Fight Aging! Newsletter, January 23rd 2023
This study explored the association between tap drinking water and longevity in Cilento, Italy, to understand whether trace elements in local drinking water may have an influence on old, nonagenarian, and centenarian people and promote their health and longevity.
Data on population and water sources were collected through the National Demographic Statistics, the Cilento Municipal Archives, and the Cilento Integrated Water Service. Ordinary least squares (OLS) regression and a geographically weight regression (GWR) model were used to study the spatial relationship between the explanatory and outcome variables of long...
Source: Fight Aging! - January 22, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Method of Inducing Epigenetic Aging via Damage to DNA
You may recall the work linking DNA double strand break repair to epigenetic changes characteristic of aging. Repeated cycles of this repair cause some form of depletion of necessary factors or other disarray in the mechanisms controlling gene expression. This is a compelling way to link random DNA damage, largely occurring in parts of the genome that are inactive in any given cell, largely occurring in cells that will not go on to divide many times, and occurring in completely different locations from cell to cell, to a consistent, characteristic aspect of aging. Beyond the question of cancer risk, the only other compelli...
Source: Fight Aging! - January 19, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Farewell, Landleigh Nelson. I (and others) in the Diabetes Community Will Miss You.
Over the weekend, I learned that Landileigh Lee (James) Nelson died on Tuesday, January 10, 2023. As many of her friends knew, in recent years, Landileigh (or as those closest to her called her " Landi " ) had been dealing with a number of health issues. She faced seemingly one health issue after another, including dialysis which began at one point. And yet she handled it all incredibly gracefully and with her typical sense of humor, which was one reason I was proud to call Landileigh my friend.In 2017, Landi posted that she had gotten a new haircut on Facebook. I thought it was a nice photo of her, and this is how I wish ...
Source: Scott's Web Log - January 18, 2023 Category: Endocrinology Tags: 2023 Landi Landileigh Nelson Obituary passage tribute Source Type: blogs
Farewell, Landleigh Nelson. I (and others in the Diabetes Community) Will Miss You.
Over the weekend, I learned that Landileigh Lee (nee James) Nelson died on Tuesday, January 10, 2023. As many of her friends knew, in recent years, Landileigh (or as those closest to her called her " Landi " ) had been dealing with a number of health issues. She faced seemingly one health issue after another, including dialysis which began at one point. And yet she handled it all incredibly gracefully and with her typical sense of humor, which was one reason I was proud to call Landileigh my friend.In 2017, Landi posted that she had gotten a new haircut on Facebook. I thought it was a nice photo of her, and this is how I w...
Source: Scott's Web Log - January 18, 2023 Category: Endocrinology Tags: 2023 Landi Landileigh Nelson Obituary passage tribute Source Type: blogs
Fight Aging! Newsletter, January 16th 2023
Conclusions
Implanted Hair Follicle Cells Produce Remodeling of Scar Tissue
Assessment of Somatic Mosaicism as a Biomarker of Aging
The Gut Microbiome of Centenarians
https://www.fightaging.org/archives/2023/01/the-gut-microbiome-of-centenarians/
The state of the gut microbiome is arguably as influential on health as exercise. Various microbial species present in the gut produce beneficial metabolites, such as butyrate, or harmful metabolites, such as isoamylamine, or can provoke chronic inflammation in a variety of ways. An individual can have a better or worse microbiome, assessing these and other...
Source: Fight Aging! - January 15, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Which is the Ideal site to ablate VT circuit ?
Management of recurrent ventricular tachycardia has developed a lot in recent times. Anti-arrhythmic drugs(AADs) were a cornerstone for recurrent and refractory VTs .Surgeries including CABG, repair of the aneurysm, and subendocardial resection has helped to control many post-MI ischemic VTs. Soon they became obsolete. Realistically, PCIs had little impact on post-MI VT for some unknown reasons. However, with the advent of ICDs and RF, ablation, a new dimension is added to this field.
ICDs, though an attractive device, don’t prevent a VT but vow to nullify the consequence of VT. This is problematic. ICDs in spit...
Source: Dr.S.Venkatesan MD - January 12, 2023 Category: Cardiology Authors: dr s venkatesan Tags: Uncategorized Source Type: blogs
Commentary on More Drastic Scenarios of Partial Brain and Full Body Replacement
Is outright replacement of tissues a viable option for the treatment of aging? There are factions within the longevity-interested community who think that the paths to either (a) engineering replacement brain tissue for parts of the brain not involved in memory, or (b) transplantation of an old head onto a young body or brain into a young body, are short enough to be worth pursuing, where "short enough" means a few decades of work given sufficient funding. To my mind, major surgery of the sort implied by replacement of large sections of tissue or entire organs is something to be avoided in later life, given the risks and c...
