Fecal Microbiota Transplantation Improves Clinical Symptoms of Fibromyalgia: An open-label, Randomized, Nonplacebo-Controlled Study
This study was aimed to investigate the potential benefits of fecal microbiota transplantation (FMT) in patients with FM. A total of 45 patients completed this open-label randomized, nonplacebo-controlled clinical study. The Numerical Rating Scale (NRS) scores in the FMT group were slightly lower than the control group at 1 month (P> 0.05), and they decreased significantly at 2, 3, 6, and 12 months after treatment (P (Source: The Journal of Pain)
Source: The Journal of Pain - April 23, 2024 Category: Materials Science Authors: Hongwei Fang, Qianhao Hou, Wei Zhang, Zehua Su, Jinyuan Zhang, Jingze Li, Jiaqi Lin, Zetian Wang, Xiuqin Yu, Yu Yang, Qing Wang, Xin Li, Yuling Li, Lungui Hu, Shun Li, Xiangrui Wang, Lijun Liao Source Type: research
Proteomics in Patients with Fibromyalgia Syndrome: A Systematic Review of Observational Studies
AbstractPurpose of ReviewFibromyalgia syndrome (FMS) is a disease of unknown pathophysiology, with the diagnosis being based on a set of clinical criteria. Proteomic analysis can provide significant biological information for the pathophysiology of the disease but may also reveal biomarkers for diagnosis or therapeutic targets. The present systematic review aims to synthesize the evidence regarding the proteome of adult patients with FMS using data from observational studies.Recent FindingsAn extensive literature search was conducted in MEDLINE/PubMed, CENTRAL, and clinicaltrials.gov from inception until November 2022. The...
Source: Current Pain and Headache Reports - April 23, 2024 Category: Neurology Source Type: research
Severe fibromyalgia alleviated by the unique muscle relaxation method of applying low force: A case report
Medicine (Baltimore). 2024 Apr 19;103(16):e37929. doi: 10.1097/MD.0000000000037929.ABSTRACTRATIONALE: Fibromyalgia (FM) is characterized by idiopathic persistent chronic pain in the ligaments or musculoskeletal system, and more than half of the patients with FM might have migraine headaches. Direct musculoskeletal intervention could be a non-pharmacological management to relieve symptoms. However, patients with severe FM often have intense pain from only a soft touch, thereby rendering musculoskeletal intervention challenging.PATIENT CONCERNS: A 47-year-old man had progressing intense pain, and this affected his everyday l...
Source: Pain Physician - April 19, 2024 Category: Anesthesiology Authors: Haruka Amitani Ryusei Nishi Takamasa Fukumoto Kazumasa Hamada Ryuichi Kato Takako Yamamoto Yuuki Fuku Kenichiro Sagiyama Akihiro Asakawa Source Type: research
Pharmacological Evidence of Eugenia Brasiliensis Leaves in a Reserpine-Induced Fibromyalgia Model: Antinociceptive, Emotional, Anti-Inflammatory, and Neurotrophic Effects
AbstractFibromyalgia (FM) is a painful chronic condition that significantly impacts the quality of life, posing challenges for clinical management. Given the difficulty of understanding the pathophysiology and finding new therapeutics, this study explored the effects of a medicinal plant,E. brasiliensis, in an FM model induced by reserpine in Swiss mice. Animals were treated with saline 0.9% (vehicle), duloxetine 10 mg/kg (positive control), or hydroalcoholic extract ofE. brasiliensis leaves 300 mg/kg (HEEb). Nociceptive parameters, as well as locomotion, motor coordination, strength, anxiety, and depressive-like behaviors...
Source: Molecular Neurobiology - April 19, 2024 Category: Neurology Source Type: research
Whole-body cryotherapy in orthopaedics: current concepts
AbstractThe use of whole-body cryotherapy (WBC) for musculoskeletal ailments is growing. WBC, involving brief exposure to extremely low temperatures, is increasingly used for its analgesic, anti-inflammatory, and antioxidant effects. The paper examines the physiological impacts of WBC on cardiovascular, musculoskeletal, hematologic, hormonal, and metabolic systems. Specific orthopaedic applications discussed include its role in the management of fractures, osteoarthritis, osteonecrosis of the femoral head, osteomyelitis, adhesive capsulitis, tendinopathies, rheumatic pathologies, chronic pain syndromes, and fibromyalgia. T...
Source: European Journal of Orthopaedic Surgery and Traumatology - April 17, 2024 Category: Orthopaedics Source Type: research
Healthcare experiences of fibromyalgia patients and their associations with satisfaction and pain relief. A patient survey
CONCLUSIONS: Our survey describes deficiencies in FM patients' pain-related healthcare and suggests areas for improvement to increase healthcare satisfaction and pain relief. (REC# 2019/845, 09.05.19).PMID:38625666 | DOI:10.1515/sjpain-2023-0141 (Source: Pain Physician)
Source: Pain Physician - April 16, 2024 Category: Anesthesiology Authors: Sigrid H ørven Wigers Marit B Veier ød Anne Marit Mengshoel Karin Øien Forseth Mina Piiksi Dahli Niels Gunnar Juel B ård Natvig Source Type: research
Healthcare experiences of fibromyalgia patients and their associations with satisfaction and pain relief. A patient survey
CONCLUSIONS: Our survey describes deficiencies in FM patients' pain-related healthcare and suggests areas for improvement to increase healthcare satisfaction and pain relief. (REC# 2019/845, 09.05.19).PMID:38625666 | DOI:10.1515/sjpain-2023-0141 (Source: Pain Physician)
Source: Pain Physician - April 16, 2024 Category: Anesthesiology Authors: Sigrid H ørven Wigers Marit B Veier ød Anne Marit Mengshoel Karin Øien Forseth Mina Piiksi Dahli Niels Gunnar Juel B ård Natvig Source Type: research
Neuropathic and Nociplastic Pain Profiles are Common in Adult Chronic Nonbacterial Osteitis (CNO)
This study demonstrates the high prevalence of mixed pain in adult CNO, in which neuropathic and nociplastic pain exist alongside nociceptive inflammato ry bone pain. Disease burden in CNO may extend beyond inflammatory activity, highlighting the need for a multifaceted management approach. (Source: Calcified Tissue International)
Source: Calcified Tissue International - April 16, 2024 Category: Orthopaedics Source Type: research
Rheumatology: What You May Have Missed in 2023
Ann Intern Med. 2024 Apr 16. doi: 10.7326/M24-0678. Online ahead of print.ABSTRACTMany patients with rheumatologic conditions receive care from physicians other than rheumatologists. Here we note key findings from 6 studies in rheumatology published in 2023 that offer valuable insights for internal medicine specialists and subspecialists outside of rheumatology. The first study investigated the effect of low-dose glucocorticoids on patients with rheumatoid arthritis (RA) over 2 years and challenged existing perceptions about the risks of glucocorticoids in this setting. The second study focused on the updated guideline for...
