Existing Geroprotective Drugs May Not Interact Well with Exercise
The big disadvantage of the geroprotective approach to aging, which is essentially to undertake the long-term use of supplements and small molecule drugs to alter metabolism in ways that slow aging over years and decades, is that distinct supplements and small molecules and adjustments tend to combine in unexpected ways. Short of testing every combination in laboratory species, something that Brian Kennedy's team has been working on, one can never know the outcome of combining a treatment. Based on presentations and interviews given by Kennedy in the last few years, the result of combining two geroprotectors that individua...
Source: Fight Aging! - December 21, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Inflammaging in the Inner Ear, a Path to Hearing Loss
Inflammaging is a blanket term for the inappropriate inflammatory reaction of the immune system to the accumulation of molecular damage and other changes that take place with age. Constant, low-grade, unresolved inflammatory activation of the immune system is a feature of aging. It alters cell behavior for the worse and is disruptive to tissue structure and function. A number of different mechanisms contribute to forming and maintaining the state of inflammaging, such as pro-inflammatory signaling produced by ever-larger numbers of senescent cells, and innate immune recognition of mislocalized mitochondrial DNA that result...
Source: Fight Aging! - December 20, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, December 18th 2023
In conclusion, given the relative safety and the favourable effects of aspirin, its use in cancer seems justified, and ethical implications of this imply that cancer patients should be informed of the present evidence and encouraged to raise the topic with their healthcare team.
« Back to Top
Aged Transplant Organs Cause Harm to Younger Recipients
https://www.fightaging.org/archives/2023/12/aged-transplant-organs-cause-harm-to-younger-recipients/
Old tissues are dysfunctional in ways that young tissues are not. This has always been known in the context of organ transplants, but absent me...
Source: Fight Aging! - December 17, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Resolvin D2 Treatment Increases Monocyte Production and Slows Liver Aging in Mice
Researchers here report on their exploration of a way to adjust the production of monocytes in the bone marrow, cells that become macrophages of the innate immune system. This is chiefly interesting for the lasting effect that a single treatment appears to have on the progression of liver aging in mice, leading to reduced pathology connected to inflammation, such as fibrosis. Also interesting is that providing aged bone marrow to young mice accelerates this liver pathology, by altering the generation of macrophages in the direction that induces liver pathology. Fibrosis is the excessive generation of collagen structures in...
Source: Fight Aging! - December 15, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Lifestyle matters: What we can do in 2024 to optimize cognition and life, delaying cognitive problems even dementia
This article was originally published on The Conversation.
News in Context:
Solving the Brain Fitness Puzzle Is the Key to Self-Empowered Aging
What are cognitive abilities and how to boost them?
The post Lifestyle matters: What we can do in 2024 to optimize cognition and life, delaying cognitive problems even dementia appeared first on SharpBrains. (Source: SharpBrains)
Source: SharpBrains - December 14, 2023 Category: Neuroscience Authors: The Conversation Tags: Brain/ Mental Health Alzheimer’s biological Brain-Fitness cognition cognitive engagement cognitive-abilities cognitive-reserve dementia depression exercise inflammation lifestyle neuroplasticity optimize cognition Stress Source Type: blogs
From Xenobots to Anthrobots
By KIM BELLARD
There were many things I could have written bout this week – e.g., in A.I., in quantum computing, even “transparent wood” — but when I saw some news about biological robots, I knew I had my topic.
The news comes from researchers at Tufts University and Harvard’s Wyss Institute. Their paper appeared in Advanced Science, introducing “a spheroid-shaped multicellular biological robot (biobot) platform” that they fondly dubbed “Anthrobots.” Importantly, the Anthrobots are made from human cells.
Let’s back up. In 2020, senior researcher Michael Levin, Ph.D., who holds positions at ...
Source: The Health Care Blog - December 13, 2023 Category: Consumer Health News Authors: matthew holt Tags: Health Tech Biological Robots Kim Bellard Source Type: blogs
Exercise Beneficially Alters Polarization of Microglia in the Brain
Regular moderate exercise remains one of the most beneficial interventions when it comes to slowing the progression of degenerative aging, if balancing effect size against volume of supporting data. This isn't where we'd like to be! Biotechnology is capable of so very much more, but progress is slow, and robust assessment of new therapies across large populations slower still. Exercise introduces sweeping changes in cellular biochemistry and the function of higher level systems in the body, which makes it an ongoing challenge for the research community to understand exactly how it produces benefits. As is usually the case,...
