Metformin Plus Insulin for Preexisting Diabetes or Gestational Diabetes in Pregnancy
To the Editor The MOMPOD study revealed that for pregnant individuals with preexisting type 2 or early gestational diabetes, metformin 1000 mg twice daily starting before 23 weeks ’ gestation and taken until delivery did not reduce a composite adverse neonatal outcome by results in reduced numbers of large-for-gestational-age infants. However, we believe that safety issues regarding the long-term effects of metformin on male infant fertility should also be considered. (Source: JAMA - Journal of the American Medical Association)
Source: JAMA - Journal of the American Medical Association - April 3, 2024 Category: General Medicine Source Type: research
Metformin Plus Insulin for Preexisting Diabetes or Gestational Diabetes in Pregnancy —Reply
In Reply We thank Drs Pourkarim and Entezari-Maleki for their thoughtful comment about our recent study that described outcomes following metformin plus insulin for the treatment of early gestational and preexisting type 2 diabetes in pregnancy. We agree that based on available data, the use of metformin during pregnancy remains controversial and that long-term health data following in utero exposure should be collected prior to asserting that there are no unintended negative health consequences in childhood or adulthood. About reproductive health in males, a 2022 review article summarized the published data on the effect ...
Source: JAMA - Journal of the American Medical Association - April 3, 2024 Category: General Medicine Source Type: research
Molecules, Vol. 29, Pages 1614: Metformin Loaded Zein Polymeric Nanoparticles to Augment Antitumor Activity against Ehrlich Carcinoma via Activation of AMPK Pathway: D-Optimal Design Optimization, In Vitro Characterization, and In Vivo Study
This study was initiated to investigate the antitumor effects and potential molecular targets of MET in mice bearing solid Ehrlich carcinoma (SEC) as a model of breast cancer (BC) and to explore the potential of zein nanoparticles (ZNs) as a carrier for improving the anticancer effect of MET. ZNs were fabricated through ethanol injection followed by probe sonication method. The optimum ZN formulation (ZN8) was spherical and contained 5 mg zein and 30 mg sodium deoxycholate with a small particle size and high entrapment efficiency percentage and zeta potential. A stability study showed that ZN8 was stable for up to three mo...
Source: Molecules - April 3, 2024 Category: Chemistry Authors: Yasmina Elmahboub Rofida Albash Mira Magdy William Amal H. Rayan Najat O. Hamed Mona S. Ousman Nahed A Raslan Shaimaa Mosallam Tags: Article Source Type: research
Effects of dulaglutide and trelagliptin on beta-cell function in patients with type 2 diabetes: a randomized controlled study: DUET-beta study
ConclusionDulaglutide and trelagliptin had similar effects on beta-cell function according to the glucagon stimulation test-based disposition index. However, dulaglutide promoted improved HOMA2-% β levels compared to trelagliptin and body fat mass was reduced without loss of skeletal muscle mass (UMIN-CTR 000024164). (Source: Diabetology International)
Source: Diabetology International - April 3, 2024 Category: Endocrinology Source Type: research
Intestinal carcinogenicity screening of environmental pollutants using organoid-based cell transformation assay
Arch Toxicol. 2024 Apr 2. doi: 10.1007/s00204-024-03729-y. Online ahead of print.ABSTRACTThe high incidence of colorectal cancer (CRC) is closely associated with environmental pollutant exposure. To identify potential intestinal carcinogens, we developed a cell transformation assay (CTA) using mouse adult stem cell-derived intestinal organoids (mASC-IOs) and assessed the transformation potential on 14 representative chemicals, including Cd, iPb, Cr-VI, iAs-III, Zn, Cu, PFOS, BPA, MEHP, AOM, DMH, MNNG, aspirin, and metformin. We optimized the experimental protocol based on cytotoxicity, amplification, and colony formation o...
Source: Archives of Toxicology - April 2, 2024 Category: Toxicology Authors: Ziwei Wang Shen Chen Yuzhi Guo Rui Zhang Qi Zhang Xinhang Jiang Miao Li Yue Jiang Lizhu Ye Xiaoyu Guo Chuang Li Guangtong Zhang Daochuan Li Liping Chen Wen Chen Source Type: research
