Age-Related Changes in the Immune Response to Bone Injury
The aged immune system becomes consistently biased towards inflammation, existing in a state of constant low-grade unresolved inflammatory signaling. This changes cell behavior for the worse, and is disruptive to processes that require transient inflammation and participation of immune cells, such as regeneration following injury, or clearance of infectious pathogens. Here researchers discuss some of the details relating to the participation of the immune system in regeneration following bone injury. It is interesting to note the sizable differences between sexes, in addition to those introduced by aging.
Inflamma...
Source: Fight Aging! - April 10, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, April 8th 2024
In this study, we tested a stem cell secretome product, which contains extracellular vesicles and growth factors, cytoskeletal remodeling factors, and immunomodulatory factors. We examined the effects of 4 weeks of 2×/week unilateral intramuscular secretome injections (quadriceps) in ambulatory aged male C57BL/6 mice (22-24 months) compared to saline-injected aged-matched controls.
Secretome delivery substantially increased whole-body lean mass and decreased fat mass, corresponding to higher myofiber cross-sectional area and smaller adipocyte size, respectively. Secretome-treated mice also had greater whole-bod...
Source: Fight Aging! - April 7, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Arguing the Primacy of Predation in Determining Species Longevity
Researchers here review a variety of species and conclude that defense against predation is the most important determinant of species longevity. Long-lived species tend to have shells, or fly, or live underground. Evolution will not favor longevity until other factors reduce extrinsic mortality at the hands of predators. After that, proximate biochemical causes of longevity can come into play in what looks to be a wide variety of ways.
Various environmental morphological and behavioral factors can determine the longevity of representatives of various taxa. Long-lived species develop systems aimed at increasing org...
Source: Fight Aging! - April 3, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Arterial Switch Operation
Transcript of the video: Arterial switch operation is the ideal corrective surgery for D-Transposition or dextro transposition of great arteries, if it can be detected early in life. As the left ventricle is facing the pulmonary artery in dextro transposition of great arteries, if there is a delay beyond two to three weeks of life, there is possibility that the muscle mass of the left ventricle can regress, so that, later if arterial switch operation is done, it will not be able to face the systemic vascular resistance and it will fail. That is why, arterial switch operation has to be done very early in life. For the same ...
Source: Cardiophile MD - April 1, 2024 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
Fight Aging! Newsletter, April 1st 2024
This study supports the proposed model that aging-related loss of colonic crypt epithelial cell AMP gene expression can promote increased relative abundances of Gn inflammaging-associated bacteria and gene expression markers of colonic inflammaging. These data may support new targets for aging-related therapies based on intestinal genes and microbiomes.
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A Skeptical View of the Role of Nuclear DNA Damage in Aging
https://www.fightaging.org/archives/2024/03/a-skeptical-view-of-the-role-of-nuclear-dna-damage-in-aging/
It is evident and settled that stochastic nuclear DNA damag...
Source: Fight Aging! - March 31, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Surgical Treatment of Tetralogy of Fallot and Sequelae
Transcript of video: Tetralogy of Fallot is one of the commonest cyanotic congenital heart diseases. As the name implies, there are four defects. One is ventricular septal defect, second is overriding aorta, third is pulmonary stenosis, usually right ventricular outflow tract stenosis and associated right ventricular hypertrophy. Overriding aorta with ventricular septal defect causes right to left shunt and cyanosis so that in infancy, cyanotic spells may also be there and squatting is one of the important symptoms of tetralogy of Fallot. There are several surgical options for tetralogy of Fallot and also some sequelae for...
Source: Cardiophile MD - March 29, 2024 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
A Skeptical View of the Role of Nuclear DNA Damage in Aging
It is evident and settled that stochastic nuclear DNA damage contributes to cancer. The more of it that you have, the worse your risk. What is still very much debated is whether nuclear DNA damage contributes meaningfully to degenerative aging, and how it does so. Most mutational damage to DNA occurs in regions that are inactive, in cells that have comparatively few divisions remaining before reaching the Hayflick limit. Even if damage alters the function of such a cell, in some non-cancerous way, it is unclear as to how this could amount to a meaningful contribution to loss of tissue function.
The one school of tho...
Source: Fight Aging! - March 28, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Predicting the Order of Arrival of the First Rejuvenation Therapies
It has been going on eight years since I last speculated on the order of arrival of the first rejuvenation therapies. Tempus fugit, and time for an updated version! Eight years is a long enough span of time for the first of those rejuvenation therapies to now exist, albeit in a prototypical form, arguably proven in principle but not concretely. The world progresses but my biases remain much the same: the first rejuvenation therapies to work well enough to merit the name will be based on the SENS vision, that aging is at root caused by a few classes of accumulated cell and tissue damage, and biotechnologies that either repa...