Source: Annals of Internal Medicine - April 15, 2024 Category: Internal Medicine Authors: Kafaf Jalali Lisa A Mandl Source Type: research
Fibromyalgia and the Difficult Synthesis
J Rheumatol. 2024 Apr 15:jrheum.2024-0321. doi: 10.3899/jrheum.2024-0321. Online ahead of print.ABSTRACTThe pathophysiological uncertainties in fibromyalgia (FM) mean that its diagnosis, to this day, remains a strictly clinical exercise. The physician's evaluation of symptoms is therefore of fundamental importance both for the correct diagnostic framing of the patient and also for guiding a personalized therapeutic approach.1.PMID:38621795 | DOI:10.3899/jrheum.2024-0321 (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - April 15, 2024 Category: Rheumatology Authors: Marco Di Carlo Benedetta Bianchi Fausto Salaffi Source Type: research
Cognitive horizons in chronic pain: unraveling neuroscientific insights and innovative interventions for fibromyalgia
Eur Arch Psychiatry Clin Neurosci. 2024 Apr 15. doi: 10.1007/s00406-024-01811-1. Online ahead of print.NO ABSTRACTPMID:38619617 | DOI:10.1007/s00406-024-01811-1 (Source: European Archives of Psychiatry and Clinical Neuroscience)
Source: European Archives of Psychiatry and Clinical Neuroscience - April 15, 2024 Category: Psychiatry Authors: Jie Sun Xiaoxing Liu Lin Lu Source Type: research
Fibromyalgia and the Difficult Synthesis
J Rheumatol. 2024 Apr 15:jrheum.2024-0321. doi: 10.3899/jrheum.2024-0321. Online ahead of print.ABSTRACTThe pathophysiological uncertainties in fibromyalgia (FM) mean that its diagnosis, to this day, remains a strictly clinical exercise. The physician's evaluation of symptoms is therefore of fundamental importance both for the correct diagnostic framing of the patient and also for guiding a personalized therapeutic approach.1.PMID:38621795 | DOI:10.3899/jrheum.2024-0321 (Source: J Rheumatol)
Source: J Rheumatol - April 15, 2024 Category: Rheumatology Authors: Marco Di Carlo Benedetta Bianchi Fausto Salaffi Source Type: research
Rheumatology: What You May Have Missed in 2023
Ann Intern Med. 2024 Apr 16. doi: 10.7326/M24-0678. Online ahead of print.ABSTRACTMany patients with rheumatologic conditions receive care from physicians other than rheumatologists. Here we note key findings from 6 studies in rheumatology published in 2023 that offer valuable insights for internal medicine specialists and subspecialists outside of rheumatology. The first study investigated the effect of low-dose glucocorticoids on patients with rheumatoid arthritis (RA) over 2 years and challenged existing perceptions about the risks of glucocorticoids in this setting. The second study focused on the updated guideline for...
Source: Annals of Internal Medicine - April 15, 2024 Category: Internal Medicine Authors: Kafaf Jalali Lisa A Mandl Source Type: research
Fibromyalgia and the Difficult Synthesis
J Rheumatol. 2024 Apr 15:jrheum.2024-0321. doi: 10.3899/jrheum.2024-0321. Online ahead of print.ABSTRACTThe pathophysiological uncertainties in fibromyalgia (FM) mean that its diagnosis, to this day, remains a strictly clinical exercise. The physician's evaluation of symptoms is therefore of fundamental importance both for the correct diagnostic framing of the patient and also for guiding a personalized therapeutic approach.1.PMID:38621795 | DOI:10.3899/jrheum.2024-0321 (Source: Journal of Rheumatology)
Source: Journal of Rheumatology - April 15, 2024 Category: Rheumatology Authors: Marco Di Carlo Benedetta Bianchi Fausto Salaffi Source Type: research
Cognitive horizons in chronic pain: unraveling neuroscientific insights and innovative interventions for fibromyalgia
Eur Arch Psychiatry Clin Neurosci. 2024 Apr 15. doi: 10.1007/s00406-024-01811-1. Online ahead of print.NO ABSTRACTPMID:38619617 | DOI:10.1007/s00406-024-01811-1 (Source: European Archives of Psychiatry and Clinical Neuroscience)
Source: European Archives of Psychiatry and Clinical Neuroscience - April 15, 2024 Category: Psychiatry Authors: Jie Sun Xiaoxing Liu Lin Lu Source Type: research
