Valproate attenuates somatic hyperalgesia induced by orofacial inflammation combined with stress through inhibiting spinal IL-6 and STAT1 phosphorylation
Brain Res Bull. 2024 Jan 28;208:110889. doi: 10.1016/j.brainresbull.2024.110889. Online ahead of print.ABSTRACTTemporomandibular disorder (TMD) and fibromyalgia syndrome (FMS) may present as comorbid conditions, but treatment options are ineffective. The purpose of this study was to investigate whether valproate (VPA) attenuates somatic hyperalgesia induced by orofacial inflammation combined with stress, which represents a model of pain associated with TMD and FMS comorbidity, and to explore the potential mechanisms. The results showed that VPA inhibited somatic hyperalgesia induced by orofacial inflammation combined with ...
Source: Brain Research Bulletin - January 30, 2024 Category: Neurology Authors: Chen-Xi Xu Xin-Yi Qiu Yi Guo Tian-Ming Xu Richard J Traub Hai-Nan Feng Dong-Yuan Cao Source Type: research
Valproate attenuates somatic hyperalgesia induced by orofacial inflammation combined with stress through inhibiting spinal IL-6 and STAT1 phosphorylation
Brain Res Bull. 2024 Jan 28;208:110889. doi: 10.1016/j.brainresbull.2024.110889. Online ahead of print.ABSTRACTTemporomandibular disorder (TMD) and fibromyalgia syndrome (FMS) may present as comorbid conditions, but treatment options are ineffective. The purpose of this study was to investigate whether valproate (VPA) attenuates somatic hyperalgesia induced by orofacial inflammation combined with stress, which represents a model of pain associated with TMD and FMS comorbidity, and to explore the potential mechanisms. The results showed that VPA inhibited somatic hyperalgesia induced by orofacial inflammation combined with ...
Source: Brain Research - January 30, 2024 Category: Neurology Authors: Chen-Xi Xu Xin-Yi Qiu Yi Guo Tian-Ming Xu Richard J Traub Hai-Nan Feng Dong-Yuan Cao Source Type: research
Implication of intestinal microbiota in the etiopathogenesis of fibromyalgia: A systematic review
AbstractFibromyalgia (FM) is a highly prevalent chronic disease. About 4.7% of the world's population suffers from generalized pain and hypersensitivity, in addition to a wide range of physical and psychological symptoms. The etiopathogenesis of this disease is multifactorial, which makes its diagnosis and treatment challenging. Recently, the increase in the number of studies on microbiota has provided new data that can help to understand the onset and development of FM. An updated systematic review of the causes of FM has been carried out in this work. Particularly in the last decade, research has focused on the gut –br...
Source: International Journal of Rheumatic Diseases - January 27, 2024 Category: Rheumatology Authors: Juan Francisco Palma ‐Ordóñez,
Ana María Moreno‐Fernández,
Jorge Antolín Ramírez‐Tejero,
Elena Durán‐González,
Antonio Martínez‐Lara,
David Cotán Tags: REVIEW Source Type: research
Effects of traditional Chinese exercise therapy on pain scores, sleep quality, and anxiety-depression symptoms in fibromyalgia patients: a systematic review and meta-analysis
This study aims to assess the effectiveness of traditional Chinese exercise therapy in alleviating pain, improving sleep quality, and reducing symptoms of anxiety and depression among fibromyalgia patients. (Source: BMC Musculoskeletal Disorders)
Source: BMC Musculoskeletal Disorders - January 27, 2024 Category: Orthopaedics Authors: Xinzheng Wang and Hongbin Luo Tags: Research Source Type: research
Phenotypic characteristics of patients with chronic widespread pain and fibromyalgia: a cross-sectional cluster analysis
CONCLUSION: We identified one cluster, where participants were characterized by a potentially favourable clinical profile. More studies are needed to evaluate whether these characteristics could be used to guide the management of patients with CWP and FM.PMID:38275145 | DOI:10.1080/03009742.2023.2297514 (Source: Scandinavian Journal of Rheumatology)
Source: Scandinavian Journal of Rheumatology - January 26, 2024 Category: Rheumatology Authors: P H Duhn R Christensen H Locht M Henriksen E Ginnerup-Nielsen H Bliddal E E W æhrens K Thielen K Amris Source Type: research
Reduced Cortico ‐Cortical Resting‐State Connectivity in Sensory Systems Related to Bodily Pain in Juvenile Fibromyalgia
ConclusionReduced cortico-cortical sensory integration involving PCL/S1 and spanning the sensory systems may underly critical pain sensory features in youth with JFM. Reduced sensory integration is paralleled by augmented cross-talk between sensory and affective/salience-processing regions, potentially indicating a shift toward more affectively colored sensory experiences to the detriment of specific sensory discrimination. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - January 26, 2024 Category: Rheumatology Authors: Maria Su ñol,
Jon Dudley,
Michael F. Payne,
Han Tong,
Tracy V. Ting,
Susmita Kashikar‐Zuck,
Robert C. Coghill,
Marina López‐Solà Tags: Full Length Source Type: research
Genetic Influence on Osteoarthritis Versus Other Rheumatic Diseases
