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Antifungal effects of echinocandins diminish when exposed to intestinal lumen contents: a finding with potentially significant clinical implications
In this study, caspofungin and micafungin, the two most commonly used echinocandins, were evaluated in various in vitro environments simulating intestinal lumen. The results revealed that while both antifungals are effective in standard medium, their efficacy significantly diminishes in the presence of human small bowel aspirates and bovine bile. The study suggests that bowel contents and specifically bile acids may be a suppressive component, hindering the antifungal effects of echinocandins. This novel exploration sheds light on the poor oral bioavailability of echinocandins. The findings imply that echinocandins alone, ...
Source: Frontiers in Pharmacology - March 27, 2024 Category: Drugs & Pharmacology Source Type: research

Characteristics and risk factors for invasive fungal infection in hospitalized patients with acute-on-chronic hepatitis B liver failure: a retrospective cohort study from 2010 to 2023
ConclusionIFI is a rare complication that leads to high mortality in hospitalized ACHBLF patients, and a high neutrophilic granulocyte percentage and length of hospitalization are independent risk factors for the occurrence of IFI. (Source: Frontiers in Microbiology)
Source: Frontiers in Microbiology - March 27, 2024 Category: Microbiology Source Type: research

Pore-forming peptide C14R exhibits potent antifungal activity against clinical isolates of Candida albicans and Candida auris
DiscussionC14R has a potent antifungal activity against a large set of clinical isolates of both C. albicans and C. auris, showing its capacity to disrupt Candida membranes. This antifungal activity remains consistent across isolates regardless of their clinical source. Furthermore, the absence of correlation between MICs to C14R and resistance to fluconazole indicates the peptide’s potential effectiveness against fluconazole-resistant strains. Our results suggest the potential of C14R, a pore-forming peptide, as a treatment option for fungal infections, such as invasive candidiasis, including fluconazole and amphoterici...
Source: Frontiers in cellular and infection microbiology - March 27, 2024 Category: Microbiology Source Type: research

Case Report: Itraconazole Oral Solution Continuous Therapy for Infantile Tinea Capitis
This study assesses the efficacy and safety of itraconazole oral solution continuous therapy, expanding our understanding by demonstrating its effectiveness for infantile tinea capitis caused by T. tonsurans and N. gypsea.PMID:38531098 | DOI:10.4269/ajtmh.23-0741 (Source: The American Journal of Tropical Medicine and Hygiene)
Source: The American Journal of Tropical Medicine and Hygiene - March 26, 2024 Category: Tropical Medicine Authors: Ya Bin Zhou Jin Jing Chao Lin Ma Yuan Yuan Xiao Source Type: research

Case Report: Itraconazole Oral Solution Continuous Therapy for Infantile Tinea Capitis
This study assesses the efficacy and safety of itraconazole oral solution continuous therapy, expanding our understanding by demonstrating its effectiveness for infantile tinea capitis caused by T. tonsurans and N. gypsea.PMID:38531098 | DOI:10.4269/ajtmh.23-0741 (Source: Am J Trop Med Hyg)
Source: Am J Trop Med Hyg - March 26, 2024 Category: Infectious Diseases Authors: Ya Bin Zhou Jin Jing Chao Lin Ma Yuan Yuan Xiao Source Type: research