Systemic therapy for psoriasis and the risk of cutaneous infections
In conclusion, our study reveals that systemic therapies may increase the risk of cutaneous viral infections. Therefore, dermatologists should exercise caution in this regard.PMID:38660962 | DOI:10.1111/1346-8138.17245 (Source: Herpes)
Source: Herpes - April 25, 2024 Category: Infectious Diseases Authors: Yuko Higashi Shinichi Imafuku Noriko Tsuruta Kenta Murotani Western Japan Inflammatory Skin Disease Research Group Source Type: research
Molecules, Vol. 29, Pages 1972: Pharmacological Activities of Lonicerae japonicae flos and Its Derivative & mdash; & ldquo;Chrysoeriol & rdquo; in Skin Diseases
Conclusion: The cutaneous route is the best delivery approach to chrysoeriol across the skin barrier. However, toxicity, dosage, and safety assessments of chrysoeriol in a formulation or nanochrysoeriol on the human epidermis for application in skin diseases must be further investigated. (Source: Molecules)
Source: Molecules - April 25, 2024 Category: Chemistry Authors: Siu Kan Law Xiao Xiao Wu Zhou Jiang Christy Wing Sum Tong Wesley Yeuk Lung Chow Dawn Ching Tung Au Tags: Review Source Type: research
Antifungal and Antivirulence Activity of Vanillin and Tannic Acid Against Aspergillus fumigatus and Fusarium solani
In this study, we evaluated the antifungal and antivirulence effects of vanillin and tannic acid against Aspergillus fumigatus and Fusarium solani. The minimum inhibitory concentrations of the compounds were determined by the microdilution method in RPMI broth in 96-well microplates according to CLSI. Conidial germination, protease production, biofilm formation, and in vivo therapeutic efficacy assays were performed. The results demonstrated that vanillin and tannic acid had antifungal activity against Aspergillus fumigatus, while tannic acid only exhibited antifungal activity against Fusarium solani. We found that vanilli...
Source: Current Microbiology - April 24, 2024 Category: Microbiology Authors: Ana L R íos-López Jorge D ávila-Aviña Gloria M Gonz ález Orlando Flores-Maldonado Source Type: research
The prevalence of pneumothorax in human immunodeficiency virus patients. < em > A single center study < /em >
CONCLUSION: Pneumothorax in patients with HIV is a manifestation of the progression of the disease and its poor outcome. It has a complicated treatment course and a high mortality rate.PMID:38657977 | DOI:10.15537/smj.2024.45.4.20230807 (Source: Saudi Medical Journal)
Source: Saudi Medical Journal - April 24, 2024 Category: Middle East Health Authors: Mohammed S Ishaq Esraa Y Arabi Source Type: research
Safety and effectiveness of isavuconazole in real-life non-neutropenic patients
There is a notable change in the profile of patients with invasive fungal infections (IFI): there has been a progressive rise of such infections in non-neutropenic population (i.e., COVID-19, influenza, biologic agents, corticosteroids, cancer, chronic obstructive pulmonary disorder [COPD] or cirrhosis) [1 –3]. However, information concerning the management of non-neutropenic patients with IFI remains limited. Caution should be exercised before these patients are treated like those who are neutropenic, given a considerable variability in pathogenesis and clinical manifestations of IFI [4]. (Source: International Journal ...
Source: International Journal of Infectious Diseases - April 23, 2024 Category: Infectious Diseases Authors: Patricia Monz ó-Gallo, Carlos Lopera, Ana M Badía-Tejero, Marina Machado, Julio García-Rodríguez, Pablo Vidal-Cortés, Esperanza Merino, Jorge Calderón, Jesús Fortún, Zaira R. Palacios-Baena, Javier Pemán, Joan Roig Sanchis, Manuela Aguilar-Guisad Source Type: research
Calcineurin-NFAT signaling controls neutrophils ´ ability of chemoattraction upon fungal infection
J Leukoc Biol. 2024 Apr 22:qiae091. doi: 10.1093/jleuko/qiae091. Online ahead of print.ABSTRACTCalcineurin - nuclear factor of activated T-cell (CN-NFAT) inhibitors are widely clinically used drugs for immunosuppression but besides their required T-cell response inhibition, they also undesirably affect innate immune cells. Disruption of innate immune cell function can explain the observed susceptibility of CN-NFAT inhibitors-treated patients to opportunistic fungal infections. Neutrophils play an essential role in innate immunity as a defense against pathogens, however, the effect of CN-NFAT inhibitors on neutrophil functi...
