How to tame a toxic yet life-saving antifungal
In this episode:00:46 Modifying a fungal drug to make it less toxicAmphotericin B is a drug used to treat life-threatening fungal infections. But while it is effective against many fungal species, it is also extremely toxic to kidneys, meaning it is mostly used as a drug of last-resort. This week, a team has unpicked the mechanism behind the drug’s toxicity, allowing them to modify it and reduce side effects in human kidney cells. The researchers hope this new version of the drug could become a useful tool in fighting fungal diseases.Research article: Maji et al.09:00 Research HighlightsReconstructing woolly rhino DNA us...
Source: Nature Podcast - November 8, 2023 Category: Science Authors: Springer Nature Limited Source Type: podcasts
TWiV 772: COVID-19 clinical update #68 with Dr. Daniel Griffin
In COVID-19 clinical update #68, Daniel Griffin discusses children acquiring infection at birthday parties, immunogenicity of vaccines in solid organ transplant patients, reinfection rates in recovered patients, lack of efficacy of azithromycin, bacterial and fungal infections in hospitalized patients, effect of monoclonal antibody treatment on clinical outcomes of ambulatory patients, and reduction in mortality of hospitalized patients treated with remedesivir. Hosts: Daniel Griffin and Vincent Racaniello Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode COVID-19...
Source: This Week in Virology - MP3 Edition - June 26, 2021 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
TWiV 541: Cloaking devices
The TWiVers present mitoviruses, which infect mitochondria, and how quasi-enveloped hepatitis A virus gets naked again. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, and Kathy Spindler Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Evidence for plant mitoviruses (Virology) Uncoating of quasi-enveloped HAV (eLife) Image credit Letters read on TWiV 541 Timestamps by Jolene. Thanks! Weekly Science Picks Alan- Where and when to see cherry blossoms Dickson- Nebraska floods Kathy- Peeps fungal infection experiment Vincent - Emergency declared in NY over ...
Source: This Week in Virology - MP3 Edition - March 31, 2019 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
Thomas F. Patterson, MD, FACP, FIDSA - Overcoming Barriers to Optimal Diagnosis and Treatment of Invasive Fungal Infections: Practical Guidance for the Hospital-Based Healthcare Provider
Overcoming Barriers to Optimal Diagnosis and Treatment of Invasive Fungal Infections: Practical Guidance for the Hospital-Based Healthcare Provider (Source: PeerView Press CME/CE International Audio Podcast - Internal Medicine)
Source: PeerView Press CME/CE International Audio Podcast - Internal Medicine - September 10, 2018 Category: Internal Medicine Authors: PVI, PeerView Institute for Medical Education Tags: Science, Medicine Source Type: podcasts
Issue Summary 2: July 2018
David A. Bluemke, MD, PhD, Editor of Radiology discusses three research articles from the July 2018 issue of Radiology. ARTICLES DISCUSSED Summary of US Time-Harmonic Elastography: Detection of Liver Fibrosis in Adolescents with Extreme Obesity with Nonalcoholic Fatty Liver Disease. Radiology 2018; 288(1):99-106. Summary of General Practitioners Referring Adults to MR Imaging for Knee Pain: A Randomized Controlled Trial to Assess Cost-effectiveness. Radiology 2018; 2018; 288(1):170-176. Summary of Radiation Dose Reduction by Using CT with Iterative Model Reconstruction in Patients with Pulmonary Invasive Fungal Infection. ...
Source: Radiology Podcasts - July 19, 2018 Category: Radiology Authors: The Radiological Society of North America Tags: Podcasts Source Type: podcasts
Dimitrios P. Kontoyiannis, MD, ScD, FACP, FIDSA, FECMM - Preventing and Managing Cytomegalovirus and Invasive Fungal Infection After Hematopoietic Stem Cell Transplantation: Key Questions, Expert Answers
Preventing and Managing Cytomegalovirus and Invasive Fungal Infection After Hematopoietic Stem Cell Transplantation: Key Questions, Expert Answers (Source: PeerView CME/CE Audio Podcast - Immunology)
Source: PeerView CME/CE Audio Podcast - Immunology - April 17, 2017 Category: Allergy & Immunology Authors: PVI, PeerView Institute for Medical Education Tags: Science, Medicine Source Type: podcasts
John R. Wingard, MD - Invasive Fungal Infections in HCT Recipients: Case-Based Perspectives on Prevention and Treatment
Invasive Fungal Infections in HCT Recipients: Case-Based Perspectives on Prevention and Treatment (Source: PeerView CME/CE Audio Podcast - Immunology)
Source: PeerView CME/CE Audio Podcast - Immunology - June 27, 2016 Category: Allergy & Immunology Authors: PVI, PeerView Institute for Medical Education Tags: Science, Medicine Source Type: podcasts
FDA Drug Safety Podcast: FDA warns that prescribing of Nizoral (ketoconazole) oral tablets for unapproved uses including skin and nail infections continues; linked to patient death
On May 19, 2016, FDA announced it is warning health care professionals to avoid prescribing the antifungal medicine ketoconazole oral tablets to treat skin and nail fungal infections. (Source: FDA Drug Safety Podcasts)
Source: FDA Drug Safety Podcasts - June 3, 2016 Category: Drugs & Pharmacology Authors: U.S. Food and Drug Administration, Center for Drug Evaluation and Research Source Type: podcasts
FDA Drug Safety Podcast: FDA cautions about dosing errors when switching between different oral formulations of antifungal Noxafil (posaconazole); label changes approved
On January 4, 2016 FDA cautioned that differences in dosing regimens between the two oral formulations of the antifungal Noxafil (active ingredient posaconazole) have resulted in dosing errors. To help prevent additional medication errors, the drug labels were revised to indicate that the two oral formulations cannot be directly substituted for each other but require a change in dose. Direct milligram for milligram substitution of the two formulations can result in drug levels that are lower or higher than needed to effectively treat certain fungal infections. (Source: FDA Drug Safety Podcasts)
Source: FDA Drug Safety Podcasts - March 30, 2016 Category: Drugs & Pharmacology Authors: U.S. Food and Drug Administration, Center for Drug Evaluation and Research Source Type: podcasts
Antifungal agents for preventing fungal infections in critically ill adults and children with a normal number of neutrophils in the blood
Invasive fungal infections are important causes of morbidity and mortality among critically ill patients, and an updated Cochrane Review in January 2016 examines the effects of antifungal agents to prevent these infections. The lead author, Andrea Cortegiani, from the University of Palermo in Italy summarises the latest evidence in this podcast. (Source: Podcasts from The Cochrane Library)
Source: Podcasts from The Cochrane Library - March 23, 2016 Category: Journals (General) Authors: Cochrane Source Type: podcasts
Dimitrios P. Kontoyiannis, MD, MS, ScD, FACP, FIDSA - Principles and Application of Antifungal Pharmacology: A Case-Based Approach to Optimizing Treatment Decisions in Individual Patients With Invasive Fungal Infections
Principles and Application of Antifungal Pharmacology: A Case-Based Approach to Optimizing Treatment Decisions in Individual Patients With Invasive Fungal Infections (Source: PeerView CME/CE Audio Podcast - Immunology)
Source: PeerView CME/CE Audio Podcast - Immunology - December 11, 2015 Category: Allergy & Immunology Authors: PVI, PeerView Institute for Medical Education Tags: Science, Medicine Source Type: podcasts
Dimitrios P. Kontoyiannis, MD, MS, ScD, FACP, FIDSA - Minimizing the Burden of Invasive Fungal Infections: Practical Strategies to Improve Outcomes in the Inpatient Setting
Minimizing the Burden of Invasive Fungal Infections: Practical Strategies to Improve Outcomes in the Inpatient Setting (Source: PeerView Press CME/CE International Audio Podcast - Internal Medicine)
Source: PeerView Press CME/CE International Audio Podcast - Internal Medicine - May 8, 2015 Category: Internal Medicine Authors: PVI, PeerView Institute for Medical Education Tags: Science, Medicine Source Type: podcasts
John R. Wingard, MD - Invasive Fungal Infections in Patients With Hematologic Malignancies: Expert Perspectives on Current and Future Approaches to Prevention and Treatment
Invasive Fungal Infections in Patients With Hematologic Malignancies: Expert Perspectives on Current and Future Approaches to Prevention and Treatment (Source: PeerView CME/CE Audio Podcast - Oncology)
Source: PeerView CME/CE Audio Podcast - Oncology - September 22, 2014 Category: Cancer & Oncology Authors: PVI, PeerView Institute for Medical Education Tags: Science, Medicine Source Type: podcasts
