Impact of Metformin on Neocortical Development during Pregnancy: Involvements of ERK and p35/CDK5 Pathways
Chemosphere. 2024 Apr 25:142124. doi: 10.1016/j.chemosphere.2024.142124. Online ahead of print.ABSTRACTMetformin, the most commonly prescribed drug for the treatment of diabetes, is increasingly used during pregnancy to address various disorders such as diabetes, obesity, preeclampsia, and metabolic diseases. However, its impact on neocortex development remains unclear. Here, we investigated the direct effects of metformin on neocortex development, focusing on ERK and p35/CDK5 regulation. Using a pregnant rat model, we found that metformin treatment during pregnancy induces small for gestational age (SGA) and reduces relat...
Source: Chemosphere - April 27, 2024 Category: Chemistry Authors: Muhammet Oner Mei-Chih Chen Pang-Ting Cheng Yu-Hsuan Li Yu-Chiao Cheng Ayse Celik Shiuan-Woei Soong Li-Wen Hsu Din-You Lin G M Shazzad Hossain Prince Trayee Dhar Hsu-Chen Cheng Pin-Chi Tang Ho Lin Source Type: research
Effects of Metformin Therapy on Thyroid Volume and Functions in Patients with Newly Diagnosed Type 2 Diabetes Mellitus: A Single-center Prospective Study
CONCLUSION: Our results suggest that metformin treatment significantly reduces body weight, BMI, thyroid volume, and serum TSH, ALT, and Anti-TPO levels in patients with newly diagnosed T2DM. Moreover, serum TSH levels showed a significant decrease in non-obese subjects, while thyroid volume showed a significant decrease in obese subjects.PMID:38676519 | DOI:10.2174/0118715303307313240315162000 (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - April 27, 2024 Category: Drugs & Pharmacology Authors: Mehtap Evran Gizem Pire İsa Burak Güney Source Type: research
A review on side effect management of second generation antipsychotics to treat schizophrenia: a drug safety perspective
Expert Opin Drug Saf. 2024 Apr 27. doi: 10.1080/14740338.2024.2348561. Online ahead of print.ABSTRACTINTRODUCTION: Effective side effects management present a challenge in antipsychotic treatment with second generation antipsychotics (SGAs). In recent years, most of the commonly used SGAs, except for clozapine, have been shown to differ only slightly in their effectiveness, but considerably regarding perceived side effects, safety profiles, and compatibility to preexisting medical conditions.AREAS COVERED: The current state of available evidence on side effect management in SGA treatment of patients with schizophrenia spec...
Source: Expert Opinion on Drug Safety - April 27, 2024 Category: Drugs & Pharmacology Authors: Wolfgang Strube Elias Wagner Jurjen J Luykx Alkomiet Hasan Source Type: research
Impact of Combination Therapy with Chemical Drugs and Megavoltage X-ray Exposure on Breast Cancer Stem Cells' Viability and Proliferation of MCF-7 and MDA-MB-231 Cell Lines
CONCLUSION: Anti-cancer and cytotoxic effects of metformin can be effective in this strategy. In conclusion, the combination of conventional chemotherapeutic drugs, including SB203580, metformin, and takinib with X-ray exposure can be a new approach to diminish the drug resistance of breast cancer.PMID:38676476 | DOI:10.2174/0113816128287325240329085055 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - April 27, 2024 Category: Drugs & Pharmacology Authors: Fatemeh Banisharif Dehkordi Mahdi Ghatrehsamani Maryam Abdolvand Amin Soltani Seyed Hossein Masoumi Source Type: research
Effects of Metformin Therapy on Thyroid Volume and Functions in Patients with Newly Diagnosed Type 2 Diabetes Mellitus: A Single-center Prospective Study
CONCLUSION: Our results suggest that metformin treatment significantly reduces body weight, BMI, thyroid volume, and serum TSH, ALT, and Anti-TPO levels in patients with newly diagnosed T2DM. Moreover, serum TSH levels showed a significant decrease in non-obese subjects, while thyroid volume showed a significant decrease in obese subjects.PMID:38676519 | DOI:10.2174/0118715303307313240315162000 (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - April 27, 2024 Category: Endocrinology Authors: Mehtap Evran Gizem Pire İsa Burak Güney Source Type: research
Metformin inhibits activation of NLRP3 inflammasome and inflammatory response in preeclamptic rats
CONCLUSIONS: MET demonstrates a protective effect against L-NAME-induced PE rats, potentially mediated through inhibition of the inflammatory response, downregulation of NLRP3 inflammasome expression in the placenta, and regulation of the balance between anti-angiogenic and pro-angiogenic factors.PMID:38677349 | DOI:10.1016/j.gene.2024.148509 (Source: Gene)
Source: Gene - April 27, 2024 Category: Genetics & Stem Cells Authors: Ran Jia Huijing Ma Huiniu Hao Fang Wang Hailan Yang Source Type: research