Source: Journal of Leukocyte Biology - April 22, 2024 Category: Hematology Authors: O Vymazal I Papatheodorou I Andrej činová V Bos áková G Vascelli K Bend íčková T Zelante M Hortov á-Kohoutková J Fri č Source Type: research
Oral mucormycosis associated with COVID-19 and diabetes mellitus: Case report and literature review
We present a case of a patient with diabetes mellitus and diagnosed with oral mucormycosis associated with COVID-19.PMID:38648346 | DOI:10.7705/biomedica.6970 (Source: Biomedica : Revista del Instituto Nacional de Salud)
Source: Biomedica : Revista del Instituto Nacional de Salud - April 22, 2024 Category: International Medicine & Public Health Authors: Julio C ésar Velasco Ledmar Jovanny Vargas Lorena Garc ía Iv án José Torres Iv án Camilo González Source Type: research
Characterization of Bacillus amyloliquefaciens PM415 as a potential bio-preserving probiotic
Arch Microbiol. 2024 Apr 20;206(5):222. doi: 10.1007/s00203-024-03953-1.ABSTRACTAnimal feed is vulnerable to fungal infections, and the use of bio-preserving probiotics has received increasing attention. In contrast to Lactobacillus and Bifidobacteria spp., fewer Bacillus spp. have been recognized as antifungal probiotics. Therefore, our objective was to screen antifungal strains and provide more Bacillus candidates to bridge this gap. Here, we screened 56 bacterial strains for cyclic lipopeptide genes and conducted an antifungal assay with Aspergillus niger as a representative fungus. We found that a Bacillus strain Bacil...
Source: Archives of Microbiology - April 20, 2024 Category: Microbiology Authors: Jingkang Ye Haiyang Wu Li Feng Qinghua Huang Qingxin Li Weiming Liao Jin Chuan Wu Source Type: research
Fluconazole-Loaded Ibuprofen In Situ Gel-Based Oral Spray for Oropharyngeal Candidiasis Treatment
AAPS PharmSciTech. 2024 Apr 19;25(5):89. doi: 10.1208/s12249-024-02804-y.ABSTRACTOral candidiasis is a fungal infection affecting the oral mucous membrane, and this research specifically addresses on a localized treatment through fluconazole-loaded ibuprofen in situ gel-based oral spray. The low solubility of ibuprofen is advantageous for forming a gel when exposed to an aqueous phase. The 1% w/w fluconazole-loaded in situ gel oral sprays were developed utilizing various concentrations of ibuprofen in N-methyl pyrrolidone. The prepared solutions underwent evaluation for viscosity, surface tension, contact angle, water tole...
Source: AAPS PharmSciTech - April 19, 2024 Category: Drugs & Pharmacology Authors: Ei Mon Khaing Setthapong Senarat Kritamorn Jitrangsri Thawatchai Phaechamud Source Type: research
Role of MDA5 Deficiency in Pathogenesis of Fungal Infections
(Source: Indian Journal of Pediatrics)
Source: Indian Journal of Pediatrics - April 19, 2024 Category: Pediatrics Source Type: research
Marine-derived bioactive materials as antibiofilm and antivirulence agents
Trends Biotechnol. 2024 Apr 18:S0167-7799(24)00090-8. doi: 10.1016/j.tibtech.2024.03.009. Online ahead of print.ABSTRACTMicrobial infections are major human health issues, and, recently, the mortality rate owing to bacterial and fungal infections has been increasing. In addition to intrinsic and extrinsic antimicrobial resistance mechanisms, biofilm formation is a key adaptive resistance mechanism. Several bioactive compounds from marine organisms have been identified for use in biofilm therapy owing to their structural complexity, biocompatibility, and economic viability. In this review, we discuss recent trends in the ap...
