Masking the Taste of Fixed-Dose Combination Drugs: Particular NSAIDs Can Efficiently Mask the Bitterness of Famotidine
This study aimed to evaluate the bitterness of famotidine (FAM) combined with each of three non-steroidal anti-inflammatory drugs (NSAIDs): ibuprofen (IBU), flurbiprofen (FLU), and naproxen (NAP), which have potential as fixed-dose combination (FDC) drugs. We evaluated the bitterness of FAM and each NSAID by taste sensor AN0 and C00, respectively. FAM showed high sensor output representing sensitivity to bitterness, whereas three NSAIDs did not show large sensor output, suggesting that the bitterness intensities of three NSAIDs were lower than that of FAM. The bitterness of FAM on sensor AN0 was suppressed in a concentrati...
Source: Chemical and Pharmaceutical Bulletin - February 1, 2023 Category: Drugs & Pharmacology Authors: Rio Uno Kyoko Ohkawa Honami Kojima Tamami Haraguchi Minoru Ozeki Ikuo Kawasaki Miyako Yoshida Masaaki Habara Hidekazu Ikezaki Takahiro Uchida Source Type: research
Promoting Activity of Terpenes on Skin Permeation of Famotidine
Chem Pharm Bull (Tokyo). 2023;71(2):111-119. doi: 10.1248/cpb.c22-00568.ABSTRACTFamotidine (FMT) is a competitive histamine-2 (H2) receptor antagonist that inhibits gastric acid secretion for the treatment of Gastroesophageal reflux disease. To study the promoting effect and mechanism of terpenes, including l-menthol, borneol, and geraniol, as chemical enhancers, FMT was used as a model drug. Attenuated total reflectance-Fourier transform IR spectroscopy (ATR-FTIR) and differential scanning calorimetry (DSC) were used to explore the effects of terpenes on the skin. Hairless mouse skin was mounted on Franz-type diffusion ce...
Source: Chemical and Pharmaceutical Bulletin - February 1, 2023 Category: Drugs & Pharmacology Authors: Qihui Xu Yifan Wu Hiroki Saito Yuki Ofuchi Haruna Setoyama Takayuki Furuishi Kaori Fukuzawa Etsuo Yonemochi Yasuko Obata Source Type: research
Masking the Taste of Fixed-Dose Combination Drugs: Particular NSAIDs Can Efficiently Mask the Bitterness of Famotidine
This study aimed to evaluate the bitterness of famotidine (FAM) combined with each of three non-steroidal anti-inflammatory drugs (NSAIDs): ibuprofen (IBU), flurbiprofen (FLU), and naproxen (NAP), which have potential as fixed-dose combination (FDC) drugs. We evaluated the bitterness of FAM and each NSAID by taste sensor AN0 and C00, respectively. FAM showed high sensor output representing sensitivity to bitterness, whereas three NSAIDs did not show large sensor output, suggesting that the bitterness intensities of three NSAIDs were lower than that of FAM. The bitterness of FAM on sensor AN0 was suppressed in a concentrati...
Source: Chemical and Pharmaceutical Bulletin - February 1, 2023 Category: Drugs & Pharmacology Authors: Rio Uno Kyoko Ohkawa Honami Kojima Tamami Haraguchi Minoru Ozeki Ikuo Kawasaki Miyako Yoshida Masaaki Habara Hidekazu Ikezaki Takahiro Uchida Source Type: research
Promoting Activity of Terpenes on Skin Permeation of Famotidine
Chem Pharm Bull (Tokyo). 2023;71(2):111-119. doi: 10.1248/cpb.c22-00568.ABSTRACTFamotidine (FMT) is a competitive histamine-2 (H2) receptor antagonist that inhibits gastric acid secretion for the treatment of Gastroesophageal reflux disease. To study the promoting effect and mechanism of terpenes, including l-menthol, borneol, and geraniol, as chemical enhancers, FMT was used as a model drug. Attenuated total reflectance-Fourier transform IR spectroscopy (ATR-FTIR) and differential scanning calorimetry (DSC) were used to explore the effects of terpenes on the skin. Hairless mouse skin was mounted on Franz-type diffusion ce...
