Conditioned Media from Mesenchymal Stem Cells as a Basis for Therapy
When culturing any type of cell, the culture media contents come to reflect the secreted molecules and extracellular vesicles of that cell type - what is called "conditioned media". It is a snapshot of the communications produced by the cell type in its current state. First generation stem cell therapies, in which the transplanted cells die rather than integrate with tissues in any useful number, influence health via the effects of their secretions and vesicles on native cells. It is much easier to build therapies based on the contents of the media rather than it is to transplant the cells themselves, from the perspective ...
Source: Fight Aging! - November 8, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Provoking Greater Stem Cell Activity to Reverse Cartilage Loss in Osteoarthritis
Osteoarthritis is a degenerative joint disease characterized by loss of cartilage and associated bone tissue. It is a major, widespread issue in old age. A promising study in mice here suggests that osteoarthritis might be reversed via suitable manipulation of stem cell and progenitor cell populations capable of producing cartilage regrowth. In this model, the known contributing factors, such as chronic inflammation in and around joint tissues, are contributing factors because they suppress the activity of the small population of cells responsible for maintenance of cartilage.
Osteoarthritis is the degeneration of...
Source: Fight Aging! - November 7, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, November 6th 2023
This study aimed to gather valuable insights from pharmaceutical experts and healthcare practitioners regarding the potential and challenges of translating senolytic drugs for treatment of vascular aging-related disorders. This study employed a qualitative approach by conducting in-depth interviews with healthcare practitioners and pharmaceutical experts. Participants were selected through purposeful sampling. Thematic analysis was used to identify themes from the interview transcripts. A total of six individuals were interviewed, with three being pharmaceutical experts and the remaining three healthcare practitioners.
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Source: Fight Aging! - November 5, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Accelerated Epigenetic Age and Cardiovascular Risk Factors
Epigenetic patterns determine the behavior of a cell, and change constantly in response to cell state and the surrounding tissue environment. Epigenetic state can be used to measure biological age, the epigenetic clock. When an epigenetic clock indicates an age older than chronological age, that is referred to as epigenetic age acceleration. While the clocks are not fully understood in detail, it is thought that the specific epigenetic changes measured are reflective of the burden of cell and tissue damage and dysfunction that causes aging. This acceleration has been shown to correlate with risk and status of a number of a...
Source: Fight Aging! - November 2, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Anabolic Resistance in Sarcopenia
Anabolic resistance is a description of a state, not a starting point for a therapy. Anabolism is the metabolism of growth and repair, and in a state of anabolic resistance cells become less responsive to the signaling environment that normally encourages growth and repair. If the goal is therapies, then why this anabolic resistance occurs becomes the question. Muscles lose mass and strength with age, leading to the condition called sarcopenia. This, obviously, must involve anabolic resistance, and here researchers discuss what is known of this view of the sarcopenia of old age.
The development of sarcopenia in th...
Source: Fight Aging! - November 2, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Small Molecule Induction of Stem Cell Behavior Applied to Tendon Aging
In this study, we employed the newly developed system, DLEPS, which is an efficacy prediction system using transcriptional profiles with deep learning, to identify potential drugs to stimulate stemness.
In our study, we found that the top-ranked candidate compound prim-O-glucosylcimifugin (POG) could efficiently inhibit TSPC senescence and promote their tenogenic differentiation potential in an in vitro serial passaging cell senescence model. We also found that the top-ranked POG potently rejuvenated the proliferation and tenogenic potential of TSPCs from both aged rats and middle-aged humans by maintaining stemnes...
Source: Fight Aging! - November 1, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Lung Chip Mimics Radiation Injury
Researchers at the Wyss Institute at Harvard University have developed a microfluidic chip that can recreate some of the features of radiation-induced lung injury. The lungs are very sensitive to radiation, and this can limit the application of radiotherapy to treat cancer. Accurately modeling radiation-induced lung injury could assist in developing new methods to prevent and treat the phenomenon, but it has been difficult to study this before the advent of advanced organ-on-a-chip models. The lung chip presented here contains human lung alveolar epithelial cells interfacing with lung capillary cells. The goal is to recrea...
Source: Medgadget - November 1, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Oncology Radiation Oncology harvard wyssinstitute Source Type: blogs
Senescent Schwann Cells Impair Nerve Regeneration in Older Individuals
Senescent cells of many types accumulate in tissues throughout the body with age due to an imbalance between the pace of creation and pace of destruction, the immune system progressively losing its ability to destroy these senescent cells in a timely manner. Senescent cells cease to replicate and secrete a potent mix of pro-inflammatory signals, harmful to surrounding tissue when sustained over the long term. Here, researchers note one of the many specific ways in which senescent cells can impair function; this one example is multiplied a thousand times across locations, tissue types, and cell types throughout the aging bo...
