Improvement of high-density lipoprotein atheroprotective properties in patients with systemic lupus erythematosus after belimumab treatment

CONCLUSIONS: HDL of SLE patients with active disease displays impaired atheroprotective properties accompanied by distinct lipidomic signature compared with controls. Belimumab treatment may improve the HDL atheroprotective properties and modify the HDL lipidomic signature in SLE patients, thus potentially mitigating atherosclerosis development.PMID:38514392 | DOI:10.1093/rheumatology/keae192

Source: Atherosclerosis - March 21, 2024 Category: Cardiology Authors: Anastasia-Georgia Dedemadi Christina Gkolfinopoulou Dimitra Nikoleri Myrto Nikoloudaki Hanna Ruhanen Minna Holopainen Reijo Kakela Georgia Christopoulou Stavros Bournazos Pantelis Constantoulakis Prodromos Sidiropoulos George Bertsias Angeliki Chroni Source Type: research