Source: Chemical and Pharmaceutical Bulletin - February 1, 2023 Category: Drugs & Pharmacology Authors: Qihui Xu Yifan Wu Hiroki Saito Yuki Ofuchi Haruna Setoyama Takayuki Furuishi Kaori Fukuzawa Etsuo Yonemochi Yasuko Obata Source Type: research
Masking the Taste of Fixed-Dose Combination Drugs: Particular NSAIDs Can Efficiently Mask the Bitterness of Famotidine
This study aimed to evaluate the bitterness of famotidine (FAM) combined with each of three non-steroidal anti-inflammatory drugs (NSAIDs): ibuprofen (IBU), flurbiprofen (FLU), and naproxen (NAP), which have potential as fixed-dose combination (FDC) drugs. We evaluated the bitterness of FAM and each NSAID by taste sensor AN0 and C00, respectively. FAM showed high sensor output representing sensitivity to bitterness, whereas three NSAIDs did not show large sensor output, suggesting that the bitterness intensities of three NSAIDs were lower than that of FAM. The bitterness of FAM on sensor AN0 was suppressed in a concentrati...
Source: Chemical and Pharmaceutical Bulletin - February 1, 2023 Category: Drugs & Pharmacology Authors: Rio Uno Kyoko Ohkawa Honami Kojima Tamami Haraguchi Minoru Ozeki Ikuo Kawasaki Miyako Yoshida Masaaki Habara Hidekazu Ikezaki Takahiro Uchida Source Type: research
Promoting Activity of Terpenes on Skin Permeation of Famotidine
Chem Pharm Bull (Tokyo). 2023;71(2):111-119. doi: 10.1248/cpb.c22-00568.ABSTRACTFamotidine (FMT) is a competitive histamine-2 (H2) receptor antagonist that inhibits gastric acid secretion for the treatment of Gastroesophageal reflux disease. To study the promoting effect and mechanism of terpenes, including l-menthol, borneol, and geraniol, as chemical enhancers, FMT was used as a model drug. Attenuated total reflectance-Fourier transform IR spectroscopy (ATR-FTIR) and differential scanning calorimetry (DSC) were used to explore the effects of terpenes on the skin. Hairless mouse skin was mounted on Franz-type diffusion ce...
Source: Chemical and Pharmaceutical Bulletin - February 1, 2023 Category: Drugs & Pharmacology Authors: Qihui Xu Yifan Wu Hiroki Saito Yuki Ofuchi Haruna Setoyama Takayuki Furuishi Kaori Fukuzawa Etsuo Yonemochi Yasuko Obata Source Type: research
Anaphylaxis in the operating room treated with an anaphylaxis response kit: A case report
We report a case of sugammadex-induced anaphylaxis, which we could properly diagnose and treat because an anaphylaxis kit was available in our department. (Source: Saudi Journal of Anaesthesia)
Source: Saudi Journal of Anaesthesia - January 2, 2023 Category: Anesthesiology Authors: Akae Shu Takuo Hoshi Keiichi Hagiya Source Type: research
No evidence of clinical efficacy of famotidine for the treatment of COVID-19 in a systematic review and meta-analysis
Dear Editor, (Source: Journal of Infection)
Source: Journal of Infection - November 30, 2022 Category: Infectious Diseases Authors: Huzaifa Ahmad Cheema, Arman Shafiee, Mohammad Mobin Teymouri Athar, Abia Shahid, Rehmat Ullah Awan, Ahmed M Afifi, Jaffer Shah, Prasun K Jalal Source Type: research
No evidence of clinical efficacy of famotidine for the treatment of COVID-19: a systematic review and meta-analysis
We read with great interest the recent article by Qian et al. that reported paxlovid as an efficacious treatment for COVID-19 patients.1 However, the relatively high cost of paxlovid and the other currently available oral antiviral, molnupiravir, will likely curtail their access in lower-income countries.2,3 Therefore, as the quest to find efficacious an d cost-effective therapies for COVID-19 patients is still ongoing, repurposing drugs, that are approved for other indications, to treat COVID-19 is an attractive option. (Source: Journal of Infection)
Source: Journal of Infection - November 30, 2022 Category: Infectious Diseases Authors: Huzaifa Ahmad Cheema, Arman Shafiee, Mohammad Mobin Teymouri Athar, Abia Shahid, Rehmat Ullah Awan, Ahmed M Afifi, Jaffer Shah, Prasun K Jalal Tags: Letter to the Editor Source Type: research
Pharmacological interventions for prevention of weight gain in people with schizophrenia
