VCAM1 and APOE Involved in Microglial Clearance of Amyloid- β
One of the characteristics of neurodegenerative conditions such as Alzheimer's disease is the inflammatory activation and dysfunction of microglia. These are cells of the innate immune system distinct to the brain, analogous to macrophages elsewhere in the body. They undertake a similar portfolio of tasks, including chasing down pathogens, destroying errant cells, cleaning up waste and debris such as toxic aggregated proteins found outside cells, and aiding in tissue maintenance and repair. When microglia are in an inflammatory state, they are less inclined to aid in tissue maintenance and clearance of harmful metabolic wa...
Source: Fight Aging! - December 6, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
A Longevity Industry Feature in Biopharma Dealmakers: Repair Biotechnologies, Deciduous Therapeutics, and More
In this study, a single treatment at the peak of disease resulted in the ablation of senescent cells in the lung and attenuation of key fibrotic and inflammatory markers, which ultimately resolved fibrosis. Deciduous Therapeutics has used computational assisted design to synthesise a suite of proprietary therapies that could be used in the clinic to re-activate tissue-resident iNKT cells. To date, the company's lead program has shown single-dose efficacy in resolving both metabolic and fibrotic diseases along with a favorable safety profile at doses significantly higher than the efficacious dose. (Source: Fight Aging!)
Source: Fight Aging! - December 4, 2023 Category: Research Authors: Reason Tags: Longevity Industry Source Type: blogs
Kintsugi: Embracing brokenness and empathy
In the Japanese tradition of kintsugi, broken things are repaired with gold joinery. The repaired object is even lovelier than the original. The breakage and repair become an acknowledged part of the object’s history. The scars and wounds are cherished rather than disguised. What a beautiful reminder to harness the powers of darkness and light
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Kintsugi: Embracing brokenness and empathy originally appeared in KevinMD.com. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - December 4, 2023 Category: General Medicine Authors: Nessa Meshkaty, MD Tags: Physician Primary Care Source Type: blogs
Fight Aging! Newsletter, December 4th 2023
This study produced a great deal of data that continues to be mined for insights into human aging and effects of calorie restriction in a long-lived species such as our own, to contrast with the sizable effects on health and longevity in short-lived species such as mice.
In particular, and the topic for today, cellular senescence and its role in degenerative aging has garnered far greater interest in the research community in the years since the CALERIE study took place. Thus in today's open access paper, scientists examine CALERIE study data to find evidence for calorie restriction to reduce the burden of cellular ...
Source: Fight Aging! - December 3, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
What Do We Need To Have AI-Equipped Nanobots In Medicine
Disease, noun [archaic]: A historical term used to describe various physical and mental ailments that affected organisms, primarily humans, in an era before the advent of comprehensive nanomedical and genetic interventions. In the technologically primitive past, diseases were common causes of discomfort, dysfunction, and mortality, often requiring medical treatment and care. Modern advances and nanobots in medicine have rendered this term obsolete, as conditions previously classified as diseases are now either preventable or entirely curable at the molecular level.
Are we on the brink of a brave new world where disease...
Source: The Medical Futurist - November 30, 2023 Category: Information Technology Authors: Andrea Koncz Tags: TMF Future of Medicine Nanotechnology nanobots nanobots in medicine AI Source Type: blogs
Year End Fundraisers For Rejuvenation Research at SENS Research Foundation and LEV Foundation
When it comes to treating aging as a medical condition, it is important to fund the right sort of research program. All too much of the field of translational aging research is focused on finding ways to produce small benefits, such as via the use of repurposed existing supplements. This may produce gains for investors, but it won't meaningfully change the present shape of a human life. We need to do better than that. Fortunately, there are a small number of non-profit organizations and academic groups focused on development of the means of rejuvenation, rather than on means of modestly slowing aging. Two of the best are t...
Source: Fight Aging! - November 20, 2023 Category: Research Authors: Reason Tags: Activism, Advocacy and Education Source Type: blogs
Fight Aging! Newsletter, November 20th 2023
In this study, we attempted to further explain the role, exact mechanism and target of ICA in treating AD from the ferroptosis perspective. We found that ICA could improve the neurobehavioral, memory, and motor abilities of AD mice. It could lower the ferroptosis level and enhance the resistance to oxidative stress. After inhibition of MDM2, ICA could no longer improve the cognitive ability of AD mice, nor could it further inhibit ferroptosis. Network pharmacological analysis revealed that MDM2 might be the target of ICA action.
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Particulate Air Pollution and Its Effects on the Mechan...
