Reviewing Cellular Senescence in Idiopathic Pulmonary Fibrosis
Fibrosis is the excessive deposition of extracellular matrix, forming scar-like structures that are disruptive to tissue function. It is a feature of aging in many organs, such as heart, liver, kidney, and lungs, and when particularly pronounced it is declared to be fibrotic disease. So far medical science has struggled to make much headway in the reversal of fibrosis once it is established, which makes these conditions particularly threatening.
Fibrosis is connected to the chronic inflammation characteristic of old age, and in recent years evidence has amassed for senescent cells to drive fibrosis. Senescent cells ...
Source: Fight Aging! - February 28, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Connecting NANOG Expression with the Response to Methionine Restriction
Calorie restriction is known to slow aging, albeit to a much greater degree in short-lived species than in long-lived species. Finding important mechanisms involved in the beneficial response to calorie restriction continues to be a major focus on the research community, even though it is questionable as to whether this is a good approach to the treatment of aging. A sizable fraction of the response to calorie restriction appears to be mediated by methionine sensing, at least judging by the degree to which reducing methioninine intake can reproduce the benefits of full calorie restriction.
In today's open access pap...
Source: Fight Aging! - February 27, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Biochemical Differences Between the Response to High Intensity versus Moderate Exercise
In this study, we asked the question whether the cellular senescence-lowering effect of exercise in human skeletal muscle can occur only at the intensity sufficient to induce DNA damage and inflammation. Biopsied vastus lateralis of 9 sedentary men (age 26.1 ± 2.5 y) were assessed before and after a single bout of moderate steady state exercise (SSE, 60% maximal aerobic power) and high intensity interval exercise (HIIE, 120% maximal aerobic power). Increases in cell infiltration (+1.2 folds), DNA strand break (+1.3 folds), and γ-H2AX+ myofibers (+1.1 folds) occurred immediately after HIIE and returned to baseline in 24 h...
Source: Fight Aging! - February 27, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Starting Out on the Long Road to Tissue Engineering for the Brain
Can one replace parts of the brain? In principle, yes. It is a tissue, and tissue engineering is a field intent on regrowth and replacement of lost or damaged tissue. There are parts of the brain immediately vital to life, and parts that hold the memory that defines the self; if those are lost, that is irrecoverable. But much of the brain might be tissue engineered in the same way as muscle or liver might be replaced. Researchers are still in the early stages of the long road towards replacement tissues created to order, as illustrated by the scientific work noted here, but much of the brain will be a part of that field of...
Source: Fight Aging! - February 27, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, February 27th 2023
This study tested the hypothesis that ischemic vascular repair in aging by Ang-(1-7) involves attenuation of myelopoietic potential in the bone marrow and decreased mobilization of inflammatory cells.
Young or Old male mice of age 3-4 and 22-24 months, respectively, received Ang-(1-7) for four weeks. Myelopoiesis was evaluated in the bone marrow (BM) cells by carrying out the colony forming unit (CFU-GM) assay followed by flow cytometry of monocyte-macrophages. Expression of pro-myelopoietic factors and alarmins in the hematopoietic progenitor-enriched BM cells was evaluated. Hindlimb ischemia (HLI) was induced by ...
Source: Fight Aging! - February 26, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Greater Thymic Atrophy Correlates with More Rapid Progression of Chronic Kidney Disease
In this study, we explored the impact of T cell senescence on the renal prognosis and mortality of patients with chronic kidney disease (CKD). We found that decreased recent thymic emigrant (RTE) T cells, which corresponds to decreased thymic output, was associated with CKD progression and high mortality, and an increase in highly differentiated CD28-CD4+ T cells, which increases with age, tended to be associated with CKD progression. Thymic atrophy is a characteristic of an aging immune system and has been implicated in age-related diseases such as infection, malignancy, atherosclerosis, and CKD. However, epidemiologic da...
Source: Fight Aging! - February 24, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Angiotensin-(1-7) Reverses Age-Related Increase in Myelopoiesis
This study tested the hypothesis that ischemic vascular repair in aging by Ang-(1-7) involves attenuation of myelopoietic potential in the bone marrow and decreased mobilization of inflammatory cells.
Young or Old male mice of age 3-4 and 22-24 months, respectively, received Ang-(1-7) for four weeks. Myelopoiesis was evaluated in the bone marrow (BM) cells by carrying out the colony forming unit (CFU-GM) assay followed by flow cytometry of monocyte-macrophages. Expression of pro-myelopoietic factors and alarmins in the hematopoietic progenitor-enriched BM cells was evaluated. Hindlimb ischemia (HLI) was induced by ...