CONCLUSIONS: There is low-certainty evidence to suggest that metformin may be effective in preventing weight gain. Interpretation of this result and those for other agents, is limited by the small number of studies, small sample size, and short study duration. In future, we need studies that are adequately powered and with longer treatment durations to further evaluate the efficacy and safety of interventions for managing weight gain.PMID:36190739 | DOI:10.1002/14651858.CD013337.pub2 (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - October 3, 2022 Category: General Medicine Authors: Sri Mahavir Agarwal Nicolette Stogios Zohra A Ahsan Jonathan T Lockwood Markus J Duncan Hiroyoshi Takeuchi Tony Cohn Valerie H Taylor Gary Remington Guy E J Faulkner Margaret Hahn Source Type: research
IJERPH, Vol. 19, Pages 12469: Pharmacoepidemiological Research on N-Nitrosodimethylamine-Contaminated Ranitidine Use and Long-Term Cancer Risk: A Population-Based Longitudinal Cohort Study
g Tseng
N-Nitrosodimethylamine (NDMA), a carcinogenic chemical, has recently been identified in ranitidine. We conducted a population-based study to explore ranitidine use and cancer emergence over time. Using the Taiwan National Health Insurance Research Database, a population-based cohort study was conducted. A total of 55,110 eligible patients who received ranitidine between January 2000 and December 2018 were enrolled in the treated cohort. We conducted a 1:1 propensity-score-matching procedure to match the ranitidine-treated group with the ranitidine-untreated group and famotidine controls for a longitudinal study...
Source: International Journal of Environmental Research and Public Health - September 30, 2022 Category: Environmental Health Authors: Chun-Hsiang Wang I-I Chen Chung-Hung Chen Yuan-Tsung Tseng Tags: Article Source Type: research
Effect of Acid Suppressants on Non –Helicobacter pylori Helicobacters Within Parietal Cells
We investigated the effect of increased pH induced by acid suppressants on the viability of non–Helicobacter pylori helicobacters (NHPHs) within parietal cell intracellular canaliculi and fundic glandular lumina by immunohistochemistry, electron microscopy, quantitative PCR, urea breath tests, and using a bilayer culture system. Three months before the experiment, mice were infected with the NHPH H. suis and then treated with famotidine (2 mg/kg body weight [BW], once daily), lansoprazole (30 mg/kg BW, once daily), or vonoprazan (20 mg/kg BW, once daily) for 3 days. Immunohistochemical studies using the TUNEL method,...
Source: Frontiers in Pharmacology - July 22, 2022 Category: Drugs & Pharmacology Source Type: research
What causes Long Covid? Here are the three leading theories
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A version of this story appeared in Science, Vol 376, Issue 6599.
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Source: Science of Aging Knowledge Environment - June 16, 2022 Category: Geriatrics Source Type: research
Famotidine activates the vagus nerve inflammatory reflex to attenuate cytokine storm
CONCLUSIONS: These observations reveal a previously unidentified vagus nerve-dependent anti-inflammatory effect of famotidine in the setting of cytokine storm which is not replicated by high dosages of other H2R antagonists in clinical use. Because famotidine is more potent when administered intrathecally, these findings are also consistent with a primarily central nervous system mechanism of action.PMID:35578169 | DOI:10.1186/s10020-022-00483-8 (Source: Molecular Medicine)
Source: Molecular Medicine - May 16, 2022 Category: Molecular Biology Authors: Huan Yang Sam J George Dane A Thompson Harold A Silverman T éa Tsaava Aisling Tynan Valentin A Pavlov Eric H Chang Ulf Andersson Michael Brines Sangeeta S Chavan Kevin J Tracey Source Type: research
Histamine H3 receptor antagonist, ciproxifan, alleviates cognition and synaptic plasticity alterations in a valproic acid-induced animal model of autism
ConclusionsCPX 3 mg/kg improved VPA-induced impairments of LTP as well as learning and memory deficits through H2R. (Source: Psychopharmacology)
Source: Psychopharmacology - May 11, 2022 Category: Psychiatry Source Type: research
