A Nanocrystal Platform Based on Metal-Phenolic Network Wrapping for Drug Solubilization
This study reports an exquisite platform for nanocrystal production based on a metal-phenolic network (MPN). MPN-wrapped nanocrystal particles (MPN-NPs) were fabricated through an anti-solvent precipitation method using tannic acid and FeIII or AlIII as coupling agents and characterized by dynamic light scattering, transmission electron microscope, ultraviolet and visible spectrophotometry, fourier-transform infrared spectroscopy, and X-ray powder diffraction. In vitro release, cytotoxicity, and stability were mainly studied with MPN-NPs loading paclitaxel. The suitability of MPN as a nanocrystal stabilizer was also invest...
Source: AAPS PharmSciTech - February 18, 2022 Category: Drugs & Pharmacology Authors: Feifei Huang Xiaohong Jiang Marwa A Sallam Xingwang Zhang Wei He Source Type: research
Mechanical Anisotropy and Tabletability of Famotidine Polymorphs
CrystEngComm, 2022, Accepted Manuscript DOI: 10.1039/D1CE01406D, PaperPratik Upadhyay, Manish Kumar Mishra, Upadrasta Ramamurty, Andrew David Bond In the drug development process, early characterization of solid forms can help to envisage the bulk processability of a powder, which should assist in selecting an optimal solid form. In... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - CrystEngComm latest articles)
Source: RSC - CrystEngComm latest articles - February 9, 2022 Category: Chemistry Authors: Pratik Upadhyay Source Type: research
Pentagalloyl Glucose, a Major Compound in Mango Seed Kernel, Exhibits Distinct Gastroprotective Effects in Indomethacin-Induced Gastropathy in Rats via Modulating the NO/eNOS/iNOS Signaling Pathway
Gastric ulcers are a common health disorder that affect up to 10% of the world’s population. The gastroprotective potential of pentagalloyl glucose (PGG) against indomethacin-induced ulcer in rats and the possible underlying mechanisms were investigated. Gastric ulceration was induced by indomethacin (single dose, 60 mg/kg). Pretreatment with PGG (100 or 200 mg/kg, orally) for 8 days prior to the administration of indomethacin furnished significant reductions in gastric mucosal lesions as well as a significant increase in mucus concentration. Also, PGG significantly declined the elevations in gastric mucosal MDA, TNF-...
Source: Frontiers in Pharmacology - February 4, 2022 Category: Drugs & Pharmacology Source Type: research
Therapeutic Status of Famotidine in COVID-19 Patients: A Review
Infect Disord Drug Targets. 2022 Jan 7. doi: 10.2174/1871526522666220107125511. Online ahead of print.ABSTRACTThe novel coronavirus, SARS-coV-2, which emerged in Wuhan in November 2019, has increasingly spread worldwide. More than 272 million cases of infection have been identified. COVID-19 affects 223 countries and territories across the world. The principal target of the SARS-CoV-2 infection is the lower respiratory tract. Series of moderate to non-specific severe clinical signs and symptoms that appear two to fourteen days after exposure to SARS-CoV-2 can occur in patients with COVID-19 disease. There is cough, breath ...
Source: Infectious Disorders Drug Targets - January 7, 2022 Category: Infectious Diseases Authors: Moein Mohseni Vahid Raissi Yasamin Sharifan Kimia Barikro Sasan Amiri Maedeh Sadat Mohseni Farid Raeisi Kimia Masoumi Sina Khodakarami Omid Raiesi Source Type: research
Therapeutic Status of Famotidine in COVID-19 Patients: A Review
Infect Disord Drug Targets. 2022 Jan 7. doi: 10.2174/1871526522666220107125511. Online ahead of print.ABSTRACTThe novel coronavirus, SARS-coV-2, which emerged in Wuhan in November 2019, has increasingly spread worldwide. More than 272 million cases of infection have been identified. COVID-19 affects 223 countries and territories across the world. The principal target of the SARS-CoV-2 infection is the lower respiratory tract. Series of moderate to non-specific severe clinical signs and symptoms that appear two to fourteen days after exposure to SARS-CoV-2 can occur in patients with COVID-19 disease. There is cough, breath ...