Source: Fight Aging! - March 25, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, March 25th 2024
This study also reports the expansion of satellite cells in human muscle with CR. This finding is critical to suggest translational relevance to the rodent data observed for more than a decade. Moreover, the increased expression of the plasminogen receptor Plg-RKT observed on human satellite cells during CR provided additional support for the theory that our rodent model is relevant to human biology.
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Interesting Insight into the Relationship Between TP53, Telomerase, and Telomere Length
https://www.fightaging.org/archives/2024/03/interesting-insight-into-the-relationship-between-t...
Source: Fight Aging! - March 24, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Human Exosomes Harvested from Stem Cells in Urine Produce Rejuvenation in Mice
In this study, we further analyzed these data and found that a class of USC-EVs-enriched proteins have been previously shown to possess anti-aging function, such as tissue inhibitor of metalloproteinases 1 (TIMP1), plasminogen activator urokinase (PLAU), insulin-like growth factor binding protein 5, senescence marker protein-30, and connective tissue growth factor. Thus, we hypothesized that USC-EVs might be capable of rejuvenating old organs from aging via transferring of anti-aging proteins.
Here, we tested the effects of USC-EVs on cellular senescence in vitro and on the aging-related phenotypes in different orga...
Source: Fight Aging! - March 22, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Calorie Restriction Induces Plasminogen Production to Protect Muscle Tissue
This study also reports the expansion of satellite cells in human muscle with CR. This finding is critical to suggest translational relevance to the rodent data observed for more than a decade. Moreover, the increased expression of the plasminogen receptor Plg-RKT observed on human satellite cells during CR provided additional support for the theory that our rodent model is relevant to human biology.
Link: https://doi.org/10.1016/j.celrep.2024.113881 (Source: Fight Aging!)
Source: Fight Aging! - March 18, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
poem
Broken HomeDivorce is Wednesday nights at Villas For pizza and all you can drink cokesAsking Dad for another quarterTo stick in the table side jukeboxSo I can listen toFunkytownAnd Another One Bites the DustIt ’s drawing pictures of your new stepmomWith horns coming out of her headAnd flames for hair It ’s getting in big trouble forCracking an egg on the skullOf your toddler half brother.It ’s calling Dad collect on his birthdayBecause Mom didn ’t get a child support check. Divorce is figuring out ridesTo weeknight baseball practice. It ’s hearing the phrase “broken home”And realizin...
Source: Buckeye Surgeon - March 18, 2024 Category: Surgery Authors: Jeffrey Parks MD FACS Source Type: blogs
Distributive justice
One last point about Economics 101 may be the most important, is likely to be overlooked or even denied in the U.S. today. Economists claim they can show that if all their assumptions are true – perfect information, willing sellers and willing buyers, perfect competition, no externalities – the hypothetical free market will create what is called a Pareto optimum. That is a situation in which no person can be made better off without making someone else worse off. This is the basis of t he claim that the free market allocates resources “efficiently.” But there can be a Pareto optimum in which everybody has an equal o...
Source: Stayin' Alive - March 16, 2024 Category: American Health Source Type: blogs
Towards Better Bioprinted Skin, Created and Applied During Surgery
Skin is a complex organ of many distinct layers, in which different cell types and structures interact to maintain function and ability to regenerate. Creating a skin-like structure is one thing, but introducing sweat glands, hair follicles, and other complex features is quite another. Still, the accessibility of skin and the frequency of serious injuries that remove large sections of skin makes the skin a good testbed for the development of improved bioprinting techniques that are capable of inserting complex small-scale structures, manufacturing the different layers of skin, and that can be used in situ, directly printin...
Source: Fight Aging! - March 12, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
MMI Raises $110 Million in Series C Financing
Largest Ever Investment in Microsurgery will Further MMI’s Mission to Transform Open Surgery with Robotic Technology
MMI (Medical Microinstruments, Inc.), a robotics company dedicated to increasing treatment options and improving clinical outcomes for patients with complex conditions, today announced that it has raised $110 million in Series C financing. The round, led by Fidelity Management & Research Company, marks the largest-ever investment in microsurgery innovation.
The funds will support the commercialization of the Symani Surgical System in high-growth markets and continued investment in studies that generat...
Source: EMR and HIPAA - March 11, 2024 Category: Information Technology Authors: Healthcare IT News Tags: Health IT Company Healthcare IT Andera Partners BioStar Deerfield Management Fidelity Management & Research Company Fountain Healthcare Partners Health IT Funding Health IT Fundings Health IT Investment Mark Toland Medical Microinstr Source Type: blogs
