Osthole ameliorates early diabetic kidney damage by suppressing oxidative stress, inflammation and inhibiting TGF- β1/Smads signaling pathway
CONCLUSION: Our findings indicate that osthole exhibits potential preventive and therapeutic effects on DKD. It deserves further investigation as a promising drug for preventing and treating DKD.PMID:38669945 | DOI:10.1016/j.intimp.2024.112131 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 26, 2024 Category: Allergy & Immunology Authors: Qiangsheng Li Yifei Wang Jia Yan Ruyan Yuan Jiamin Zhang Xinhao Guo Mingming Zhao Fenfen Li Xiaotian Li Source Type: research
Clinical and Laboratory Characteristics of MODY (Maturity Onset Diabetes of Young) Cases, Genetic Mutation Spectrum and Phenotype-genotype Relationship
CONCLUSION: This was the largest genetically diagnosed series from Turkey. The most common gene variants were GCK and HNF1A with much lower proportions for other MODY types. Hyperglycemia was the most common presenting symptom while 11% of patients had diabetes-associated autoantibodies and 7% were obese. The majority of patients received dietary management only.PMID:38665000 | DOI:10.4274/jcrpe.galenos.2024.2023-10-16 (Source: JCRPE Journal of Clinical Research in Pediatric Endocrinology)
Source: JCRPE Journal of Clinical Research in Pediatric Endocrinology - April 26, 2024 Category: Endocrinology Authors: Elif Özsu Semra Çetinkaya Semih Bolu Nihal Hatipo ğlu Şenay Savaş Erdeve Olcay Evliyao ğlu Firdevs Ba ş Atilla Çayır İsmail Dündar Emine Demet Akba ş Seyid Ahmet U çaktürk Merih Berbero ğlu Zeynep Şıklar Şervan Özalkak Nursel Murato ğl Source Type: research
Changes and Significance of Central Carbon Metabolism before and after Metformin Treatment of Type 2 Diabetes Based on Mass Spectrometry
CONCLUSIONS: We employed HPIC-MS/MS to uncover alterations in CCM among individuals recently diagnosed with T2D before and after metformin treatment. The findings suggest that metformin may ameliorate the energy metabolism imbalance in T2D by reducing intermediates within the CCM pathway.PMID:38665017 | DOI:10.24976/Discov.Med.202436183.64 (Source: Discovery Medicine)
Source: Discovery Medicine - April 26, 2024 Category: Research Authors: Yang Shu Fujie Yang Weidong Li Lisha Li Qiongying Hu Daqian Xiong Source Type: research
Osthole ameliorates early diabetic kidney damage by suppressing oxidative stress, inflammation and inhibiting TGF- β1/Smads signaling pathway
CONCLUSION: Our findings indicate that osthole exhibits potential preventive and therapeutic effects on DKD. It deserves further investigation as a promising drug for preventing and treating DKD.PMID:38669945 | DOI:10.1016/j.intimp.2024.112131 (Source: International Immunopharmacology)
Source: International Immunopharmacology - April 26, 2024 Category: Allergy & Immunology Authors: Qiangsheng Li Yifei Wang Jia Yan Ruyan Yuan Jiamin Zhang Xinhao Guo Mingming Zhao Fenfen Li Xiaotian Li Source Type: research
Clinical and Laboratory Characteristics of MODY (Maturity Onset Diabetes of Young) Cases, Genetic Mutation Spectrum and Phenotype-genotype Relationship
CONCLUSION: This was the largest genetically diagnosed series from Turkey. The most common gene variants were GCK and HNF1A with much lower proportions for other MODY types. Hyperglycemia was the most common presenting symptom while 11% of patients had diabetes-associated autoantibodies and 7% were obese. The majority of patients received dietary management only.PMID:38665000 | DOI:10.4274/jcrpe.galenos.2024.2023-10-16 (Source: JCRPE Journal of Clinical Research in Pediatric Endocrinology)
Source: JCRPE Journal of Clinical Research in Pediatric Endocrinology - April 26, 2024 Category: Endocrinology Authors: Elif Özsu Semra Çetinkaya Semih Bolu Nihal Hatipo ğlu Şenay Savaş Erdeve Olcay Evliyao ğlu Firdevs Ba ş Atilla Çayır İsmail Dündar Emine Demet Akba ş Seyid Ahmet U çaktürk Merih Berbero ğlu Zeynep Şıklar Şervan Özalkak Nursel Murato ğl Source Type: research