Source: Fight Aging! - November 19, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Endothelial Cell Senescence in Atherosclerosis
Senescent cells accumulate throughout the body with age. They are created constantly due to stresses placed upon cells, and when somatic cells reach the Hayflick limit on replication, and are cleared by the immune system. This process of clearance slows down with age, unfortunately, and so a burden of lingering senescent cells begins to build up. Senescent cells are disruptive to tissue structure and function, even when present in comparatively small numbers relative to other cells in a tissue, as a result of the pro-growth, pro-inflammatory signals that they generate.
Atherosclerosis involves the generation of fatt...
Source: Fight Aging! - November 16, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
A Path to Increasing Glutathione Levels in Mitochondria
Glutathione is an interesting cellular antioxidant, as increased levels can improve health in humans and slow aging in animal models. You might recall recent small human trials of high dose supplementation of glutathione precursors in order to achieve upregulation of glutathione, and corresponding studies in mice. It is thought that glutathione upregulation may largely improve health via mitochondrial function, as mitochondria are a prominent source of oxidative stress in aging cells. Here, researchers find a mechanism that regulates the amount of glutathione that enters the mitochondria, and thus a possible target to incr...
Source: Fight Aging! - November 15, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Assessing Phenotypic Age Acceleration Differences by Lifestyle Choice
Phenotypic age is one of the less complicated biological age measures developed in recent years. As for all of the others, it was developed by using machine learning on a large set of human data, in this case commonly assessed blood biomarkers and their values at different ages. Thus while we know exactly what is being measured, it is an open question as to how those measurements relate to the underlying processes of aging, or indeed whether they accurately reflect all of those processes. Once one starts down the path of using lifestyle interventions to slow aging or novel therapies to repair the cell and tissue damage tha...
Source: Fight Aging! - November 15, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Considering the Non-Genomic Hallmarks of Aging
The Hallmarks of Aging were first published some years ago now, long enough to be expanded upon and much debated. The hallmarks are a list of characteristic changes in cell and tissue biochemistry noted to take place with advancing age, some of which are likely causes of age-related degeneration, some of which are likely downstream consequences, and all of which interact with one another. As often happens in such matters, the original hallmarks of aging drew from, and then eclipsed in terms of attention, the much earlier Strategies for Engineered Negligible Senescence (SENS) list of forms of cell and tissue damage that are...
Source: Fight Aging! - November 14, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Lifestyle Choices Do Slow Aging, Just Not as Much as We'd Like
In recent years, a number of epidemiological studies have demonstrated that people with healthier lifestyles tend to live longer, at least within the bounds of later life from 60 to 100. That in turn is reflected by a lesser burden of various forms of cell and tissue damage, such as the accumulation of senescent cells. This isn't a controversial statement, though there is room enough to argue for an eternity over just how large the effect of any specific choice might be, how that effect size varies between populations, how different choices combine, and so forth. Then on top of all of this, the question of what happens and...
Source: Fight Aging! - November 13, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, November 13th 2023
This study investigated the correlation among muscle strength, working memory (WM), and cortical hemodynamics during the N-back task of memory performance, and further explored whether cortical hemodynamics during N-back task mediated the relationship between muscle strength and WM performance. We observed that muscle strength (particularly grip strength) predicted WM of older adults in this cross-sectional study, which validated our hypothesis and expanded on previous research findings. Studies demonstrated that grip strength predicted executive function decline in patients with mild cognitive impairment. Other cross-sect...
Source: Fight Aging! - November 12, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Magnetic Dressing Improves Diabetic Wound Healing
Researchers at the National University of Singapore have developed a magneto-responsive hydrogel wound dressing that also contains two different regenerative cell types. The hydrogel is also embedded with magnetic particles that can be stimulated using an external magnetic field. The action of the magnetic field on the gel-encapsulated particles causes mechanical stresses within the gel to act on the cells, stimulating them to grow and enhancing their regenerative potential. The advanced dressing is intended to assist in healing diabetic wounds, which can be difficult to treat.
In diabetes, various issues can impair wou...
Source: Medgadget - November 9, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Materials Medicine Surgery diabetic wound hydrogel NUSingapore Source Type: blogs
GTP Level Influences DNA Repair
Evidence suggests that enhanced DNA repair may act to slow the progression of aging. Researchers here note that increased levels of the metabolite guanosine triphosphate (GTP), a building block and energy source used in a variety of ways in the cell, can improve the pace of DNA repair. There are numerous ways by which GTP levels might be upregulated over the long term, but as researchers here note, the opposite is desirable in the case of cancer, in order to impair DNA repair and make cancerous cells more vulnerable to genotoxic therapies.
Researchers have long known that levels of nucleotides like GTP control how...
Source: Fight Aging! - November 9, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
