Current understanding of nociplastic pain
Korean J Pain. 2024 Mar 20. doi: 10.3344/kjp.23326. Online ahead of print.ABSTRACTNociplastic pain by the "International Association for the Study of Pain" is defined as pain that arises from altered nociception despite no clear evidence of nociceptive or neuropathic pain. Augmented central nervous system pain and sensory processing with altered pain modulation are suggested to be the mechanism of nociplastic pain. Clinical criteria for possible nociplastic pain affecting somatic structures include chronic regional pain and evoked pain hypersensitivity including allodynia with after-sensation. In addition to possible nocip...
Source: Korean Journal of Pain - March 20, 2024 Category: Anesthesiology Authors: Yeong-Min Yoo Kyung-Hoon Kim Source Type: research
Social health in young women with chronic pain
CONCLUSIONS: Experience of chronic pain-regardless of the specific pain condition-may negatively affect some areas of social functioning in young women.PMID:38505830 | PMC:PMC10950150 | DOI:10.1097/PR9.0000000000001146 (Source: Pain Physician)
Source: Pain Physician - March 20, 2024 Category: Anesthesiology Authors: Ian A Boggero Linda Sangalli Lauryn Brasch Christopher D King Source Type: research
Current understanding of nociplastic pain
Korean J Pain. 2024 Mar 20. doi: 10.3344/kjp.23326. Online ahead of print.ABSTRACTNociplastic pain by the "International Association for the Study of Pain" is defined as pain that arises from altered nociception despite no clear evidence of nociceptive or neuropathic pain. Augmented central nervous system pain and sensory processing with altered pain modulation are suggested to be the mechanism of nociplastic pain. Clinical criteria for possible nociplastic pain affecting somatic structures include chronic regional pain and evoked pain hypersensitivity including allodynia with after-sensation. In addition to possible nocip...
Source: Korean Journal of Pain - March 20, 2024 Category: Anesthesiology Authors: Yeong-Min Yoo Kyung-Hoon Kim Source Type: research
Evaluation of Type 2 SLE symptoms in patients with a range of lupus nephritis activity
ConclusionsWhile Type 2 SLE symptoms are common in SLE, our findings suggest that patients with active nephritis experience significant Type 2 SLE symptoms that may be ameliorated as nephritis improves. We also observed that non-nephritis patients had a similar burden of Type 2 SLE symptoms as patients with active nephritis, despite having on average lower Type 1 SLE activity. Therefore, the etiology of Type 2 SLE symptoms is likely multifactorial and may be driven by inflammatory and non-inflammatory biopsychosocial factors.Key Points• Patients with active nephritis experienced significant Type 2 symptoms that may be am...
Source: Clinical Rheumatology - March 18, 2024 Category: Rheumatology Source Type: research
The diagnostic assessment of fibromyalgia and the role of small fiber pathology
(Source: Neurological Sciences)
Source: Neurological Sciences - March 15, 2024 Category: Neurology Source Type: research
The Role of SARS-CoV-2 Spike Protein in Long-term Damage of Tissues and Organs, the Underestimated Role of Retrotransposons and Stem Cells, a Working Hypothesis
Endocr Metab Immune Disord Drug Targets. 2024 Mar 11. doi: 10.2174/0118715303283480240227113401. Online ahead of print.ABSTRACTCoronavirus disease-2019 (COVID-19) is a respiratory disease in which Spike protein from SARS-CoV-2 plays a key role in transferring virus genomic code into target cells. Spike protein, which is found on the surface of the SARS-CoV-2 virus, latches onto angiotensin-converting enzyme 2 receptors (ACE2r) on target cells. The RNA genome of coronaviruses, with an average length of 29 kb, is the longest among all RNA viruses and comprises six to ten open reading frames (ORFs) responsible for encoding re...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - March 12, 2024 Category: Drugs & Pharmacology Authors: Mario G Balzanelli Reza Rastanesh Pietro Distratis Rita Lazzaro Francesco Inchingolo Raffaele Del Prete Van H Pham Sergey K Aityan Toai Tran Cong Kieu C D Nguyen Ciro Gargiulo Isacco Source Type: research
The Role of SARS-CoV-2 Spike Protein in Long-term Damage of Tissues and Organs, the Underestimated Role of Retrotransposons and Stem Cells, a Working Hypothesis
Endocr Metab Immune Disord Drug Targets. 2024 Mar 11. doi: 10.2174/0118715303283480240227113401. Online ahead of print.ABSTRACTCoronavirus disease-2019 (COVID-19) is a respiratory disease in which Spike protein from SARS-CoV-2 plays a key role in transferring virus genomic code into target cells. Spike protein, which is found on the surface of the SARS-CoV-2 virus, latches onto angiotensin-converting enzyme 2 receptors (ACE2r) on target cells. The RNA genome of coronaviruses, with an average length of 29 kb, is the longest among all RNA viruses and comprises six to ten open reading frames (ORFs) responsible for encoding re...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - March 12, 2024 Category: Endocrinology Authors: Mario G Balzanelli Reza Rastanesh Pietro Distratis Rita Lazzaro Francesco Inchingolo Raffaele Del Prete Van H Pham Sergey K Aityan Toai Tran Cong Kieu C D Nguyen Ciro Gargiulo Isacco Source Type: research
The Role of SARS-CoV-2 Spike Protein in Long-term Damage of Tissues and Organs, the Underestimated Role of Retrotransposons and Stem Cells, a Working Hypothesis
