Age-Related DNA Damage and Epigenetic Changes
This review paper covers both genetic and epigenetic changes that occur with age, taking a broad look at everything from telomere length to stochastic mutational damage to alterations in chromatin structure. As for all aspects of aging at the level of cellular biochemistry, it is easier to catalog than it is to determine relationships between these items, or to determine whether one characteristic of aging cellular biochemistry is more or less important than another when it comes to age-related disease and loss of function. Greater funding for the field would allow researchers to take the best of brute force approaches, wh...
Source: Fight Aging! - October 11, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Schwann Cells Contribute to Neuromuscular Junction Aging
A range of evidence points to degeneration of neuromuscular junctions as an important contribution to the characteristic loss of muscle mass and strength that takes place with age, leading to sarcopenia. Neuromuscular junctions are the structurally complex link between muscle fibers and the nervous system. While the fine details are not well understood at this time, it seems plausible that some downstream effect of neuromuscular junction activity is necessary for tissue maintenance in muscles to function correctly. When neuromuscular junctions suffer dysfunction due to the underlying molecular damage of aging, muscles suff...
Source: Fight Aging! - October 10, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Disabling the Notch Pathway in Skeletal Stem Cells Greatly Improves Bone Density
Skeletal stem cells in the bone marrow produce cells responsible for creating bone tissue. Researchers here show that disabling the well-known notch pathway in these cells leads to a considerable increase in bone mineral density with age. This is a desirable outcome, slowing the onset of osteoporosis, a widespread condition of old age. Better ways to encourage greater deposition of bone extracellular matrix are much needed, given the only modest efficacy of present drugs used in the treatment of osteoporosis.
Skeletal stem and progenitor cells (SSPCs) perform bone maintenance and repair. With age, they produce few...
Source: Fight Aging! - October 9, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, October 9th 2023
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
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Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - October 8, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Inhibition of Fatty Acid Oxidation Provokes Greater Regenerative Capacity in the Injured Heart
The heart is one of the least regenerative organs in the adult body, and this makes the lasting consequences of a heart attack that much worse. While the best approach to the challenge of cardiovascular disease is to find a way to reverse atheroslerosis, and thus prevent heart attacks from ever occurring, much of the focus of the research community is on improving the regenerative capacity of heart tissue. Here, researcher find a comparatively straightforward way to make cardiomyocyte cells in the heart behave more like those in developing tissue, increasing their regenerative capacity. Since the target is well defined, th...
Source: Fight Aging! - October 5, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
We ’re All In The Hot Seat Now.
BY MIKE MAGEE
It’s not that easy living in the “Big Easy” these days and co-existing with a world dominated by water concerns. When Times-Picayune gossip columnist Betty Guillaud (as the folklore goes) “coined New Orleans’ undisputed nickname” in the 1960’s, it was a lifestyle eponym meant to favorably contrast life in “The Big Easy” with hard living in “The Big Apple.”
That was well before August 23, 2004, when the levies failed to hold back the Gulf waters, and 1,392 souls perished leaving two names to last in infamy – Katrina and Brownie, of “Brownie, you’re doing a heck of a job”...
Source: The Health Care Blog - October 4, 2023 Category: Consumer Health News Authors: Ryan Bose-Roy Tags: Health Policy Cholera Mike Magee New York City Saltwater Source Type: blogs
Towards More Selective Senolytic Drugs to Clear Senescent Cells from Aged Tissues
Cells enter a senescent state constantly throughout life, largely as a result of reaching the Hayflick limit on cellular replication, but also due to damage and stress. Senescent cells cease to replicate and begin to secrete pro-inflammatory, pro-growth signals. This attracts the immune system to sites of potential concern, and in the case of physical injuries to tissue the signaling of senescent cells helps to coordinate repair. Senescent cells are normally cleared from tissues fairly quickly, being destroyed either by immune cells, or via programmed cell death mechanisms. With age, however, the pace of clearance slows an...
Source: Fight Aging! - October 4, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
What is Known of the Mechanisms of Age-Related Hearing Loss
Hearing loss is prevalent in older individuals, either involving the destruction of sensory hair cells in the inner ear, or the axonal connections between those hair cells and the brain, or both. Hair cells do not normally regenerate to any great degree in adults, which has led to efforts to grow patient matched replacement cells, or reprogram native cells to convince them to produce new hair cells. Despite promising advances, it is not as yet a solved problem.
