Progress with the Learning Health System 2.0: a rapid review of Learning Health Systems ’ responses to pandemics and climate change
Pandemics and climate change each challenge health systems through increasing numbers and new types of patients. To adapt to these challenges, leading health systems have embraced a Learning Health System (LHS... (Source: BMC Medicine)
Source: BMC Medicine - March 22, 2024 Category: Internal Medicine Authors: Carolynn L. Smith, Georgia Fisher, Putu Novi Arfirsta Dharmayani, Shalini Wijekulasuriya, Louise A. Ellis, Samantha Spanos, Genevieve Dammery, Yvonne Zurynski and Jeffrey Braithwaite Tags: Research article Source Type: research
Improvement of high-density lipoprotein atheroprotective properties in patients with systemic lupus erythematosus after belimumab treatment
CONCLUSIONS: HDL of SLE patients with active disease displays impaired atheroprotective properties accompanied by distinct lipidomic signature compared with controls. Belimumab treatment may improve the HDL atheroprotective properties and modify the HDL lipidomic signature in SLE patients, thus potentially mitigating atherosclerosis development.PMID:38514392 | DOI:10.1093/rheumatology/keae192 (Source: Atherosclerosis)
Source: Atherosclerosis - March 21, 2024 Category: Cardiology Authors: Anastasia-Georgia Dedemadi Christina Gkolfinopoulou Dimitra Nikoleri Myrto Nikoloudaki Hanna Ruhanen Minna Holopainen Reijo Kakela Georgia Christopoulou Stavros Bournazos Pantelis Constantoulakis Prodromos Sidiropoulos George Bertsias Angeliki Chroni Source Type: research
Improvement of high-density lipoprotein atheroprotective properties in patients with systemic lupus erythematosus after belimumab treatment
CONCLUSIONS: HDL of SLE patients with active disease displays impaired atheroprotective properties accompanied by distinct lipidomic signature compared with controls. Belimumab treatment may improve the HDL atheroprotective properties and modify the HDL lipidomic signature in SLE patients, thus potentially mitigating atherosclerosis development.PMID:38514392 | DOI:10.1093/rheumatology/keae192 (Source: Atherosclerosis)
Source: Atherosclerosis - March 21, 2024 Category: Cardiology Authors: Anastasia-Georgia Dedemadi Christina Gkolfinopoulou Dimitra Nikoleri Myrto Nikoloudaki Hanna Ruhanen Minna Holopainen Reijo Kakela Georgia Christopoulou Stavros Bournazos Pantelis Constantoulakis Prodromos Sidiropoulos George Bertsias Angeliki Chroni Source Type: research
Geographical Differences in Surgeon Reimbursement, Volume, and Patient Characteristics in Primary Total Hip Arthroplasty
The purpose of this study was to evaluate changes in regional and national variations in reimbursement to arthroplasty surgeons, procedural volumes, and patient populations for total hip arthroplasty (THA) from 2013 to 2021. (Source: The Journal of Arthroplasty)
Source: The Journal of Arthroplasty - March 21, 2024 Category: Orthopaedics Authors: Vikram S. Gill, Sailesh V. Tummala, Jack M. Haglin, Georgia Sullivan, Mark J. Spangehl, Joshua S. Bingham Source Type: research
Is Whole Body Computed Tomography (CT) Warranted in Elderly Patients After a Fall?
The purpose of this study was to assess the prognostic value of demographic and clinical characteristics and to determine which elderly patients will benefit from CT chest and/or abdomen/pelvis (CT CAP) during their trauma evaluation. (Source: Journal of Vascular Surgery)
Source: Journal of Vascular Surgery - March 20, 2024 Category: Surgery Authors: Georgia Syrnioti, Jacob Eisdorfer, Ravi Kothuru, Paul Haser, Lucio Flores, Patricia O'Neill, Charles Lapunzina, Ramy Abdel-Naby, Aparna Radhakrishna, Pranav Hinduja, Andrew Harrington, Nicholas J. Gargiulo Source Type: research
Fluoropyrimidine Toxicity: the Hidden Secrets of DPYD
CONCLUSIONS: DPYD polymorphisms are the main source of DPD variability. A study on DPYD epigenetics (both transcriptionally and post-transcriptionally) holds promise to provide insights into molecular pathways of fluoropyrimidine toxicity. Additional post-translational DPD modifications, as well as DPD inhibition by other drugs, may explain a proportion of enzyme activity variability. Therefore, there is still a lot we can learn about the DPYD/DPD fluoropyrimidine-induced toxicity machinery.PMID:38504562 | DOI:10.2174/0113892002296707240311105527 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - March 20, 2024 Category: Drugs & Pharmacology Authors: Vangelis G Manolopoulos Georgia Ragia Source Type: research
Fluoropyrimidine Toxicity: the Hidden Secrets of DPYD
CONCLUSIONS: DPYD polymorphisms are the main source of DPD variability. A study on DPYD epigenetics (both transcriptionally and post-transcriptionally) holds promise to provide insights into molecular pathways of fluoropyrimidine toxicity. Additional post-translational DPD modifications, as well as DPD inhibition by other drugs, may explain a proportion of enzyme activity variability. Therefore, there is still a lot we can learn about the DPYD/DPD fluoropyrimidine-induced toxicity machinery.PMID:38504562 | DOI:10.2174/0113892002296707240311105527 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - March 20, 2024 Category: Drugs & Pharmacology Authors: Vangelis G Manolopoulos Georgia Ragia Source Type: research
Combining randomized and non ‐randomized data to predict heterogeneous effects of competing treatments
AbstractSome patients benefit from a treatment while others may do so less or do not benefit at all. We have previously developed a two-stage network meta-regression prediction model that synthesized randomized trials and evaluates how treatment effects vary across patient characteristics. In this article, we extended this model to combine different sources of types in different formats: aggregate data (AD) and individual participant data (IPD) from randomized and non-randomized evidence. In the first stage, a prognostic model is developed to predict the baseline risk of the outcome using a large cohort study. In the secon...
