Histamine Potentiates SARS-CoV-2 Spike Protein Entry Into Endothelial Cells
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which causes coronavirus disease (COVID-19) is one of the most serious global health crises in recent history. COVID-19 patient symptoms range from life-threatening to mild and asymptomatic, which presents unique problems in identifying, quarantining, and treating the affected individuals. The emergence of unusual symptoms among survivors, now referred to as “Long COVID”, is concerning, especially since much about the condition and the treatment of it is still relatively unknown. Evidence so far also suggests that some of these symptoms can be attributed to v...
Source: Frontiers in Pharmacology - April 25, 2022 Category: Drugs & Pharmacology Source Type: research

Famotidine activates the vagus nerve inflammatory reflex to attenuate cytokine storm
Conclusions. These observations reveal a previously unidentified vagus nerve-dependent anti-inflammatory effect of famotidine in the setting of cytokine storm which is not replicated by high dosages of other H2R antagonists in clinical use. Because famotidine is more potent when administered intrathecally, these findings are also consistent with a primarily central nervous system mechanism of action.PMID:35441176 | PMC:PMC9016653 | DOI:10.21203/rs.3.rs-1493296/v1 (Source: Cell Research)
Source: Cell Research - April 20, 2022 Category: Cytology Authors: Huan Yang Sam J George Dane- Thompson Harold A Silverman Tea Tsaava Aisling Tynan Valentin A Pavlov Eric Chang Ulf Andersson Michael Brines Sangeeta S Chavan Kevin J Tracey Source Type: research

Effect of common maintenance drugs on the risk and severity of COVID-19 in elderly patients
ConclusionMaintenance use of ACEI, ARB, warfarin, statins, direct factor Xa inhibitors and P2Y12 inhibitors was associated with reduction in risk of acquiring COVID-19 and dying from it. (Source: PLoS One)
Source: PLoS One - April 18, 2022 Category: Biomedical Science Authors: Kin Wah Fung Source Type: research

Oral famotidine versus placebo in non-hospitalised patients with COVID-19: a randomised, double-blind, data-intense, phase 2 clinical trial
Conclusions Famotidine was safe and well tolerated in outpatients with mild to moderate COVID-19. Famotidine led to earlier resolution of symptoms and inflammation without reducing anti-SARS-CoV-2 immunity. Additional randomised trials are required. (Source: Gut)
Source: Gut - April 8, 2022 Category: Gastroenterology Authors: Brennan, C. M., Nadella, S., Zhao, X., Dima, R. J., Jordan-Martin, N., Demestichas, B. R., Kleeman, S. O., Ferrer, M., von Gablenz, E. C., Mourikis, N., Rubin, M. E., Adnani, H., Lee, H., Ha, T., Prum, S., Schleicher, C. B., Fox, S. S., Ryan, M. G., Pili, Tags: Open access, Gut, COVID-19 Source Type: research

Montmorillonite-Famotidine/Chitosan Bio-nanocomposite Hydrogels as a Mucoadhesive/Gastro-Retentive Drug Delivery System
The main purpose of the present study was to fabricate the mucoadhesive bio-nanocomposite hydrogels to prolong the drug retention time in the stomach. In these bio-nanocomposite hydrogels, chitosan (CH) was used as the bioadhesive matrix, montmorillonite (MMT) was applied to modulate the release rate, and tripolyphosphate (TPP) was the crosslinking agent. The test samples analyzed via different methods such as XRD, FT-IR, TGA, and SEM. Drug incorporation efficacy and mucoadhesive strength of these nanocomposite hydrogel beads were studied. Swelling and in vitro drug release behaviors of these bio-nanocomposite hydrogels we...
Source: Iranian Journal of Pharmaceutical Research - April 6, 2022 Category: Drugs & Pharmacology Source Type: research