Endocr Metab Immune Disord Drug Targets. 2024 Mar 11. doi: 10.2174/0118715303283480240227113401. Online ahead of print.ABSTRACTCoronavirus disease-2019 (COVID-19) is a respiratory disease in which Spike protein from SARS-CoV-2 plays a key role in transferring virus genomic code into target cells. Spike protein, which is found on the surface of the SARS-CoV-2 virus, latches onto angiotensin-converting enzyme 2 receptors (ACE2r) on target cells. The RNA genome of coronaviruses, with an average length of 29 kb, is the longest among all RNA viruses and comprises six to ten open reading frames (ORFs) responsible for encoding re...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - March 12, 2024 Category: Drugs & Pharmacology Authors: Mario G Balzanelli Reza Rastanesh Pietro Distratis Rita Lazzaro Francesco Inchingolo Raffaele Del Prete Van H Pham Sergey K Aityan Toai Tran Cong Kieu C D Nguyen Ciro Gargiulo Isacco Source Type: research
The Role of SARS-CoV-2 Spike Protein in Long-term Damage of Tissues and Organs, the Underestimated Role of Retrotransposons and Stem Cells, a Working Hypothesis
Endocr Metab Immune Disord Drug Targets. 2024 Mar 11. doi: 10.2174/0118715303283480240227113401. Online ahead of print.ABSTRACTCoronavirus disease-2019 (COVID-19) is a respiratory disease in which Spike protein from SARS-CoV-2 plays a key role in transferring virus genomic code into target cells. Spike protein, which is found on the surface of the SARS-CoV-2 virus, latches onto angiotensin-converting enzyme 2 receptors (ACE2r) on target cells. The RNA genome of coronaviruses, with an average length of 29 kb, is the longest among all RNA viruses and comprises six to ten open reading frames (ORFs) responsible for encoding re...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - March 12, 2024 Category: Endocrinology Authors: Mario G Balzanelli Reza Rastanesh Pietro Distratis Rita Lazzaro Francesco Inchingolo Raffaele Del Prete Van H Pham Sergey K Aityan Toai Tran Cong Kieu C D Nguyen Ciro Gargiulo Isacco Source Type: research
The Role of SARS-CoV-2 Spike Protein in Long-term Damage of Tissues and Organs, the Underestimated Role of Retrotransposons and Stem Cells, a Working Hypothesis
Endocr Metab Immune Disord Drug Targets. 2024 Mar 11. doi: 10.2174/0118715303283480240227113401. Online ahead of print.ABSTRACTCoronavirus disease-2019 (COVID-19) is a respiratory disease in which Spike protein from SARS-CoV-2 plays a key role in transferring virus genomic code into target cells. Spike protein, which is found on the surface of the SARS-CoV-2 virus, latches onto angiotensin-converting enzyme 2 receptors (ACE2r) on target cells. The RNA genome of coronaviruses, with an average length of 29 kb, is the longest among all RNA viruses and comprises six to ten open reading frames (ORFs) responsible for encoding re...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - March 12, 2024 Category: Drugs & Pharmacology Authors: Mario G Balzanelli Reza Rastanesh Pietro Distratis Rita Lazzaro Francesco Inchingolo Raffaele Del Prete Van H Pham Sergey K Aityan Toai Tran Cong Kieu C D Nguyen Ciro Gargiulo Isacco Source Type: research
The Role of SARS-CoV-2 Spike Protein in Long-term Damage of Tissues and Organs, the Underestimated Role of Retrotransposons and Stem Cells, a Working Hypothesis
Endocr Metab Immune Disord Drug Targets. 2024 Mar 11. doi: 10.2174/0118715303283480240227113401. Online ahead of print.ABSTRACTCoronavirus disease-2019 (COVID-19) is a respiratory disease in which Spike protein from SARS-CoV-2 plays a key role in transferring virus genomic code into target cells. Spike protein, which is found on the surface of the SARS-CoV-2 virus, latches onto angiotensin-converting enzyme 2 receptors (ACE2r) on target cells. The RNA genome of coronaviruses, with an average length of 29 kb, is the longest among all RNA viruses and comprises six to ten open reading frames (ORFs) responsible for encoding re...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - March 12, 2024 Category: Endocrinology Authors: Mario G Balzanelli Reza Rastanesh Pietro Distratis Rita Lazzaro Francesco Inchingolo Raffaele Del Prete Van H Pham Sergey K Aityan Toai Tran Cong Kieu C D Nguyen Ciro Gargiulo Isacco Source Type: research
Prevalence of fibromyalgia and irritable bowel syndrome and its association with studying medicine, a cross ‐sectional study in Al‐Baath University, Syria
ConclusionWe found an increased prevalence of IBS among medical students. The prevalence of FM did not show any relation to studying medicine. We recommend additional prospective studies to assess whether studying medicine could be a risk factor for these disorders or not. (Source: Brain and Behavior)
Source: Brain and Behavior - March 12, 2024 Category: Neurology Authors: Mohanad Daher,
Sara Abbas,
Zainab Asaad,
Karam Khalil,
Ghania Jadid Tags: ORIGINAL ARTICLE Source Type: research
The prevalence of fibromyalgia in adults at Al-Karak Jordan: a cross-sectional study
CONCLUSION: This study sheds light on fibromyalgia's prevalence and associated factors in the Al-Karak population. The identified predictors highlight the necessity for comprehensive healthcare strategies and interventions to mitigate the disease burden. These findings aid policymakers and healthcare professionals in planning and implementing effective measures for fibromyalgia management and prevention. Further research is warranted to deepen our understanding of fibromyalgia's complexity and its implications in this region.PMID:38463111 | PMC:PMC10923264 | DOI:10.1097/MS9.0000000000001722 (Source: Annals of Medicine)
Source: Annals of Medicine - March 11, 2024 Category: Internal Medicine Authors: Alaa Akel Mohammed Y Sarhan Majed Al Dwairy Belal Al-Zu'bi Ala Al-Qudah Omar A Alsmarat Taif Alsaraireh Mohammad Abu-Jeyyab Source Type: research