Effects of Metformin Therapy on Thyroid Volume and Functions in Patients with Newly Diagnosed Type 2 Diabetes Mellitus: A Single-center Prospective Study
CONCLUSION: Our results suggest that metformin treatment significantly reduces body weight, BMI, thyroid volume, and serum TSH, ALT, and Anti-TPO levels in patients with newly diagnosed T2DM. Moreover, serum TSH levels showed a significant decrease in non-obese subjects, while thyroid volume showed a significant decrease in obese subjects.PMID:38676519 | DOI:10.2174/0118715303307313240315162000 (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - April 27, 2024 Category: Drugs & Pharmacology Authors: Mehtap Evran Gizem Pire İsa Burak Güney Source Type: research
A review on side effect management of second generation antipsychotics to treat schizophrenia: a drug safety perspective
Expert Opin Drug Saf. 2024 Apr 27. doi: 10.1080/14740338.2024.2348561. Online ahead of print.ABSTRACTINTRODUCTION: Effective side effects management present a challenge in antipsychotic treatment with second generation antipsychotics (SGAs). In recent years, most of the commonly used SGAs, except for clozapine, have been shown to differ only slightly in their effectiveness, but considerably regarding perceived side effects, safety profiles, and compatibility to preexisting medical conditions.AREAS COVERED: The current state of available evidence on side effect management in SGA treatment of patients with schizophrenia spec...
Source: Expert Opinion on Drug Safety - April 27, 2024 Category: Drugs & Pharmacology Authors: Wolfgang Strube Elias Wagner Jurjen J Luykx Alkomiet Hasan Source Type: research
Impact of Combination Therapy with Chemical Drugs and Megavoltage X-ray Exposure on Breast Cancer Stem Cells' Viability and Proliferation of MCF-7 and MDA-MB-231 Cell Lines
CONCLUSION: Anti-cancer and cytotoxic effects of metformin can be effective in this strategy. In conclusion, the combination of conventional chemotherapeutic drugs, including SB203580, metformin, and takinib with X-ray exposure can be a new approach to diminish the drug resistance of breast cancer.PMID:38676476 | DOI:10.2174/0113816128287325240329085055 (Source: Current Pharmaceutical Design)
Source: Current Pharmaceutical Design - April 27, 2024 Category: Drugs & Pharmacology Authors: Fatemeh Banisharif Dehkordi Mahdi Ghatrehsamani Maryam Abdolvand Amin Soltani Seyed Hossein Masoumi Source Type: research
Effects of Metformin Therapy on Thyroid Volume and Functions in Patients with Newly Diagnosed Type 2 Diabetes Mellitus: A Single-center Prospective Study
CONCLUSION: Our results suggest that metformin treatment significantly reduces body weight, BMI, thyroid volume, and serum TSH, ALT, and Anti-TPO levels in patients with newly diagnosed T2DM. Moreover, serum TSH levels showed a significant decrease in non-obese subjects, while thyroid volume showed a significant decrease in obese subjects.PMID:38676519 | DOI:10.2174/0118715303307313240315162000 (Source: Endocrine, Metabolic and Immune Disorders Drug Targets)
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - April 27, 2024 Category: Endocrinology Authors: Mehtap Evran Gizem Pire İsa Burak Güney Source Type: research
Clinical and Laboratory Characteristics of MODY (Maturity Onset Diabetes of Young) Cases, Genetic Mutation Spectrum and Phenotype-genotype Relationship
CONCLUSION: This was the largest genetically diagnosed series from Turkey. The most common gene variants were GCK and HNF1A with much lower proportions for other MODY types. Hyperglycemia was the most common presenting symptom while 11% of patients had diabetes-associated autoantibodies and 7% were obese. The majority of patients received dietary management only.PMID:38665000 | DOI:10.4274/jcrpe.galenos.2024.2023-10-16 (Source: Cell Research)
Source: Cell Research - April 26, 2024 Category: Cytology Authors: Elif Özsu Semra Çetinkaya Semih Bolu Nihal Hatipo ğlu Şenay Savaş Erdeve Olcay Evliyao ğlu Firdevs Ba ş Atilla Çayır İsmail Dündar Emine Demet Akba ş Seyid Ahmet U çaktürk Merih Berbero ğlu Zeynep Şıklar Şervan Özalkak Nursel Murato ğl Source Type: research
Microbial Features Linked to Medication Strategies in Cardiometabolic Disease Management
ACS Pharmacol Transl Sci. 2024 Feb 5;7(4):991-1001. doi: 10.1021/acsptsci.3c00261. eCollection 2024 Apr 12.ABSTRACTHuman gut microbiota are recognized as critical players in both metabolic disease and drug metabolism. However, medication-microbiota interactions in cardiometabolic diseases are not well understood. To gain a comprehensive understanding of how medication intake impacts the gut microbiota, we investigated the association of microbial structure with the use of single or multiple medications in a cohort of 134 middle-aged adults diagnosed with cardiometabolic disease, recruited from Alberta's Tomorrow Project. P...