Source: Fight Aging! - February 23, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
More Visible Examples of Progress in the Longevity Biotech Industry in 2022
Much of the progress that takes place year after year in any segment of the broader biotech industry is invisible, and the growing portion of that industry focused on aging and longevity is no exception. Biotech is not a high profile industry, particularly because of the heavy dependence on intellectual property and trade secrets as a basis for government-granted monopolies on particular treatments. Details are kept quiet least larger entities in the industry to decide replicate a therapy and call it their own, because the potential rewards are worth the near certainty of a lawsuit. Thus every visible presentation or press...
Source: Fight Aging! - February 22, 2023 Category: Research Authors: Reason Tags: Longevity Industry Source Type: blogs
Alternative Approaches to the Treatment of Mitochondrial Aging at the SENS Research Foundation
The primary approach to the prevention and treatment of mitochondrial aging undertaken by the SENS Research Foundation is allotopic expression, putting backup copies of mitochondrial genes into the nuclear genome. This prevents mitochondrial DNA mutations from degrading mitochondrial function in ways that can become pathological. This isn't the only approach on the table, however, and here some of the others are outlined.
Mitochondrial mutations - and above all, large deletions in the mitochondrial DNA - accumulate in long-lived cells over our lifetime. And until we can do something to repair or bypass that proble...
Source: Fight Aging! - February 21, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Endothelial Progenitor Cell Senescence as a Contributing Cause of Declining Angiogenesis
Angiogenesis is the process of building new blood vessels in response to circumstances, such as a relative lack of oxygenation in tissues, or repair of injury. It is quite complicated, involving several distinct stages and the interactions of a variety of different cell populations. Angiogenesis declines with age, particularly in the context of maintaining capillaries. The density of capillary networks is reduced with age, and this may be quite influential in the aging of energy-hungry issues such as the brain and muscles. It isn't just a reduction in delivery of nutrients and oxygen. Loss of microvascular blood flow throu...
Source: Fight Aging! - February 20, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, February 20th 2023
In this study, researchers stimulate the ghrelin receptor using a suitable small molecule for much of the lifespan of mice, and observe the results. The overall extension of life span is a quarter of that produced by calorie restriction, and so we might draw some conclusions from that as to the relative importance of hunger in the benefits resulting from the practice of calorie restriction or fasting. Interestingly, the short term weight gains observed in mice given this ghrelin receptor agonist in the past don't appear in this long term study, in which the controls are the heaver animals. This is possibly because the rese...
Source: Fight Aging! - February 19, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Revolutionizing vascular surgery: How embracing endovascular techniques saved the specialty
An excerpt from The Medical Jungle: A Pioneering Surgeon’s Battle to Revolutionize Vascular Care and Challenge the Medical Mafia. Still no matter what anyone said, I knew in my heart that endovascular grafts and endovascular aneurysm repair were going to be a game-changer and that vascular surgeons had to get involved to prevent interventional specialists
Read more…
Revolutionizing vascular surgery: How embracing endovascular techniques saved the specialty originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - February 15, 2023 Category: General Medicine Authors: Frank Veith, MD Tags: Physician Surgery Source Type: blogs
Fight Aging! Newsletter, February 13th 2023
This study investigated whether taller Polish adults live longer than their shorter counterparts. Data on declared height were available from 848,860 individuals who died in the years 2004-2008 in Poland. To allow for the cohort effect, the Z-values were generated. Separately for both sexes, Pearson's r coefficients of correlation were calculated. Subsequently, one way ANOVA was performed.
The correlation between adult height and longevity was negative and statistically significant in both men and women. After eliminating the effects of secular trends in height, the correlation was very weak (r = -0.0044 in men and ...
Source: Fight Aging! - February 12, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Senescent Cells in Proficient Regeneration of Organs
Some higher species, such as salamanders and zebrafish, are capable of complete regeneration of damage to organs as adults, including central nervous system tissue such as the retina. In mammals, with a very few limited exceptions, this type of regeneration is only possible during embryonic development. Is it possible to enable adult mammals to regenerate like zebrafish through some adjustment to the regulation of genes? That is the reason why researchers are attempting to understand the cellular differences that enable proficient regeneration. In recent years, attention has focused on the interaction of macrophages and se...
Source: Fight Aging! - February 9, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
The Jones Act Exacerbates Northeast Traffic Woes
Colin GrabowThe Northeast United States is choking on traffic. According to data analysis firm INRIX, the regionis home to six of the ten most congested roads in the United States as well as two of the five most congested citiesin the world (New York City and Boston). That ’s an obvious problem for motorists trying to get to work (or anywhere else) as well as truckers hauling freight through the region. But this raises a question: why not instead move freight using more efficient, moreenvironmentally ‐friendly ships plying the coastal waters that parallel I ‑95? The answer is largely found in the protectionistJon...
Source: Cato-at-liberty - February 8, 2023 Category: American Health Authors: Colin Grabow Source Type: blogs