Source: Fight Aging! - January 10, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, January 9th 2023
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - January 8, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Laparoscopy Before Tubal Ligation Reversal
Having a laparoscopy during tubal reversal surgery is a great idea. Refunds are provided if repair is not possible.
The post Laparoscopy Before Tubal Ligation Reversal appeared first on A Personal Choice. (Source: Tubal Reversal Blog)
Source: Tubal Reversal Blog - January 5, 2023 Category: Reproduction Medicine Authors: Dr. Monteith Tags: tubal reversal surgery diagnostic laparoscopy fallopian tube laparoscopic operative report screening laparoscopy tubal ligation tubal ligation reversal Source Type: blogs
Extracellular Mitochondria Have Some Ability to Selectively Target Tissues Experiencing Mitochondrial Dysfunction
Mitochondria can be ejected and taken up by cells, or transferred via connections between cells, and this appears to one of the many ways in which cells communicate or attempt to assist in cases of damage. It is of great interest to the research community that intracellular mitochondria can be taken up and used by cells, given the existence of inherited diseases resulting from mitochondrial mutations, and given the late life decline in mitochondrial function that contributes to many age-related conditions. It may be possible to deliver fully functional mitochondria as a therapy, to be ingested by cells in order to repair t...
Source: Fight Aging! - January 4, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Discussing the Target Cells for Allotopic Expression of Mitochondrial DNA
The Strategies for Engineered Negligible Senescence (SENS) view of the relevance of mitochondrial DNA damage to aging is that certain types of damage, large deletions for example, can produce pathological mitochondria that are both broken and able to outcompete their peers. Clones of the original damaged mitochondrion take over a cell, turning it into an exporter of large amounts of damaging reactive molecules. Only a small number of cells are affected by this type of damage in aged tissues, but it doesn't take that many cells acting in this way to produce pervasive changes to the signaling environment, as well as signific...
Source: Fight Aging! - January 3, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
What is Known of Anti-Cancer Mechanisms in Longer-Lived Species
Risk of cancer is a function of cell numbers and division rates, but also of the efficiency of cancer suppression mechanisms. In order for a species to evolve a longer life span, cancer suppression must improve. In order for a species to evolve a larger body mass, cancer suppression must improve. As this paper notes, comparatively little is definitively known of the anti-cancer strategies of various long-lived mammals. Elephants duplicate the tumor suppressor gene TP53, but that doesn't occur in other large and long-lived species, so it is likely that each species takes its own path. It is far too early to say whether what...
Source: Fight Aging! - January 2, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, January 2nd 2023
In conclusion, circulating monocytes in older adults exhibit increased expression of activation, adhesion, and migration markers, but decreased expression of co-inhibitory molecules.
MERTK Inhibition Increases Bone Density via Increased Osteoblast Activity
https://www.fightaging.org/archives/2022/12/mertk-inhibition-increases-bone-density-via-increased-osteoblast-activity/
Bone density results from the balance of constant activity on the part of osteoblasts and osteoclasts, the former building bone, the latter breaking it down. With advancing age, the balance of activity shifts to favor osteoclasts, pro...
Source: Fight Aging! - January 1, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Senescent Cells Inhibit Muscle Stem Cell Function and Regenerative Capacity
Researchers here report on evidence for senescent cells in the stem cell niches supporting muscle tissue to reduce stem cell function and the capacity for muscle regeneration. Senescent cells accumulate with age throughout the body, and their inflammatory secretions are disruptive to tissue function. The development of many varied approaches to selectively destroy these errant cells is well underway in the biotech community, with the hope that late life health will be greatly improved as a result.
Tissue regeneration requires coordination between resident stem cells and local niche cells. Here we identify that sen...
Source: Fight Aging! - December 30, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Progress Towards Decoupling Epigenetic Rejuvenation from Cell Identity Change in Partial Reprogramming
Reprogramming cells using the Yamanaka factors produces both a reset of epigenetic patterns to a more youthful configuration and a change in cell identify. One of the primary challenges inherent in reprogramming to achieve rejuvenation is avoidance of this altered cell identity. Reprogramming isn't an immediate switch, it is a slow process over hours to days, but a fraction of reprogrammed cells do change into induced pluripotent stem cells after some period of exposure to reprogramming factors. This is an undesirable outcome when delivering a reprogramming therapy; if new approaches can be found that do not alter cell ide...
Source: Fight Aging! - December 26, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