ConclusionOA has relatively large heritability as compared with other RMDs. The coexistence of OA and shoulder pain, as well as back pain, was common and could often be explained by genetic factors. Findings imply similar etiologies of OA and several pain conditions. (Source: Arthritis and Rheumatology)
Source: Arthritis and Rheumatology - January 26, 2024 Category: Rheumatology Authors: Karin Magnusson,
Aleksandra Turkiewicz,
Martin Ryd én,
Martin Englund Tags: Full Length Source Type: research
Risk of fibromyalgia following antibiotic prescriptions: A population‐based case–control study
ConclusionsThe results lend support for prior antibiotics being an important risk factor for a diagnosis of FM.SignificanceThis study shows an association between the volume as well as timing of prior antibiotic prescriptions and of a subsequent diagnosis of fibromyalgia in primary care. (Source: European Journal of Pain)
Source: European Journal of Pain - January 24, 2024 Category: Anesthesiology Authors: David Armstrong,
Alex Dregan,
Mark Ashworth,
Patrick White Tags: ORIGINAL ARTICLE Source Type: research
Patient experiences with requests for medical assistance in dying: Perspectives of those with complex chronic conditions
CONCLUSION: Participants described experiences with CCCs and requests for MAID. This information may provide family doctors with new insight to inform interactions with patients with CCCs.PMID:38262757 | DOI:10.46747/cfp.700141 (Source: Canadian Family Physician Medecin de Famille Canadien)
Source: Canadian Family Physician Medecin de Famille Canadien - January 23, 2024 Category: Primary Care Authors: Clark Fruhstorfer Michaela Kelly Laura Spiegel Peter J Baylis Justine Dembo Ellen Wiebe Source Type: research
Patient experiences with requests for medical assistance in dying: Perspectives of those with complex chronic conditions
CONCLUSION: Participants described experiences with CCCs and requests for MAID. This information may provide family doctors with new insight to inform interactions with patients with CCCs.PMID:38262757 | DOI:10.46747/cfp.700141 (Source: Canadian Family Physician Medecin de Famille Canadien)
Source: Canadian Family Physician Medecin de Famille Canadien - January 23, 2024 Category: Primary Care Authors: Clark Fruhstorfer Michaela Kelly Laura Spiegel Peter J Baylis Justine Dembo Ellen Wiebe Source Type: research
Patient experiences with requests for medical assistance in dying: Perspectives of those with complex chronic conditions
CONCLUSION: Participants described experiences with CCCs and requests for MAID. This information may provide family doctors with new insight to inform interactions with patients with CCCs.PMID:38262757 | DOI:10.46747/cfp.700141 (Source: Canadian Family Physician Medecin de Famille Canadien)
Source: Canadian Family Physician Medecin de Famille Canadien - January 23, 2024 Category: Primary Care Authors: Clark Fruhstorfer Michaela Kelly Laura Spiegel Peter J Baylis Justine Dembo Ellen Wiebe Source Type: research
Patient experiences with requests for medical assistance in dying: Perspectives of those with complex chronic conditions
CONCLUSION: Participants described experiences with CCCs and requests for MAID. This information may provide family doctors with new insight to inform interactions with patients with CCCs.PMID:38262757 | DOI:10.46747/cfp.700141 (Source: Canadian Family Physician Medecin de Famille Canadien)
Source: Canadian Family Physician Medecin de Famille Canadien - January 23, 2024 Category: Primary Care Authors: Clark Fruhstorfer Michaela Kelly Laura Spiegel Peter J Baylis Justine Dembo Ellen Wiebe Source Type: research
Patient experiences with requests for medical assistance in dying: Perspectives of those with complex chronic conditions
CONCLUSION: Participants described experiences with CCCs and requests for MAID. This information may provide family doctors with new insight to inform interactions with patients with CCCs.PMID:38262757 | DOI:10.46747/cfp.700141 (Source: Canadian Family Physician Medecin de Famille Canadien)
Source: Canadian Family Physician Medecin de Famille Canadien - January 23, 2024 Category: Primary Care Authors: Clark Fruhstorfer Michaela Kelly Laura Spiegel Peter J Baylis Justine Dembo Ellen Wiebe Source Type: research
Effectiveness of Complementary and Alternative Medicine in Fibromyalgia Syndrome: A Network Meta-Analysis
(Source: Journal of Pain Research)
Source: Journal of Pain Research - January 20, 2024 Category: Anesthesiology Tags: Journal of Pain Research Source Type: research
The Impact of Type D Personality Traits on Quality of Life, Sleep, Anxiety, and Depression in Fibromyalgia Patients: A Comparative Study with Healthy Controls
CONCLUSIONS This study draws attention to the high prevalence of type D personality in patients with fibromyalgia and demonstrates that this personality trait has a negative impact on patients' clinical parameters.PMID:38238996 | PMC:PMC10804653 | DOI:10.12659/MSM.942606 (Source: Medical Science Monitor)
Source: Medical Science Monitor - January 19, 2024 Category: Research Authors: İlknur Topal Taha Can Tuman Source Type: research
