Coordination chemistry suggests that independently observed benefits of metformin and Zn < sup > 2+ < /sup > against COVID-19 are not independent
Biometals. 2024 Apr 5. doi: 10.1007/s10534-024-00590-5. Online ahead of print.ABSTRACTIndependent trials indicate that either oral Zn2+ or metformin can separately improve COVID-19 outcomes by approximately 40%. Coordination chemistry predicts a mechanistic relationship and therapeutic synergy. Zn2+ deficit is a known risk factor for both COVID-19 and non-infectious inflammation. Most dietary Zn2+ is not absorbed. Metformin is a naked ligand that presumably increases intestinal Zn2+ bioavailability and active absorption by cation transporters known to transport metformin. Intracellular Zn2+ provides a natural buffer of man...
Source: Biometals - April 5, 2024 Category: Biochemistry Authors: Thomas D Lockwood Source Type: research
From liver to hormones: The endocrine consequences of cirrhosis
This article provides a comprehensive review of the epidemiology, pathophysiology, diagnosis, and treatment of endocrine disturbances in liver cirrhosis. The review was conducted using the PubMed/Medline, EMBASE, and Scielo databases, encompassing 172 articles. Liver cirrhosis is associated with endocrine disturbances, including diabetes, hypoglycemia, sarcopenia, thyroid dysfunction, hypogonadotropic hypogonadism, bone disease, adrenal insufficiency, growth hormone dysfunction, and secondary hyperaldosteronism. The optimal tools for diagnosing diabetes and detecting hypoglycemia are the oral glucose tolerance test and con...
Source: World Journal of Gastroenterology - April 5, 2024 Category: Gastroenterology Authors: Juan Eduardo Quiroz-Aldave Elman Rolando Gamarra-Osorio Mar ía Del Carmen Durand-Vásquez Luciana Del Pilar Rafael-Robles Jhean Gabriel Gonz áles-Yovera Mar ía Alejandra Quispe-Flores Luis Alberto Concepci ón-Urteaga Alejandro Rom án-González Jos é Source Type: research
Coordination chemistry suggests that independently observed benefits of metformin and Zn < sup > 2+ < /sup > against COVID-19 are not independent
Biometals. 2024 Apr 5. doi: 10.1007/s10534-024-00590-5. Online ahead of print.ABSTRACTIndependent trials indicate that either oral Zn2+ or metformin can separately improve COVID-19 outcomes by approximately 40%. Coordination chemistry predicts a mechanistic relationship and therapeutic synergy. Zn2+ deficit is a known risk factor for both COVID-19 and non-infectious inflammation. Most dietary Zn2+ is not absorbed. Metformin is a naked ligand that presumably increases intestinal Zn2+ bioavailability and active absorption by cation transporters known to transport metformin. Intracellular Zn2+ provides a natural buffer of man...
Source: Biometals - April 5, 2024 Category: Biochemistry Authors: Thomas D Lockwood Source Type: research
From liver to hormones: The endocrine consequences of cirrhosis
This article provides a comprehensive review of the epidemiology, pathophysiology, diagnosis, and treatment of endocrine disturbances in liver cirrhosis. The review was conducted using the PubMed/Medline, EMBASE, and Scielo databases, encompassing 172 articles. Liver cirrhosis is associated with endocrine disturbances, including diabetes, hypoglycemia, sarcopenia, thyroid dysfunction, hypogonadotropic hypogonadism, bone disease, adrenal insufficiency, growth hormone dysfunction, and secondary hyperaldosteronism. The optimal tools for diagnosing diabetes and detecting hypoglycemia are the oral glucose tolerance test and con...
Source: World Journal of Gastroenterology : WJG - April 5, 2024 Category: Gastroenterology Authors: Juan Eduardo Quiroz-Aldave Elman Rolando Gamarra-Osorio Mar ía Del Carmen Durand-Vásquez Luciana Del Pilar Rafael-Robles Jhean Gabriel Gonz áles-Yovera Mar ía Alejandra Quispe-Flores Luis Alberto Concepci ón-Urteaga Alejandro Rom án-González Jos é Source Type: research
From liver to hormones: The endocrine consequences of cirrhosis
This article provides a comprehensive review of the epidemiology, pathophysiology, diagnosis, and treatment of endocrine disturbances in liver cirrhosis. The review was conducted using the PubMed/Medline, EMBASE, and Scielo databases, encompassing 172 articles. Liver cirrhosis is associated with endocrine disturbances, including diabetes, hypoglycemia, sarcopenia, thyroid dysfunction, hypogonadotropic hypogonadism, bone disease, adrenal insufficiency, growth hormone dysfunction, and secondary hyperaldosteronism. The optimal tools for diagnosing diabetes and detecting hypoglycemia are the oral glucose tolerance test and con...
