Ductus Dependent Circulation
Ductus dependent circulation is one in which a patent ductus arteriosus is useful in maintaining the circulation after birth. It is important to rule out such conditions before any PDA closure is planned. PDA dependent circulations can be PDA dependent pulmonary circulation, PDA dependent systemic circulation and PDA dependent mixed circulation. The first group includes pulmonary atresia, tricuspid atresia and tetralogy of Fallot with pulmonary atresia. In those cases, post natal physiological constriction of ductus arteriosus can cause severe hypoxemia, cyanosis and even death. In these cases, there is severe restriction...
Source: Cardiophile MD - June 13, 2023 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
Bowhead Whales Exhibit Efficient DNA Repair
All large mammals must evolve ways to suppress cancer risk more effectively than their smaller relatives. More mass means more cells, and thus more chances for a cell to suffer the mutations that will lead to cancer. Elephants evolved additional copies of P53 and other tumor suppression genes, for example. Bowhead whales, on the other hand, appear to manage with more efficient DNA repair mechanisms. We can hope that some of these explorations may lead to ways to improve human resistance to cancer. Improved DNA repair in particular is an attractive goal, given that DNA damage is linked to aging in a number of ways, such as ...
Source: Fight Aging! - June 13, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Hit by Scandal, Petro Can Still Ruin Colombia
Daniel RaisbeckLess than a year ago, I wrote of the almost certain regret that awaited the prosperous, urban, multiple ‐degree‐holding types who voted for Gustavo Petro, Colombia’s Chavista president. They thought they had supported a Nordic‐style social democrat—failing to notice that they had helped to elect a tropical socialist who, given his past as a guerrilla group member and Hugo Chávez supporter, was also a potential autocrat.Caveat emptor (or rathersuffragator) indeed. But I never thought that voter’s remorse would set in so quickly. Or so extremely.According to poll data from June 1...
Source: Cato-at-liberty - June 11, 2023 Category: American Health Authors: Daniel Raisbeck Source Type: blogs
Fight Aging! Newsletter, June 12th 2023
In this study, we investigated the effect of NXP032 on neurovascular stabilization through the changes of PECAM-1, PDGFR-β, ZO-1, laminin, and glial cells involved in maintaining the integrity of the blood-brain barrier (BBB) in aged mice. NXP032 was orally administered daily for 8 weeks. Compared to young mice and NXP032-treated mice, 20-month-old mice displayed cognitive impairments in Y-maze and passive avoidance tests. NXP032 treatment contributed to reducing the BBB damage by attenuating the fragmentation of microvessels and reducing PDGFR-β, ZO-1, and laminin expression, thereby mitigating astrocytes and microglia ...
Source: Fight Aging! - June 11, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Looking Back at the Growth and Maturation of the Field of Aging Research
A great deal has changed in these last few decades in the field of aging research. From the 60s onward to the 90s, aging research was increasingly characterized by a philosophy of "look but don't touch", an effort to distance academia from the growing anti-aging industry and its hype. It made itself a backwater science in which talk of intervention was aggressively discouraged by leaders in the field. Starting in the 90s, with studies showing significant life extension in lower animals following single gene mutations, it became impossible to ignore the potential to treat aging as a medical condition in humans.
Nonet...
Source: Fight Aging! - June 9, 2023 Category: Research Authors: Reason Tags: Healthy Life Extension Community Source Type: blogs
The Promise of Regenerative Medicine
Is is now going on three decades since the first flush of excitement for regenerative medicine in the form of stem cell therapies. Unfortunately, producing meaningful, reliable regeneration with cell therapies turned out to be a great deal harder then hoped. It is still not a solved problem, outside a few narrow applications. In the intervening time, the field of regenerative medicine has expanded considerably beyond cell therapies, now of many varieties, to encompass approaches such as immune modulation and reprogramming native cell behavior. As today's commentary notes, there is still no magic button to turn on regenerat...
Source: Fight Aging! - June 8, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Chronic Inflammation in Age-Related Anemia
In this study, low Hb concentration was observed to be associated with subclinical, chronic inflammation, exhibited by high levels of IL-1β and TNFα. In the large InCHIANTI study, the unexplained anemia cohort (36% of all the anemic population) was found to have higher levels of pro-inflammatory markers and higher resistance of bone marrow erythroid progenitors to erythropoietin compared to non-anemic controls. The mechanisms underlying low Hb levels in older adults are multifactorial and complex. Our study suggested that the underlying mechanisms involve subclinical chronic low-grade inflammation, bone marrow resistance...
Source: Fight Aging! - June 8, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
COAPT Trial of Transcatheter Mitral Valve Repair in Patients with Heart Failure
Patients with heart failure and left ventricular dilatation may have secondary or functional mitral regurgitation. This is due to alteration of the left ventricular geometry producing changes in the functioning of papillary muscles and chordae tendineae and poor coaptation of the mitral leaflets. Secondary mitral regurgitation causes volume overloading of the left ventricle and is associated with reduced survival, increased hospitalization rates and decreased quality of life [1, 2]. Secondary mitral regurgitation can be reduced by guideline directed medical therapy and cardiac resynchronization therapy. This will also pro...
