Metformin Plus Insulin for Preexisting Diabetes or Gestational Diabetes in Pregnancy —Reply

In Reply We thank Drs Pourkarim and Entezari-Maleki for their thoughtful comment about our recent study that described outcomes following metformin plus insulin for the treatment of early gestational and preexisting type 2 diabetes in pregnancy. We agree that based on available data, the use of metformin during pregnancy remains controversial and that long-term health data following in utero exposure should be collected prior to asserting that there are no unintended negative health consequences in childhood or adulthood. About reproductive health in males, a 2022 review article summarized the published data on the effect of metformin on male reproductive function, demonstrating that in preclinical models, metformin appears to have a beneficial effect on spermatogenesis and sperm motility. Whether this translates in benefit or harm in young males will need to be determined in long-term follow-up studies.
Source: JAMA - Journal of the American Medical Association - Category: General Medicine Source Type: research