Changes and Significance of Central Carbon Metabolism before and after Metformin Treatment of Type 2 Diabetes Based on Mass Spectrometry
CONCLUSIONS: We employed HPIC-MS/MS to uncover alterations in CCM among individuals recently diagnosed with T2D before and after metformin treatment. The findings suggest that metformin may ameliorate the energy metabolism imbalance in T2D by reducing intermediates within the CCM pathway.PMID:38665017 | DOI:10.24976/Discov.Med.202436183.64 (Source: Discovery Medicine)
Source: Discovery Medicine - April 26, 2024 Category: Research Authors: Yang Shu Fujie Yang Weidong Li Lisha Li Qiongying Hu Daqian Xiong Source Type: research
SGLT2-independent effects of canagliflozin on NHE3 and mitochondrial complex I activity inhibit proximal tubule fluid transport and albumin uptake
Am J Physiol Renal Physiol. 2024 Apr 25. doi: 10.1152/ajprenal.00005.2024. Online ahead of print.ABSTRACTBeyond glycemic control, SGLT2 inhibitors (SGLT2i) have protective effects on cardiorenal function. Renoprotection has been suggested to involve inhibition of NHE3 leading to reduced ATP-dependent tubular workload and mitochondrial oxygen consumption. NHE3 activity is also important for regulation of endosomal pH, but the effects of SGLT2i on endocytosis are unknown. We used a highly differentiated cell culture model of proximal tubule (PT) cells to determine the direct effects of SGLT2i on Na+-dependent fluid transport...
Source: Am J Physiol Renal P... - April 25, 2024 Category: Urology & Nephrology Authors: Wafaa N Albalawy Elynna B Youm Katherine E Shipman Keelan J Trull Catherine J Baty Kimberly R Long Youssef Rbaibi Xue-Ping Wang Olayemi G Fagunloye Katharine A White Michael J Jurczak Ossama B Kashlan Ora A Weisz Source Type: research
SGLT2-independent effects of canagliflozin on NHE3 and mitochondrial complex I activity inhibit proximal tubule fluid transport and albumin uptake
Am J Physiol Renal Physiol. 2024 Apr 25. doi: 10.1152/ajprenal.00005.2024. Online ahead of print.ABSTRACTBeyond glycemic control, SGLT2 inhibitors (SGLT2i) have protective effects on cardiorenal function. Renoprotection has been suggested to involve inhibition of NHE3 leading to reduced ATP-dependent tubular workload and mitochondrial oxygen consumption. NHE3 activity is also important for regulation of endosomal pH, but the effects of SGLT2i on endocytosis are unknown. We used a highly differentiated cell culture model of proximal tubule (PT) cells to determine the direct effects of SGLT2i on Na+-dependent fluid transport...
Source: American Journal of Physiology. Renal Physiology - April 25, 2024 Category: Physiology Authors: Wafaa N Albalawy Elynna B Youm Katherine E Shipman Keelan J Trull Catherine J Baty Kimberly R Long Youssef Rbaibi Xue-Ping Wang Olayemi G Fagunloye Katharine A White Michael J Jurczak Ossama B Kashlan Ora A Weisz Source Type: research
Comparative analysis of oral and local intraovarian administration of metformin and nanoparticles (NPs11) in alleviating testosterone-induced polycystic ovary syndrome in rats
This study aims to compare the oral and local treatments of metformin or its nanoparticles (NPs11) for ameliorating PCOS in rats. Rats were divided into 4 groups: the control group with no drug treatment; the PCOS group, where subcutaneous testosterone was given (10 mg/kg/day) for 28 days; the MET group, where metformin was administered orally or locally; and the NP group, where metformin NPs11 were also administered orally or locally. Oral administrations were for 21 days, while local injection was performed once surgically. After 7 weeks, all rats were sacrificed; blood glucose and serum hormonal levels and lipid profile...
