Fight Aging! Newsletter, February 13th 2023

This study investigated whether taller Polish adults live longer than their shorter counterparts. Data on declared height were available from 848,860 individuals who died in the years 2004-2008 in Poland. To allow for the cohort effect, the Z-values were generated. Separately for both sexes, Pearson's r coefficients of correlation were calculated. Subsequently, one way ANOVA was performed.

The correlation between adult height and longevity was negative and statistically significant in both men and women. After eliminating the effects of secular trends in height, the correlation was very weak (r = -0.0044 in men and r = -0.0038 in women) but significant (p = 0.023 and p = 0.022, respectively). On balance, these findings do not bear out the hypothesis that taller individuals have a longevity advantage. Since taller stature had a predictable effect on lifespan in the oldest old (85+), these results strongly suggest that longevity favours smaller people.

We discuss these findings in an attempt to identify the biological mechanisms that might be responsible for greater longevity in smaller people. We also analyze selected anthropological factors that pertain to height and longevity.

Targeting the Mitochondrial Unfolded Protein Response to Improve Mitochondrial Function
https://www.fightaging.org/archives/2023/02/targeting-the-mitochondrial-unfolded-protein-response-to-improve-mitochondrial-function/

Every cell contains hundreds of mitochondria, ge...

Source: Fight Aging! - February 12, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs