Patients with STAT1 Gain-of-function Mutations Display Increased Apoptosis which is Reversed by the JAK Inhibitor Ruxolitinib
ConclusionIn STAT1-GOF patients, T lymphocyte apoptosis is increased, and T lymphopenia may determine higher risk of severe infections. The JAKinib target therapy should be evaluated to treat severe chronic candidiasis and lymphopenia, and to downregulate the IFNs in patients with autoinflammatory or autoimmune manifestations. (Source: Journal of Clinical Immunology)
Source: Journal of Clinical Immunology - April 5, 2024 Category: Allergy & Immunology Source Type: research
Diagnosis and Management of Common Pediatric Cutaneous Infections
We describe clinical presentation, pathogenesis, and current treatments. The goal of this guide is to increase pediatricians' comfort in diagnosing and managing common skin infections, as well as determining when a dermatology referral may be necessary. [Pediatr Ann. 2024;53(4):e138-e145.].PMID:38574073 | DOI:10.3928/19382359-20240205-01 (Source: Pediatric Annals)
Source: Pediatric Annals - April 4, 2024 Category: Pediatrics Authors: Pooja Gurnani Reesa L Monir Jennifer J Schoch Source Type: research
Diagnosis and Management of Common Pediatric Cutaneous Infections
We describe clinical presentation, pathogenesis, and current treatments. The goal of this guide is to increase pediatricians' comfort in diagnosing and managing common skin infections, as well as determining when a dermatology referral may be necessary. [Pediatr Ann. 2024;53(4):e138-e145.].PMID:38574073 | DOI:10.3928/19382359-20240205-01 (Source: Pediatric Annals)
Source: Pediatric Annals - April 4, 2024 Category: Pediatrics Authors: Pooja Gurnani Reesa L Monir Jennifer J Schoch Source Type: research
