Should Metformin Continue as First-Line Pharmacotherapy for Patients With Type 2 Diabetes? No: Other Drugs Have Stronger Evidence of Benefit
Am Fam Physician. 2024 Mar;109(3):202-203.NO ABSTRACTPMID:38574205 (Source: American Family Physician)
Source: American Family Physician - April 4, 2024 Category: Primary Care Authors: Henry C Barry Allen F Shaughnessy Source Type: research
Should Metformin Continue as First-Line Pharmacotherapy for Patients With Type 2 Diabetes? Yes: Metformin Is Still the Best Choice
Am Fam Physician. 2024 Mar;109(3):200-201.NO ABSTRACTPMID:38574204 (Source: American Family Physician)
Source: American Family Physician - April 4, 2024 Category: Primary Care Authors: Gregory Castelli Stacy J Barlett Source Type: research
Extract mixture of plants (OXYLIA) inhibits fat accumulation by blocking FAS-related factors and promoting lipolysis via cAMP-dependent PKA activation
CONCLUSIONS: These findings suggest that Oxylia has potential as a functional food ingredient for the prevention and treatment of obesity and related metabolic disorders.PMID:38571921 | PMC:PMC10989236 | DOI:10.29219/fnr.v68.10180 (Source: Food and Nutrition Research)
Source: Food and Nutrition Research - April 4, 2024 Category: Nutrition Authors: Seong-Hoo Park Sun-Jung Baek Minhee Lee Hyun-A Shin Hye Jin Lee Ok-Kyung Kim Jeongmin Lee Source Type: research
Extract mixture of plants (OXYLIA) inhibits fat accumulation by blocking FAS-related factors and promoting lipolysis via cAMP-dependent PKA activation
CONCLUSIONS: These findings suggest that Oxylia has potential as a functional food ingredient for the prevention and treatment of obesity and related metabolic disorders.PMID:38571921 | PMC:PMC10989236 | DOI:10.29219/fnr.v68.10180 (Source: Food and Nutrition Research)
Source: Food and Nutrition Research - April 4, 2024 Category: Nutrition Authors: Seong-Hoo Park Sun-Jung Baek Minhee Lee Hyun-A Shin Hye Jin Lee Ok-Kyung Kim Jeongmin Lee Source Type: research
Extract mixture of plants (OXYLIA) inhibits fat accumulation by blocking FAS-related factors and promoting lipolysis via cAMP-dependent PKA activation
CONCLUSIONS: These findings suggest that Oxylia has potential as a functional food ingredient for the prevention and treatment of obesity and related metabolic disorders.PMID:38571921 | PMC:PMC10989236 | DOI:10.29219/fnr.v68.10180 (Source: Food and Nutrition Research)
Source: Food and Nutrition Research - April 4, 2024 Category: Nutrition Authors: Seong-Hoo Park Sun-Jung Baek Minhee Lee Hyun-A Shin Hye Jin Lee Ok-Kyung Kim Jeongmin Lee Source Type: research
Extract mixture of plants (OXYLIA) inhibits fat accumulation by blocking FAS-related factors and promoting lipolysis via cAMP-dependent PKA activation
CONCLUSIONS: These findings suggest that Oxylia has potential as a functional food ingredient for the prevention and treatment of obesity and related metabolic disorders.PMID:38571921 | PMC:PMC10989236 | DOI:10.29219/fnr.v68.10180 (Source: Food and Nutrition Research)
Source: Food and Nutrition Research - April 4, 2024 Category: Nutrition Authors: Seong-Hoo Park Sun-Jung Baek Minhee Lee Hyun-A Shin Hye Jin Lee Ok-Kyung Kim Jeongmin Lee Source Type: research
Extract mixture of plants (OXYLIA) inhibits fat accumulation by blocking FAS-related factors and promoting lipolysis via cAMP-dependent PKA activation
CONCLUSIONS: These findings suggest that Oxylia has potential as a functional food ingredient for the prevention and treatment of obesity and related metabolic disorders.PMID:38571921 | PMC:PMC10989236 | DOI:10.29219/fnr.v68.10180 (Source: Food and Nutrition Research)
Source: Food and Nutrition Research - April 4, 2024 Category: Nutrition Authors: Seong-Hoo Park Sun-Jung Baek Minhee Lee Hyun-A Shin Hye Jin Lee Ok-Kyung Kim Jeongmin Lee Source Type: research
Extract mixture of plants (OXYLIA) inhibits fat accumulation by blocking FAS-related factors and promoting lipolysis via cAMP-dependent PKA activation
CONCLUSIONS: These findings suggest that Oxylia has potential as a functional food ingredient for the prevention and treatment of obesity and related metabolic disorders.PMID:38571921 | PMC:PMC10989236 | DOI:10.29219/fnr.v68.10180 (Source: Food and Nutrition Research)
Source: Food and Nutrition Research - April 4, 2024 Category: Nutrition Authors: Seong-Hoo Park Sun-Jung Baek Minhee Lee Hyun-A Shin Hye Jin Lee Ok-Kyung Kim Jeongmin Lee Source Type: research
Extract mixture of plants (OXYLIA) inhibits fat accumulation by blocking FAS-related factors and promoting lipolysis via cAMP-dependent PKA activation
CONCLUSIONS: These findings suggest that Oxylia has potential as a functional food ingredient for the prevention and treatment of obesity and related metabolic disorders.PMID:38571921 | PMC:PMC10989236 | DOI:10.29219/fnr.v68.10180 (Source: Food and Nutrition Research)
