Clinicopathologic Spectrum and Outcomes of Infections Diagnosed on Graft Biopsies and Nephrectomy in Live Renal Allograft Recipients: An Institutional Experience
CONCLUSIONS: BK polyoma virus infection was the most common infection affecting the renal allograft in our study. Although fungal infections caused the highest mortality among our patients, bacterial graft pyelonephritis was responsible for maximum graft failure. Correctly identifying infections on histology is important so that graft and patient life can be prolonged.PMID:38695589 | DOI:10.6002/ect.2023.0200 (Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation)
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - May 2, 2024 Category: Transplant Surgery Authors: Pallav Gupta Vinant Bhargava Manish Malik Anurag Gupta A K Bhalla Ashwani Gupta Vaibhav Tiwari Shiv Chadha D S Rana Source Type: research
A Diels – Alder probe for discovery of natural products containing furan moieties
Abstract
Natural products (NPs) are fantastic sources of inspiration for novel pharmaceuticals, oftentimes showing unique bioactivity against interesting targets. Specifically, NPs containing furan moieties show activity against a variety of diseases including fungal infections, and cancers. However, it is challenging to discover and isolate these small molecules from cell supernatant. The work described herein showcases the development of a molecular probe that can covalently modify furan moieties via a [4 + 2] Diels–Alder cycloaddition, making them easily identifiable on liquid chromatography–mass spectrometr...
Source: Beilstein Journal of Organic Chemistry - May 2, 2024 Category: Chemistry Authors: Beilstein Journal of Organic Chemistry - Syndicated Feeds Tags: Diels – Alder reaction furans methylenomycin furan hormones natural products reactivity-based probes Full Research Paper Source Type: research
Efficacy of an oral lipid nanocrystal formulation of amphotericin B (MAT2203) in the neutropenic mouse model of pulmonary mucormycosis
Antimicrob Agents Chemother. 2024 Apr 30:e0154023. doi: 10.1128/aac.01540-23. Online ahead of print.ABSTRACTInvasive mucormycosis (IM) is associated with high mortality and morbidity. MAT2203 is an orally administered lipid nanocrystal formulation of amphotericin B, which has been shown to be safe and effective against other fungal infections. We sought to compare the efficacy of MAT2203 to liposomal amphotericin B (LAMB) treatment in a neutropenic mouse model of IM due to Rhizopus arrhizus var. delemar or Mucor circinelloides f. jenssenii DI15-131. In R. arrhizus var. delemar-infected mice, 15 mg/kg of MAT2203 qd was as e...
Source: Antimicrobial Agents and Chemotherapy - April 30, 2024 Category: Microbiology Authors: Yiyou Gu Teclegiorgis Gebremariam Sondus Alkhazraji Eman Youssef Sabrina El-Gamal Theresa Matkovits Jenel Cobb Raphael Mannino Ashraf S Ibrahim Source Type: research
Rate, Risk Factors, and Outcomes of Invasive Fungal Infections in Patients with Hematologic Malignancies
Conclusion: IFI represents a frequent complication for HM patients with high mortality. Aspergillus species are the predominant etiology in these settings. Considering our results, in high-risk patients, manifestations of warning signs in the sinus and lungs, which would not be cleared despite receiving antibiotics, should raise the possibility of IFIs.PMID:38680718 | PMC:PMC11055423 | DOI:10.18502/ijhoscr.v18i1.14746 (Source: Cell Research)
Source: Cell Research - April 29, 2024 Category: Cytology Authors: Shirin Afhami Alireza Adibimehr Seyed Asadollah Mousavi Mohammad Vaezi Mahnaz Montazeri Mohammadreza Salehi Mohsen Meidani Mahshid Saleh Kazem Ahmadikia Emmanuel Roilides Johan Maertens Neda Alijani Source Type: research
Current status and new experimental diagnostic methods of invasive fungal infections after hematopoietic stem cell transplantation
Arch Microbiol. 2024 Apr 28;206(5):237. doi: 10.1007/s00203-024-03905-9.ABSTRACTInvasive fungal infections (IFIs) are common and life-threatening complications in post-hematopoietic stem cell transplantation (post-HSCT) recipients, Severe IFIs can lead to systemic infection and organ damage, which results in high mortality in HSCT recipients. With the development of the field of fungal infection diagnosis, more and more advanced non-culture diagnostic tools have been developed, such as glip biosensors, metagenomic next-generation sequencing, Magnetic Nanoparticles and Identified Using SERS via AgNPs+ , and artificial intel...
