< i > Spilanthes filicaulis < /i > (Schumach. & Thonn.) C.D. Adams leaves protects against streptozotocin-induced diabetic nephropathy
ConclusionTherefore, our results indicate that MESFL alleviates the development of diabetic nephropathy via suppression of the cAMP/PKA/CREB/cFOS pathways. (Source: PLoS One)
Source: PLoS One - April 19, 2024 Category: Biomedical Science Authors: Oluwafemi Adeleke Ojo Source Type: research
Effects of quercetin on polycystic ovary syndrome in animal models: a systematic review and meta-analysis
Metformin is an insulin sensitizer that is widely used for the treatment of insulin resistance in polycystic ovary syndrome patients. However, metformin can cause gastrointestinal side effects. (Source: Reproductive Biology and Endocrinology)
Source: Reproductive Biology and Endocrinology - April 18, 2024 Category: Endocrinology Authors: Pingping Su, Chao Chen, Liang Pang, Kai Wu and Yun Sun Tags: Review Source Type: research
Selected markers of ovarian cancer and their relation to targeted therapy (Review)
Exp Ther Med. 2024 Mar 27;27(5):236. doi: 10.3892/etm.2024.12523. eCollection 2024 May.ABSTRACTDespite advances in surgical treatment techniques and chemotherapy-including anti-angiogenic and immune poly (ADP-ribose) polymerase inhibitors, the 5-year survival rate in ovarian cancer (OC) remains low. The reasons for this are the diagnosis of cancer in advanced clinical stages, chemoresistance and cancer recurrence. New therapeutic approaches are being developed, including the search for new biomarkers that are also targets for targeted therapy. The present review describes new molecular markers with relevance to targeted th...
Source: Experimental and Therapeutic Medicine - April 17, 2024 Category: General Medicine Authors: Anna Markowska Zbigniew Kojs Damian Twardawa Joanna Pietras Janina Markowska Source Type: research
AMPK restricts HHV-6A replication by inhibiting glycolysis and mTOR signaling
In this study, we investigated the role of AMPK in response to human herpesvirus 6A (HHV-6A) infection. We show that HHV-6A infection significantly downregulates the active phosphorylated state of AMPK in infected T cells. Pharmacological activation of AMPK highly attenuated HHV-6A propagation. Mechanistically, we found that the activation of AMPK by AICAR blocked HHV-6-induced glycolysis by inhibiting glucose metabolism and lactate secretion, as well as decreasing expressions of key glucose transporters and glycolytic enzymes. In addition, mTOR signaling has been inactivated in HHV-6A infected T cells by AICAR treatment. ...
Source: Virology - April 17, 2024 Category: Virology Authors: Xiaodi Yang Siyu Tian Zhujiang Min Emanuela Garbarino Jingjing Ma Junli Jia Huamin Tang Lingyun Li Source Type: research
Biomarkers of frailty
Mol Aspects Med. 2024 Apr 16;97:101271. doi: 10.1016/j.mam.2024.101271. Online ahead of print.ABSTRACTSeveral biomarkers have been proposed to identify frailty, a multisystemic age-related syndrome. However, the complex pathophysiology and the absence of a consensus on a comprehensive and universal definition make it challenging to pinpoint a singular biomarker or set of biomarkers that conclusively characterize frailty. This review delves into the main laboratory biomarkers, placing special emphasis on those associated with various pathways closely tied to the frailty condition, such as inflammation, oxidative stress, mit...
Source: Molecular Medicine - April 17, 2024 Category: Molecular Biology Authors: Mariam El Assar Isabel Rodr íguez-Sánchez Alejandro Álvarez-Bustos Leocadio Rodr íguez-Mañas Source Type: research
Aspirin versus metformin in pregnancies at high risk of preterm pre-eclampsia in China (AVERT): protocol for a multicentre, double-blind, 3-arm randomised controlled trial
This study will compare the incidence of preterm-PE with delivery at <37 weeks’ gestation, as the primary outcome, of three different interventional groups: (1) aspirin 75 mg daily, (2) aspirin 150 mg daily and (3) aspirin 75 mg with metformin 1.5 g daily. 957 participants per treatment group are required to detect a significant difference of 59% in the reduction of the incidence of preterm-PE with 80% power and type I error of 5%. Pregnancy and neonatal outcomes will be collected and analysed.
Ethics and dissemination
Ethical approval for the study was obtained from the Joint Chinese University of Hong Kong&ndas...
Source: BMJ Open - April 17, 2024 Category: General Medicine Authors: Liu, J., Shen, L., Nguyen-Hoang, L., Zhou, Q., Wang, C. C., Lu, X., Sahota, D., Chong, K. C., Ying, H., Gu, W., Zhou, R., Yang, H., Jiang, Y., Chen, D., Li, X., Poon, L. Tags: Open access, Obstetrics & Gynaecology Obstetrics and gynaecology Source Type: research
A case of exacerbated encephalopathy with stroke-like episodes and lactic acidosis triggered by metformin in a patient with MELAS
AbstractMitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) is a maternally inherited multisystemic disorder caused by mutations in mitochondrial DNA that result in cellular energy deficiency. MELAS affects the most metabolically active organs, including the brain, skeletal muscles, cochlea, retina, heart, kidneys, and pancreas. As a result, about 85% of carriers of m.3243A > G, the most common mutation in MELAS, develop diabetes by the age of 70. Although metformin is the most widely prescribed drug for diabetes, its usefulness in mitochondrial dysfunction remains controversi...