Source: Infectious Disorders Drug Targets - January 7, 2022 Category: Infectious Diseases Authors: Moein Mohseni Vahid Raissi Yasamin Sharifan Kimia Barikro Sasan Amiri Maedeh Sadat Mohseni Farid Raeisi Kimia Masoumi Sina Khodakarami Omid Raiesi Source Type: research
Orolingual Angioedema after Recombinant Tissue Plasminogen Activator Treatment in Acute Cardiogenic Cerebral Embolism Patient Using Olmesartan: A Case Report
We report a case of orolingual angioedema in an 82-year-old male patient who is taking ARB, which occurred after rt-PA administration for acute cerebral infarction. The patient, who has been on medications for hypertension including ARB (olmesartan 40 mg/day) and for hyperuricemia, was transported to our hospital with the chief complaint of right conjugate deviation of the eyes and left hemiplegia. Head magnetic resonance imaging revealed cerebral infarction in the right mesencephalic artery area including the insular cortex. He was diagnosed with cardiogenic cerebral embolism, and rt-PA administration was started 4 h afte...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - January 4, 2022 Category: Drugs & Pharmacology Authors: Chisa Minami Ryosuke Araki Tomoyuki Hamamoto Hideki Yamada Source Type: research
Orolingual Angioedema after Recombinant Tissue Plasminogen Activator Treatment in Acute Cardiogenic Cerebral Embolism Patient Using Olmesartan: A Case Report
We report a case of orolingual angioedema in an 82-year-old male patient who is taking ARB, which occurred after rt-PA administration for acute cerebral infarction. The patient, who has been on medications for hypertension including ARB (olmesartan 40 mg/day) and for hyperuricemia, was transported to our hospital with the chief complaint of right conjugate deviation of the eyes and left hemiplegia. Head magnetic resonance imaging revealed cerebral infarction in the right mesencephalic artery area including the insular cortex. He was diagnosed with cardiogenic cerebral embolism, and rt-PA administration was started 4 h afte...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - January 4, 2022 Category: Drugs & Pharmacology Authors: Chisa Minami Ryosuke Araki Tomoyuki Hamamoto Hideki Yamada Source Type: research
Orolingual Angioedema after Recombinant Tissue Plasminogen Activator Treatment in Acute Cardiogenic Cerebral Embolism Patient Using Olmesartan: A Case Report
We report a case of orolingual angioedema in an 82-year-old male patient who is taking ARB, which occurred after rt-PA administration for acute cerebral infarction. The patient, who has been on medications for hypertension including ARB (olmesartan 40 mg/day) and for hyperuricemia, was transported to our hospital with the chief complaint of right conjugate deviation of the eyes and left hemiplegia. Head magnetic resonance imaging revealed cerebral infarction in the right mesencephalic artery area including the insular cortex. He was diagnosed with cardiogenic cerebral embolism, and rt-PA administration was started 4 h afte...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - January 4, 2022 Category: Drugs & Pharmacology Authors: Chisa Minami Ryosuke Araki Tomoyuki Hamamoto Hideki Yamada Source Type: research
Orolingual Angioedema after Recombinant Tissue Plasminogen Activator Treatment in Acute Cardiogenic Cerebral Embolism Patient Using Olmesartan: A Case Report
We report a case of orolingual angioedema in an 82-year-old male patient who is taking ARB, which occurred after rt-PA administration for acute cerebral infarction. The patient, who has been on medications for hypertension including ARB (olmesartan 40 mg/day) and for hyperuricemia, was transported to our hospital with the chief complaint of right conjugate deviation of the eyes and left hemiplegia. Head magnetic resonance imaging revealed cerebral infarction in the right mesencephalic artery area including the insular cortex. He was diagnosed with cardiogenic cerebral embolism, and rt-PA administration was started 4 h afte...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - January 4, 2022 Category: Drugs & Pharmacology Authors: Chisa Minami Ryosuke Araki Tomoyuki Hamamoto Hideki Yamada Source Type: research
Orolingual Angioedema after Recombinant Tissue Plasminogen Activator Treatment in Acute Cardiogenic Cerebral Embolism Patient Using Olmesartan: A Case Report
We report a case of orolingual angioedema in an 82-year-old male patient who is taking ARB, which occurred after rt-PA administration for acute cerebral infarction. The patient, who has been on medications for hypertension including ARB (olmesartan 40 mg/day) and for hyperuricemia, was transported to our hospital with the chief complaint of right conjugate deviation of the eyes and left hemiplegia. Head magnetic resonance imaging revealed cerebral infarction in the right mesencephalic artery area including the insular cortex. He was diagnosed with cardiogenic cerebral embolism, and rt-PA administration was started 4 h afte...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - January 4, 2022 Category: Drugs & Pharmacology Authors: Chisa Minami Ryosuke Araki Tomoyuki Hamamoto Hideki Yamada Source Type: research
Orolingual Angioedema after Recombinant Tissue Plasminogen Activator Treatment in Acute Cardiogenic Cerebral Embolism Patient Using Olmesartan: A Case Report
We report a case of orolingual angioedema in an 82-year-old male patient who is taking ARB, which occurred after rt-PA administration for acute cerebral infarction. The patient, who has been on medications for hypertension including ARB (olmesartan 40 mg/day) and for hyperuricemia, was transported to our hospital with the chief complaint of right conjugate deviation of the eyes and left hemiplegia. Head magnetic resonance imaging revealed cerebral infarction in the right mesencephalic artery area including the insular cortex. He was diagnosed with cardiogenic cerebral embolism, and rt-PA administration was started 4 h afte...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - January 4, 2022 Category: Drugs & Pharmacology Authors: Chisa Minami Ryosuke Araki Tomoyuki Hamamoto Hideki Yamada Source Type: research
Association of the patterns of use of medications with mortality of COVID-19 infection: a hospital-based observational study
Conclusions
Recent randomised clinical trials support the safety of continuing ACE-I and ARB treatment in patients with COVID-19 where indicated. Our study extends these findings to suggest a possible COVID-19 survival benefit for continuing or initiating ACE-I, ARB and metformin medications. Randomised trials are appropriate to confirm or refute the therapeutic potential for ACE-I, ARBs and metformin. (Source: BMJ Open)
Source: BMJ Open - December 31, 2021 Category: General Medicine Authors: Wallace, A. W., Cirillo, P. M., Ryan, J. C., Krigbaum, N. Y., Badathala, A., Cohn, B. A. Tags: Open access, Epidemiology, COVID-19 Source Type: research
COVID-19: morphology and mechanism of the SARS-CoV-2, global outbreak, medication, vaccines and future of the virus
Front Biosci (Elite Ed). 2021 Dec 20;13(2):272-290. doi: 10.52586/E884.ABSTRACTSevere Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is a lethal virus that was detected back on 31st December 2019 in Wuhan, Hubei province in China, and since then this virus has been spreading across the globe causing a global outbreak and has left the world fighting against the virus. The disease caused by the SARS-CoV-2 was named COVID-19 and this was declared a pandemic disease by the World Health Organization on 11th March 2020. Several nations are trying to develop a vaccine that can save millions of lives. This review outlines t...
Source: Frontiers in Bioscience - Elite - December 23, 2021 Category: Biomedical Science Authors: Prithu Bhattacharyya Sunandana Das Sahasrabdi Aich Joy Sarkar Source Type: research