Source: Cancer Control - April 26, 2024 Category: Cancer & Oncology Authors: Jane Shearer Shrushti Shah Grace Shen-Tu Kristina Schlicht Matthias Laudes Chunlong Mu Source Type: research
Clinical and Laboratory Characteristics of MODY (Maturity Onset Diabetes of Young) Cases, Genetic Mutation Spectrum and Phenotype-genotype Relationship
CONCLUSION: This was the largest genetically diagnosed series from Turkey. The most common gene variants were GCK and HNF1A with much lower proportions for other MODY types. Hyperglycemia was the most common presenting symptom while 11% of patients had diabetes-associated autoantibodies and 7% were obese. The majority of patients received dietary management only.PMID:38665000 | DOI:10.4274/jcrpe.galenos.2024.2023-10-16 (Source: JCRPE Journal of Clinical Research in Pediatric Endocrinology)
Source: JCRPE Journal of Clinical Research in Pediatric Endocrinology - April 26, 2024 Category: Endocrinology Authors: Elif Özsu Semra Çetinkaya Semih Bolu Nihal Hatipo ğlu Şenay Savaş Erdeve Olcay Evliyao ğlu Firdevs Ba ş Atilla Çayır İsmail Dündar Emine Demet Akba ş Seyid Ahmet U çaktürk Merih Berbero ğlu Zeynep Şıklar Şervan Özalkak Nursel Murato ğl Source Type: research
Changes and Significance of Central Carbon Metabolism before and after Metformin Treatment of Type 2 Diabetes Based on Mass Spectrometry
CONCLUSIONS: We employed HPIC-MS/MS to uncover alterations in CCM among individuals recently diagnosed with T2D before and after metformin treatment. The findings suggest that metformin may ameliorate the energy metabolism imbalance in T2D by reducing intermediates within the CCM pathway.PMID:38665017 | DOI:10.24976/Discov.Med.202436183.64 (Source: Discovery Medicine)
Source: Discovery Medicine - April 26, 2024 Category: Research Authors: Yang Shu Fujie Yang Weidong Li Lisha Li Qiongying Hu Daqian Xiong Source Type: research
Clinical and Laboratory Characteristics of MODY (Maturity Onset Diabetes of Young) Cases, Genetic Mutation Spectrum and Phenotype-genotype Relationship
CONCLUSION: This was the largest genetically diagnosed series from Turkey. The most common gene variants were GCK and HNF1A with much lower proportions for other MODY types. Hyperglycemia was the most common presenting symptom while 11% of patients had diabetes-associated autoantibodies and 7% were obese. The majority of patients received dietary management only.PMID:38665000 | DOI:10.4274/jcrpe.galenos.2024.2023-10-16 (Source: Cell Research)
Source: Cell Research - April 26, 2024 Category: Cytology Authors: Elif Özsu Semra Çetinkaya Semih Bolu Nihal Hatipo ğlu Şenay Savaş Erdeve Olcay Evliyao ğlu Firdevs Ba ş Atilla Çayır İsmail Dündar Emine Demet Akba ş Seyid Ahmet U çaktürk Merih Berbero ğlu Zeynep Şıklar Şervan Özalkak Nursel Murato ğl Source Type: research