Source: Food and Nutrition Research - April 4, 2024 Category: Nutrition Authors: Seong-Hoo Park Sun-Jung Baek Minhee Lee Hyun-A Shin Hye Jin Lee Ok-Kyung Kim Jeongmin Lee Source Type: research
Extract mixture of plants (OXYLIA) inhibits fat accumulation by blocking FAS-related factors and promoting lipolysis via cAMP-dependent PKA activation
CONCLUSIONS: These findings suggest that Oxylia has potential as a functional food ingredient for the prevention and treatment of obesity and related metabolic disorders.PMID:38571921 | PMC:PMC10989236 | DOI:10.29219/fnr.v68.10180 (Source: Food and Nutrition Research)
Source: Food and Nutrition Research - April 4, 2024 Category: Nutrition Authors: Seong-Hoo Park Sun-Jung Baek Minhee Lee Hyun-A Shin Hye Jin Lee Ok-Kyung Kim Jeongmin Lee Source Type: research
Extract mixture of plants (OXYLIA) inhibits fat accumulation by blocking FAS-related factors and promoting lipolysis via cAMP-dependent PKA activation
CONCLUSIONS: These findings suggest that Oxylia has potential as a functional food ingredient for the prevention and treatment of obesity and related metabolic disorders.PMID:38571921 | PMC:PMC10989236 | DOI:10.29219/fnr.v68.10180 (Source: Food and Nutrition Research)
Source: Food and Nutrition Research - April 4, 2024 Category: Nutrition Authors: Seong-Hoo Park Sun-Jung Baek Minhee Lee Hyun-A Shin Hye Jin Lee Ok-Kyung Kim Jeongmin Lee Source Type: research
Extract mixture of plants (OXYLIA) inhibits fat accumulation by blocking FAS-related factors and promoting lipolysis via cAMP-dependent PKA activation
CONCLUSIONS: These findings suggest that Oxylia has potential as a functional food ingredient for the prevention and treatment of obesity and related metabolic disorders.PMID:38571921 | PMC:PMC10989236 | DOI:10.29219/fnr.v68.10180 (Source: Food and Nutrition Research)
Source: Food and Nutrition Research - April 4, 2024 Category: Nutrition Authors: Seong-Hoo Park Sun-Jung Baek Minhee Lee Hyun-A Shin Hye Jin Lee Ok-Kyung Kim Jeongmin Lee Source Type: research
Exploring the association between weight loss-inducing medications and multiple sclerosis: insights from the FDA adverse event reporting system database
CONCLUSION: Our findings suggest a potential consideration for repurposing anti-diabetic weight loss-inducing drugs including semaglutide, dulaglutide, and liraglutide (glucagon-like peptide-1 receptor agonists), empagliflozin (sodium-glucose cotransporter-2 inhibitor), and metformin (biguanide), for MS. This warrants validation through rigorous methodologies and prospective studies.PMID:38566910 | PMC:PMC10986166 | DOI:10.1177/17562864241241383 (Source: Adv Data)
Source: Adv Data - April 3, 2024 Category: Epidemiology Authors: Afsaneh Shirani Anne H Cross Olaf Stuve Source Type: research
PyrAtes: Modular Organic Salts with Large Stokes Shifts for Fluo-rescence Microscopy
Angew Chem Int Ed Engl. 2024 Apr 3:e202318127. doi: 10.1002/anie.202318127. Online ahead of print.ABSTRACTThe deployment of small-molecule fluorescent agents plays an ever-growing role in medicine and drug development. Herein, we complement the portfolio of powerful fluorophores, reporting the serendipitous discovery and development of a novel class with an imidazo[1,2-a]pyridinium triflate core, which we term PyrAtes. These fluorophores are synthesized in a single step from readily available materials (>60 examples) and display Stokes shifts as large as 240 nm, while also reaching NIR-I emissions at λmax as long as 72...
Source: Angewandte Chemie - April 3, 2024 Category: Chemistry Authors: Iakovos Saridakis Margaux Riomet Oliver J V Belleza Guilhem Coussanes Nadja K Singer Nina Kastner Yi Xiao Elliot Smith Veronica Tona Aur élien de la Torre Eric F Lopes Pedro A S ánchez-Murcia Leticia Gonz ález Harald H Sitte Nuno Maulide Source Type: research
Metformin: Past, Present, and Future
AbstractPurpose of ReviewThis review provides the most recent update of metformin, a biguanide oral antihyperglycemic drug used as a first-line treatment in type 2 diabetes mellitus.Recent FindingsMetformin continues to dominate in the world of antidiabetics, and its use will continue to rise because of its high efficiency and easy availability. Apart from type 2 diabetes, research is exploring its potential in other conditions such as cancer, memory loss, bone disorders, immunological diseases, and aging.SummaryMetformin is the most prescribed oral antidiabetic worldwide. It has been in practical use for the last six deca...
Source: Current Diabetes Reports - April 3, 2024 Category: Endocrinology Source Type: research