Isolated Hypoglossal Neuropathy due to Cervical Spondylosis Mimicking Lingual Angioedema
A woman in her 80s presented to the emergency department with a 4-month history of “tongue swelling,” mild drooling, difficulty in swallowing, and slurred speech that worsened during 1 day. Asymmetric lingual angioedema predominantly of the right side of the tongue secondary to lisinopril was suspected. The patient was treated with diphenhydramine, dexamethasone, famotidine, a nd tranexamic acid, then admitted to the hospital for observation. Lisinopril was discontinued after 4 years of treatment. (Source: Mayo Clinic Proceedings)
Source: Mayo Clinic Proceedings - April 1, 2022 Category: Internal Medicine Authors: Sri R. Sista, Greta B. Liebo, Nathan P. Young Tags: Medical image Source Type: research

A Novel Immune-Related Prognostic Signature Predicting Survival in Patients with Pancreatic Adenocarcinoma
J Oncol. 2022 Mar 18;2022:8909631. doi: 10.1155/2022/8909631. eCollection 2022.ABSTRACTPancreatic adenocarcinoma (PAAD) carries the lowest survival rate of all major organ cancers, which is of dismal prognosis and high mortality rate. Thus, the present study attempted to identify a few novel prognostic biomarkers and establish an immune-related prognostic signature which could predict the prognosis of PAAD. Four prognostic immune-related genes (IRGs) including S100A6, S100A10, S100A16, and SDC1 were screened by differentially expressed gene (DEG) identification and weighted gene coexpression network analysis (WGCNA). Subse...
Source: Journal of Oncology - March 28, 2022 Category: Cancer & Oncology Authors: Xiao Zhang Xiaomian Li Jun Xie Qian Zhu Yufeng Yuan Source Type: research

DDSolver Software Application for Quantitative Analysis of In Vitro Drug Release Behavior of the Gastroretentive Floating Tablets Combined with Radiological Study in Rabbits
CONCLUSION: DDSolver software was helpful in deciding the optimized formulation of FMT floating tablets. The radiological examination in rabbits for gastric retention was consistent with the release data analysis in vitro.PMID:35249487 | DOI:10.2174/1567201819666220304203014 (Source: Current Drug Delivery)
Source: Current Drug Delivery - March 7, 2022 Category: Drugs & Pharmacology Authors: Bazigha K Abdul Rasool Rana Sammour Source Type: research

DDSolver Software Application for Quantitative Analysis of In Vitro Drug Release Behavior of the Gastroretentive Floating Tablets Combined with Radiological Study in Rabbits
CONCLUSION: DDSolver software was helpful in deciding the optimized formulation of FMT floating tablets. The radiological examination in rabbits for gastric retention was consistent with the release data analysis in vitro.PMID:35249487 | DOI:10.2174/1567201819666220304203014 (Source: Current Drug Delivery)
Source: Current Drug Delivery - March 7, 2022 Category: Drugs & Pharmacology Authors: Bazigha K Abdul Rasool Rana Sammour Source Type: research

Valproic acid –associated proximal tubulopathy
A 6-year-old Asian boy with ring chromosome 14, global developmental delay, seizure disorder, asthma, chronic respiratory failure requiring ventilatory support, and gastrostomy tube dependence presented with acute kidney injury and Fanconi syndrome. He had been treated with valproic acid (800 mg daily via gastrostomy tube) for 3.5 years for seizure disorder. Other medications included zonisamide, clobazam, fluticasone, albuterol, montelukast, and famotidine. (Source: Kidney International)
Source: Kidney International - February 18, 2022 Category: Urology & Nephrology Authors: Satoru Kudose, Marissa Lipton, Namrata G. Jain, Vivette D. D ’Agati Tags: Nephrology Image Source Type: research

Comparison Table: Some Nonopioid Analgesics for Pain (online only)
Date: March 7, 2022 Issue #:  1645Summary:  View the Comparison Table: Some Nonopioid Analgesics for Pain (Source: The Medical Letter)
Source: The Medical Letter - February 18, 2022 Category: Drugs & Pharmacology Authors: admin Tags: Acetaminophen Advil Aleve Anaprox Arthrotec Aspirin Bayer Caldolor Cancer pain Celebrex Celecoxib Codeine Cytotec Diclofenac Diflunisal Duexis Dyloject Esomeprazole etodolac Famotidine Fenoprofen Feverall Flurbi Source Type: research