Source: Fight Aging! - November 1, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Towards Clearance of Senescent Cells to Improve Heart Regeneration
Senescent cells accumulate with age in tissues throughout the body. Cells enter a senescent state constantly throughout life, largely the result of cells reaching the Hayflick limit on replication, but also due to stress, injury, and damage. A senescent cell ceases replication and instead produces a potent mix of pro-growth, pro-inflammatory signals. The primary purpose of senescence in an adult is to signal to the immune system that a cell needs to be removed, and potentially that the surrounding region of tissue requires further attention, such as in the case of an injury or toxic environment that is damaging other cells...
Source: Fight Aging! - October 31, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, October 30th 2023
In conclusion, reported adherence to a healthy lifestyle is associated with reduced risk of all-cause and cause-specific mortality. Adherence to all four lifestyle factors resulted in the strongest protection.
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Source: Fight Aging! - October 29, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
“ Proportionate ” vs “ Disproportionate ” Mitral regurgitation : A new concept in the making
Cardiologists have always struggled to classify, assess, and grade one important valve disease, which is Mitral regurgitation. While valve replacement is the ultimate treatment, the timing of MVR is still a big debate. Apart from valve replacement, valve repair is a strong contender in selected patients. In recent times, cardiologists have made great strides to grab MR patients from cardaic surgeons. MitraClip, a percutaneous edge stitching , is possible with a varying degree of success.
Mitral valve edge-to-edge repair (MEER) is an interventional clone of Alfieri surgery that has shown conflicting results in the MITRA-...
Source: Dr.S.Venkatesan MD - October 25, 2023 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized acc aha esc alfiery repair annals of thoracic surgery carillon device functional MR meer millipede itis device mitra clip mitra fr cs coapt mitral annulus mitral regurtitation mitral valve replacement mitral vlave e Source Type: blogs
Concerns About Harms Caused by Senolytics are Not Supported by the Mouse Studies
Senescent cells accumulate with age to cause harm via their pro-inflammatory secretions. Senolytic therapies can selectively destroy these cells, to benefit the patient quite rapidly. Hypothesized harms that might be caused by senolytics generally revolve around the idea that some senescent cells might be structurally useful and hard to replace, so while having those senescent cells is bad, getting rid of them could be worse. The response to these concerns is to point to the mouse studies, in which no such problems appear to occur. The article here is a lengthy examination of this sort of argument of hypothetical concern v...
Source: Fight Aging! - October 23, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Modest Calorie Restriction Improves Muscle Quality in Humans
The practice of calorie restriction is known to improve health in many ways. Researchers continue to perform analyses on the samples taken from the human CALERIE study that was conducted some years ago, in which comparatively mild calorie restriction produced worthwhile results in the study participants. Here, researchers note improvements in markers of muscle quality, as one might expect given the animal studies of calorie restriction in which similar improvements were observed in skeletal muscle.
The lifespan extension induced by 40% caloric restriction (CR) in rodents is accompanied by postponement of disease, ...
Source: Fight Aging! - October 20, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, October 16th 2023
In conclusion, a number of studies have shown that CD4+ Treg cells are crucial in the maintenance of peripheral tolerance and have an important role in the control of atherosclerosis-related inflammation. Therefore, Treg cells are a promising target of major research efforts focused on immune-modulating therapies against atherosclerosis. Developing anti-atherosclerotic Treg-based therapies faces challenges. However, rapid progress in genetic, epigenetic, and molecular aspects of cellular immunology gives hope for a fast-track solution.
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Delivering Senolytic Nanoparticles to Atheroscle...
Source: Fight Aging! - October 15, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Towards More Selective Ways to Block Unwanted Inflammation
Control of chronic inflammation may turn out to be one of the more important themes in the treatment of aging as a medical condition. Senescent cells generate inflammatory signaling, but removing that contribution is likely the easiest aspect of the problem. Many forms of age-related cellular damage and dysfunction generate constant, unwanted, excess inflammation through interactions and signals that are used during a normal, desirable inflammatory reaction, such as to injury or infection. Thus interfering in these mechanisms must be very selective; simply blockading a given signal has undesirable side-effects, such as a w...
Source: Fight Aging! - October 13, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
