Evaluation of Type 2 SLE symptoms in patients with a range of lupus nephritis activity
ConclusionsWhile Type 2 SLE symptoms are common in SLE, our findings suggest that patients with active nephritis experience significant Type 2 SLE symptoms that may be ameliorated as nephritis improves. We also observed that non-nephritis patients had a similar burden of Type 2 SLE symptoms as patients with active nephritis, despite having on average lower Type 1 SLE activity. Therefore, the etiology of Type 2 SLE symptoms is likely multifactorial and may be driven by inflammatory and non-inflammatory biopsychosocial factors.Key Points• Patients with active nephritis experienced significant Type 2 symptoms that may be am...
Source: Clinical Rheumatology - March 18, 2024 Category: Rheumatology Source Type: research

The diagnostic assessment of fibromyalgia and the role of small fiber pathology
(Source: Neurological Sciences)
Source: Neurological Sciences - March 15, 2024 Category: Neurology Source Type: research

The Role of SARS-CoV-2 Spike Protein in Long-term Damage of Tissues and Organs, the Underestimated Role of Retrotransposons and Stem Cells, a Working Hypothesis
Endocr Metab Immune Disord Drug Targets. 2024 Mar 11. doi: 10.2174/0118715303283480240227113401. Online ahead of print.ABSTRACTCoronavirus disease-2019 (COVID-19) is a respiratory disease in which Spike protein from SARS-CoV-2 plays a key role in transferring virus genomic code into target cells. Spike protein, which is found on the surface of the SARS-CoV-2 virus, latches onto angiotensin-converting enzyme 2 receptors (ACE2r) on target cells. The RNA genome of coronaviruses, with an average length of 29 kb, is the longest among all RNA viruses and comprises six to ten open reading frames (ORFs) responsible for encoding re...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - March 12, 2024 Category: Drugs & Pharmacology Authors: Mario G Balzanelli Reza Rastanesh Pietro Distratis Rita Lazzaro Francesco Inchingolo Raffaele Del Prete Van H Pham Sergey K Aityan Toai Tran Cong Kieu C D Nguyen Ciro Gargiulo Isacco Source Type: research

The Role of SARS-CoV-2 Spike Protein in Long-term Damage of Tissues and Organs, the Underestimated Role of Retrotransposons and Stem Cells, a Working Hypothesis
Endocr Metab Immune Disord Drug Targets. 2024 Mar 11. doi: 10.2174/0118715303283480240227113401. Online ahead of print.ABSTRACTCoronavirus disease-2019 (COVID-19) is a respiratory disease in which Spike protein from SARS-CoV-2 plays a key role in transferring virus genomic code into target cells. Spike protein, which is found on the surface of the SARS-CoV-2 virus, latches onto angiotensin-converting enzyme 2 receptors (ACE2r) on target cells. The RNA genome of coronaviruses, with an average length of 29 kb, is the longest among all RNA viruses and comprises six to ten open reading frames (ORFs) responsible for encoding re...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - March 12, 2024 Category: Endocrinology Authors: Mario G Balzanelli Reza Rastanesh Pietro Distratis Rita Lazzaro Francesco Inchingolo Raffaele Del Prete Van H Pham Sergey K Aityan Toai Tran Cong Kieu C D Nguyen Ciro Gargiulo Isacco Source Type: research

The Role of SARS-CoV-2 Spike Protein in Long-term Damage of Tissues and Organs, the Underestimated Role of Retrotransposons and Stem Cells, a Working Hypothesis
Endocr Metab Immune Disord Drug Targets. 2024 Mar 11. doi: 10.2174/0118715303283480240227113401. Online ahead of print.ABSTRACTCoronavirus disease-2019 (COVID-19) is a respiratory disease in which Spike protein from SARS-CoV-2 plays a key role in transferring virus genomic code into target cells. Spike protein, which is found on the surface of the SARS-CoV-2 virus, latches onto angiotensin-converting enzyme 2 receptors (ACE2r) on target cells. The RNA genome of coronaviruses, with an average length of 29 kb, is the longest among all RNA viruses and comprises six to ten open reading frames (ORFs) responsible for encoding re...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - March 12, 2024 Category: Drugs & Pharmacology Authors: Mario G Balzanelli Reza Rastanesh Pietro Distratis Rita Lazzaro Francesco Inchingolo Raffaele Del Prete Van H Pham Sergey K Aityan Toai Tran Cong Kieu C D Nguyen Ciro Gargiulo Isacco Source Type: research

