, Amit Bardia, Adam A. Dalia Tags: Letter to the Editor Source Type: research
Deep Learning for Automated Measurement of Total Cardiac Volume for Heart Transplantation Size Matching
This study aims to determine the accuracy of a Deep Learning (DL) approach using 3-dimensional Convolutional Neural Networks (3D-CNN) to calculate TCV, with the clinical aim of enabling fast and accurate TCV use at all transplant centers. Ground truth TCV was segmented on CT scans of subjects aged 0 –30 years, identified retrospectively. Ground truth segmentation masks were used to train and test a custom 3D-CNN model consisting of a DenseNet architecture in combination with residual blocks of ResNet architecture. The model was trained on a cohort of 270 subjects and a validation cohort of 4 4 subjects (36 normal, 8 hea...
Source: Pediatric Cardiology - April 3, 2024 Category: Cardiology Source Type: research
Artificial intelligence-enhanced risk stratification of cancer therapeutics-related cardiac dysfunction using electrocardiographic images
CONCLUSION: AI applied to baseline ECG images can stratify the risk of CTRCD associated with anthracycline or trastuzumab exposure.CONDENSED ABSTRACT: There is an unmet need for scalable and affordable biomarkers to stratify the risk of cancer therapeutics-related cardiac dysfunction (CTRCD). In this hospital system-based, decade-long cohort of patients without cardiomyopathy receiving anthracyclines or trastuzumab, a validated artificial intelligence algorithm applied to baseline electrocardiographic (AI-ECG) images identified individuals with a 2-fold and 4.8-fold risk of developing any cardiomyopathy or left ventricular...
Source: Cancer Control - April 2, 2024 Category: Cancer & Oncology Authors: Evangelos K Oikonomou Veer Sangha Lovedeep S Dhingra Arya Aminorroaya Andreas Coppi Harlan M Krumholz Lauren A Baldassarre Rohan Khera Source Type: research
Rare complications of heart transplant: Autopsy findings
CONCLUSION: Hence, autopsy remains the key procedure that can help establish the cause of death after cardiac transplant. It is also imperative for clinicians to have awareness and high index of suspicion for early detection of the ongoing complications and intervene either surgically or medically to prevent catastrophic events.PMID:38563698 | DOI:10.4103/ijpm.ijpm_690_23 (Source: Indian Journal of Pathology and Microbiology)
Source: Indian Journal of Pathology and Microbiology - April 2, 2024 Category: Pathology Authors: Devika Gupta Lavan Singh Sameer Kumar Kanwaljeet Singh Satish Mendonca Tathagat Chatterjee Source Type: research
Rare complications of heart transplant: Autopsy findings
CONCLUSION: Hence, autopsy remains the key procedure that can help establish the cause of death after cardiac transplant. It is also imperative for clinicians to have awareness and high index of suspicion for early detection of the ongoing complications and intervene either surgically or medically to prevent catastrophic events.PMID:38563698 | DOI:10.4103/ijpm.ijpm_690_23 (Source: Indian Journal of Pathology and Microbiology)
Source: Indian Journal of Pathology and Microbiology - April 2, 2024 Category: Pathology Authors: Devika Gupta Lavan Singh Sameer Kumar Kanwaljeet Singh Satish Mendonca Tathagat Chatterjee Source Type: research
Rare complications of heart transplant: Autopsy findings
CONCLUSION: Hence, autopsy remains the key procedure that can help establish the cause of death after cardiac transplant. It is also imperative for clinicians to have awareness and high index of suspicion for early detection of the ongoing complications and intervene either surgically or medically to prevent catastrophic events.PMID:38563698 | DOI:10.4103/ijpm.ijpm_690_23 (Source: Indian Journal of Pathology and Microbiology)
Source: Indian Journal of Pathology and Microbiology - April 2, 2024 Category: Pathology Authors: Devika Gupta Lavan Singh Sameer Kumar Kanwaljeet Singh Satish Mendonca Tathagat Chatterjee Source Type: research
Rare complications of heart transplant: Autopsy findings
CONCLUSION: Hence, autopsy remains the key procedure that can help establish the cause of death after cardiac transplant. It is also imperative for clinicians to have awareness and high index of suspicion for early detection of the ongoing complications and intervene either surgically or medically to prevent catastrophic events.PMID:38563698 | DOI:10.4103/ijpm.ijpm_690_23 (Source: Indian Journal of Pathology and Microbiology)
Source: Indian Journal of Pathology and Microbiology - April 2, 2024 Category: Pathology Authors: Devika Gupta Lavan Singh Sameer Kumar Kanwaljeet Singh Satish Mendonca Tathagat Chatterjee Source Type: research
Rare complications of heart transplant: Autopsy findings
CONCLUSION: Hence, autopsy remains the key procedure that can help establish the cause of death after cardiac transplant. It is also imperative for clinicians to have awareness and high index of suspicion for early detection of the ongoing complications and intervene either surgically or medically to prevent catastrophic events.PMID:38563698 | DOI:10.4103/ijpm.ijpm_690_23 (Source: Indian Journal of Pathology and Microbiology)
Source: Indian Journal of Pathology and Microbiology - April 2, 2024 Category: Pathology Authors: Devika Gupta Lavan Singh Sameer Kumar Kanwaljeet Singh Satish Mendonca Tathagat Chatterjee Source Type: research
GSE262742 Redefining the molecular rejection states in 3230 heart transplant biopsies: relationships to parenchymal injury and graft survival
Contributor : Jessica ChangSeries Type : Expression profiling by arrayOrganism : Homo sapiensThe first-generation Molecular Microscope ® (MMDx) system for heart transplant endomyocardial biopsies used expression of rejection-associated transcripts (RATs) to diagnose T cell-mediated rejection (TCMR) and antibody-mediated rejection (ABMR) but also detected acute injury. However, the ideal system should detect rejection without being influenced by injury, to permit analysis of the relationship between rejection and parenchymal injury. To achieve this, we developed a new rejection classification in an expanded cohort of 323...
Source: GEO: Gene Expression Omnibus - April 2, 2024 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
Utah flouts FDA with law greenlighting placental stem cell therapies
The state of Utah is challenging the authority of the U.S. Food and Drug Administration (FDA) with a new, unusually bold law that allows patients to receive unapproved placental stem cell “therapies.” Observers predict that the law, which takes effect on 1 May, could significantly undermine FDA’s authority to regulate drugs and other treatments.
The
new statute
, passed almost unanimously by both houses of the Utah legislature in February and signed by Governor Spencer Cox (R) last month, declares that Utah health care providers “may perform a [placental] stem cell therapy that is not approved by [F...
Source: Science of Aging Knowledge Environment - April 1, 2024 Category: Geriatrics Source Type: research
