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Stability of Six Drugs in Total Parenteral Nutrition Solution
In this study, we investigated the stability of six drugs, including famotidine, scopolamine butylbromide, furosemide, bromhexine hydrochloride, betamethasone sodium phosphate, and metoclopramide hydrochloride in the infusion bags under dark conditions at 4℃ for 7 days. Additionally, we developed a high-performance liquid chromatography method to determine drug concentrations in the infusions. The concentrations of injected famotidine, scopolamine butylbromide, and betamethasone sodium phosphate remained unchanged when the four chambers of Elneopa NF No. 1 and No. 2 were opened and the infusions were mixed. Their respect...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - April 1, 2021 Category: Drugs & Pharmacology Authors: Takefumi Kumagai Naoko Narahara Eiji Sato Yoshitaka Kihira Yoshino Fujimura Eijiro Kojima Shojiro Ogawa Yuko Date Yasuto Tsuruta Hironori Yoshitomi Hirofumi Inoue Source Type: research

COVID-19: Famotidine, Histamine, Mast Cells, and Mechanisms
SARS-CoV-2 infection is required for COVID-19, but many signs and symptoms of COVID-19 differ from common acute viral diseases. SARS-CoV-2 infection is necessary but not sufficient for development of clinical COVID-19 disease. Currently, there are no approved pre- or post-exposure prophylactic COVID-19 medical countermeasures. Clinical data suggest that famotidine may mitigate COVID-19 disease, but both mechanism of action and rationale for dose selection remain obscure. We have investigated several plausible hypotheses for famotidine activity including antiviral and host-mediated mechanisms of action. We propose that the ...
Source: Frontiers in Pharmacology - March 23, 2021 Category: Drugs & Pharmacology Source Type: research

Famotidine Repurposing for Novel Corona Virus Disease of 2019: A Systematic Review
Conclusion Famotidine has the potential to answer the ongoing global challenge owing to its selective action on viral replication. Additionally, clinical findings in COVID-19 patients support its efficacy to reduce clinical symptoms of COVID-19.We suggest that further optimally powered randomized clinical trials should be carried out to come up with definitive conclusions. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents | Abstract | Full text (Source: Drug Research)
Source: Drug Research - March 23, 2021 Category: Drugs & Pharmacology Authors: Chenchula, Santenna Ray, Avik Sadasivam, Balakrishnan Tags: Review Source Type: research

A 64-Year-Old Man With Multifocal Infiltrates
Chest. 2021 Mar;159(3):e151-e154. doi: 10.1016/j.chest.2020.09.082.ABSTRACTA 64-year-old previously healthy man presented with 8 weeks of progressive dyspnea on exertion and cough. Prior to presentation, the patient was able to bicycle > 60 miles per week and work full-time in a home improvement store. He was up-to-date with age-appropriate cancer screening and immunizations, and home medications included famotidine for reflux and nonsteroidal antiinflammatories for osteoarthritis, both as-needed. He had no significant respiratory exposure, aside from previous work as an electrician. His symptoms began in mid-February 2...
Source: Chest - March 8, 2021 Category: Respiratory Medicine Authors: Dylan Werst Brittany Scarpato Sean J Callahan Mary Beth Scholand Source Type: research