Source: Tissue and Cell - April 25, 2024 Category: Cytology Authors: Sadeq Al-Thamarani Shadeed Gad Islam Omar Abdel Fattah Sami H Hammadi Taha M Hammady Source Type: research
Metformin for Type 2 diabetes mellitus
Acad Emerg Med. 2024 Apr 25. doi: 10.1111/acem.14922. Online ahead of print.NO ABSTRACTPMID:38661224 | DOI:10.1111/acem.14922 (Source: Accident and Emergency Nursing)
Source: Accident and Emergency Nursing - April 25, 2024 Category: Emergency Medicine Authors: Blair J MacDonald Ricky D Turgeon James McCormack Source Type: research
SGLT2-independent effects of canagliflozin on NHE3 and mitochondrial complex I activity inhibit proximal tubule fluid transport and albumin uptake
Am J Physiol Renal Physiol. 2024 Apr 25. doi: 10.1152/ajprenal.00005.2024. Online ahead of print.ABSTRACTBeyond glycemic control, SGLT2 inhibitors (SGLT2i) have protective effects on cardiorenal function. Renoprotection has been suggested to involve inhibition of NHE3 leading to reduced ATP-dependent tubular workload and mitochondrial oxygen consumption. NHE3 activity is also important for regulation of endosomal pH, but the effects of SGLT2i on endocytosis are unknown. We used a highly differentiated cell culture model of proximal tubule (PT) cells to determine the direct effects of SGLT2i on Na+-dependent fluid transport...
Source: Am J Physiol Renal P... - April 25, 2024 Category: Urology & Nephrology Authors: Wafaa N Albalawy Elynna B Youm Katherine E Shipman Keelan J Trull Catherine J Baty Kimberly R Long Youssef Rbaibi Xue-Ping Wang Olayemi G Fagunloye Katharine A White Michael J Jurczak Ossama B Kashlan Ora A Weisz Source Type: research
SGLT2-independent effects of canagliflozin on NHE3 and mitochondrial complex I activity inhibit proximal tubule fluid transport and albumin uptake
Am J Physiol Renal Physiol. 2024 Apr 25. doi: 10.1152/ajprenal.00005.2024. Online ahead of print.ABSTRACTBeyond glycemic control, SGLT2 inhibitors (SGLT2i) have protective effects on cardiorenal function. Renoprotection has been suggested to involve inhibition of NHE3 leading to reduced ATP-dependent tubular workload and mitochondrial oxygen consumption. NHE3 activity is also important for regulation of endosomal pH, but the effects of SGLT2i on endocytosis are unknown. We used a highly differentiated cell culture model of proximal tubule (PT) cells to determine the direct effects of SGLT2i on Na+-dependent fluid transport...
Source: American Journal of Physiology. Renal Physiology - April 25, 2024 Category: Physiology Authors: Wafaa N Albalawy Elynna B Youm Katherine E Shipman Keelan J Trull Catherine J Baty Kimberly R Long Youssef Rbaibi Xue-Ping Wang Olayemi G Fagunloye Katharine A White Michael J Jurczak Ossama B Kashlan Ora A Weisz Source Type: research
Comparative analysis of oral and local intraovarian administration of metformin and nanoparticles (NPs11) in alleviating testosterone-induced polycystic ovary syndrome in rats
This study aims to compare the oral and local treatments of metformin or its nanoparticles (NPs11) for ameliorating PCOS in rats. Rats were divided into 4 groups: the control group with no drug treatment; the PCOS group, where subcutaneous testosterone was given (10 mg/kg/day) for 28 days; the MET group, where metformin was administered orally or locally; and the NP group, where metformin NPs11 were also administered orally or locally. Oral administrations were for 21 days, while local injection was performed once surgically. After 7 weeks, all rats were sacrificed; blood glucose and serum hormonal levels and lipid profile...
Source: Tissue and Cell - April 25, 2024 Category: Cytology Authors: Sadeq Al-Thamarani Shadeed Gad Islam Omar Abdel Fattah Sami H Hammadi Taha M Hammady Source Type: research
Metformin for Type 2 diabetes mellitus
Acad Emerg Med. 2024 Apr 25. doi: 10.1111/acem.14922. Online ahead of print.NO ABSTRACTPMID:38661224 | DOI:10.1111/acem.14922 (Source: Accident and Emergency Nursing)
Source: Accident and Emergency Nursing - April 25, 2024 Category: Emergency Medicine Authors: Blair J MacDonald Ricky D Turgeon James McCormack Source Type: research