Source: Archives of Microbiology - April 28, 2024 Category: Microbiology Authors: Zhenhua Tang HaiTao Wang Yuankai Liu Chen Wang Xinye Li Qiong Yang Source Type: research
Current status and new experimental diagnostic methods of invasive fungal infections after hematopoietic stem cell transplantation
Arch Microbiol. 2024 Apr 28;206(5):237. doi: 10.1007/s00203-024-03905-9.ABSTRACTInvasive fungal infections (IFIs) are common and life-threatening complications in post-hematopoietic stem cell transplantation (post-HSCT) recipients, Severe IFIs can lead to systemic infection and organ damage, which results in high mortality in HSCT recipients. With the development of the field of fungal infection diagnosis, more and more advanced non-culture diagnostic tools have been developed, such as glip biosensors, metagenomic next-generation sequencing, Magnetic Nanoparticles and Identified Using SERS via AgNPs+ , and artificial intel...
Source: Archives of Microbiology - April 28, 2024 Category: Microbiology Authors: Zhenhua Tang HaiTao Wang Yuankai Liu Chen Wang Xinye Li Qiong Yang Source Type: research
Lomentospora prolificans Fungemia in a Patient With T-Cell Large Granular Leukemia: A Rare Pathogen in T ürkiye
In conclusion, although L.prolificans infections are rare, they can be life-threatening, especially in immunosuppressed individuals. Diagnosis and treatment of such infections may be difficult, therefore rapid diagnostic methods and appropriate treatment protocols should be developed. Consideration of infections caused by rare fungal pathogens in patients with risk factors may be critical for patient care. The literature review revealed that the first case of L.prolificans fungemia from Türkiye was reported in 2023. This case presentation represents the second reported case. However, in our case, L.prolificans fungemia oc...
Source: Mikrobiyoloji Bulteni - April 27, 2024 Category: Microbiology Authors: Esat K ıvanç Kaya Mustafa Berkay Ta ştekin Sevtap Arikan Akda ğli Dolunay G ülmez Arzu Topeli Ömrüm Uzun Source Type: research
Low incidence of invasive fungal infection and risk factors in a large observational cohort of patients initiating TNF-alpha inhibitors for dermatologic conditions
(Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - April 27, 2024 Category: Dermatology Authors: Ian P. Hennessee, Kaitlin Benedict, Nathan C. Bahr, Shari R. Lipner, Jeremy A.W. Gold Tags: Research letter Source Type: research
Disseminated Histoplasmosis in a Patient with Myelofibrosis on Ruxolitinib: A Case Report and Review of the Literature on Ruxolitinib-Associated Invasive Fungal Infections
In this report, we present the case of a 59-year-old woman with MF who developed disseminated histoplasmosis after seven months of ruxolitinib use. The patient clinically improved after ten weeks of combined amphotericin B and azole therapy, and ruxolitinib was discontinued. Later, the patient received fedratinib, a relatively JAK2-selective inhibitor, without relapse of histoplasmosis. We also reviewed the literature on published cases of proven IFIs in patients with MF who received ruxolitinib. Including ours, we identified 28 such cases, most commonly due to Cryptococcus species (46%). IFIs were most commonly disseminat...
Source: Herpes - April 26, 2024 Category: Infectious Diseases Authors: Chia-Yu Chiu Teny M John Takahiro Matsuo Sebastian Wurster Rachel S Hicklen Raihaan Riaz Khattak Ella J Ariza-Heredia Prithviraj Bose Dimitrios P Kontoyiannis Source Type: research