A Nanocrystal Platform Based on Metal-Phenolic Network Wrapping for Drug Solubilization
This study reports an exquisite platform for nanocrystal production based on a metal-phenolic network (MPN). MPN-wrapped nanocrystal particles (MPN-NPs) were fabricated through an anti-solvent precipitation method using tannic acid and FeIII or AlIII as coupling agents and characterized by dynamic light scattering, transmission electron microscope, ultraviolet and visible spectrophotometry, fourier-transform infrared spectroscopy, and X-ray powder diffraction. In vitro release, cytotoxicity, and stability were mainly studied with MPN-NPs loading paclitaxel. The suitability of MPN as a nanocrystal stabilizer was also invest...
Source: AAPS PharmSciTech - February 18, 2022 Category: Drugs & Pharmacology Authors: Feifei Huang Xiaohong Jiang Marwa A Sallam Xingwang Zhang Wei He Source Type: research

A Nanocrystal Platform Based on Metal-Phenolic Network Wrapping for Drug Solubilization
This study reports an exquisite platform for nanocrystal production based on a metal-phenolic network (MPN). MPN-wrapped nanocrystal particles (MPN-NPs) were fabricated through an anti-solvent precipitation method using tannic acid and FeIII or AlIII as coupling agents and characterized by dynamic light scattering, transmission electron microscope, ultraviolet and visible spectrophotometry, fourier-transform infrared spectroscopy, and X-ray powder diffraction. In vitro release, cytotoxicity, and stability were mainly studied with MPN-NPs loading paclitaxel. The suitability of MPN as a nanocrystal stabilizer was also invest...
Source: AAPS PharmSciTech - February 18, 2022 Category: Drugs & Pharmacology Authors: Feifei Huang Xiaohong Jiang Marwa A Sallam Xingwang Zhang Wei He Source Type: research

A Nanocrystal Platform Based on Metal-Phenolic Network Wrapping for Drug Solubilization
This study reports an exquisite platform for nanocrystal production based on a metal-phenolic network (MPN). MPN-wrapped nanocrystal particles (MPN-NPs) were fabricated through an anti-solvent precipitation method using tannic acid and FeIII or AlIII as coupling agents and characterized by dynamic light scattering, transmission electron microscope, ultraviolet and visible spectrophotometry, fourier-transform infrared spectroscopy, and X-ray powder diffraction. In vitro release, cytotoxicity, and stability were mainly studied with MPN-NPs loading paclitaxel. The suitability of MPN as a nanocrystal stabilizer was also invest...
Source: AAPS PharmSciTech - February 18, 2022 Category: Drugs & Pharmacology Authors: Feifei Huang Xiaohong Jiang Marwa A Sallam Xingwang Zhang Wei He Source Type: research

A Nanocrystal Platform Based on Metal-Phenolic Network Wrapping for Drug Solubilization
This study reports an exquisite platform for nanocrystal production based on a metal-phenolic network (MPN). MPN-wrapped nanocrystal particles (MPN-NPs) were fabricated through an anti-solvent precipitation method using tannic acid and FeIII or AlIII as coupling agents and characterized by dynamic light scattering, transmission electron microscope, ultraviolet and visible spectrophotometry, fourier-transform infrared spectroscopy, and X-ray powder diffraction. In vitro release, cytotoxicity, and stability were mainly studied with MPN-NPs loading paclitaxel. The suitability of MPN as a nanocrystal stabilizer was also invest...
Source: AAPS PharmSciTech - February 18, 2022 Category: Drugs & Pharmacology Authors: Feifei Huang Xiaohong Jiang Marwa A Sallam Xingwang Zhang Wei He Source Type: research