The Role of SARS-CoV-2 Spike Protein in Long-term Damage of Tissues and Organs, the Underestimated Role of Retrotransposons and Stem Cells, a Working Hypothesis
Endocr Metab Immune Disord Drug Targets. 2024 Mar 11. doi: 10.2174/0118715303283480240227113401. Online ahead of print.ABSTRACTCoronavirus disease-2019 (COVID-19) is a respiratory disease in which Spike protein from SARS-CoV-2 plays a key role in transferring virus genomic code into target cells. Spike protein, which is found on the surface of the SARS-CoV-2 virus, latches onto angiotensin-converting enzyme 2 receptors (ACE2r) on target cells. The RNA genome of coronaviruses, with an average length of 29 kb, is the longest among all RNA viruses and comprises six to ten open reading frames (ORFs) responsible for encoding re...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - March 12, 2024 Category: Endocrinology Authors: Mario G Balzanelli Reza Rastanesh Pietro Distratis Rita Lazzaro Francesco Inchingolo Raffaele Del Prete Van H Pham Sergey K Aityan Toai Tran Cong Kieu C D Nguyen Ciro Gargiulo Isacco Source Type: research

The Role of SARS-CoV-2 Spike Protein in Long-term Damage of Tissues and Organs, the Underestimated Role of Retrotransposons and Stem Cells, a Working Hypothesis
Endocr Metab Immune Disord Drug Targets. 2024 Mar 11. doi: 10.2174/0118715303283480240227113401. Online ahead of print.ABSTRACTCoronavirus disease-2019 (COVID-19) is a respiratory disease in which Spike protein from SARS-CoV-2 plays a key role in transferring virus genomic code into target cells. Spike protein, which is found on the surface of the SARS-CoV-2 virus, latches onto angiotensin-converting enzyme 2 receptors (ACE2r) on target cells. The RNA genome of coronaviruses, with an average length of 29 kb, is the longest among all RNA viruses and comprises six to ten open reading frames (ORFs) responsible for encoding re...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - March 12, 2024 Category: Drugs & Pharmacology Authors: Mario G Balzanelli Reza Rastanesh Pietro Distratis Rita Lazzaro Francesco Inchingolo Raffaele Del Prete Van H Pham Sergey K Aityan Toai Tran Cong Kieu C D Nguyen Ciro Gargiulo Isacco Source Type: research

The Role of SARS-CoV-2 Spike Protein in Long-term Damage of Tissues and Organs, the Underestimated Role of Retrotransposons and Stem Cells, a Working Hypothesis
Endocr Metab Immune Disord Drug Targets. 2024 Mar 11. doi: 10.2174/0118715303283480240227113401. Online ahead of print.ABSTRACTCoronavirus disease-2019 (COVID-19) is a respiratory disease in which Spike protein from SARS-CoV-2 plays a key role in transferring virus genomic code into target cells. Spike protein, which is found on the surface of the SARS-CoV-2 virus, latches onto angiotensin-converting enzyme 2 receptors (ACE2r) on target cells. The RNA genome of coronaviruses, with an average length of 29 kb, is the longest among all RNA viruses and comprises six to ten open reading frames (ORFs) responsible for encoding re...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - March 12, 2024 Category: Endocrinology Authors: Mario G Balzanelli Reza Rastanesh Pietro Distratis Rita Lazzaro Francesco Inchingolo Raffaele Del Prete Van H Pham Sergey K Aityan Toai Tran Cong Kieu C D Nguyen Ciro Gargiulo Isacco Source Type: research