Source: Research Synthesis Methods - March 20, 2024 Category: Chemistry Authors: Konstantina Chalkou,
Tasnim Hamza,
Pascal Benkert,
Jens Kuhle,
Chiara Zecca,
Gabrielle Simoneau,
Fabio Pellegrini,
Andrea Manca,
Matthias Egger,
Georgia Salanti Tags: RESEARCH ARTICLE Source Type: research
Prevalence of ocular toxoplasmosis among people living with HIV: a systematic review and meta-analysis
Future Microbiology, Ahead of Print. (Source: Future Microbiology)
Source: Future Microbiology - March 20, 2024 Category: Microbiology Authors: Maria Kantzanou Evangelos Kostares Georgia Kostare Fotini Boufidou Antzela Tzanai Michael Kostares Athanasios Tsakris Source Type: research
Safety and immunogenicity of a subtype C ALVAC-HIV (vCP2438) vaccine prime plus bivalent subtype C gp120 vaccine boost adjuvanted with MF59 or alum in healthy adults without HIV (HVTN 107): A phase 1/2a randomized trial
ConclusionsAlthough MF59 was expected to enhance immune responses, alum induced similar responses to MF59, suggesting that the choice between these adjuvants may not be critical for the ALVAC+gp120 regimen. Trial registrationHVTN 107 was registered with the South African National Clinical Trials Registry (DOH-27-0715-4894) and ClinicalTrials.gov (NCT03284710). (Source: PLoS Medicine)
Source: PLoS Medicine - March 19, 2024 Category: Internal Medicine Authors: Zoe Moodie Source Type: research
Scientists in Antarctica track ‘baffling’ virus that could decimate penguins and other polar animals
A 23-meter-long sailboat set off last week from Argentina for Antarctica’s Weddell Sea with eight scientists, lots of cloacal swabs, and a genetic fingerprinting machine aboard. The
Australis
is headed for the southern continent’s teeming colonies of Adélie penguins, other seabirds, and marine mammals. The
goal
: to search for signs of a deadly virus that has nearly circled the world over the past 4 years, leaving behind a trail of devastated wildlife.
Last month, Spanish researchers
confirmed
that H5N1, the highly pathogenic form of avian influenza, had finally turned up—as long ...
Source: Science of Aging Knowledge Environment - March 18, 2024 Category: Geriatrics Source Type: research
GSE260760 Primary osteoarthritis chondrocyte map of chromatin conformation (Hi-C)
Contributors : Norbert Bittner ; Chenfu Shi ; Danyun Zhao ; James Ding ; Lorraine Southam ; Diane Swift ; Peter Kreitmaier ; Mauro Tutino ; Odysseas S Stergiou ; Jackson T Cheung ; Georgia Katsoula ; Jenny Hankinson ; J M Wilkinson ; Gisela Orozco ; Eleftheria ZegginiSeries Type : OtherOrganism : Homo sapiensOsteoarthritis is a complex disease with a huge public health burden. Genome-wide association studies (GWAS) have identified hundreds of osteoarthritis-associated sequence variants, but the effector genes underpinning these signals remain largely elusive. Understanding chromosome organization in 3D space is...
Source: GEO: Gene Expression Omnibus - March 18, 2024 Category: Genetics & Stem Cells Tags: Other Homo sapiens Source Type: research
Gender-Affirming Voice Training for Trans Women: Acoustic Outcomes and Their Associations With Listener Perceptions Related to Gender
To investigate acoustic outcomes of gender-affirming voice training for trans women wanting to develop a female sounding voice and to describe what happens acoustically when male sounding voices become more female sounding. (Source: Journal of Voice)
Source: Journal of Voice - March 18, 2024 Category: ENT & OMF Authors: Maria S ödersten, Jennifer Oates, Anders Sand, Svante Granqvist, Sterling Quinn, Georgia Dacakis, Ulrika Nygren Source Type: research
GSE227618 MicroRNA-494 augments fibroproliferation in human retinal pigment epithelial cells and targets p27 with cell-type specificity
Contributors : Theodore Leng ; Georgia Kamboj ; Creed StarySeries Type : Non-coding RNA profiling by arrayOrganism : Homo sapiensEpiretinal membranes (ERMs) are the result of fibro-cellular proliferation that cause distortion and impairment of central vision. We hypothesized that select microRNAs (miRs) regulate retinal fibroproliferation and ERM formation. Following IRB approval, a pilot study was performed in patients presenting for retina surgery with and without clinical ERMs. Total RNA was isolated from ERM tissue and controls from non-ERM vitreous and subjected to miR profiling via microarray analysis. MiR-494 was...
Source: GEO: Gene Expression Omnibus - March 17, 2024 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by array Homo sapiens Source Type: research
Examining the association of rurality with opioid-related morbidity and mortality in Georgia: A geospatial analysis
This study aims to provide a geospatial snapshot of the opioid epidemic in Georgia using several metrics of opioid-related morbidity and mortality and explore differences by rurality across counties. (Source: Journal of Substance Abuse Treatment)
Source: Journal of Substance Abuse Treatment - March 15, 2024 Category: Addiction Authors: Kimberly B. Roth, Dana K. Goplerud, Jennifer S. Babjak, Jennifer L. Nguyen, Lauren R. Gilbert Source Type: research