Age-related hearing loss, or presbycusis, is a common cause of hearing loss in elderly people worldwide. It typically presents as progressive, irreversible...
Source: Fight Aging! - October 4, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Malnutrition Can Impact Wound Healing
Malnutrition can have a significant impact on wound healing. Proper wound healing is a complex process that involves various cellular and biochemical reactions. When the body is malnourished, it lacks the essential nutrients necessary for these processes, which can lead to delayed or impaired wound healing. Here are some key relationships between malnutrition and wound healing:
1. Protein Deficiency: Protein is crucial for tissue repair and the production of collagen, which is essential for wound healing. Malnourishment, especially a lack of adequate protein intake, can lead to a delay in wound closure and reduced tensile ...
Source: Jeffrey M. Levine MD | Geriatric Specialist | Wound Care | Pressure Ulcers - October 2, 2023 Category: Geriatrics Authors: Jeffrey M Levine Tags: An Aging World Featured Medical Articles Geriatric Medicine Long-Term Care Pressure Injuries & Wound Care bedsore bedsores decubiti decubitus ulcer end-of-life care geriatrics gerontology Improving Medical Care Jeff Levine MD J Source Type: blogs
Fight Aging! Newsletter, October 2nd 2023
In conclusion, we identified several candidate genes that may confer cancer resistance in cetaceans, providing a new avenue for further research into the mechanisms of lifespan extension.
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A Relationship Between the Gut Microbiome and Bone Density
https://www.fightaging.org/archives/2023/09/a-relationship-between-the-gut-microbiome-and-bone-density/
Changes in the gut microbiome take place with advancing age, an increase in populations that provoke chronic inflammation, a reduction in the populations producing beneficial metabolites. Even only considering rising levels of in...
Source: Fight Aging! - October 1, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A View of Aging Centered Around the Capacity for Hormesis
It is not too far from the truth to say that everyone in the field of aging research has their own theory of aging. Enormous amounts of data exists, measurements of near every aspect of cellular biochemistry, to note the ways in which these aspects change with age, yet we lack the framework to link all of the data together, to firmly state what is important and what is not, what is cause, what is consequence, and how exactly the network of age-related changes are linked to one another. Aging is a dark forest in which the boundaries are well mapped, but only a few of the interior features have been well explored.
So ...
Source: Fight Aging! - September 28, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Biomimetic Scaffolds to Encourage Bone and Cartilage Regrowth
One of the areas of research that seems constantly on the verge of producing an impressive advance is the use of nanoscale scaffold materials to encourage regrowth of tissue, such as bone and cartilage. The space of possible combinations of techniques is vast, and there only so many researchers, and only so much funding. Advances such as the one noted here are published by research groups several times a year, and this has been the case for more than a decade now. This part of the field seems eternally in a state of progress and exploration, with promising leads, yet it remains the case that clinical options for regenerati...
Source: Fight Aging! - September 27, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, September 25th 2023
In conclusion, this individual patient data meta-analysis of longitudinal cohort studies found that antihypertensive use was associated with decreased dementia risk compared with individuals with untreated hypertension through all ages in late life. Individuals with treated hypertension had no increased risk of dementia compared with healthy controls.
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Results from Human Clinical Trials Do Not Support Metformin as a Longevity Drug
https://www.fightaging.org/archives/2023/09/results-from-human-clinical-trials-do-not-support-metformin-as-a-longevity-drug/
The SENS Research Fou...
Source: Fight Aging! - September 24, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Call for Matching Donors for the LEV Foundation " Robust Mouse Rejuvenation 2 " Fundraiser
The Longevity Escape Velocity (LEV) Foundation was founded by Aubrey de Grey to address an important missing aspect of the ongoing work to produce treatments that target the underlying mechanisms of aging. While the research and development community has made sizable strides in the past decade, and the first rejuvenation therapies now exist in at least prototype form, it remains the case that next to no-one is conducting combination studies that use two or more of these interventions. When considering therapies that can repair forms of the cell and tissue damage that cause aging, it seems plausible that two different thera...
Source: Fight Aging! - September 22, 2023 Category: Research Authors: Reason Tags: Activism, Advocacy and Education Source Type: blogs