Source: Fight Aging! - December 11, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Toll-Like Receptors React to Molecular Damage to Contribute to the Inflammation of Aging
This review paper covers what is known of toll-like receptors in the development of age-related chronic inflammation, with a particular focus on toll-like receptor 4 (TLR4). A sizable number of researchers are focused on finding ways to suppress the constant overactivation of the immune system in later life by interfering in its regulation. Unfortunately, the sensing mechanisms involved are also required for normal immune function, so it is hard to envisage even sophisticated implementations of this strategy producing therapies that don't inhibit necessary immune functions, such as defense against pathogens and destruction...
Source: Fight Aging! - December 11, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Cellular Stress Signaling in the Development of Ventricular Fibrillation
Researchers here report on a mechanism by which increased cellular stress in heart tissue can disrupt the regulation of the heartbeat, thus leading to arrhythmia and potentially fibrillation. The accumulated molecular damage of aging, of course, provides increased contributions to cell stress, whether from inflammatory signaling, mitochondrial dysfunction, increased presence of molecular waste, or other causes. When researchers characterize more of the ways in which regulatory pathways in cells can produce maladaptive reactions to this damage, they tend to then search for means to alter the response, rather than means to r...
Source: Fight Aging! - December 11, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, December 11th 2023
In this study, a single treatment at the peak of disease resulted in the ablation of senescent cells in the lung and attenuation of key fibrotic and inflammatory markers, which ultimately resolved fibrosis. Deciduous Therapeutics has used computational assisted design to synthesise a suite of proprietary therapies that could be used in the clinic to re-activate tissue-resident iNKT cells. To date, the company's lead program has shown single-dose efficacy in resolving both metabolic and fibrotic diseases along with a favorable safety profile at doses significantly higher than the efficacious dose.
« Back to ...
Source: Fight Aging! - December 10, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Progressing Towards Regulatory Approval of Veterinary Therapies Targeting Aging
Veterinary medicine is typically less impeded by FDA regulatory costs than human medicine. A cynic would note that the publicity-related incentives operating on FDA staff and leadership are quite different in these two cases, with a great deal more attention given by the media to matters regarding human medicine. With the relative costs being what they are, a number of entrepreneurs in the longevity industry chose to work towards veterinary therapies targeting mechanisms of aging. One of those companies, Loyal, here reports on progress towards the FDA essentially agreeing to a regulatory framework for therapies targeting a...
Source: Fight Aging! - December 8, 2023 Category: Research Authors: Reason Tags: Longevity Industry Source Type: blogs
Clumps of Cells as a Novel Basis for Regenerative Medicine
Researchers here note an interesting project, the production of self-assembling, mobile clumps of cells propelled by cilia, formed from lung epithelium. These mobile bodies can encourage growth in nerve cells, at least in vitro. How exactly that happens remains to be determined, but the usual mechanism is via release of pro-growth factors, either directly, or encapsulated in extracellular vesicles. Whether this is a useful basis for future regenerative therapies remains to be seen; one might imagine concerns attending the introduction of large numbers of these epithelial cell bodies into other tissues. The full paper is no...
Source: Fight Aging! - December 8, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Reviewing the Role of Cellular Senescence in Pulmonary Fibrosis
The first small human clinical trial of the senolytic therapy of dasatinib and quercetin targeted idiopathic pulmonary fibrosis, showing some benefit to patients. Later trials for kidney disease demonstrated that this treatment does remove a fraction of lingering senescent cells in human tissues in much the same way as it does in mice. Senescent cells accumulate with age in tissues throughout the body, the burden of these cells resulting from a growing gap between pace of creation and pace of clearance by the immune system. Researchers are coming to see a prominent role for senescent cells in all fibrotic conditions, in wh...
Source: Fight Aging! - December 7, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
MITF in the Regulation of Schwann Cell Nerve Repair Activity
The peripheral nervous system is far more capable of self-repair than the central nervous system. Nonetheless, nerve damage typically results in far less functional regeneration than is the case for other tissues. The research community is thus interested in finding ways to enhance existing repair processes. Here, researchers investigate a portion of the regulatory mechanisms that control the activity of Schwann cells in nerve repair, in search of targets for drug development programs aimed at enhancing regeneration of nerve damage, both in the peripheral nervous system, and also potentially in the central nervous system.
...
Source: Fight Aging! - December 7, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
