Fluoropyrimidine Toxicity: the Hidden Secrets of DPYD

CONCLUSIONS: DPYD polymorphisms are the main source of DPD variability. A study on DPYD epigenetics (both transcriptionally and post-transcriptionally) holds promise to provide insights into molecular pathways of fluoropyrimidine toxicity. Additional post-translational DPD modifications, as well as DPD inhibition by other drugs, may explain a proportion of enzyme activity variability. Therefore, there is still a lot we can learn about the DPYD/DPD fluoropyrimidine-induced toxicity machinery.PMID:38504562 | DOI:10.2174/0113892002296707240311105527
Source: Current Drug Metabolism - Category: Drugs & Pharmacology Authors: Source Type: research