Source: World Journal of Gastroenterology - April 5, 2024 Category: Gastroenterology Authors: Juan Eduardo Quiroz-Aldave Elman Rolando Gamarra-Osorio Mar ía Del Carmen Durand-Vásquez Luciana Del Pilar Rafael-Robles Jhean Gabriel Gonz áles-Yovera Mar ía Alejandra Quispe-Flores Luis Alberto Concepci ón-Urteaga Alejandro Rom án-González Jos é Source Type: research
Correction to: Anticarcinogenic Effects of Gold Nanoparticles and Metformin Against MCF-7 and A549 Cells
Biol Trace Elem Res. 2024 Apr 4. doi: 10.1007/s12011-024-04155-y. Online ahead of print.NO ABSTRACTPMID:38573475 | DOI:10.1007/s12011-024-04155-y (Source: Biological Trace Element Research)
Source: Biological Trace Element Research - April 4, 2024 Category: Biology Authors: Ali Ye şildağ Halime Topal K ızıloğlu Ebubekir Dirican Elif Erba ş Volkan Gelen Adem Kara Source Type: research
Extract mixture of plants (OXYLIA) inhibits fat accumulation by blocking FAS-related factors and promoting lipolysis via cAMP-dependent PKA activation
CONCLUSIONS: These findings suggest that Oxylia has potential as a functional food ingredient for the prevention and treatment of obesity and related metabolic disorders.PMID:38571921 | PMC:PMC10989236 | DOI:10.29219/fnr.v68.10180 (Source: Food and Nutrition Research)
Source: Food and Nutrition Research - April 4, 2024 Category: Nutrition Authors: Seong-Hoo Park Sun-Jung Baek Minhee Lee Hyun-A Shin Hye Jin Lee Ok-Kyung Kim Jeongmin Lee Source Type: research
Extract mixture of plants (OXYLIA) inhibits fat accumulation by blocking FAS-related factors and promoting lipolysis via cAMP-dependent PKA activation
CONCLUSIONS: These findings suggest that Oxylia has potential as a functional food ingredient for the prevention and treatment of obesity and related metabolic disorders.PMID:38571921 | PMC:PMC10989236 | DOI:10.29219/fnr.v68.10180 (Source: Food and Nutrition Research)
Source: Food and Nutrition Research - April 4, 2024 Category: Nutrition Authors: Seong-Hoo Park Sun-Jung Baek Minhee Lee Hyun-A Shin Hye Jin Lee Ok-Kyung Kim Jeongmin Lee Source Type: research
Should Metformin Continue as First-Line Pharmacotherapy for Patients With Type 2 Diabetes? No: Other Drugs Have Stronger Evidence of Benefit
Am Fam Physician. 2024 Mar;109(3):202-203.NO ABSTRACTPMID:38574205 (Source: American Family Physician)
Source: American Family Physician - April 4, 2024 Category: Primary Care Authors: Henry C Barry Allen F Shaughnessy Source Type: research
Should Metformin Continue as First-Line Pharmacotherapy for Patients With Type 2 Diabetes? Yes: Metformin Is Still the Best Choice
Am Fam Physician. 2024 Mar;109(3):200-201.NO ABSTRACTPMID:38574204 (Source: American Family Physician)
Source: American Family Physician - April 4, 2024 Category: Primary Care Authors: Gregory Castelli Stacy J Barlett Source Type: research
Conceptual Overview of Prevalence of Prediabetes
Curr Diabetes Rev. 2024 Apr 3. doi: 10.2174/0115733998285294240307052909. Online ahead of print.ABSTRACTPrediabetes increases the risk of type 2 diabetes, metabolic syndrome, chronic renal disease, and cardiovascular disease in a person. In current practice, five alternative definitions of prediabetes are utilized, each based on different HbA1C, fasting glucose, and 2-hour glucose cut points. Prediabetes is a common condition that occurs between normal glycemia and diabetes. It is more common in elderly and obese people. The prevalence of prediabetes and diabetes can be influenced by a variety of individual, family, and so...
Source: Current Diabetes Reviews - April 4, 2024 Category: Endocrinology Authors: None Monika Pragi Arora Varun Kumar Pankaj Popli Source Type: research
Correction to: Anticarcinogenic Effects of Gold Nanoparticles and Metformin Against MCF-7 and A549 Cells
Biol Trace Elem Res. 2024 Apr 4. doi: 10.1007/s12011-024-04155-y. Online ahead of print.NO ABSTRACTPMID:38573475 | DOI:10.1007/s12011-024-04155-y (Source: Biological Trace Element Research)
Source: Biological Trace Element Research - April 4, 2024 Category: Biology Authors: Ali Ye şildağ Halime Topal K ızıloğlu Ebubekir Dirican Elif Erba ş Volkan Gelen Adem Kara Source Type: research
Extract mixture of plants (OXYLIA) inhibits fat accumulation by blocking FAS-related factors and promoting lipolysis via cAMP-dependent PKA activation
CONCLUSIONS: These findings suggest that Oxylia has potential as a functional food ingredient for the prevention and treatment of obesity and related metabolic disorders.PMID:38571921 | PMC:PMC10989236 | DOI:10.29219/fnr.v68.10180 (Source: Food and Nutrition Research)
Source: Food and Nutrition Research - April 4, 2024 Category: Nutrition Authors: Seong-Hoo Park Sun-Jung Baek Minhee Lee Hyun-A Shin Hye Jin Lee Ok-Kyung Kim Jeongmin Lee Source Type: research
Extract mixture of plants (OXYLIA) inhibits fat accumulation by blocking FAS-related factors and promoting lipolysis via cAMP-dependent PKA activation
CONCLUSIONS: These findings suggest that Oxylia has potential as a functional food ingredient for the prevention and treatment of obesity and related metabolic disorders.PMID:38571921 | PMC:PMC10989236 | DOI:10.29219/fnr.v68.10180 (Source: Food and Nutrition Research)
Source: Food and Nutrition Research - April 4, 2024 Category: Nutrition Authors: Seong-Hoo Park Sun-Jung Baek Minhee Lee Hyun-A Shin Hye Jin Lee Ok-Kyung Kim Jeongmin Lee Source Type: research
Should Metformin Continue as First-Line Pharmacotherapy for Patients With Type 2 Diabetes? No: Other Drugs Have Stronger Evidence of Benefit
Am Fam Physician. 2024 Mar;109(3):202-203.NO ABSTRACTPMID:38574205 (Source: American Family Physician)
Source: American Family Physician - April 4, 2024 Category: Primary Care Authors: Henry C Barry Allen F Shaughnessy Source Type: research