Source: Neurological Sciences - April 16, 2024 Category: Neurology Source Type: research
Exosomes biogenesis was increased in metformin-treated human ovary cancer cells; possibly to mediate resistance
Exosomes derived from tumor cells contribute to the pathogenesis of cancers. Metformin, the most usually used drug for type 2 diabetes, has been frequently investigated for anticancer effects. Here, we examine... (Source: Cancer Cell International)
Source: Cancer Cell International - April 16, 2024 Category: Cancer & Oncology Authors: Reza Abbasi, Vahid Nejati and Jafar Rezaie Tags: Research Source Type: research
Metformin ameliorates endometrial thickness in a rat model of thin endometrium
In conclusion, the study demonstrated that metformin ameliorates endometrial thickness in a rat model of thin endometrium by increasing endometrial proliferation and angiogenesis, without restoration of embryo implantation.PMID:38621769 | DOI:10.1111/1440-1681.13862 (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - April 15, 2024 Category: Drugs & Pharmacology Authors: M Imran Aditya Khandvilkar Siddhanath Metkari Geetanjali Sachdeva Uddhav Chaudhari Source Type: research
Weight Management with Orlistat in Type 2 Diabetes - An Electronic Healthcare Records Study
CONCLUSIONS: Orlistat was significantly associated with weight loss in T2DM/prediabetes when taken for at least 12 weeks. However, orlistat is infrequently prescribed and often taken for <12 weeks. Orlistat may be a useful adjunct to lifestyle modifications in T2DM/prediabetes however barriers to continuing orlistat means it may not be effective for everyone in managing weight loss.PMID:38621802 | DOI:10.3399/BJGP.2023.0684 (Source: The British Journal of General Practice)
Source: The British Journal of General Practice - April 15, 2024 Category: Primary Care Authors: Shraboni Ghosal Neil Heron Kayleigh Mason James Bailey Kelvin Jordan Source Type: research
Interplay between lipid dysregulation and ferroptosis in chondrocytes and the targeted therapy effect of metformin on osteoarthritis
CONCLUSION: We establish a critical role of polyunsaturated fatty acids metabolic process in OA cartilage degradation and define metformin as a potential OA treatment. Metformin reshapes lipid availability and ameliorates chondrocyte ferroptosis sensitivity via the AMPK/ACC pathway. In the future, gene-edited animals and extensive omics technologies will be utilized to reveal detailed lipids' involvement in cartilage lesions.PMID:38621621 | DOI:10.1016/j.jare.2024.04.012 (Source: Adv Data)
Source: Adv Data - April 15, 2024 Category: Epidemiology Authors: Zhi Zou Wenhui Hu Fei Kang Zhonghua Xu Yuheng Li Jing Zhang Jianmei Li Yuan Zhang Shiwu Dong Source Type: research
Metformin ameliorates endometrial thickness in a rat model of thin endometrium
In conclusion, the study demonstrated that metformin ameliorates endometrial thickness in a rat model of thin endometrium by increasing endometrial proliferation and angiogenesis, without restoration of embryo implantation.PMID:38621769 | DOI:10.1111/1440-1681.13862 (Source: Clinical and Experimental Pharmacology and Physiology)
Source: Clinical and Experimental Pharmacology and Physiology - April 15, 2024 Category: Drugs & Pharmacology Authors: M Imran Aditya Khandvilkar Siddhanath Metkari Geetanjali Sachdeva Uddhav Chaudhari Source Type: research
SGLT2i vs Sulfonylureas for Gout Prevention Among Patients With Type 2 Diabetes Receiving Metformin
This cohort study uses target trial emulation to evaluate risk of incident gout and rate of recurrent gout flares in patients with type 2 diabetes initiating sodium-glucose cotransporter-2 inhibitors (SGLT2i) vs sulfonylurea. (Source: JAMA Internal Medicine)
Source: JAMA Internal Medicine - April 15, 2024 Category: Internal Medicine Source Type: research
Cardiovascular safety of evogliptin dual and triple therapy in patients with type 2 diabetes: a nationwide cohort study
Conclusions
These findings suggest that dual or triple therapies of evogliptin for the management of type 2 diabetes in routine clinical practice present no cardiovascular harms, but could alternatively offer cardiovascular benefits in this patient population. (Source: BMJ Open)
Source: BMJ Open - April 15, 2024 Category: General Medicine Authors: Park, S., Jeong, H. E., Oh, I.-S., Hong, S., Yu, S. H., Lee, C. B., Shin, J.-Y. Tags: Open access, Diabetes and Endocrinology Source Type: research