Source: Trends in Biotechnology - April 18, 2024 Category: Biotechnology Authors: Geum-Jae Jeong Fazlurrahman Khan Nazia Tabassum Kyung-Jin Cho Young-Mog Kim Source Type: research
Marine-derived bioactive materials as antibiofilm and antivirulence agents
Trends Biotechnol. 2024 Apr 18:S0167-7799(24)00090-8. doi: 10.1016/j.tibtech.2024.03.009. Online ahead of print.ABSTRACTMicrobial infections are major human health issues, and, recently, the mortality rate owing to bacterial and fungal infections has been increasing. In addition to intrinsic and extrinsic antimicrobial resistance mechanisms, biofilm formation is a key adaptive resistance mechanism. Several bioactive compounds from marine organisms have been identified for use in biofilm therapy owing to their structural complexity, biocompatibility, and economic viability. In this review, we discuss recent trends in the ap...
Source: Trends in Biotechnology - April 18, 2024 Category: Biotechnology Authors: Geum-Jae Jeong Fazlurrahman Khan Nazia Tabassum Kyung-Jin Cho Young-Mog Kim Source Type: research
Dematiaceous fungal infections: clinical and pathologic conundrums
We report our institutional experience with diagnosis of dematiaceous fungal infections from 2005 to 2022 and highlight four instructive cases that clinically and pathologically mimicked other diseases for which the diagnosis was confirmed by fungal culture (one case) or supported by PCR with 28S rRNA and internal transcribed spacer primers (three cases). Two patients were immunocompromised and two had presumed exposure to the organism. In each highlighted case, fungal infection was not clinically suspected, and the pathologist was critical in making the diagnosis and ensuring appropriate clinical management, which was sup...
Source: Journal of Clinical Pathology - April 18, 2024 Category: Pathology Authors: Hartsough, E. M., Foreman, R. K., Martinez-Lage, M., Branda, J., Sohani, A. R., Zukerberg, L. Tags: Short report Source Type: research
An update on antifungal resistance in Dermatophytosis
Expert Opin Pharmacother. 2024 Apr 16. doi: 10.1080/14656566.2024.2343079. Online ahead of print.ABSTRACTINTRODUCTION: The reports of resistance to antifungal agents used for treating onychomycosis and other superficial fungal infections are increasing. This rise in antifungal resistance poses a public health challenge that requires attention.AREAS COVERED: This review explores the prevalence of dermatophytes and the current relationship between dermatophyte species, their minimum inhibitory concentrations (MICs) for terbinafine (an allylamine) and itraconazole (an azole), and various mutations prevalent in these species. ...
Source: Expert Opinion on Pharmacotherapy - April 16, 2024 Category: Drugs & Pharmacology Authors: Aditya K Gupta Avantika Mann Shruthi Polla Ravi Tong Wang Source Type: research
A Palearctic view of a bat fungal disease
Conserv Biol. 2024 Apr 15:e14265. doi: 10.1111/cobi.14265. Online ahead of print.ABSTRACTThe fungal infection causing white-nose disease in hibernating bats in North America has resulted in dramatic population declines of affected species, since the introduction of the causative agent Pseudogymnoascus destructans. The fungus is native to the Palearctic, where it also infects several bat species, yet rarely causes severe pathology or the death of the host. Pseudogymnoascus destructans infects bats during hibernation by invading and digesting the skin tissue, resulting in the disruption of torpor patterns and consequent emac...
Source: Conservation Biology - April 15, 2024 Category: Biology Authors: F Whiting-Fawcett A S Blomberg T Troitsky M B Meierhofer K A Field S J Puechmaille T M Lilley Source Type: research