Source: Cardiophile MD - June 5, 2023 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Structural Heart Disease Interventions Source Type: blogs
Fight Aging! Newsletter, June 5th 2023
In conclusion, higher BMR might reduce lifespan. The underlying pathways linking to major causes of death and relevant interventions warrant further investigation.
Betting Against Progress Turns Out Poorly, But Can Work in the Short Term in a Slow Field
https://www.fightaging.org/archives/2023/06/betting-against-progress-turns-out-poorly-but-can-work-in-the-short-term-in-a-slow-field/
Setting oneself up as a spokesperson for "we will not achieve this goal", as the fellow noted here is choosing to do, is a bet against technological progress. A glance at any few decade period in the past two hundred yea...
Source: Fight Aging! - June 4, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Long Term Hypoxia Slows Aging in an Accelerated Aging Mouse Model
Researchers here show that a mouse model of accelerated aging lives considerably longer when in a low-oxygen atmosphere for most of its life span. This is quite interesting, even given that large effect sizes in accelerated aging models should be taken with a grain of salt. It is most likely that any effect on normal mice would be smaller, and also likely that any form of life extension achieved through manipulation of stress responses, such as the response to hypoxia, will produce much smaller effects in long-lived mammals than in short-lived mammals.
As is always the case, recall that when we say "accelerated agin...
Source: Fight Aging! - June 2, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Does an Actin Cytoskeletal Stress Response Exist and Have Relevance to Aging?
As often mentioned here, cells and living organisms are built out of an enormous array of very complex subsystems, and those very complex subsystems are prone to dysfunction over the course of aging. As soon as any one part of a subsystem is sufficiently impacted by the mechanisms of aging to run awry, the whole subsystem starts to run awry. An army of scientists ten times the size of the one we have now would take a century to catalog every last important detail of the way in which aging causes disarray.
These mechanisms are all interesting in their own right, and the goal of science is full understanding. But the...
Source: Fight Aging! - May 30, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Smart Sutures Sense Inflammation, Deliver Drugs, Cells
Researchers at MIT have developed smart sutures with a hydrogel coating that contains sensing and drug delivery components, and could even be used to implant therapeutic cells. The sutures are made using pig tissues that have been decellularized with detergents to reduce the possibility that they could provoke an immune reaction. The surrounding hydrogel layer contains microparticles that can release peptides when enzymes involved in inflammation are present, and other microparticles that allow for controlled release of drugs. Another potential cargo is therapeutic stem cells that can assist with tissue repair. So far, the...
Source: Medgadget - May 30, 2023 Category: Medical Devices Authors: Conn Hastings Tags: GI Materials Medicine Surgery mit sutures Source Type: blogs
Clinical Examination of Cardiovascular System For Medical Students
Discussion on blood pressure is not included here as a separate topic is dedicated to it.
Though the most commonly examined pulse is the radial, to check some of the characteristics, a more proximal pulse like the brachial or carotid needs to be examined. Following parameters of the pulse are routinely documented: 1. The rate: Normal rate in adult is 60-100 per minute. It is higher in children. Younger the child, higher the pulse rate.
Rhythm: Regular and irregular rhythms are possible. Mild variation with respiration is called respiratory sinus arrhythmia, with higher rate in inspiration. Respiratory sinus arrhythmia may...
Source: Cardiophile MD - May 30, 2023 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
Fight Aging! Newsletter, May 29th 2023
In this study, we used a Drosophila model to understand the role of the dec2P384R mutation on animal health and elucidate the mechanisms driving these physiological changes. We found that the expression of the mammalian dec2P384R transgene in fly sleep neurons was sufficient to mimic the short sleep phenotype observed in mammals. Remarkably, dec2P384Rmutants lived significantly longer with improved health despite sleeping less. In particular, dec2P384R mutants were more stress resistant and displayed improved mitochondrial fitness in flight muscles. Differential gene expression analyses went on to reveal several altered tr...
Source: Fight Aging! - May 28, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Innate Immune Regulation in Life Extension via Calorie Restriction
In this study, we found that the F-box gene fbxc-58 is a downstream effector of the S6K signaling pathway, and that it regulates both pathogen resistance and aging in C. elegans. Furthermore, fbxc-58 is necessary for the effects of DR on lifespan extension. F-box protein acts as a modular E3 ubiquitin ligase adaptor protein, and the ubiquitin-dependent mechanisms have been shown to determine lifespan in response to DR or modulate the innate immune response. Therefore, we suggest that gaining insights into the detailed mechanistic aspects of fbxc-58 signaling pathway could elucidate the conserved signaling mechanism that li...
Source: Fight Aging! - May 24, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