Prevalence of fibromyalgia and irritable bowel syndrome and its association with studying medicine, a cross ‐sectional study in Al‐Baath University, Syria
ConclusionWe found an increased prevalence of IBS among medical students. The prevalence of FM did not show any relation to studying medicine. We recommend additional prospective studies to assess whether studying medicine could be a risk factor for these disorders or not. (Source: Brain and Behavior)
Source: Brain and Behavior - March 12, 2024 Category: Neurology Authors: Mohanad Daher, Sara Abbas, Zainab Asaad, Karam Khalil, Ghania Jadid Tags: ORIGINAL ARTICLE Source Type: research

The prevalence of fibromyalgia in adults at Al-Karak Jordan: a cross-sectional study
CONCLUSION: This study sheds light on fibromyalgia's prevalence and associated factors in the Al-Karak population. The identified predictors highlight the necessity for comprehensive healthcare strategies and interventions to mitigate the disease burden. These findings aid policymakers and healthcare professionals in planning and implementing effective measures for fibromyalgia management and prevention. Further research is warranted to deepen our understanding of fibromyalgia's complexity and its implications in this region.PMID:38463111 | PMC:PMC10923264 | DOI:10.1097/MS9.0000000000001722 (Source: Annals of Medicine)
Source: Annals of Medicine - March 11, 2024 Category: Internal Medicine Authors: Alaa Akel Mohammed Y Sarhan Majed Al Dwairy Belal Al-Zu'bi Ala Al-Qudah Omar A Alsmarat Taif Alsaraireh Mohammad Abu-Jeyyab Source Type: research

Minimal clinically important change of movement pain in musculoskeletal pain conditions
Movement pain, which is distinct from resting pain, is frequently reported by individuals with musculoskeletal pain. There is growing interest in measuring movement pain as a primary outcome in clinical trials, but no minimally clinically important change (MCIC) has been established, limiting interpretations. We analyzed data from 315 participants who participated in previous clinical trials (65 with chronic Achilles tendinopathy; 250 with fibromyalgia) to establish an MCIC for movement pain. A composite movement pain score was defined as the average pain (Numeric Rating Scale (NRS): 0 to 10) during two clinically relevant...
Source: The Journal of Pain - March 11, 2024 Category: Materials Science Authors: Timothy R. Fleagle, Andrew A. Post, Dana L. Dailey, Carol G.T. Vance, M. Bridget Zimmerman, Emine O Bayman, Leslie J. Crofford, Kathleen A. Sluka, Ruth L. Chimenti Source Type: research

Is Pilates more effective than aerobic exercise in the treatment of fibromyalgia? Discussing a clinical trial
(Source: European Journal of Pain)
Source: European Journal of Pain - March 9, 2024 Category: Anesthesiology Authors: Andr é Pontes‐Silva Tags: LETTER TO THE EDITOR Source Type: research

Neurodevelopmental disorders as a risk factor for temporomandibular disorder: evidence from Mendelian randomization studies
Conclusion: This study reveals the elevated risk of various TMD aspects due to ADHD. Furthermore, we discuss the link between low vitamin D levels ADHD and TMD. Future research should address these limitations and delve further into the complex interactions between ADHD, ASD, TD, and TMD. (Source: Frontiers in Genetics)
Source: Frontiers in Genetics - March 8, 2024 Category: Genetics & Stem Cells Source Type: research

Neuromodulation with aerobic exercise reduces fatigue in systemic lupus erythematosus: a randomised, sham-controlled, double-blind study
CONCLUSIONS: Despite isolated AEs, there was an improvement in fatigue, however, only tDCS-AE maintained significant and sustained improvement.PMID:38451142 | DOI:10.55563/clinexprheumatol/yvrdgm (Source: Clinical and Experimental Rheumatology)
Source: Clinical and Experimental Rheumatology - March 7, 2024 Category: Rheumatology Authors: Vanessa P de Andrade Alexandre M Dos Santos Luciana P C Seguro Emily F N Yuki Michelle R U Lopes Marcus V Grecco Eduardo F Borba Julia M A Greve Samuel K Shinjo Source Type: research